Pseudolymphomatous cutaneous angiosarcoma: a rare variant of cutaneous angiosarcoma readily mistaken for cutaneous lymphoma.
Identifieur interne : 007137 ( Main/Exploration ); précédent : 007136; suivant : 007138Pseudolymphomatous cutaneous angiosarcoma: a rare variant of cutaneous angiosarcoma readily mistaken for cutaneous lymphoma.
Auteurs : Luis Requena [Espagne] ; Carlos Santonja ; Nathalie Stutz ; Steven Kaddu ; Roger H. Weenig ; Heinz Kutzner ; Thomas Menzel ; Lorenzo CerroniSource :
- The American Journal of dermatopathology [ 0193-1091 ] ; 2007.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Cellules endothéliales (anatomopathologie), Cuir chevelu (anatomopathologie), Diagnostic différentiel, Endothélium vasculaire (anatomopathologie), Femelle, Humains, Hémangiosarcome (anatomopathologie), Hémangiosarcome (diagnostic), Lymphocytes (anatomopathologie), Lymphome folliculaire (diagnostic), Lymphomes (anatomopathologie), Lymphomes (diagnostic), Maladies de la peau (diagnostic), Mâle, Néovascularisation pathologique (anatomopathologie), Pseudolymphome (diagnostic), Sujet âgé, Tumeurs cutanées (anatomopathologie), Tumeurs cutanées (diagnostic), Tumeurs de la face (diagnostic), Tumeurs du sein (diagnostic).
- MESH :
- anatomopathologie : Cellules endothéliales, Cuir chevelu, Endothélium vasculaire, Hémangiosarcome, Lymphocytes, Lymphomes, Néovascularisation pathologique, Tumeurs cutanées.
- diagnostic : Hémangiosarcome, Lymphome folliculaire, Lymphomes, Maladies de la peau, Pseudolymphome, Tumeurs cutanées, Tumeurs de la face, Tumeurs du sein.
- Adulte d'âge moyen, Diagnostic différentiel, Femelle, Humains, Mâle, Sujet âgé.
English descriptors
- KwdEn :
- Aged, Breast Neoplasms (diagnosis), Diagnosis, Differential, Endothelial Cells (pathology), Endothelium, Vascular (pathology), Facial Neoplasms (diagnosis), Female, Hemangiosarcoma (diagnosis), Hemangiosarcoma (pathology), Humans, Lymphocytes (pathology), Lymphoma (diagnosis), Lymphoma (pathology), Lymphoma, Follicular (diagnosis), Male, Middle Aged, Neovascularization, Pathologic (pathology), Pseudolymphoma (diagnosis), Scalp (pathology), Skin Diseases (diagnosis), Skin Neoplasms (diagnosis), Skin Neoplasms (pathology).
- MESH :
- diagnosis : Breast Neoplasms, Facial Neoplasms, Hemangiosarcoma, Lymphoma, Lymphoma, Follicular, Pseudolymphoma, Skin Diseases, Skin Neoplasms.
- pathology : Endothelial Cells, Endothelium, Vascular, Hemangiosarcoma, Lymphocytes, Lymphoma, Neovascularization, Pathologic, Scalp, Skin Neoplasms.
- Aged, Diagnosis, Differential, Female, Humans, Male, Middle Aged.
