Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice
Identifieur interne : 006B29 ( Main/Exploration ); précédent : 006B28; suivant : 006B30Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice
Auteurs : Jianxin Fu [États-Unis] ; Holger Gerhardt [Royaume-Uni] ; J. Michael Mcdaniel [États-Unis] ; Baoyun Xia [États-Unis] ; Xiaowei Liu [États-Unis] ; Lacramioara Ivanciu [États-Unis] ; Annelii Ny [Belgique] ; Karlien Hermans [Belgique] ; Robert Silasi-Mansat [États-Unis] ; Samuel Mcgee [États-Unis] ; Emma Nye [Royaume-Uni] ; Tongzhong Ju [États-Unis] ; Maria I. Ramirez [États-Unis] ; Peter Carmeliet [Belgique] ; Richard D. Cummings [États-Unis] ; Florea Lupu [États-Unis] ; Lijun Xia [États-Unis]Source :
- The Journal of Clinical Investigation [ 0021-9738 ] ; 2008.
Abstract
Mucin-type O-glycans (O-glycans) are highly expressed in vascular ECs. However, it is not known whether they are important for vascular development. To investigate the roles of EC O-glycans, we generated mice lacking T-synthase, a glycosyltransferase encoded by the gene
Url:
DOI: 10.1172/JCI36077
PubMed: 18924607
PubMed Central: 2567837
Affiliations:
- Belgique, Royaume-Uni, États-Unis
- Angleterre, Grand Londres, Géorgie (États-Unis), Massachusetts, Oklahoma, Province du Brabant flamand, Région flamande
- Londres, Louvain
- Katholieke Universiteit Leuven
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002725
- to stream Pmc, to step Curation: 002724
- to stream Pmc, to step Checkpoint: 003987
- to stream Ncbi, to step Merge: 003010
- to stream Ncbi, to step Curation: 003010
- to stream Ncbi, to step Checkpoint: 003010
- to stream Main, to step Merge: 006C34
- to stream Main, to step Curation: 006B29
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice</title>
<author><name sortKey="Fu, Jianxin" sort="Fu, Jianxin" uniqKey="Fu J" first="Jianxin" last="Fu">Jianxin Fu</name>
<affiliation wicri:level="2"><nlm:aff id="JCI36077">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gerhardt, Holger" sort="Gerhardt, Holger" uniqKey="Gerhardt H" first="Holger" last="Gerhardt">Holger Gerhardt</name>
<affiliation wicri:level="3"><nlm:aff id="JCI36077">Vascular Biology Laboratory, Cancer Research UK London Research Institute, London, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Vascular Biology Laboratory, Cancer Research UK London Research Institute, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcdaniel, J Michael" sort="Mcdaniel, J Michael" uniqKey="Mcdaniel J" first="J. Michael" last="Mcdaniel">J. Michael Mcdaniel</name>
<affiliation wicri:level="2"><nlm:aff id="JCI36077">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xia, Baoyun" sort="Xia, Baoyun" uniqKey="Xia B" first="Baoyun" last="Xia">Baoyun Xia</name>
<affiliation wicri:level="2"><nlm:aff id="JCI36077">Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Xiaowei" sort="Liu, Xiaowei" uniqKey="Liu X" first="Xiaowei" last="Liu">Xiaowei Liu</name>
<affiliation wicri:level="2"><nlm:aff id="JCI36077">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ivanciu, Lacramioara" sort="Ivanciu, Lacramioara" uniqKey="Ivanciu L" first="Lacramioara" last="Ivanciu">Lacramioara Ivanciu</name>
<affiliation wicri:level="2"><nlm:aff id="JCI36077">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ny, Annelii" sort="Ny, Annelii" uniqKey="Ny A" first="Annelii" last="Ny">Annelii Ny</name>
<affiliation wicri:level="4"><nlm:aff id="JCI36077">The Center for Transgene Technology and Gene Therapy, Katholieke Universiteit Leuven, Leuven, Belgium.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Belgique</country>
<wicri:regionArea>The Center for Transgene Technology and Gene Therapy, Katholieke Universiteit Leuven, Leuven</wicri:regionArea>
<orgName type="university">Katholieke Universiteit Leuven</orgName>
<placeName><settlement type="city">Louvain</settlement>
<region>Région flamande</region>
<region type="district" nuts="2">Province du Brabant flamand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hermans, Karlien" sort="Hermans, Karlien" uniqKey="Hermans K" first="Karlien" last="Hermans">Karlien Hermans</name>
