Molecular pathways for lymphangiogenesis and their role in human disease.
Identifieur interne : 007189 ( Main/Exploration ); précédent : 007188; suivant : 007190Molecular pathways for lymphangiogenesis and their role in human disease.
Auteurs : Steven A. Stacker [Australie] ; Rae H. Farnsworth ; Tara Karnezis ; Ramin Shayan ; Darrin P. Smith ; Karri Paavonen ; Natalia Davydova ; Carol Caesar ; Rachael Inder ; Megan E. Baldwin ; Bradley K. Mccoll ; Sally Roufail ; Richard A. Williams ; Richard A. Hughes ; Kari Alitalo [Finlande] ; Marc G. AchenSource :
- Novartis Foundation symposium [ 1528-2511 ] ; 2007.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Lymphangiogenèse, Transduction du signal.
- métabolisme : Facteurs de croissance endothéliale vasculaire, Tumeurs.
- physiologie : Lymphangiogenèse, Transduction du signal.
- Humains.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Vascular Endothelial Growth Factors.
- genetics : Lymphangiogenesis, Signal Transduction.
- metabolism : Neoplasms.
- physiology : Lymphangiogenesis, Signal Transduction.
- Humans.
Abstract
The lymphatic network functions to return fluid, cells and macromolecules to the circulation. Recent characterization of growth factors that control the growth and development of the lymphatics, and markers which specify lymphatic endothelial cells have enhanced our understanding of this system. Members of the VEGF family of factors are key regulators of these vessels with VEGF-C/VEGF-D and VEGFR-3 being the best validated signalling pathways in lymphangiogenesis. The study of these molecules in various pathologies has shown that they are important in the processes of cancer metastasis and in the formation of lymphoedema. Knowledge of these molecular pathways allows for the generation of modulators of these pathways which could form the basis of novel therapeutic approaches.
PubMed: 17534064
Affiliations:
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Le document en format XML
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<term>Signal Transduction (physiology)</term>
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<front><div type="abstract" xml:lang="en">The lymphatic network functions to return fluid, cells and macromolecules to the circulation. Recent characterization of growth factors that control the growth and development of the lymphatics, and markers which specify lymphatic endothelial cells have enhanced our understanding of this system. Members of the VEGF family of factors are key regulators of these vessels with VEGF-C/VEGF-D and VEGFR-3 being the best validated signalling pathways in lymphangiogenesis. The study of these molecules in various pathologies has shown that they are important in the processes of cancer metastasis and in the formation of lymphoedema. Knowledge of these molecular pathways allows for the generation of modulators of these pathways which could form the basis of novel therapeutic approaches.</div>
</front>
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<name sortKey="Caesar, Carol" sort="Caesar, Carol" uniqKey="Caesar C" first="Carol" last="Caesar">Carol Caesar</name>
<name sortKey="Davydova, Natalia" sort="Davydova, Natalia" uniqKey="Davydova N" first="Natalia" last="Davydova">Natalia Davydova</name>
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<name sortKey="Karnezis, Tara" sort="Karnezis, Tara" uniqKey="Karnezis T" first="Tara" last="Karnezis">Tara Karnezis</name>
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