Effects of Semelil (ANGIPARS™) on focal cerebral ischemia in male rats
Identifieur interne : 005931 ( Main/Exploration ); précédent : 005930; suivant : 005932Effects of Semelil (ANGIPARS™) on focal cerebral ischemia in male rats
Auteurs : M. Asadi-Shekaari ; H. Eftekhar Vaghefi ; A. Talakoub ; Hr Khorram Khorshid [Iran]Source :
- DARU : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences [ 1560-8115 ] ; 2010.
Abstract
Cerebral ischemia is one of the main causes of long term disability and death in aged populations. Many herbal drugs and extracts have been used for the treatment of cerebral ischemia induced insults. This study was designed to investigate the protective effect of Semelil (ANGIPARS™), a new herbal drug, on focal cerebral ischemia in male rats.
Male rats were divided into five groups: sham-operated, ischemic animals treated with distilled water as vehicle, ischemic animals treated with 1, 10 and 100 mg/kg of Semilil respectively. Middle cerebral artery occlusion (MCAO) model was used in NMRI rats and neuronal injury analyzed in hippocampal CA1 sector after 48 hrs of Middle Cerebral Artery (MCAO).
Results of this study showed that treatment with semelil attenuated ischemic damages and has positive effects on focal cerebral ischemia.
Url:
PubMed: 22615626
PubMed Central: 3304352
Affiliations:
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Asadi-Shekaari</name><affiliation><nlm:aff id="AF0001">Neuroscience Research Center</nlm:aff></affiliation></author><author><name sortKey="Eftekhar Vaghefi, H" sort="Eftekhar Vaghefi, H" uniqKey="Eftekhar Vaghefi H" first="H" last="Eftekhar Vaghefi">H. Eftekhar Vaghefi</name><affiliation><nlm:aff id="AF0002">Department of Anatomy, Faculty of Medicine, Kerman Medical University of Medical Sciences, Kerman</nlm:aff><wicri:noCountry code="subfield">Kerman</wicri:noCountry></affiliation></author><author><name sortKey="Talakoub, A" sort="Talakoub, A" uniqKey="Talakoub A" first="A" last="Talakoub">A. Talakoub</name><affiliation><nlm:aff id="AF0001">Neuroscience Research Center</nlm:aff></affiliation></author><author><name sortKey="Khorram Khorshid, Hr" sort="Khorram Khorshid, Hr" uniqKey="Khorram Khorshid H" first="Hr" last="Khorram Khorshid">Hr Khorram Khorshid</name><affiliation wicri:level="1"><nlm:aff id="AF0003">Genetic Research Center, Social Welfare and Rehabilitation Sciences University, Tehran, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Genetic Research Center, Social Welfare and Rehabilitation Sciences University, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author></analytic><series><title level="j">DARU : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences</title><idno type="ISSN">1560-8115</idno><idno type="eISSN">2008-2231</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background and the purpose of the study</title><p>Cerebral ischemia is one of the main causes of long term disability and death in aged populations. Many herbal drugs and extracts have been used for the treatment of cerebral ischemia induced insults. This study was designed to investigate the protective effect of Semelil (ANGIPARS™), a new herbal drug, on focal cerebral ischemia in male rats.</p></sec><sec id="st2"><title>Material and methods</title><p>Male rats were divided into five groups: sham-operated, ischemic animals treated with distilled water as vehicle, ischemic animals treated with 1, 10 and 100 mg/kg of Semilil respectively. Middle cerebral artery occlusion (MCAO) model was used in NMRI rats and neuronal injury analyzed in hippocampal CA1 sector after 48 hrs of Middle Cerebral Artery (MCAO).</p></sec><sec id="st3"><title>Results</title><p>Results of this study showed that treatment with semelil attenuated ischemic damages and has positive effects on focal cerebral ischemia.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hosseinzadeh, H" uniqKey="Hosseinzadeh H">H Hosseinzadeh</name></author><author><name sortKey="Jaafari, Mr" uniqKey="Jaafari M">MR Jaafari</name></author><author><name sortKey="Khoei, Ar" uniqKey="Khoei A">AR Khoei</name></author><author><name sortKey="Rahmani, M" uniqKey="Rahmani M">M Rahmani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hong, Jt" uniqKey="Hong J">JT Hong</name></author><author><name sortKey="Ryu, Sr" uniqKey="Ryu S">SR Ryu</name></author><author><name sortKey="Kim, Hj" 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Tatlisumak</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Iran</li></country></list><tree><noCountry><name sortKey="Asadi Shekaari, M" sort="Asadi Shekaari, M" uniqKey="Asadi Shekaari M" first="M" last="Asadi-Shekaari">M. Asadi-Shekaari</name><name sortKey="Eftekhar Vaghefi, H" sort="Eftekhar Vaghefi, H" uniqKey="Eftekhar Vaghefi H" first="H" last="Eftekhar Vaghefi">H. Eftekhar Vaghefi</name><name sortKey="Talakoub, A" sort="Talakoub, A" uniqKey="Talakoub A" first="A" last="Talakoub">A. Talakoub</name></noCountry><country name="Iran"><noRegion><name sortKey="Khorram Khorshid, Hr" sort="Khorram Khorshid, Hr" uniqKey="Khorram Khorshid H" first="Hr" last="Khorram Khorshid">Hr Khorram Khorshid</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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