Modulation of the intramedullary pressure responses by calcium dobesilate in a rabbit knee model of osteoarthritis
Identifieur interne : 004D13 ( Main/Exploration ); précédent : 004D12; suivant : 004D14Modulation of the intramedullary pressure responses by calcium dobesilate in a rabbit knee model of osteoarthritis
Auteurs : James E. Miles [Danemark] ; Asger Wenck [Danemark] ; Christian Fricker [Suisse] ; Eiliv L. Svalastoga [Danemark]Source :
- Acta Orthopaedica [ 1745-3674 ] ; 2011.
Abstract
The presence of bone marrow edema in patients with osteoarthritis is associated with pain and disease progression. Management of bone edema with the synthetic prostacyclin iloprost may be complicated by side effects. Calcium dobesilate, a treatment for chronic venous disease, shares some pharmacological actions with iloprost but appears to be better tolerated. Anecdotal reports have suggested that calcium dobesilate may be useful for medical management of osteoarthritis, possibly by reducing bone marrow edema, and this study was performed to investigate possible benefits of treatment.
The effects of a 6-week period of oral calcium dobesilate administration on tibial intramedullary pressure dynamics and physical joint characteristics were evaluated in 20 rabbits with unilaterally induced knee osteoarthritis that were randomly allocated to either a treatment group or a placebo control group. Treatment or placebo started 8 weeks after induction of osteoarthritis, and was followed by a 4-week washout period.
Calcium dobesilate did not affect joint thickness or range of motion, nor individual pressure measurements, compared to placebo. Pressure ranges in the operated limb were greater than in the intact limb after 8 weeks, and approached those of the intact limb after 6 weeks of treatment with calcium dobesilate but not with placebo. Inter-limb differences were lower (p = 0.02) in the dobesilate group following the washout period.
Calcium dobesilate had a detectable effect on pressure dynamics in the subchondral bone of osteoarthritic joints in this model. The significance of these effects for pain and function should be established.
Url:
DOI: 10.3109/17453674.2011.618916
PubMed: 21895501
PubMed Central: 3242962
Affiliations:
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Miles</name><affiliation wicri:level="1"><nlm:aff id="AF0001"><institution>Department of Small Animal Clinical Sciences</institution>,<addr-line>Faculty of Life Sciences (LIFE), University of Copenhagen</addr-line>,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wenck, Asger" sort="Wenck, Asger" uniqKey="Wenck A" first="Asger" last="Wenck">Asger Wenck</name><affiliation wicri:level="1"><nlm:aff id="AF0001"><institution>Department of Small Animal Clinical Sciences</institution>,<addr-line>Faculty of Life Sciences (LIFE), University of Copenhagen</addr-line>,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fricker, Christian" sort="Fricker, Christian" uniqKey="Fricker C" first="Christian" last="Fricker">Christian Fricker</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><addr-line>Chaltbrunnstrasse 18, 8165 Schöfflisdorf</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Svalastoga, Eiliv L" sort="Svalastoga, Eiliv L" uniqKey="Svalastoga E" first="Eiliv L" last="Svalastoga">Eiliv L. 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Miles</name><affiliation wicri:level="1"><nlm:aff id="AF0001"><institution>Department of Small Animal Clinical Sciences</institution>,<addr-line>Faculty of Life Sciences (LIFE), University of Copenhagen</addr-line>,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wenck, Asger" sort="Wenck, Asger" uniqKey="Wenck A" first="Asger" last="Wenck">Asger Wenck</name><affiliation wicri:level="1"><nlm:aff id="AF0001"><institution>Department of Small Animal Clinical Sciences</institution>,<addr-line>Faculty of Life Sciences (LIFE), University of Copenhagen</addr-line>,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fricker, Christian" sort="Fricker, Christian" uniqKey="Fricker C" first="Christian" last="Fricker">Christian Fricker</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><addr-line>Chaltbrunnstrasse 18, 8165 Schöfflisdorf</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Svalastoga, Eiliv L" sort="Svalastoga, Eiliv