Yellow nail syndrome: treatment with octreotide
Identifieur interne : 007402 ( Main/Exploration ); précédent : 007401; suivant : 007403Yellow nail syndrome: treatment with octreotide
Auteurs : Gunnar Hillerdal [Suède]Source :
- The Clinical Respiratory Journal [ 1752-6981 ] ; 2007-12.
Abstract
Introduction: The yellow nail syndrome (YNS) is the triad of ‘yellow’ nails, peripheral oedema and pleural effusions. For diagnosis, which is clinical, at least two of these findings are necessary. Also typical is a long‐standing chronic cough often caused by low‐grade bronchiectases. The pleural effusions often require pleurodesis. The pathogenesis is probably a dysfunction of the lymphatic system (1, 2). Octreotide regulates the release of growth hormone and thyrotropin, and also has effects on the gastro‐intestinal tract, where it inhibits glandular secretion, neurotransmission, smooth‐muscle contraction and absorption of nutrients. Adverse effects are nausea, abdominal cramps, diarrhoea, malabsorption of fat and flatulence (3). Because of the inhibition of absorption of fats and other nutrients, octreotide has been useful in chylothorax from many different causes (4). The pleural effusion in YNS is usually an exudate, but in rare cases a frank chylothorax. One such case with successful octreotide treatment has been described in the literature (5).
Url:
DOI: 10.1111/j.1752-699X.2007.00022.x
Affiliations:
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