<affiliation wicri:level="4"><nlm:aff id="JCI36077">The Center for Transgene Technology and Gene Therapy, Katholieke Universiteit Leuven, Leuven, Belgium.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Belgique</country>
<wicri:regionArea>The Center for Transgene Technology and Gene Therapy, Katholieke Universiteit Leuven, Leuven</wicri:regionArea>
<orgName type="university">Katholieke Universiteit Leuven</orgName>
<placeName><settlement type="city">Louvain</settlement>
<region>Région flamande</region>
<region type="district" nuts="2">Province du Brabant flamand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Silasi Mansat, Robert" sort="Silasi Mansat, Robert" uniqKey="Silasi Mansat R" first="Robert" last="Silasi-Mansat">Robert Silasi-Mansat</name>
<affiliation wicri:level="2"><nlm:aff id="JCI36077">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcgee, Samuel" sort="Mcgee, Samuel" uniqKey="Mcgee S" first="Samuel" last="Mcgee">Samuel Mcgee</name>
<affiliation wicri:level="2"><nlm:aff id="JCI36077">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nye, Emma" sort="Nye, Emma" uniqKey="Nye E" first="Emma" last="Nye">Emma Nye</name>
<affiliation wicri:level="3"><nlm:aff id="JCI36077">Vascular Biology Laboratory, Cancer Research UK London Research Institute, London, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Vascular Biology Laboratory, Cancer Research UK London Research Institute, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ju, Tongzhong" sort="Ju, Tongzhong" uniqKey="Ju T" first="Tongzhong" last="Ju">Tongzhong Ju</name>
<affiliation wicri:level="2"><nlm:aff id="JCI36077">Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ramirez, Maria I" sort="Ramirez, Maria I" uniqKey="Ramirez M" first="Maria I." last="Ramirez">Maria I. Ramirez</name>
<affiliation wicri:level="2"><nlm:aff id="JCI36077">Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Department of Medicine, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Carmeliet, Peter" sort="Carmeliet, Peter" uniqKey="Carmeliet P" first="Peter" last="Carmeliet">Peter Carmeliet</name>
<affiliation wicri:level="4"><nlm:aff id="JCI36077">The Center for Transgene Technology and Gene Therapy, Katholieke Universiteit Leuven, Leuven, Belgium.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Belgique</country>
<wicri:regionArea>The Center for Transgene Technology and Gene Therapy, Katholieke Universiteit Leuven, Leuven</wicri:regionArea>
<orgName type="university">Katholieke Universiteit Leuven</orgName>
<placeName><settlement type="city">Louvain</settlement>
<region>Région flamande</region>
<region type="district" nuts="2">Province du Brabant flamand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cummings, Richard D" sort="Cummings, Richard D" uniqKey="Cummings R" first="Richard D." last="Cummings">Richard D. Cummings</name>
<affiliation wicri:level="2"><nlm:aff id="JCI36077">Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lupu, Florea" sort="Lupu, Florea" uniqKey="Lupu F" first="Florea" last="Lupu">Florea Lupu</name>
<affiliation wicri:level="2"><nlm:aff id="JCI36077">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xia, Lijun" sort="Xia, Lijun" uniqKey="Xia L" first="Lijun" last="Xia">Lijun Xia</name>
<affiliation wicri:level="2"><nlm:aff id="JCI36077">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="JCI36077">Department of Biochemistry and Molecular Biology and Oklahoma Center for Medical Glycobiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Department of Biochemistry and Molecular Biology and Oklahoma Center for Medical Glycobiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">18924607</idno>
<idno type="pmc">2567837</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567837</idno>
<idno type="RBID">PMC:2567837</idno>
<idno type="doi">10.1172/JCI36077</idno>
<date when="2008">2008</date>
<idno type="wicri:Area/Pmc/Corpus">002725</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002725</idno>
<idno type="wicri:Area/Pmc/Curation">002724</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002724</idno>
<idno type="wicri:Area/Pmc/Checkpoint">003987</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003987</idno>
