Dynamic imaging of lymphatic vessels and lymph nodes using a bimodal nanoparticulate contrast agent.
Identifieur interne : 007292 ( Main/Exploration ); précédent : 007291; suivant : 007293Dynamic imaging of lymphatic vessels and lymph nodes using a bimodal nanoparticulate contrast agent.
Auteurs : Rawad Mounzer [États-Unis] ; Pavel Shkarin ; Xenophon Papademetris ; Todd Constable ; Nancy H. Ruddle ; Tarek M. FahmySource :
- Lymphatic research and biology [ 1539-6851 ] ; 2007.
Descripteurs français
- KwdFr :
- Animaux, Dendrimères, Femelle, Humains, Imagerie par résonance magnétique, Lymphographie, Maladies lymphatiques (diagnostic), Microscopie de fluorescence, Nanoparticules (), Noeuds lymphatiques (anatomie et histologie), Polyamines (), Produits de contraste (), Souris, Souris de lignée C57BL, Vaisseaux lymphatiques (anatomie et histologie).
- MESH :
- anatomie et histologie : Noeuds lymphatiques, Vaisseaux lymphatiques.
- diagnostic : Maladies lymphatiques.
- Animaux, Dendrimères, Femelle, Humains, Imagerie par résonance magnétique, Lymphographie, Microscopie de fluorescence, Nanoparticules, Polyamines, Produits de contraste, Souris, Souris de lignée C57BL.
English descriptors
- KwdEn :
- Animals, Contrast Media (chemistry), Dendrimers, Female, Humans, Lymph Nodes (anatomy & histology), Lymphatic Diseases (diagnosis), Lymphatic Vessels (anatomy & histology), Lymphography, Magnetic Resonance Imaging, Mice, Mice, Inbred C57BL, Microscopy, Fluorescence, Nanoparticles (chemistry), Polyamines (chemistry).
- MESH :
- chemical , chemistry : Contrast Media, Polyamines.
- anatomy & histology : Lymph Nodes, Lymphatic Vessels.
- chemistry : Nanoparticles.
- diagnosis : Lymphatic Diseases.
- Animals, Dendrimers, Female, Humans, Lymphography, Magnetic Resonance Imaging, Mice, Mice, Inbred C57BL, Microscopy, Fluorescence.
Abstract
Evaluation of lymphedema and lymph node metastasis in humans has relied primarily on invasive or radioactive modalities. While noninvasive technologies such as magnetic resonance imaging (MRI) offer the potential for true three-dimensional imaging of lymphatic structures, invasive modalities, such as optical fluorescence microscopy, provide higher resolution and clearer delineation of both lymph nodes and lymphatic vessels. Thus, contrast agents that image lymphatic vessels and lymph nodes by both fluorescence and MRI may further enhance our understanding of the structure and function of the lymphatic system. Recent applications of bimodal (fluorescence and MR) contrast agents in mice have not achieved clear visualization of lymphatic vessels and nodes. Here the authors describe the development of a nanoparticulate contrast agent that is taken up by lymphatic vessels to draining lymph nodes and detected by both modalities.
DOI: 10.1089/lrb.2007.5302
PubMed: 18035933
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 003467
- to stream PubMed, to step Curation: 003467
- to stream PubMed, to step Checkpoint: 003467
- to stream Ncbi, to step Merge: 002A26
- to stream Ncbi, to step Curation: 002A26
- to stream Ncbi, to step Checkpoint: 002A26
- to stream Main, to step Merge: 007437
- to stream Main, to step Curation: 007292
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dynamic imaging of lymphatic vessels and lymph nodes using a bimodal nanoparticulate contrast agent.</title>
<author><name sortKey="Mounzer, Rawad" sort="Mounzer, Rawad" uniqKey="Mounzer R" first="Rawad" last="Mounzer">Rawad Mounzer</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520</wicri:regionArea>
<wicri:noRegion>Connecticut 06520</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shkarin, Pavel" sort="Shkarin, Pavel" uniqKey="Shkarin P" first="Pavel" last="Shkarin">Pavel Shkarin</name>
</author>
<author><name sortKey="Papademetris, Xenophon" sort="Papademetris, Xenophon" uniqKey="Papademetris X" first="Xenophon" last="Papademetris">Xenophon Papademetris</name>
</author>
<author><name sortKey="Constable, Todd" sort="Constable, Todd" uniqKey="Constable T" first="Todd" last="Constable">Todd Constable</name>
</author>
<author><name sortKey="Ruddle, Nancy H" sort="Ruddle, Nancy H" uniqKey="Ruddle N" first="Nancy H" last="Ruddle">Nancy H. Ruddle</name>
</author>
<author><name sortKey="Fahmy, Tarek M" sort="Fahmy, Tarek M" uniqKey="Fahmy T" first="Tarek M" last="Fahmy">Tarek M. Fahmy</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2007">2007</date>
<idno type="RBID">pubmed:18035933</idno>
<idno type="pmid">18035933</idno>
<idno type="doi">10.1089/lrb.2007.5302</idno>
<idno type="wicri:Area/PubMed/Corpus">003467</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003467</idno>
<idno type="wicri:Area/PubMed/Curation">003467</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003467</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003467</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003467</idno>
<idno type="wicri:Area/Ncbi/Merge">002A26</idno>
<idno type="wicri:Area/Ncbi/Curation">002A26</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002A26</idno>
<idno type="wicri:doubleKey">1539-6851:2007:Mounzer R:dynamic:imaging:of</idno>
<idno type="wicri:Area/Main/Merge">007437</idno>
<idno type="wicri:Area/Main/Curation">007292</idno>
<idno type="wicri:Area/Main/Exploration">007292</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Dynamic imaging of lymphatic vessels and lymph nodes using a bimodal nanoparticulate contrast agent.</title>
<author><name sortKey="Mounzer, Rawad" sort="Mounzer, Rawad" uniqKey="Mounzer R" first="Rawad" last="Mounzer">Rawad Mounzer</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520</wicri:regionArea>
