Axillary Irradiation as an Imperative Alternative to Axillary Dissection in Clinically Lymph Node-Negative but Sentinel Node-Positive Breast Cancer Patients?
Identifieur interne : 005065 ( Main/Exploration ); précédent : 005064; suivant : 005066Axillary Irradiation as an Imperative Alternative to Axillary Dissection in Clinically Lymph Node-Negative but Sentinel Node-Positive Breast Cancer Patients?
Auteurs : Mirko Nitsche [Allemagne] ; Robert HermannSource :
- Breast Care [ 1661-3791 ] ; 2011.
Abstract
At the moment, positive sentinel lymph node dissection (SLND) of the axilla is followed by axillary lymph node dissection (ALND) as standard of care. Recent data proves that omitting ALND after positive SLND in clinically lymph node-negative early stage breast cancer patients is feasible with low recurrence rates. The well known effect of radiotherapy to destroy occult tumor cells highly contributes to these results as a large extent of level I and II lymph nodes are unavoidably included in standard tangential radiation treatment fields. Reviewing the up to date published data on axillary lymph node treatment with radiotherapy, we hypothesize that full dosage coverage of level I and II of the axilla in early stage breast cancer will improve outcome and should be further evaluated.
Url:
DOI: 10.1159/000333835
PubMed: 22619644
PubMed Central: 3357141
Affiliations:
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Recent data proves that omitting ALND after positive SLND in clinically lymph node-negative early stage breast cancer patients is feasible with low recurrence rates. The well known effect of radiotherapy to destroy occult tumor cells highly contributes to these results as a large extent of level I and II lymph nodes are unavoidably included in standard tangential radiation treatment fields. Reviewing the up to date published data on axillary lymph node treatment with radiotherapy, we hypothesize that full dosage coverage of level I and II of the axilla in early stage breast cancer will improve outcome and should be further evaluated.</p></div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Brême (Land)</li></region><settlement><li>Brême</li></settlement></list><tree><noCountry><name sortKey="Hermann, Robert" sort="Hermann, Robert" uniqKey="Hermann R" first="Robert" last="Hermann">Robert Hermann</name></noCountry><country name="Allemagne"><region name="Brême (Land)"><name sortKey="Nitsche, Mirko" sort="Nitsche, Mirko" uniqKey="Nitsche M" first="Mirko" last="Nitsche">Mirko Nitsche</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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