<idno type="wicri:Area/Ncbi/Merge">003010</idno>
<idno type="wicri:Area/Ncbi/Curation">003010</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003010</idno>
<idno type="wicri:doubleKey">0021-9738:2008:Fu J:endothelial:cell:o</idno>
<idno type="wicri:Area/Main/Merge">006C34</idno>
<idno type="wicri:Area/Main/Curation">006B29</idno>
<idno type="wicri:Area/Main/Exploration">006B29</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice</title>
<author><name sortKey="Fu, Jianxin" sort="Fu, Jianxin" uniqKey="Fu J" first="Jianxin" last="Fu">Jianxin Fu</name>
<affiliation wicri:level="2"><nlm:aff id="JCI36077">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gerhardt, Holger" sort="Gerhardt, Holger" uniqKey="Gerhardt H" first="Holger" last="Gerhardt">Holger Gerhardt</name>
<affiliation wicri:level="3"><nlm:aff id="JCI36077">Vascular Biology Laboratory, Cancer Research UK London Research Institute, London, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Vascular Biology Laboratory, Cancer Research UK London Research Institute, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcdaniel, J Michael" sort="Mcdaniel, J Michael" uniqKey="Mcdaniel J" first="J. Michael" last="Mcdaniel">J. Michael Mcdaniel</name>
<affiliation wicri:level="2"><nlm:aff id="JCI36077">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xia, Baoyun" sort="Xia, Baoyun" uniqKey="Xia B" first="Baoyun" last="Xia">Baoyun Xia</name>
<affiliation wicri:level="2"><nlm:aff id="JCI36077">Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Xiaowei" sort="Liu, Xiaowei" uniqKey="Liu X" first="Xiaowei" last="Liu">Xiaowei Liu</name>
<affiliation wicri:level="2"><nlm:aff id="JCI36077">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ivanciu, Lacramioara" sort="Ivanciu, Lacramioara" uniqKey="Ivanciu L" first="Lacramioara" last="Ivanciu">Lacramioara Ivanciu</name>
<affiliation wicri:level="2"><nlm:aff id="JCI36077">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ny, Annelii" sort="Ny, Annelii" uniqKey="Ny A" first="Annelii" last="Ny">Annelii Ny</name>
<affiliation wicri:level="4"><nlm:aff id="JCI36077">The Center for Transgene Technology and Gene Therapy, Katholieke Universiteit Leuven, Leuven, Belgium.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Belgique</country>
<wicri:regionArea>The Center for Transgene Technology and Gene Therapy, Katholieke Universiteit Leuven, Leuven</wicri:regionArea>
<orgName type="university">Katholieke Universiteit Leuven</orgName>
<placeName><settlement type="city">Louvain</settlement>
<region>Région flamande</region>
<region type="district" nuts="2">Province du Brabant flamand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hermans, Karlien" sort="Hermans, Karlien" uniqKey="Hermans K" first="Karlien" last="Hermans">Karlien Hermans</name>
<affiliation wicri:level="4"><nlm:aff id="JCI36077">The Center for Transgene Technology and Gene Therapy, Katholieke Universiteit Leuven, Leuven, Belgium.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Belgique</country>
<wicri:regionArea>The Center for Transgene Technology and Gene Therapy, Katholieke Universiteit Leuven, Leuven</wicri:regionArea>
<orgName type="university">Katholieke Universiteit Leuven</orgName>
<placeName><settlement type="city">Louvain</settlement>
<region>Région flamande</region>
<region type="district" nuts="2">Province du Brabant flamand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Silasi Mansat, Robert" sort="Silasi Mansat, Robert" uniqKey="Silasi Mansat R" first="Robert" last="Silasi-Mansat">Robert Silasi-Mansat</name>
<affiliation wicri:level="2"><nlm:aff id="JCI36077">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcgee, Samuel" sort="Mcgee, Samuel" uniqKey="Mcgee S" first="Samuel" last="Mcgee">Samuel Mcgee</name>
<affiliation wicri:level="2"><nlm:aff id="JCI36077">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nye, Emma" sort="Nye, Emma" uniqKey="Nye E" first="Emma" last="Nye">Emma Nye</name>