L" uniqKey="Svalastoga E" first="Eiliv L" last="Svalastoga">Eiliv L. Svalastoga</name><affiliation wicri:level="1"><nlm:aff id="AF0001"><institution>Department of Small Animal Clinical Sciences</institution>,<addr-line>Faculty of Life Sciences (LIFE), University of Copenhagen</addr-line>,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Acta Orthopaedica</title><idno type="ISSN">1745-3674</idno><idno type="eISSN">1745-3682</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background and purpose</title><p>The presence of bone marrow edema in patients with osteoarthritis is associated with pain and disease progression. Management of bone edema with the synthetic prostacyclin iloprost may be complicated by side effects. Calcium dobesilate, a treatment for chronic venous disease, shares some pharmacological actions with iloprost but appears to be better tolerated. Anecdotal reports have suggested that calcium dobesilate may be useful for medical management of osteoarthritis, possibly by reducing bone marrow edema, and this study was performed to investigate possible benefits of treatment.</p></sec><sec><title>Methods</title><p>The effects of a 6-week period of oral calcium dobesilate administration on tibial intramedullary pressure dynamics and physical joint characteristics were evaluated in 20 rabbits with unilaterally induced knee osteoarthritis that were randomly allocated to either a treatment group or a placebo control group. Treatment or placebo started 8 weeks after induction of osteoarthritis, and was followed by a 4-week washout period.</p></sec><sec><title>Results</title><p>Calcium dobesilate did not affect joint thickness or range of motion, nor individual pressure measurements, compared to placebo. Pressure ranges in the operated limb were greater than in the intact limb after 8 weeks, and approached those of the intact limb after 6 weeks of treatment with calcium dobesilate but not with placebo. Inter-limb differences were lower (p = 0.02) in the dobesilate group following the washout period.</p></sec><sec><title>Interpretation</title><p>Calcium dobesilate had a detectable effect on pressure dynamics in the subchondral bone of osteoarthritic joints in this model. The significance of these effects for pain and function should be established.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Aigner, N" uniqKey="Aigner N">N Aigner</name></author><author><name sortKey="Petje, G" uniqKey="Petje G">G Petje</name></author><author><name sortKey="Steinboeck, G" uniqKey="Steinboeck G">G Steinboeck</name></author><author><name sortKey="Schneider, W" uniqKey="Schneider W">W Schneider</name></author><author><name sortKey="Krasny, C" uniqKey="Krasny C">C Krasny</name></author><author><name sortKey="Landsiedl, F" uniqKey="Landsiedl F">F Landsiedl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aigner, N" uniqKey="Aigner N">N Aigner</name></author><author><name sortKey="Radda, C" uniqKey="Radda C">C Radda</name></author><author><name sortKey="Meizer, R" uniqKey="Meizer R">R Meizer</name></author><author><name sortKey="Petje, G" uniqKey="Petje G">G Petje</name></author><author><name sortKey="Kotsaris, S" uniqKey="Kotsaris S">S Kotsaris</name></author><author><name sortKey="Krasny, C" uniqKey="Krasny C">C Krasny</name></author><author><name sortKey="Landsiedl, F" uniqKey="Landsiedl F">F Landsiedl</name></author><author><name sortKey="Steinboeck, G" uniqKey="Steinboeck G">G Steinboeck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arnoldi, Cc" uniqKey="Arnoldi C">CC Arnoldi</name></author><author><name sortKey="Reimann, I" uniqKey="Reimann I">I Reimann</name></author><author><name sortKey="Mortensen, S" uniqKey="Mortensen S">S Mortensen</name></author><author><name sortKey="Christensen, Sb" uniqKey="Christensen S">SB Christensen</name></author><author><name sortKey="Kristoffersen, J" uniqKey="Kristoffersen J">J Kristoffersen</name></author><author><name sortKey="Sonnichsen, Hv" uniqKey="Sonnichsen H">HV Sonnichsen</name></author><author><name sortKey="Smith, M" uniqKey="Smith M">M Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brennan, Mp" uniqKey="Brennan M">MP Brennan</name></author><author><name sortKey="Sinusas, Aj" uniqKey="Sinusas A">AJ Sinusas</name></author><author><name sortKey="Horvath, Tl" uniqKey="Horvath