LymphedemaV1, Main, Exploration, bibRecord, 007A29

CRSBP-1/LYVE-1-null Mice Exhibit Identifiable Morphological and Functional Alterations of Lymphatic Capillary Vessels

Identifieur interne : 007A29 ( Main/Exploration ); précédent : 007A28; suivant : 007A30

CRSBP-1/LYVE-1-null Mice Exhibit Identifiable Morphological and Functional Alterations of Lymphatic Capillary Vessels

Auteurs : Shuan S. Huang [États-Unis] ; I-Hua Liu [États-Unis] ; Tracy Smith [États-Unis] ; Maulik R. Shah [États-Unis] ; Frank E. Johnson [États-Unis] ; Jung S. Huang [États-Unis]

Source :

FEBS letters [ 0014-5793 ] ; 2006.

RBID : PMC:3125019

Abstract

CRSBP-1, a membrane glycoprotein, can mediate cell-surface retention of secreted growth factors containing CRS motifs such as PDGF-BB. CRSBP-1 has recently been found to be identical to LYVE-1, a specific marker for lymphatic capillary endothelial cells. The in vivo role of CRSBP-1/LYVE-1 is unknown. CRSBP-1-null mice are overtly normal and fertile but exhibit identifiable morphological and functional alterations of lymphatic capillary vessels in certain tissues, marked by the constitutively increased interstitial-lymphatic flow and lack of typical irregularly-shaped lumens. The CRSBP-1 ligands PDGF-BB and HA enhance interstitial-lymphatic flow in wild-type mice but not in CRSBP-1-null animals.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125019

DOI: 10.1016/j.febslet.2006.10.028
PubMed: 17070806
PubMed Central: 3125019

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p id="P1">CRSBP-1, a membrane glycoprotein, can mediate cell-surface retention of secreted growth factors containing CRS motifs such as PDGF-BB. CRSBP-1 has recently been found to be identical to LYVE-1, a specific marker for lymphatic capillary endothelial cells. The <italic>in vivo</italic>
 role of CRSBP-1/LYVE-1 is unknown. CRSBP-1-null mice are overtly normal and fertile but exhibit identifiable morphological and functional alterations of lymphatic capillary vessels in certain tissues, marked by the constitutively increased interstitial-lymphatic flow and lack of typical irregularly-shaped lumens. The CRSBP-1 ligands PDGF-BB and HA enhance interstitial-lymphatic flow in wild-type mice but not in CRSBP-1-null animals.</p>
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CRSBP-1/LYVE-1-null Mice Exhibit Identifiable Morphological and Functional Alterations of Lymphatic Capillary Vessels

CRSBP-1/LYVE-1-null Mice Exhibit Identifiable Morphological and Functional Alterations of Lymphatic Capillary Vessels

Source :

Abstract

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