<affiliation wicri:level="3"><nlm:aff id="JCI36077">Vascular Biology Laboratory, Cancer Research UK London Research Institute, London, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Vascular Biology Laboratory, Cancer Research UK London Research Institute, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ju, Tongzhong" sort="Ju, Tongzhong" uniqKey="Ju T" first="Tongzhong" last="Ju">Tongzhong Ju</name>
<affiliation wicri:level="2"><nlm:aff id="JCI36077">Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ramirez, Maria I" sort="Ramirez, Maria I" uniqKey="Ramirez M" first="Maria I." last="Ramirez">Maria I. Ramirez</name>
<affiliation wicri:level="2"><nlm:aff id="JCI36077">Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Department of Medicine, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Carmeliet, Peter" sort="Carmeliet, Peter" uniqKey="Carmeliet P" first="Peter" last="Carmeliet">Peter Carmeliet</name>
<affiliation wicri:level="4"><nlm:aff id="JCI36077">The Center for Transgene Technology and Gene Therapy, Katholieke Universiteit Leuven, Leuven, Belgium.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Belgique</country>
<wicri:regionArea>The Center for Transgene Technology and Gene Therapy, Katholieke Universiteit Leuven, Leuven</wicri:regionArea>
<orgName type="university">Katholieke Universiteit Leuven</orgName>
<placeName><settlement type="city">Louvain</settlement>
<region>Région flamande</region>
<region type="district" nuts="2">Province du Brabant flamand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cummings, Richard D" sort="Cummings, Richard D" uniqKey="Cummings R" first="Richard D." last="Cummings">Richard D. Cummings</name>
<affiliation wicri:level="2"><nlm:aff id="JCI36077">Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lupu, Florea" sort="Lupu, Florea" uniqKey="Lupu F" first="Florea" last="Lupu">Florea Lupu</name>
<affiliation wicri:level="2"><nlm:aff id="JCI36077">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xia, Lijun" sort="Xia, Lijun" uniqKey="Xia L" first="Lijun" last="Xia">Lijun Xia</name>
<affiliation wicri:level="2"><nlm:aff id="JCI36077">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="JCI36077">Department of Biochemistry and Molecular Biology and Oklahoma Center for Medical Glycobiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Department of Biochemistry and Molecular Biology and Oklahoma Center for Medical Glycobiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of Clinical Investigation</title>
<idno type="ISSN">0021-9738</idno>
<idno type="eISSN">1558-8238</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Mucin-type O-glycans (O-glycans) are highly expressed in vascular ECs. However, it is not known whether they are important for vascular development. To investigate the roles of EC O-glycans, we generated mice lacking T-synthase, a glycosyltransferase encoded by the gene <italic>C1galt1</italic>
that is critical for the biosynthesis of core 1–derived O-glycans, in ECs and hematopoietic cells (termed here EHC T-syn<sup>–/–</sup>
mice). EHC T-syn<sup>–/–</sup>
mice exhibited embryonic and neonatal lethality associated with disorganized and blood-filled lymphatic vessels. Bone marrow transplantation and EC <italic>C1galt1</italic>
transgene rescue demonstrated that lymphangiogenesis specifically requires EC O-glycans, and intestinal lymphatic microvessels in EHC T-syn<sup>–/–</sup>
mice expressed a mosaic of blood and lymphatic EC markers. The level of O-glycoprotein podoplanin was significantly reduced in EHC T-syn<sup>–/–</sup>
lymphatics, and podoplanin-deficient mice developed blood-filled lymphatics resembling EHC T-syn<sup>–/–</sup>
defects. In addition, postnatal inactivation of <italic>C1galt1</italic>
caused blood/lymphatic vessel misconnections that were similar to the vascular defects in the EHC T-syn<sup>–/–</sup>
mice. One consequence of eliminating T-synthase in ECs and hematopoietic cells was that the EHC T-syn<sup>–/–</sup>
pups developed fatty liver disease, because of direct chylomicron deposition via misconnected portal vein and intestinal lymphatic systems. Our studies therefore demonstrate that EC O-glycans control the separation of blood and lymphatic vessels during embryonic and postnatal development, in part by regulating podoplanin expression.