<wicri:noRegion>Connecticut 06520</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shkarin, Pavel" sort="Shkarin, Pavel" uniqKey="Shkarin P" first="Pavel" last="Shkarin">Pavel Shkarin</name>
</author>
<author><name sortKey="Papademetris, Xenophon" sort="Papademetris, Xenophon" uniqKey="Papademetris X" first="Xenophon" last="Papademetris">Xenophon Papademetris</name>
</author>
<author><name sortKey="Constable, Todd" sort="Constable, Todd" uniqKey="Constable T" first="Todd" last="Constable">Todd Constable</name>
</author>
<author><name sortKey="Ruddle, Nancy H" sort="Ruddle, Nancy H" uniqKey="Ruddle N" first="Nancy H" last="Ruddle">Nancy H. Ruddle</name>
</author>
<author><name sortKey="Fahmy, Tarek M" sort="Fahmy, Tarek M" uniqKey="Fahmy T" first="Tarek M" last="Fahmy">Tarek M. Fahmy</name>
</author>
</analytic>
<series><title level="j">Lymphatic research and biology</title>
<idno type="ISSN">1539-6851</idno>
<imprint><date when="2007" type="published">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Contrast Media (chemistry)</term>
<term>Dendrimers</term>
<term>Female</term>
<term>Humans</term>
<term>Lymph Nodes (anatomy & histology)</term>
<term>Lymphatic Diseases (diagnosis)</term>
<term>Lymphatic Vessels (anatomy & histology)</term>
<term>Lymphography</term>
<term>Magnetic Resonance Imaging</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Microscopy, Fluorescence</term>
<term>Nanoparticles (chemistry)</term>
<term>Polyamines (chemistry)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Dendrimères</term>
<term>Femelle</term>
<term>Humains</term>
<term>Imagerie par résonance magnétique</term>
<term>Lymphographie</term>
<term>Maladies lymphatiques (diagnostic)</term>
<term>Microscopie de fluorescence</term>
<term>Nanoparticules ()</term>
<term>Noeuds lymphatiques (anatomie et histologie)</term>
<term>Polyamines ()</term>
<term>Produits de contraste ()</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Vaisseaux lymphatiques (anatomie et histologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Contrast Media</term>
<term>Polyamines</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomie et histologie" xml:lang="fr"><term>Noeuds lymphatiques</term>
<term>Vaisseaux lymphatiques</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Lymph Nodes</term>
<term>Lymphatic Vessels</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Nanoparticles</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Lymphatic Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Maladies lymphatiques</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Dendrimers</term>
<term>Female</term>
<term>Humans</term>
<term>Lymphography</term>
<term>Magnetic Resonance Imaging</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Microscopy, Fluorescence</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Dendrimères</term>
<term>Femelle</term>
<term>Humains</term>
<term>Imagerie par résonance magnétique</term>
<term>Lymphographie</term>
<term>Microscopie de fluorescence</term>
<term>Nanoparticules</term>
<term>Polyamines</term>
<term>Produits de contraste</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Evaluation of lymphedema and lymph node metastasis in humans has relied primarily on invasive or radioactive modalities. While noninvasive technologies such as magnetic resonance imaging (MRI) offer the potential for true three-dimensional imaging of lymphatic structures, invasive modalities, such as optical fluorescence microscopy, provide higher resolution and clearer delineation of both lymph nodes and lymphatic vessels. Thus, contrast agents that image lymphatic vessels and lymph nodes by both fluorescence and MRI may further enhance our understanding of the structure and function of the lymphatic system. Recent applications of bimodal (fluorescence and MR) contrast agents in mice have not achieved clear visualization of lymphatic vessels and nodes. Here the authors describe the development of a nanoparticulate contrast agent that is taken up by lymphatic vessels to draining lymph nodes and detected by both modalities.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
</list>
<tree><noCountry><name sortKey="Constable, Todd" sort="Constable, Todd" uniqKey="Constable T" first="Todd" last="Constable">Todd Constable</name>
<name sortKey="Fahmy, Tarek M" sort="Fahmy, Tarek M" uniqKey="Fahmy T" first="Tarek M" last="Fahmy">Tarek M. Fahmy</name>
<name sortKey="Papademetris, Xenophon" sort="Papademetris, Xenophon" uniqKey="Papademetris X" first="Xenophon" last="Papademetris">Xenophon Papademetris</name>
<name sortKey="Ruddle, Nancy H" sort="Ruddle, Nancy H" uniqKey="Ruddle N" first="Nancy H" last="Ruddle">Nancy H. Ruddle</name>
<name sortKey="Shkarin, Pavel" sort="Shkarin, Pavel" uniqKey="Shkarin P" first="Pavel" last="Shkarin">Pavel Shkarin</name>
</noCountry>
<country name="États-Unis"><noRegion><name sortKey="Mounzer, Rawad" sort="Mounzer, Rawad" uniqKey="Mounzer R" first="Rawad" last="Mounzer">Rawad Mounzer</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 007292 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 007292 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:18035933 |texte= Dynamic imaging of lymphatic vessels and lymph nodes using a bimodal nanoparticulate contrast agent. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:18035933" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
![]() | This area was generated with Dilib version V0.6.31. | ![]() |