Abstract
Cutaneous angiosarcoma is probably the most malignant neoplasm involving the skin. Three clinical variants of cutaneous angiosarcoma are recognized, including angiosarcoma of the scalp and face of elderly patients, angiosarcoma associated with chronic lymphedema, and postirradiation angiosarcoma. Histopathologically, these three variants of angiosarcoma show similar features, which consist of poorly circumscribed, irregularly dilated, and anastomosing vascular channels lined by prominent endothelial cells that dissect through the dermis. Focally, neoplastic endothelial cells show large, hyperchromatic, and pleomorphic nuclei, protruding within vascular lumina and creating small papillations. Usually, inflammatory infiltrate is sparse and consists of a patchy, perivascular lymphoid infiltrate around the neoformed vessels. In rare instances, cutaneous angiosarcomas may exhibit prominent inflammatory infiltrate, and the neoplasm may be mistaken for an inflammatory process, both from clinical and histopathologic points of view. We describe four examples of cutaneous angiosarcomas with dense lymphocytic infiltrates involving the neoplasm. Immunohistochemically, lymphocytes expressed immunoreactivity for CD3, CD5, and CD45 markers, whereas the germinal centers were positive for CD20, CD79a, and Bcl-6. The neoplastic endothelial cells expressed immunoreactivity for the CD31, CD34, podoplanin, Prox-1, Lyve-1, and D2-40. We discuss the possible relationship between neoplastic endothelial lymphatic cells and reactive lymphocytes. Cutaneous angiosarcoma with prominent lymphocytic infiltrate may be readily mistaken for cutaneous follicle center cell lymphoma or cutaneous pseudolymphoma.
DOI: 10.1097/DAD.0b013e31806f1856
PubMed: 17667166
Affiliations:
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Weenig</name></author><author><name sortKey="Kutzner, Heinz" sort="Kutzner, Heinz" uniqKey="Kutzner H" first="Heinz" last="Kutzner">Heinz Kutzner</name></author><author><name sortKey="Menzel, Thomas" sort="Menzel, Thomas" uniqKey="Menzel T" first="Thomas" last="Menzel">Thomas Menzel</name></author><author><name sortKey="Cerroni, Lorenzo" sort="Cerroni, Lorenzo" uniqKey="Cerroni L" first="Lorenzo" last="Cerroni">Lorenzo Cerroni</name></author></analytic><series><title level="j">The American Journal of dermatopathology</title><idno type="ISSN">0193-1091</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Breast Neoplasms (diagnosis)</term><term>Diagnosis, Differential</term><term>Endothelial Cells (pathology)</term><term>Endothelium, Vascular (pathology)</term><term>Facial Neoplasms (diagnosis)</term><term>Female</term><term>Hemangiosarcoma (diagnosis)</term><term>Hemangiosarcoma (pathology)</term><term>Humans</term><term>Lymphocytes (pathology)</term><term>Lymphoma (diagnosis)</term><term>Lymphoma (pathology)</term><term>Lymphoma, Follicular (diagnosis)</term><term>Male</term><term>Middle Aged</term><term>Neovascularization, Pathologic (pathology)</term><term>Pseudolymphoma (diagnosis)</term><term>Scalp (pathology)</term><term>Skin Diseases (diagnosis)</term><term>Skin Neoplasms (diagnosis)</term><term>Skin Neoplasms (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Cellules endothéliales (anatomopathologie)</term><term>Cuir chevelu (anatomopathologie)</term><term>Diagnostic différentiel</term><term>Endothélium vasculaire (anatomopathologie)</term><term>Femelle</term><term>Humains</term><term>Hémangiosarcome (anatomopathologie)</term><term>Hémangiosarcome (diagnostic)</term><term>Lymphocytes (anatomopathologie)</term><term>Lymphome folliculaire (diagnostic)</term><term>Lymphomes (anatomopathologie)</term><term>Lymphomes (diagnostic)</term><term>Maladies de la peau (diagnostic)</term><term>Mâle</term><term>Néovascularisation pathologique (anatomopathologie)</term><term>Pseudolymphome (diagnostic)</term><term>Sujet âgé</term><term>Tumeurs cutanées (anatomopathologie)</term><term>Tumeurs cutanées (diagnostic)</term><term>Tumeurs de la face (diagnostic)</term><term>Tumeurs du sein (diagnostic)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Cellules