T">TL Horvath</name></author><author><name sortKey="Collins, Jg" uniqKey="Collins J">JG Collins</name></author><author><name sortKey="Harding, Mj" uniqKey="Harding M">MJ Harding</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Casley Smith, Jr" uniqKey="Casley Smith J">JR Casley-Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Casley Smith, Jr" uniqKey="Casley Smith J">JR Casley-Smith</name></author><author><name sortKey="Casley Smith, J" uniqKey="Casley Smith J">J Casley-Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Creamer, P" uniqKey="Creamer P">P Creamer</name></author><author><name sortKey="Hunt, M" uniqKey="Hunt M">M Hunt</name></author><author><name sortKey="Dieppe, P" uniqKey="Dieppe P">P Dieppe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Edwards, Jr" uniqKey="Edwards J">JR Edwards</name></author><author><name sortKey="Williams, K" uniqKey="Williams K">K Williams</name></author><author><name sortKey="Kindblom, Lg" uniqKey="Kindblom L">LG Kindblom</name></author><author><name sortKey="Meis Kindblom, Jm" uniqKey="Meis Kindblom J">JM Meis-Kindblom</name></author><author><name sortKey="Hogendoorn P, Cw" uniqKey="Hogendoorn P C">CW Hogendoorn P</name></author><author><name sortKey="Hughes, D" uniqKey="Hughes D">D Hughes</name></author><author><name sortKey="Forsyth, Rg" uniqKey="Forsyth R">RG Forsyth</name></author><author><name sortKey="Jackson, D" uniqKey="Jackson D">D Jackson</name></author><author><name sortKey="Athanasou, Na" uniqKey="Athanasou N">NA Athanasou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Felson, Dt" uniqKey="Felson D">DT Felson</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Felson, Dt" uniqKey="Felson D">DT Felson</name></author><author><name sortKey="Chaisson, Ce" uniqKey="Chaisson C">CE Chaisson</name></author><author><name sortKey="Hill, Cl" uniqKey="Hill C">CL Hill</name></author><author><name sortKey="Totterman S, Ms" uniqKey="Totterman S M">MS Totterman S</name></author><author><name sortKey="Gale, Me" uniqKey="Gale M">ME Gale</name></author><author><name sortKey="Skinner, Km" uniqKey="Skinner K">KM Skinner</name></author><author><name sortKey="Kazis, L" uniqKey="Kazis L">L Kazis</name></author><author><name sortKey="Gale, Dr" uniqKey="Gale D">DR Gale</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Felson, Dt" uniqKey="Felson D">DT Felson</name></author><author><name sortKey="Mclaughlin, S" uniqKey="Mclaughlin S">S McLaughlin</name></author><author><name sortKey="Goggins, J" uniqKey="Goggins J">J Goggins</name></author><author><name sortKey="Lavalley, Mp" uniqKey="Lavalley M">MP LaValley</name></author><author><name sortKey="Gale, E" uniqKey="Gale E">E Gale</name></author><author><name sortKey="Totterman, S" uniqKey="Totterman S">S Totterman</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Hill, C" uniqKey="Hill C">C Hill</name></author><author><name sortKey="Gale, D" uniqKey="Gale D">D Gale</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Flota Cervera, F" uniqKey="Flota Cervera F">F Flota-Cervera</name></author><author><name sortKey="Flota Ruiz, C" uniqKey="Flota Ruiz C">C Flota-Ruiz</name></author><author><name sortKey="Trevino, C" uniqKey="Trevino C">C Trevino</name></author><author><name sortKey="Berber, A" uniqKey="Berber A">A Berber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fricker, C" uniqKey="Fricker C">C Fricker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fricker, C" uniqKey="Fricker C">C Fricker</name></author><author><name sortKey="Bucher, K" uniqKey="Bucher K">K Bucher</name></author><author><name sortKey="Stuker, G" uniqKey="Stuker G">G Stuker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grant, Sm" uniqKey="Grant S">SM Grant</name></author><author><name sortKey="Goa, Kl" uniqKey="Goa K">KL Goa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haritoglou, C" uniqKey="Haritoglou C">C Haritoglou</name></author><author><name sortKey="Gerss, J" uniqKey="Gerss J">J Gerss</name></author><author><name sortKey="Sauerland, C" uniqKey="Sauerland C">C Sauerland</name></author><author><name sortKey="Kampik, A" uniqKey="Kampik A">A Kampik</name></author><author><name sortKey="Ulbig, Mw" uniqKey="Ulbig M">MW Ulbig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jager, M" uniqKey="Jager M">M Jager</name></author><author><name