Integrated Optical Coherence Tomography and Microscopy for Ex Vivo Multiscale Evaluation of Human Breast Tissues
Identifieur interne : 005838 ( Main/Exploration ); précédent : 005837; suivant : 005839Integrated Optical Coherence Tomography and Microscopy for Ex Vivo Multiscale Evaluation of Human Breast Tissues
Auteurs : Chao Zhou [États-Unis] ; David W. Cohen [États-Unis] ; Yihong Wang [États-Unis] ; Hsiang-Chieh Lee [États-Unis] ; Amy E. Mondelblatt [États-Unis] ; Tsung-Han Tsai [États-Unis] ; Aaron D. Aguirre [États-Unis] ; James G. Fujimoto [États-Unis] ; James L. Connolly [États-Unis]Source :
- Cancer research [ 0008-5472 ] ; 2010.
Abstract
3D tissue imaging methods are expected to improve surgical management of cancer. In this study, we examined the feasibility of two 3D imaging technologies, optical coherence tomography (OCT) and optical coherence microscopy (OCM), to view human breast specimens based on intrinsic optical contrast. Specifically, we imaged 44
Url:
DOI: 10.1158/0008-5472.CAN-10-2968
PubMed: 21056988
PubMed Central: 3028517
Affiliations:
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Multiscale Evaluation of Human Breast Tissues</title>
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<front><div type="abstract" xml:lang="en"><p id="P1">3D tissue imaging methods are expected to improve surgical management of cancer. In this study, we examined the feasibility of two 3D imaging technologies, optical coherence tomography (OCT) and optical coherence microscopy (OCM), to view human breast specimens based on intrinsic optical contrast. Specifically, we imaged 44 <italic>ex vivo</italic>
breast specimens including 34 benign and 10 malignant lesions with an integrated OCT and OCM system developed in our laboratory. The system enabled 4 μm axial resolution (OCT and OCM) with 14 μm (OCT) and 2 μm (OCM) transverse resolution, respectively. OCT and OCM images were compared with corresponding histologic sections to identify characteristic features from benign and malignant breast lesions at multiple resolution scales. OCT and OCM provide complimentary information about tissue microstructure, demonstrating distinctive patterns for adipose tissue, fibrous stroma, breast lobules and ducts, cysts and microcysts, as well as <italic>in situ</italic>
and invasive carcinomas. The 3D imaging capability of OCT and OCM provided complementary information to individual 2D images, allowing tracking features from different levels to identify low contrast structures that were difficult to appreciate from single images alone. Our results lay the foundation for future <italic>in vivo</italic>
optical evaluation of breast tissues using OCT and OCM, which has the potential to guide core needle biopsies, assess surgical margins and evaluate nodal involvement in breast cancer.</p>
</div>
</front>
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<name sortKey="Connolly, James L" sort="Connolly, James L" uniqKey="Connolly J" first="James L." last="Connolly">James L. Connolly</name>
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<name sortKey="Lee, Hsiang Chieh" sort="Lee, Hsiang Chieh" uniqKey="Lee H" first="Hsiang-Chieh" last="Lee">Hsiang-Chieh Lee</name>
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<name sortKey="Tsai, Tsung Han" sort="Tsai, Tsung Han" uniqKey="Tsai T" first="Tsung-Han" last="Tsai">Tsung-Han Tsai</name>
<name sortKey="Wang, Yihong" sort="Wang, Yihong" uniqKey="Wang Y" first="Yihong" last="Wang">Yihong Wang</name>
<name sortKey="Wang, Yihong" sort="Wang, Yihong" uniqKey="Wang Y" first="Yihong" last="Wang">Yihong Wang</name>
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