Extracellular Water May Mask Actual Muscle Atrophy During Aging
Identifieur interne : 005B23 ( Main/Exploration ); précédent : 005B22; suivant : 005B24Extracellular Water May Mask Actual Muscle Atrophy During Aging
Auteurs : Yosuke Yamada [Japon] ; Dale A. Schoeller ; Eitaro Nakamura [Japon] ; Taketoshi Morimoto [Japon] ; Misaka Kimura [Japon] ; Shingo Oda [Japon]Source :
- Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences [ 1079-5006 ] ; 2010-02-04.
Abstract
Background. Skeletal muscle tissue holds a large volume of water partitioned into extracellular water (ECW) and intracellular water (ICW) fractions. As the ECW may not be related to muscle strength directly, we hypothesized that excluding ECW from muscle volume would strengthen the correlation with muscle strength. Methods. A total of 119 healthy men aged 2088 years old participated in this study. Knee isometric extension strength, vertical jump, and standing from a chair were measured as indices of muscle strength and power in the lower extremities. The regional lean volume (LV), total water (TW), ICW, and ECW in the lower leg were estimated by anthropometry (skinfold and circumference measurements) and segmental multifrequency bioelectrical impedance spectroscopy (S-BIS). Then, we calculated the ECW/TW and ICW/TW ratios. Results. Although ICW and the LV index decreased significantly with age (p < .001), no significant changes in ECW were observed (p .134). Consequently, the ECW/TW ratio increased significantly (p < .001) with age (young adult, 27.0 2.9%; elderly, 34.3 4.9%; advanced elderly, 37.2 7.0%). Adjusting for this by including the ICW/TW ratio in our models significantly improved the correlation between the LV index and strength-related measurements and correlated with strength-related measurements independently of the LV index (p < .001). Conclusions. The ECW/TW ratio increases in the lower leg with age. The results suggest that the expansion of ECW relative to ICW and the LV masked actual muscle cell atrophy with aging.
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DOI: 10.1093/gerona/glq001
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Schoeller</name></author><author><name sortKey="Nakamura, Eitaro" sort="Nakamura, Eitaro" uniqKey="Nakamura E" first="Eitaro" last="Nakamura">Eitaro Nakamura</name></author><author><name sortKey="Morimoto, Taketoshi" sort="Morimoto, Taketoshi" uniqKey="Morimoto T" first="Taketoshi" last="Morimoto">Taketoshi Morimoto</name></author><author><name sortKey="Kimura, Misaka" sort="Kimura, Misaka" uniqKey="Kimura M" first="Misaka" last="Kimura">Misaka Kimura</name></author><author><name sortKey="Oda, Shingo" sort="Oda, Shingo" uniqKey="Oda S" first="Shingo" last="Oda">Shingo Oda</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:5F7C550803D6853667437AEEC9FD899C6EF4B7C0</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1093/gerona/glq001</idno><idno type="url">https://api.istex.fr/document/5F7C550803D6853667437AEEC9FD899C6EF4B7C0/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002C64</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002C64</idno><idno type="wicri:Area/Istex/Curation">002C64</idno><idno type="wicri:Area/Istex/Checkpoint">000867</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000867</idno><idno type="wicri:doubleKey">1079-5006:2010:Yamada Y:extracellular:water:may</idno><idno type="wicri:Area/Main/Merge">005B78</idno><idno type="wicri:Area/Main/Curation">005B23</idno><idno type="wicri:Area/Main/Exploration">005B23</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Extracellular Water May Mask Actual Muscle Atrophy During Aging</title><author><name sortKey="Yamada, Yosuke" sort="Yamada, Yosuke" uniqKey="Yamada Y" first="Yosuke" last="Yamada">Yosuke Yamada</name><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>Graduate School of Human and Environmental Studies, Kyoto University</wicri:regionArea><placeName><settlement type="city">Kyoto</settlement><region type="prefecture">Région du Kansai</region></placeName><orgName type="university">Université de Kyoto</orgName></affiliation><affiliation></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Current address: The Fukuoka University Institute for Physical Activity</wicri:regionArea></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Japon</country></affiliation></author><author><name sortKey="Schoeller, Dale A" sort="Schoeller, Dale A" uniqKey="Schoeller D" first="Dale A." last="Schoeller">Dale A. Schoeller</name><affiliation><wicri:noCountry code="subField">Wisconsin-Madison</wicri:noCountry></affiliation></author><author><name sortKey="Nakamura, Eitaro" sort="Nakamura, Eitaro" uniqKey="Nakamura E" first="Eitaro" last="Nakamura">Eitaro Nakamura</name><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>Graduate School of Human and Environmental Studies, Kyoto University</wicri:regionArea><placeName><settlement