sortKey="Tillmann, Fp" uniqKey="Tillmann F">FP Tillmann</name></author><author><name sortKey="Thornhill, Ts" uniqKey="Thornhill T">TS Thornhill</name></author><author><name sortKey="Mahmoudi, M" uniqKey="Mahmoudi M">M Mahmoudi</name></author><author><name sortKey="Blondin, D" uniqKey="Blondin D">D Blondin</name></author><author><name sortKey="Hetzel, Gr" uniqKey="Hetzel G">GR Hetzel</name></author><author><name sortKey="Zilkens, C" uniqKey="Zilkens C">C Zilkens</name></author><author><name sortKey="Krauspe, R" uniqKey="Krauspe R">R Krauspe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kiaer, T" uniqKey="Kiaer T">T Kiaer</name></author><author><name sortKey="Gronlund, J" uniqKey="Gronlund J">J Gronlund</name></author><author><name sortKey="Sorensen, Kh" uniqKey="Sorensen K">KH Sorensen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kiaer, T" uniqKey="Kiaer T">T Kiaer</name></author><author><name sortKey="Gronlund, J" uniqKey="Gronlund J">J Gronlund</name></author><author><name sortKey="Jensen, B" uniqKey="Jensen B">B Jensen</name></author><author><name sortKey="Svalastoga, E" uniqKey="Svalastoga E">E Svalastoga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kofoed, H" uniqKey="Kofoed H">H Kofoed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martinez Zapata, Mj" uniqKey="Martinez Zapata M">MJ Martinez-Zapata</name></author><author><name sortKey="Moreno, Rm" uniqKey="Moreno R">RM Moreno</name></author><author><name sortKey="Gich, I" uniqKey="Gich I">I Gich</name></author><author><name sortKey="Urrutia, G" uniqKey="Urrutia G">G Urrutia</name></author><author><name sortKey="Bonfill, X" uniqKey="Bonfill X">X Bonfill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mayerhoefer, Me" uniqKey="Mayerhoefer M">ME Mayerhoefer</name></author><author><name sortKey="Kramer, J" uniqKey="Kramer J">J Kramer</name></author><author><name sortKey="Breitenseher, Mj" uniqKey="Breitenseher M">MJ Breitenseher</name></author><author><name sortKey="Norden, C" uniqKey="Norden C">C Norden</name></author><author><name sortKey="Vakil Adli, A" uniqKey="Vakil Adli A">A Vakil-Adli</name></author><author><name sortKey="Hofmann, S" uniqKey="Hofmann S">S Hofmann</name></author><author><name sortKey="Meizer, R" uniqKey="Meizer R">R Meizer</name></author><author><name sortKey="Siedentop, H" uniqKey="Siedentop H">H Siedentop</name></author><author><name sortKey="Landsiedl, F" uniqKey="Landsiedl F">F Landsiedl</name></author><author><name sortKey="Aigner, N" uniqKey="Aigner N">N Aigner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pfander, D" uniqKey="Pfander D">D Pfander</name></author><author><name sortKey="Cramer, T" uniqKey="Cramer T">T Cramer</name></author><author><name sortKey="Swoboda, B" uniqKey="Swoboda B">B Swoboda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Piermattei, Dl" uniqKey="Piermattei D">DL Piermattei</name></author><author><name sortKey="Flo, Gl" uniqKey="Flo G">GL Flo</name></author><author><name sortKey="Decamp, Ce" uniqKey="Decamp C">CE DeCamp</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pitt, E" uniqKey="Pitt E">E Pitt</name></author><author><name sortKey="Lewis, Da" uniqKey="Lewis D">DA Lewis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pool, Rr" uniqKey="Pool R">RR Pool</name></author><author><name sortKey="Meagher, Dm" uniqKey="Meagher D">DM Meagher</name></author><author><name sortKey="Stover, Sm" uniqKey="Stover S">SM Stover</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Svalastoga, E" uniqKey="Svalastoga E">E Svalastoga</name></author><author><name sortKey="Smith, M" uniqKey="Smith M">M Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tejerina, T" uniqKey="Tejerina T">T Tejerina</name></author><author><name sortKey="Ruiz, E" uniqKey="Ruiz E">E Ruiz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomas, Ih" uniqKey="Thomas I">IH Thomas</name></author><author><name sortKey="Gregg, Pj" uniqKey="Gregg P">PJ Gregg</name></author><author><name sortKey="Walder, Dn" uniqKey="Walder D">DN Walder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tiraloche, G" uniqKey="Tiraloche G">G Tiraloche</name></author><author><name sortKey="Girard, C" uniqKey="Girard C">C Girard</name></author><author><name sortKey="Chouinard, L" 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