</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Belgique</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
<li>Géorgie (États-Unis)</li>
<li>Massachusetts</li>
<li>Oklahoma</li>
<li>Province du Brabant flamand</li>
<li>Région flamande</li>
</region>
<settlement><li>Londres</li>
<li>Louvain</li>
</settlement>
<orgName><li>Katholieke Universiteit Leuven</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Oklahoma"><name sortKey="Fu, Jianxin" sort="Fu, Jianxin" uniqKey="Fu J" first="Jianxin" last="Fu">Jianxin Fu</name>
</region>
<name sortKey="Cummings, Richard D" sort="Cummings, Richard D" uniqKey="Cummings R" first="Richard D." last="Cummings">Richard D. Cummings</name>
<name sortKey="Ivanciu, Lacramioara" sort="Ivanciu, Lacramioara" uniqKey="Ivanciu L" first="Lacramioara" last="Ivanciu">Lacramioara Ivanciu</name>
<name sortKey="Ju, Tongzhong" sort="Ju, Tongzhong" uniqKey="Ju T" first="Tongzhong" last="Ju">Tongzhong Ju</name>
<name sortKey="Liu, Xiaowei" sort="Liu, Xiaowei" uniqKey="Liu X" first="Xiaowei" last="Liu">Xiaowei Liu</name>
<name sortKey="Lupu, Florea" sort="Lupu, Florea" uniqKey="Lupu F" first="Florea" last="Lupu">Florea Lupu</name>
<name sortKey="Mcdaniel, J Michael" sort="Mcdaniel, J Michael" uniqKey="Mcdaniel J" first="J. Michael" last="Mcdaniel">J. Michael Mcdaniel</name>
<name sortKey="Mcgee, Samuel" sort="Mcgee, Samuel" uniqKey="Mcgee S" first="Samuel" last="Mcgee">Samuel Mcgee</name>
<name sortKey="Ramirez, Maria I" sort="Ramirez, Maria I" uniqKey="Ramirez M" first="Maria I." last="Ramirez">Maria I. Ramirez</name>
<name sortKey="Silasi Mansat, Robert" sort="Silasi Mansat, Robert" uniqKey="Silasi Mansat R" first="Robert" last="Silasi-Mansat">Robert Silasi-Mansat</name>
<name sortKey="Xia, Baoyun" sort="Xia, Baoyun" uniqKey="Xia B" first="Baoyun" last="Xia">Baoyun Xia</name>
<name sortKey="Xia, Lijun" sort="Xia, Lijun" uniqKey="Xia L" first="Lijun" last="Xia">Lijun Xia</name>
<name sortKey="Xia, Lijun" sort="Xia, Lijun" uniqKey="Xia L" first="Lijun" last="Xia">Lijun Xia</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Gerhardt, Holger" sort="Gerhardt, Holger" uniqKey="Gerhardt H" first="Holger" last="Gerhardt">Holger Gerhardt</name>
</region>
<name sortKey="Nye, Emma" sort="Nye, Emma" uniqKey="Nye E" first="Emma" last="Nye">Emma Nye</name>
</country>
<country name="Belgique"><region name="Région flamande"><name sortKey="Ny, Annelii" sort="Ny, Annelii" uniqKey="Ny A" first="Annelii" last="Ny">Annelii Ny</name>
</region>
<name sortKey="Carmeliet, Peter" sort="Carmeliet, Peter" uniqKey="Carmeliet P" first="Peter" last="Carmeliet">Peter Carmeliet</name>
<name sortKey="Hermans, Karlien" sort="Hermans, Karlien" uniqKey="Hermans K" first="Karlien" last="Hermans">Karlien Hermans</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 006B29 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 006B29 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:2567837 |texte= Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:18924607" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
This area was generated with Dilib version V0.6.31. |