endothéliales</term><term>Cuir chevelu</term><term>Endothélium vasculaire</term><term>Hémangiosarcome</term><term>Lymphocytes</term><term>Lymphomes</term><term>Néovascularisation pathologique</term><term>Tumeurs cutanées</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Breast Neoplasms</term><term>Facial Neoplasms</term><term>Hemangiosarcoma</term><term>Lymphoma</term><term>Lymphoma, Follicular</term><term>Pseudolymphoma</term><term>Skin Diseases</term><term>Skin Neoplasms</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Hémangiosarcome</term><term>Lymphome folliculaire</term><term>Lymphomes</term><term>Maladies de la peau</term><term>Pseudolymphome</term><term>Tumeurs cutanées</term><term>Tumeurs de la face</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Endothelial Cells</term><term>Endothelium, Vascular</term><term>Hemangiosarcoma</term><term>Lymphocytes</term><term>Lymphoma</term><term>Neovascularization, Pathologic</term><term>Scalp</term><term>Skin Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Diagnostic différentiel</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cutaneous angiosarcoma is probably the most malignant neoplasm involving the skin. Three clinical variants of cutaneous angiosarcoma are recognized, including angiosarcoma of the scalp and face of elderly patients, angiosarcoma associated with chronic lymphedema, and postirradiation angiosarcoma. Histopathologically, these three variants of angiosarcoma show similar features, which consist of poorly circumscribed, irregularly dilated, and anastomosing vascular channels lined by prominent endothelial cells that dissect through the dermis. Focally, neoplastic endothelial cells show large, hyperchromatic, and pleomorphic nuclei, protruding within vascular lumina and creating small papillations. Usually, inflammatory infiltrate is sparse and consists of a patchy, perivascular lymphoid infiltrate around the neoformed vessels. In rare instances, cutaneous angiosarcomas may exhibit prominent inflammatory infiltrate, and the neoplasm may be mistaken for an inflammatory process, both from clinical and histopathologic points of view. We describe four examples of cutaneous angiosarcomas with dense lymphocytic infiltrates involving the neoplasm. Immunohistochemically, lymphocytes expressed immunoreactivity for CD3, CD5, and CD45 markers, whereas the germinal centers were positive for CD20, CD79a, and Bcl-6. The neoplastic endothelial cells expressed immunoreactivity for the CD31, CD34, podoplanin, Prox-1, Lyve-1, and D2-40. We discuss the possible relationship between neoplastic endothelial lymphatic cells and reactive lymphocytes. Cutaneous angiosarcoma with prominent lymphocytic infiltrate may be readily mistaken for cutaneous follicle center cell lymphoma or cutaneous pseudolymphoma.</div></front></TEI><affiliations><list><country><li>Espagne</li></country><region><li>Communauté de Madrid</li></region><settlement><li>Madrid</li></settlement></list><tree><noCountry><name sortKey="Cerroni, Lorenzo" sort="Cerroni, Lorenzo" uniqKey="Cerroni L" first="Lorenzo" last="Cerroni">Lorenzo Cerroni</name><name sortKey="Kaddu, Steven" sort="Kaddu, Steven" uniqKey="Kaddu S" first="Steven" last="Kaddu">Steven Kaddu</name><name sortKey="Kutzner, Heinz" sort="Kutzner, Heinz" uniqKey="Kutzner H" first="Heinz" last="Kutzner">Heinz Kutzner</name><name sortKey="Menzel, Thomas" sort="Menzel, Thomas" uniqKey="Menzel T" first="Thomas" last="Menzel">Thomas Menzel</name><name sortKey="Santonja, Carlos" sort="Santonja, Carlos" uniqKey="Santonja C" first="Carlos" last="Santonja">Carlos Santonja</name><name sortKey="Stutz, Nathalie" sort="Stutz, Nathalie" uniqKey="Stutz N" first="Nathalie" last="Stutz">Nathalie Stutz</name><name sortKey="Weenig, Roger H" sort="Weenig, Roger H" uniqKey="Weenig R" first="Roger H" last="Weenig">Roger H. Weenig</name></noCountry><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Requena, Luis" sort="Requena, Luis" uniqKey="Requena L" first="Luis" last="Requena">Luis Requena</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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