Prenatal T Cell Immunity to Wuchereria bancrofti and Its Effect on Filarial Immunity and Infection Susceptibility during Childhood
Identifieur interne : 007A72 ( Main/Exploration ); précédent : 007A71; suivant : 007A73Prenatal T Cell Immunity to Wuchereria bancrofti and Its Effect on Filarial Immunity and Infection Susceptibility during Childhood
Auteurs :Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2006-04-01.
Abstract
BackgroundAntenatal immune experience with Wuchereria bancrofti due to maternal filariasis may influence susceptibility to infection. We tested the hypothesis that filarial-specific T cell responses at birth that are indicative of in utero tolerance or sensitization affect the evolution of filarial-specific immunity and susceptibility to W. bancrofti infection during childhood MethodsA birth-cohort study of 159 Kenyan newborns was performed. Cord blood and peripheral blood were obtained annually to age 7 years and were assayed for filarial infection and filarial antigen–driven interferon (IFN)–γ, interleukin (IL)–2, IL-5, and IL-13 production by lymphocytes ResultsThere was a 12.9-fold (95% confidence interval [CI], 2.5–107.2-fold) and a 4.8-fold (95% CI, 1.7–12.9-fold) increased risk of infection for immune-tolerant newborns (maternal infection present during gestation, with no filarial antigen–driven cord blood T cell response [n=25]), compared with immune-sensitized (maternal infection present with cord blood T cell response [n=24]) and unexposed (maternal infection absent [n=110]) newborns. Cytokine responses developed at a later age in tolerant newborns, were characterized by impaired IFN-γ responses, and contrasted with those of filarial-sensitized newborns, who had sustained and elevated IL-5 and IL-13 responses to age 7 years ConclusionPrenatal immune experience, as determined by whether in utero priming to filarial antigen occurs, is a major determinant of childhood susceptibility to W. bancrofti infection
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DOI: 10.1086/500472
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