Radioprotection from radiation-induced lymphedema without tumor protection.
Identifieur interne : 005668 ( Main/Exploration ); précédent : 005667; suivant : 005669Radioprotection from radiation-induced lymphedema without tumor protection.
Auteurs : S K Daley [États-Unis] ; M J Bernas ; B D Stea ; F. Bracamonte ; M. Mckenna ; A. Stejskal ; E D Hirleman ; M H WitteSource :
- Lymphology [ 0024-7766 ] ; 2010.
Descripteurs français
- KwdFr :
- Amifostine (usage thérapeutique), Animaux, Cellules cancéreuses en culture, Cicatrisation de plaie, Femelle, Humains, Incidence, Lymphoedème (), Lymphoedème (étiologie), Mâle, Radioprotecteurs (usage thérapeutique), Radiotolérance, Rat Wistar, Rats, Souris, Souris nude, Test clonogénique, Tests d'activité antitumorale sur modèle de xénogreffe, Tumeurs expérimentales de la mamelle (métabolisme), Tumeurs expérimentales de la mamelle (radiothérapie), Vaisseaux lymphatiques (effets des radiations).
- MESH :
- effets des radiations : Vaisseaux lymphatiques.
- métabolisme : Tumeurs expérimentales de la mamelle.
- radiothérapie : Tumeurs expérimentales de la mamelle.
- usage thérapeutique : Amifostine, Radioprotecteurs.
- étiologie : Lymphoedème.
- Animaux, Cellules cancéreuses en culture, Cicatrisation de plaie, Femelle, Humains, Incidence, Lymphoedème, Mâle, Radiotolérance, Rat Wistar, Rats, Souris, Souris nude, Test clonogénique, Tests d'activité antitumorale sur modèle de xénogreffe.
English descriptors
- KwdEn :
- Amifostine (therapeutic use), Animals, Colony-Forming Units Assay, Female, Humans, Incidence, Lymphatic Vessels (radiation effects), Lymphedema (etiology), Lymphedema (prevention & control), Male, Mammary Neoplasms, Experimental (metabolism), Mammary Neoplasms, Experimental (radiotherapy), Mice, Mice, Nude, Radiation Tolerance, Radiation-Protective Agents (therapeutic use), Rats, Rats, Wistar, Tumor Cells, Cultured, Wound Healing, Xenograft Model Antitumor Assays.
- MESH :
- chemical , therapeutic use : Amifostine, Radiation-Protective Agents.
- etiology : Lymphedema.
- metabolism : Mammary Neoplasms, Experimental.
- prevention & control : Lymphedema.
- radiation effects : Lymphatic Vessels.
- radiotherapy : Mammary Neoplasms, Experimental.
- Animals, Colony-Forming Units Assay, Female, Humans, Incidence, Male, Mice, Mice, Nude, Radiation Tolerance, Rats, Rats, Wistar, Tumor Cells, Cultured, Wound Healing, Xenograft Model Antitumor Assays.
Abstract
Lymphedema or tissue swelling from impaired lymph drainage commonly occurs after regional nodal dissection and/or radiation therapy for cancer control. Treatment options for this disabling and life-altering complication involve long-term labor-intensive commitments. Sentinel node biopsy can forestall removal of negative regional nodes, offering some protection against lymphedema, however, most preventive measures are elusive, ineffective, or unproven. Our goal was to determine whether the radioprotectant amifostine could prevent or retard the development of lymphedema in a rodent radiation therapy-dependent model yet not offer tumor protection from the therapeutic effects of radiation therapy. We pre-treated rats after unilateral radical groin dissection with the organic thiophosphate radioprotectant amifostine or placebo prior to single dose post-operative groin radiation therapy and monitored hindlimb volumes, wound scores, and tissue lymphostasis. In addition, we determined whether amifostine protected human MCF7 breast cancer cells exposed to a range of radiation therapy doses in an in vitro clonogenic assay and an in vivo MCF7 tumor xenograft model. Our findings indicate that amifostine markedly reduced the volume of limb lymphedema and dramatically improved wound healing and tissue lymphostasis in the rodent lymphedema model. The in vivo and in vitro studies further demonstrated that amifostine offered no MCF7 tumor protection from radiation therapy. These pre-clinical findings provide proof-of-principle to further delineate specific mechanisms underlying amifostine's beneficial effects, determine optimal amifostine-radiation therapy dosing regimens, and thereby expedite translation into clinical trials to reduce lymphedema incidence and severity in cancer patients at high lymphedema risk in whom radiation therapy is the recommended therapy.