type="city">Kyoto</settlement><region type="prefecture">Région du Kansai</region></placeName><orgName type="university">Université de Kyoto</orgName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Sport Science, Kyoto Iken College of Medicine and Health</wicri:regionArea><wicri:noRegion>Kyoto Iken College of Medicine and Health</wicri:noRegion></affiliation></author><author><name sortKey="Morimoto, Taketoshi" sort="Morimoto, Taketoshi" uniqKey="Morimoto T" first="Taketoshi" last="Morimoto">Taketoshi Morimoto</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Kyoto Prefectural University of Medicine</wicri:regionArea></affiliation></author><author><name sortKey="Kimura, Misaka" sort="Kimura, Misaka" uniqKey="Kimura M" first="Misaka" last="Kimura">Misaka Kimura</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Kyoto Prefectural University of Medicine</wicri:regionArea></affiliation></author><author><name sortKey="Oda, Shingo" sort="Oda, Shingo" uniqKey="Oda S" first="Shingo" last="Oda">Shingo Oda</name><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>Graduate School of Human and Environmental Studies, Kyoto University</wicri:regionArea><placeName><settlement type="city">Kyoto</settlement><region type="prefecture">Région du Kansai</region></placeName><orgName type="university">Université de Kyoto</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences</title><idno type="ISSN">1079-5006</idno><idno type="eISSN">1758-535X</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2010-02-04">2010-02-04</date><biblScope unit="volume">65A</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="510">510</biblScope><biblScope unit="page" to="516">516</biblScope></imprint><idno type="ISSN">1079-5006</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1079-5006</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Background. Skeletal muscle tissue holds a large volume of water partitioned into extracellular water (ECW) and intracellular water (ICW) fractions. As the ECW may not be related to muscle strength directly, we hypothesized that excluding ECW from muscle volume would strengthen the correlation with muscle strength. Methods. A total of 119 healthy men aged 2088 years old participated in this study. Knee isometric extension strength, vertical jump, and standing from a chair were measured as indices of muscle strength and power in the lower extremities. The regional lean volume (LV), total water (TW), ICW, and ECW in the lower leg were estimated by anthropometry (skinfold and circumference measurements) and segmental multifrequency bioelectrical impedance spectroscopy (S-BIS). Then, we calculated the ECW/TW and ICW/TW ratios. Results. Although ICW and the LV index decreased significantly with age (p < .001), no significant changes in ECW were observed (p .134). Consequently, the ECW/TW ratio increased significantly (p < .001) with age (young adult, 27.0 2.9%; elderly, 34.3 4.9%; advanced elderly, 37.2 7.0%). Adjusting for this by including the ICW/TW ratio in our models significantly improved the correlation between the LV index and strength-related measurements and correlated with strength-related measurements independently of the LV index (p < .001). Conclusions. The ECW/TW ratio increases in the lower leg with age. The results suggest that the expansion of ECW relative to ICW and the LV masked actual muscle cell atrophy with aging.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région du Kansai</li></region><settlement><li>Kyoto</li></settlement><orgName><li>Université de Kyoto</li></orgName></list><tree><noCountry><name sortKey="Schoeller, Dale A" sort="Schoeller, Dale A" uniqKey="Schoeller D" first="Dale A." last="Schoeller">Dale A. Schoeller</name></noCountry><country name="Japon"><region name="Région du Kansai"><name sortKey="Yamada, Yosuke" sort="Yamada, Yosuke" uniqKey="Yamada Y" first="Yosuke" last="Yamada">Yosuke Yamada</name></region><name sortKey="Kimura, Misaka" sort="Kimura, Misaka" uniqKey="Kimura M" first="Misaka" last="Kimura">Misaka Kimura</name><name sortKey="Morimoto, Taketoshi" sort="Morimoto, Taketoshi" uniqKey="Morimoto T" first="Taketoshi" last="Morimoto">Taketoshi Morimoto</name><name sortKey="Nakamura, Eitaro" sort="Nakamura, Eitaro" uniqKey="Nakamura E" first="Eitaro" last="Nakamura">Eitaro Nakamura</name><name sortKey="Nakamura, Eitaro" sort="Nakamura, Eitaro" uniqKey="Nakamura E" first="Eitaro" last="Nakamura">Eitaro Nakamura</name><name sortKey="Oda, Shingo" sort="Oda, Shingo" uniqKey="Oda S" first="Shingo" last="Oda">Shingo Oda</name><name sortKey="Yamada, Yosuke" sort="Yamada, Yosuke" uniqKey="Yamada Y" first="Yosuke" last="Yamada">Yosuke Yamada</name><name sortKey="Yamada, Yosuke" sort="Yamada, Yosuke" uniqKey="Yamada Y" first="Yosuke" last="Yamada">Yosuke Yamada</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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