Duplex Doppler sonographic assessment of the effects of diethylcarbamazine and albendazole therapy on adult filarial worms and adjacent host tissues in Bancroftian filariasis.
Identifieur interne : 008818 ( Main/Exploration ); précédent : 008817; suivant : 008819Duplex Doppler sonographic assessment of the effects of diethylcarbamazine and albendazole therapy on adult filarial worms and adjacent host tissues in Bancroftian filariasis.
Auteurs : Omar Hussein [Égypte] ; Maged El Setouhy ; Ehab S. Ahmed ; Amr M. Kandil ; Reda M R. Ramzy ; Hanan Helmy ; Gary J. WeilSource :
- The American journal of tropical medicine and hygiene [ 0002-9637 ] ; 2004.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Albendazole (usage thérapeutique), Animaux, Association de médicaments, Diéthylcarbamazine (usage thérapeutique), Femelle, Filaricides (usage thérapeutique), Filariose lymphatique (anatomopathologie), Filariose lymphatique (imagerie diagnostique), Filariose lymphatique (parasitologie), Filariose lymphatique (traitement médicamenteux), Humains, Mâle, Résultat thérapeutique, Scrotum (imagerie diagnostique), Système lymphatique (anatomopathologie), Wuchereria bancrofti (), Échographie-doppler.
- MESH :
- anatomopathologie : Filariose lymphatique, Système lymphatique.
- imagerie diagnostique : Filariose lymphatique, Scrotum.
- parasitologie : Filariose lymphatique.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Albendazole, Diéthylcarbamazine, Filaricides.
- Adulte, Adulte d'âge moyen, Animaux, Association de médicaments, Femelle, Humains, Mâle, Résultat thérapeutique, Wuchereria bancrofti, Échographie-doppler.
English descriptors
- KwdEn :
- Adult, Albendazole (therapeutic use), Animals, Diethylcarbamazine (therapeutic use), Drug Therapy, Combination, Elephantiasis, Filarial (diagnostic imaging), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (parasitology), Elephantiasis, Filarial (pathology), Female, Filaricides (therapeutic use), Humans, Lymphatic System (pathology), Male, Middle Aged, Scrotum (diagnostic imaging), Treatment Outcome, Ultrasonography, Doppler, Wuchereria bancrofti (drug effects).
- MESH :
- chemical , therapeutic use : Albendazole, Diethylcarbamazine, Filaricides.
- diagnostic imaging : Elephantiasis, Filarial, Scrotum.
- drug effects : Wuchereria bancrofti.
- drug therapy : Elephantiasis, Filarial.
- parasitology : Elephantiasis, Filarial.
- pathology : Elephantiasis, Filarial, Lymphatic System.
- Adult, Animals, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Treatment Outcome, Ultrasonography, Doppler.
Abstract
We used duplex Doppler sonography to assess effects of diethylcarbamazine and albendazole therapy (DEC/ALB) on adult Wuchereria bancrofti in vivo. The study was performed in clinically normal Egyptian adults with blood microfilaria counts > 80/mL. Motile adult worms were observed before treatment in dilated scrotal lymphatic vessels in 28 of 36 men (78%) and over the proximal extremities in 5 of 22 women (23%). Most worm nests were inactivated in the months following treatment (90% at 12 months). Circulating filarial antigen levels (a marker for living adult worms) also fell dramatically following treatment. Some men had intrascrotal calcifications and/or non-palpable hydroceles detectable by ultrasound before they were treated. New hydroceles and intrascrotal calcifications appeared after treatment in many cases. However, most of these were transient and of no clinical significance. Prevelance rates for hydrocele and intrascrotal calcifications 24 months after treatment were essentially the same as those prior to treatment. These results show that DEC/ALB is highly active against adult W. bancrofti. They also suggest that host responses to dying adult worms are important in the pathogenesis of filarial hydroceles.
PubMed: 15516645
Affiliations:
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Ahmed</name></author><author><name sortKey="Kandil, Amr M" sort="Kandil, Amr M" uniqKey="Kandil A" first="Amr M" last="Kandil">Amr M. Kandil</name></author><author><name sortKey="Ramzy, Reda M R" sort="Ramzy, Reda M R" uniqKey="Ramzy R" first="Reda M R" last="Ramzy">Reda M R. Ramzy</name></author><author><name sortKey="Helmy, Hanan" sort="Helmy, Hanan" uniqKey="Helmy H" first="Hanan" last="Helmy">Hanan Helmy</name></author><author><name sortKey="Weil, Gary J" sort="Weil, Gary J" uniqKey="Weil G" first="Gary J" last="Weil">Gary J. 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The study was performed in clinically normal Egyptian adults with blood microfilaria counts > 80/mL. Motile adult worms were observed before treatment in dilated scrotal lymphatic vessels in 28 of 36 men (78%) and over the proximal extremities in 5 of 22 women (23%). Most worm nests were inactivated in the months following treatment (90% at 12 months). Circulating filarial antigen levels (a marker for living adult worms) also fell dramatically following treatment. Some men had intrascrotal calcifications and/or non-palpable hydroceles detectable by ultrasound before they were treated. New hydroceles and intrascrotal calcifications appeared after treatment in many cases. However, most of these were transient and of no clinical significance. Prevelance rates for hydrocele and intrascrotal calcifications 24 months after treatment were essentially the same as those prior to treatment. These results show that DEC/ALB is highly active against adult W. bancrofti. They also suggest that host responses to dying adult worms are important in the pathogenesis of filarial hydroceles.</div></front></TEI><affiliations><list><country><li>Égypte</li></country></list><tree><noCountry><name sortKey="Ahmed, Ehab S" sort="Ahmed, Ehab S" uniqKey="Ahmed E" first="Ehab S" last="Ahmed">Ehab S. Ahmed</name><name sortKey="El Setouhy, Maged" sort="El Setouhy, Maged" uniqKey="El Setouhy M" first="Maged" last="El Setouhy">Maged El Setouhy</name><name sortKey="Helmy, Hanan" sort="Helmy, Hanan" uniqKey="Helmy H" first="Hanan" last="Helmy">Hanan Helmy</name><name sortKey="Kandil, Amr M" sort="Kandil, Amr M" uniqKey="Kandil A" first="Amr M" last="Kandil">Amr M. Kandil</name><name sortKey="Ramzy, Reda M R" sort="Ramzy, Reda M R" uniqKey="Ramzy R" first="Reda M R" last="Ramzy">Reda M R. Ramzy</name><name sortKey="Weil, Gary J" sort="Weil, Gary J" uniqKey="Weil G" first="Gary J" last="Weil">Gary J. Weil</name></noCountry><country name="Égypte"><noRegion><name sortKey="Hussein, Omar" sort="Hussein, Omar" uniqKey="Hussein O" first="Omar" last="Hussein">Omar Hussein</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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