PubMed: 20848992
Affiliations:
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Bracamonte</name></author><author><name sortKey="Mckenna, M" sort="Mckenna, M" uniqKey="Mckenna M" first="M" last="Mckenna">M. Mckenna</name></author><author><name sortKey="Stejskal, A" sort="Stejskal, A" uniqKey="Stejskal A" first="A" last="Stejskal">A. Stejskal</name></author><author><name sortKey="Hirleman, E D" sort="Hirleman, E D" uniqKey="Hirleman E" first="E D" last="Hirleman">E D Hirleman</name></author><author><name sortKey="Witte, M H" sort="Witte, M H" uniqKey="Witte M" first="M H" last="Witte">M H Witte</name></author></analytic><series><title level="j">Lymphology</title><idno type="ISSN">0024-7766</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amifostine (therapeutic use)</term><term>Animals</term><term>Colony-Forming Units Assay</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Lymphatic Vessels (radiation effects)</term><term>Lymphedema (etiology)</term><term>Lymphedema (prevention & control)</term><term>Male</term><term>Mammary Neoplasms, Experimental (metabolism)</term><term>Mammary Neoplasms, Experimental (radiotherapy)</term><term>Mice</term><term>Mice, Nude</term><term>Radiation Tolerance</term><term>Radiation-Protective Agents (therapeutic use)</term><term>Rats</term><term>Rats, Wistar</term><term>Tumor Cells, Cultured</term><term>Wound Healing</term><term>Xenograft Model Antitumor Assays</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Amifostine (usage thérapeutique)</term><term>Animaux</term><term>Cellules cancéreuses en culture</term><term>Cicatrisation de plaie</term><term>Femelle</term><term>Humains</term><term>Incidence</term><term>Lymphoedème ()</term><term>Lymphoedème (étiologie)</term><term>Mâle</term><term>Radioprotecteurs (usage thérapeutique)</term><term>Radiotolérance</term><term>Rat Wistar</term><term>Rats</term><term>Souris</term><term>Souris nude</term><term>Test clonogénique</term><term>Tests d'activité antitumorale sur modèle de xénogreffe</term><term>Tumeurs expérimentales de la mamelle (métabolisme)</term><term>Tumeurs expérimentales de la mamelle (radiothérapie)</term><term>Vaisseaux lymphatiques (effets des radiations)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Amifostine</term><term>Radiation-Protective Agents</term></keywords><keywords scheme="MESH" qualifier="effets des radiations" xml:lang="fr"><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Mammary Neoplasms, Experimental</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Tumeurs expérimentales de la mamelle</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Mammary Neoplasms, Experimental</term></keywords><keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Tumeurs expérimentales de la mamelle</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Amifostine</term><term>Radioprotecteurs</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Colony-Forming Units Assay</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Mice</term><term>Mice, Nude</term><term>Radiation Tolerance</term><term>Rats</term><term>Rats, Wistar</term><term>Tumor Cells, Cultured</term><term>Wound Healing</term><term>Xenograft Model Antitumor Assays</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules cancéreuses en culture</term><term>Cicatrisation de plaie</term><term>Femelle</term><term>Humains</term><term>Incidence</term><term>Lymphoedème</term><term>Mâle</term><term>Radiotolérance</term><term>Rat Wistar</term><term>Rats</term><term>Souris</term><term>Souris nude</term><term>Test clonogénique</term><term>Tests d'activité antitumorale sur modèle de xénogreffe</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphedema or tissue swelling from impaired lymph drainage commonly occurs after regional nodal dissection and/or radiation therapy for cancer control. Treatment options for this disabling and life-altering complication involve long-term labor-intensive commitments. Sentinel node biopsy can forestall removal of negative regional nodes, offering some protection against lymphedema, however, most preventive measures are elusive, ineffective, or unproven. Our goal was to determine whether the radioprotectant amifostine could prevent or retard the development of lymphedema in a rodent radiation therapy-dependent model yet not offer tumor protection from the therapeutic effects of radiation therapy. We pre-treated rats after unilateral radical groin dissection with the organic thiophosphate radioprotectant amifostine or placebo prior to single dose post-operative groin radiation therapy and monitored hindlimb volumes, wound scores, and tissue lymphostasis. In addition, we determined whether amifostine protected human MCF7 breast cancer cells exposed to a range of radiation therapy doses in an in vitro clonogenic assay and an in vivo MCF7 tumor xenograft model. Our findings indicate that amifostine markedly reduced the volume of limb lymphedema and dramatically improved wound healing and tissue lymphostasis in the rodent lymphedema model. The in vivo and in vitro studies further demonstrated that amifostine offered no MCF7 tumor protection from radiation therapy. These pre-clinical findings provide proof-of-principle to further delineate specific mechanisms underlying amifostine's beneficial effects, determine optimal amifostine-radiation therapy dosing regimens, and thereby expedite translation into clinical trials to reduce lymphedema incidence and severity in cancer patients at high lymphedema risk in whom radiation therapy is the recommended therapy.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Bernas, M J" sort="Bernas, M J" uniqKey="Bernas M" first="M J" last="Bernas">M J Bernas</name><name sortKey="Bracamonte, F" sort="Bracamonte, F" uniqKey="Bracamonte F" first="F" last="Bracamonte">F. Bracamonte</name><name sortKey="Hirleman, E D" sort="Hirleman, E D" uniqKey="Hirleman E" first="E D" last="Hirleman">E D Hirleman</name><name sortKey="Mckenna, M" sort="Mckenna, M" uniqKey="Mckenna M" first="M" last="Mckenna">M. Mckenna</name><name sortKey="Stea, B D" sort="Stea, B D" uniqKey="Stea B" first="B D" last="Stea">B D Stea</name><name sortKey="Stejskal, A" sort="Stejskal, A" uniqKey="Stejskal A" first="A" last="Stejskal">A. Stejskal</name><name sortKey="Witte, M H" sort="Witte, M H" uniqKey="Witte M" first="M H" last="Witte">M H Witte</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Daley, S K" sort="Daley, S K" uniqKey="Daley S" first="S K" last="Daley">S K Daley</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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