LymphedemaV1, Main, Exploration, bibRecord, 008002

Diminished Monocyte Function in Microfilaremic Patients with Lymphatic Filariasis and Its Relationship to Altered Lymphoproliferative Responses

Identifieur interne : 008002 ( Main/Exploration ); précédent : 008001; suivant : 008003

Diminished Monocyte Function in Microfilaremic Patients with Lymphatic Filariasis and Its Relationship to Altered Lymphoproliferative Responses

Auteurs : B. Sasisekhar ; M. Aparna ; D. J. Augustin ; P. Kaliraj ; S. K. Kar ; T. B. Nutman ; R. B. Narayanan

Source :

Infection and Immunity [ 0019-9567 ] ; 2005.

RBID : PMC:1111826

Descripteurs français

KwdFr :
- Activation des lymphocytes, Adhérence cellulaire, Adolescent, Adulte, Adulte d'âge moyen, Antigènes CD14 (physiologie), Antigènes d'helminthe (immunologie), Enfant, Femelle, Filariose lymphatique (immunologie), Humains, Interféron gamma (biosynthèse), Interleukine-1 (biosynthèse), Monocytes (physiologie), Mâle, Parasitémie (immunologie), Protéines d'helminthes (immunologie).
MESH :
- biosynthèse : Interféron gamma, Interleukine-1.
- immunologie : Antigènes d'helminthe, Filariose lymphatique, Parasitémie, Protéines d'helminthes.
- physiologie : Antigènes CD14, Monocytes.
- Activation des lymphocytes, Adhérence cellulaire, Adolescent, Adulte, Adulte d'âge moyen, Enfant, Femelle, Humains, Mâle.

English descriptors

KwdEn :
- Adolescent, Adult, Antigens, CD14 (physiology), Antigens, Helminth (immunology), Cell Adhesion, Child, Elephantiasis, Filarial (immunology), Female, Helminth Proteins (immunology), Humans, Interferon-gamma (biosynthesis), Interleukin-1 (biosynthesis), Lymphocyte Activation, Male, Middle Aged, Monocytes (physiology), Parasitemia (immunology).
MESH :
- chemical , biosynthesis : Interferon-gamma, Interleukin-1.
- chemical , immunology : Antigens, Helminth, Helminth Proteins.
- chemical , physiology : Antigens, CD14.
- immunology : Elephantiasis, Filarial, Parasitemia.
- physiology : Monocytes.
- Adolescent, Adult, Cell Adhesion, Child, Female, Humans, Lymphocyte Activation, Male, Middle Aged.

Abstract

Antigen-specific hyporesponsiveness to filarial antigens is a phenomenon observed in patent infection with lymph-dwelling filarial parasites of humans. This phenomenon has been attributed to a multitude of factors, one of which is altered monocyte function. To examine the role played by monocytes in filarial infection, we assessed the responses of monocytes obtained from normal and filarial parasite-infected individuals to both crude filarial antigen and purified recombinant filarial antigen WbSXP-1 and attempted to relate these to the altered lymphoproliferative responses seen in filarial infection. Monocytes from microfilaremic (MF) patients demonstrated an inability to respond to lipopolysaccharide compared to monocytes from endemic normal persons or from lymphedema patients. Indeed, interleukin 1β (IL-1β) production was severely limited, a finding that did not extend to monocyte responses to filarial antigens. Serum from MF patients reduced adherence and spreading of normal monocytes, a finding not seen with serum from the other clinical groups. Interestingly, there was a significant correlation between the production of IL-1β and adherence. Moreover, the levels of spontaneous production of IL-1β correlated with high levels of spontaneous secretion of IL-10. The effects observed were not a result of diminished viability or alteration in the expression of the cell surface markers CD14 and HLA-DR. These data suggest that monocyte function is dampened in MF patients, a finding which could alter lymphoproliferative responses during patent infection.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1111826

DOI: 10.1128/IAI.73.6.3385-3393.2005
PubMed: 15908365
PubMed Central: 1111826

Affiliations:

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<front><div type="abstract" xml:lang="en"><p>Antigen-specific hyporesponsiveness to filarial antigens is a phenomenon observed in patent infection with lymph-dwelling filarial parasites of humans. This phenomenon has been attributed to a multitude of factors, one of which is altered monocyte function. To examine the role played by monocytes in filarial infection, we assessed the responses of monocytes obtained from normal and filarial parasite-infected individuals to both crude filarial antigen and purified recombinant filarial antigen WbSXP-1 and attempted to relate these to the altered lymphoproliferative responses seen in filarial infection. Monocytes from microfilaremic (MF) patients demonstrated an inability to respond to lipopolysaccharide compared to monocytes from endemic normal persons or from lymphedema patients. Indeed, interleukin 1β (IL-1β) production was severely limited, a finding that did not extend to monocyte responses to filarial antigens. Serum from MF patients reduced adherence and spreading of normal monocytes, a finding not seen with serum from the other clinical groups. Interestingly, there was a significant correlation between the production of IL-1β and adherence. Moreover, the levels of spontaneous production of IL-1β correlated with high levels of spontaneous secretion of IL-10. The effects observed were not a result of diminished viability or alteration in the expression of the cell surface markers CD14 and HLA-DR. These data suggest that monocyte function is dampened in MF patients, a finding which could alter lymphoproliferative responses during patent infection.</p>
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Diminished Monocyte Function in Microfilaremic Patients with Lymphatic Filariasis and Its Relationship to Altered Lymphoproliferative Responses

Diminished Monocyte Function in Microfilaremic Patients with Lymphatic Filariasis and Its Relationship to Altered Lymphoproliferative Responses

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

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Pour générer des pages wiki

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