LymphedemaV1, Main, Exploration, bibRecord, 007292

Dynamic imaging of lymphatic vessels and lymph nodes using a bimodal nanoparticulate contrast agent.

Identifieur interne : 007292 ( Main/Exploration ); précédent : 007291; suivant : 007293

Dynamic imaging of lymphatic vessels and lymph nodes using a bimodal nanoparticulate contrast agent.

Auteurs : Rawad Mounzer [États-Unis] ; Pavel Shkarin ; Xenophon Papademetris ; Todd Constable ; Nancy H. Ruddle ; Tarek M. Fahmy

Source :

Lymphatic research and biology [ 1539-6851 ] ; 2007.

RBID : pubmed:18035933

Descripteurs français

KwdFr :
- Animaux, Dendrimères, Femelle, Humains, Imagerie par résonance magnétique, Lymphographie, Maladies lymphatiques (diagnostic), Microscopie de fluorescence, Nanoparticules (), Noeuds lymphatiques (anatomie et histologie), Polyamines (), Produits de contraste (), Souris, Souris de lignée C57BL, Vaisseaux lymphatiques (anatomie et histologie).
MESH :
- anatomie et histologie : Noeuds lymphatiques, Vaisseaux lymphatiques.
- diagnostic : Maladies lymphatiques.
- Animaux, Dendrimères, Femelle, Humains, Imagerie par résonance magnétique, Lymphographie, Microscopie de fluorescence, Nanoparticules, Polyamines, Produits de contraste, Souris, Souris de lignée C57BL.

English descriptors

KwdEn :
- Animals, Contrast Media (chemistry), Dendrimers, Female, Humans, Lymph Nodes (anatomy & histology), Lymphatic Diseases (diagnosis), Lymphatic Vessels (anatomy & histology), Lymphography, Magnetic Resonance Imaging, Mice, Mice, Inbred C57BL, Microscopy, Fluorescence, Nanoparticles (chemistry), Polyamines (chemistry).
MESH :
- chemical , chemistry : Contrast Media, Polyamines.
- anatomy & histology : Lymph Nodes, Lymphatic Vessels.
- chemistry : Nanoparticles.
- diagnosis : Lymphatic Diseases.
- Animals, Dendrimers, Female, Humans, Lymphography, Magnetic Resonance Imaging, Mice, Mice, Inbred C57BL, Microscopy, Fluorescence.

Abstract

Evaluation of lymphedema and lymph node metastasis in humans has relied primarily on invasive or radioactive modalities. While noninvasive technologies such as magnetic resonance imaging (MRI) offer the potential for true three-dimensional imaging of lymphatic structures, invasive modalities, such as optical fluorescence microscopy, provide higher resolution and clearer delineation of both lymph nodes and lymphatic vessels. Thus, contrast agents that image lymphatic vessels and lymph nodes by both fluorescence and MRI may further enhance our understanding of the structure and function of the lymphatic system. Recent applications of bimodal (fluorescence and MR) contrast agents in mice have not achieved clear visualization of lymphatic vessels and nodes. Here the authors describe the development of a nanoparticulate contrast agent that is taken up by lymphatic vessels to draining lymph nodes and detected by both modalities.

DOI: 10.1089/lrb.2007.5302
PubMed: 18035933

Affiliations:

États-Unis

Le document en format XML

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<term>Lymph Nodes (anatomy & histology)</term>
<term>Lymphatic Diseases (diagnosis)</term>
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<front><div type="abstract" xml:lang="en">Evaluation of lymphedema and lymph node metastasis in humans has relied primarily on invasive or radioactive modalities. While noninvasive technologies such as magnetic resonance imaging (MRI) offer the potential for true three-dimensional imaging of lymphatic structures, invasive modalities, such as optical fluorescence microscopy, provide higher resolution and clearer delineation of both lymph nodes and lymphatic vessels. Thus, contrast agents that image lymphatic vessels and lymph nodes by both fluorescence and MRI may further enhance our understanding of the structure and function of the lymphatic system. Recent applications of bimodal (fluorescence and MR) contrast agents in mice have not achieved clear visualization of lymphatic vessels and nodes. Here the authors describe the development of a nanoparticulate contrast agent that is taken up by lymphatic vessels to draining lymph nodes and detected by both modalities.</div>
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Serveur d'exploration sur le lymphœdème

Dynamic imaging of lymphatic vessels and lymph nodes using a bimodal nanoparticulate contrast agent.

Dynamic imaging of lymphatic vessels and lymph nodes using a bimodal nanoparticulate contrast agent.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
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