Does longevity of adult Wuchereria bancrofti increase with decreasing intensity of parasite transmission? Insights from clinical observations.
Identifieur interne : 008000 ( Main/Exploration ); précédent : 007F99; suivant : 008001Does longevity of adult Wuchereria bancrofti increase with decreasing intensity of parasite transmission? Insights from clinical observations.
Auteurs : Gerusa Dreyer [Brésil] ; David Addiss ; Joaquim Nor EsSource :
- Transactions of the Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 2005.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Animaux, Brésil, Diéthylcarbamazine (pharmacologie), Filaricides (pharmacologie), Filariose lymphatique (imagerie diagnostique), Filariose lymphatique (parasitologie), Filariose lymphatique (transmission), Humains, Interactions hôte-parasite, Longévité, Maladie chronique, Mâle, Méthodes épidémiologiques, Résistance aux substances, Scrotum (parasitologie), Wuchereria bancrofti (), Wuchereria bancrofti (isolement et purification), Wuchereria bancrofti (physiologie), Échographie.
- MESH :
- imagerie diagnostique : Filariose lymphatique.
- isolement et purification : Wuchereria bancrofti.
- parasitologie : Filariose lymphatique, Scrotum.
- pharmacologie : Diéthylcarbamazine, Filaricides.
- physiologie : Wuchereria bancrofti.
- Adolescent, Adulte, Animaux, Brésil, Filariose lymphatique, Humains, Interactions hôte-parasite, Longévité, Maladie chronique, Mâle, Méthodes épidémiologiques, Résistance aux substances, Wuchereria bancrofti, Échographie.
English descriptors
- KwdEn :
- Adolescent, Adult, Animals, Brazil, Chronic Disease, Diethylcarbamazine (pharmacology), Drug Resistance, Elephantiasis, Filarial (diagnostic imaging), Elephantiasis, Filarial (parasitology), Elephantiasis, Filarial (transmission), Epidemiologic Methods, Filaricides (pharmacology), Host-Parasite Interactions, Humans, Longevity, Male, Scrotum (parasitology), Ultrasonography, Wuchereria bancrofti (drug effects), Wuchereria bancrofti (isolation & purification), Wuchereria bancrofti (physiology).
- MESH :
- chemical , pharmacology : Diethylcarbamazine, Filaricides.
- diagnostic imaging : Elephantiasis, Filarial.
- drug effects : Wuchereria bancrofti.
- isolation & purification : Wuchereria bancrofti.
- parasitology : Elephantiasis, Filarial, Scrotum.
- physiology : Wuchereria bancrofti.
- transmission : Elephantiasis, Filarial.
- Adolescent, Adult, Animals, Brazil, Chronic Disease, Drug Resistance, Epidemiologic Methods, Host-Parasite Interactions, Humans, Longevity, Male, Ultrasonography.
Abstract
To interrupt transmission of Wuchereria bancrofti, a parasite that causes lymphatic filariasis, mass treatment of at-risk populations with antifilarial drugs is recommended for 4-6 years, the minimum estimated adult worm lifespan. Factors associated with adult worm longevity are unknown. In Recife, Brazil, we conducted a retrospective cohort study of 57 men whose adult W. bancrofti were not sensitive to diethylcarbamazine and who were followed with semi-annual physical examinations (to detect intrascrotal nodules, indicative of adult worm death) and ultrasound examinations (to detect the 'filaria dance sign' (FDS), indicative of living adult worms). After 5 years, the FDS remained detectable in 10 (24.4%) of 41 adult worm nests in 25 men from areas of high filariasis transmission intensity and in 30 (90.9%) of 33 nests in 32 men from areas of low transmission (P<0.001). New nodules and adult worm nests were detected only in men from high-transmission areas. Of 30 men who were microfilaria-positive initially and whose FDS remained detectable after 5 years of follow-up, 19 (63.3%) remained microfilaria-positive in 5 ml blood (mean density, 0.4 per ml). In conclusion, survival of adult W. bancrofti is inversely associated with transmission intensity. These findings have implications for filariasis elimination and research.
DOI: 10.1016/j.trstmh.2005.05.006
PubMed: 16165175
Affiliations:
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Factors associated with adult worm longevity are unknown. In Recife, Brazil, we conducted a retrospective cohort study of 57 men whose adult W. bancrofti were not sensitive to diethylcarbamazine and who were followed with semi-annual physical examinations (to detect intrascrotal nodules, indicative of adult worm death) and ultrasound examinations (to detect the 'filaria dance sign' (FDS), indicative of living adult worms). After 5 years, the FDS remained detectable in 10 (24.4%) of 41 adult worm nests in 25 men from areas of high filariasis transmission intensity and in 30 (90.9%) of 33 nests in 32 men from areas of low transmission (P<0.001). New nodules and adult worm nests were detected only in men from high-transmission areas. Of 30 men who were microfilaria-positive initially and whose FDS remained detectable after 5 years of follow-up, 19 (63.3%) remained microfilaria-positive in 5 ml blood (mean density, 0.4 per ml). In conclusion, survival of adult W. bancrofti is inversely associated with transmission intensity. These findings have implications for filariasis elimination and research.</div></front></TEI><affiliations><list><country><li>Brésil</li></country><region><li>Pernambuco</li></region></list><tree><noCountry><name sortKey="Addiss, David" sort="Addiss, David" uniqKey="Addiss D" first="David" last="Addiss">David Addiss</name><name sortKey="Nor Es, Joaquim" sort="Nor Es, Joaquim" uniqKey="Nor Es J" first="Joaquim" last="Nor Es">Joaquim Nor Es</name></noCountry><country name="Brésil"><region name="Pernambuco"><name sortKey="Dreyer, Gerusa" sort="Dreyer, Gerusa" uniqKey="Dreyer G" first="Gerusa" last="Dreyer">Gerusa Dreyer</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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