Survival-adjusted health-related quality of life (HRQL) among patients with metastatic breast cancer receiving paclitaxel plus bevacizumab versus paclitaxel alone: results from Eastern Cooperative Oncology Group Study 2100 (E2100)
Identifieur interne : 004B16 ( Main/Exploration ); précédent : 004B15; suivant : 004B17Survival-adjusted health-related quality of life (HRQL) among patients with metastatic breast cancer receiving paclitaxel plus bevacizumab versus paclitaxel alone: results from Eastern Cooperative Oncology Group Study 2100 (E2100)
Auteurs : David Cella ; Molin Wang ; Lynne Wagner ; Kathy MillerSource :
- Breast cancer research and treatment [ 0167-6806 ] ; 2011.
Abstract
The purpose of this study was to examine health-related quality of life (HRQL) among women with metastatic breast cancer treated on E2100 with paclitaxel or paclitaxel plus bevacizumab. Trial participants (
Url:
DOI: 10.1007/s10549-011-1725-6
PubMed: 21874312
PubMed Central: 3684040
Affiliations:
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Survival-adjusted health-related quality of life (HRQL) among patients with metastatic breast cancer receiving paclitaxel plus bevacizumab versus paclitaxel alone: results from Eastern Cooperative Oncology Group Study 2100 (E2100)</title>
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<author><name sortKey="Miller, Kathy" sort="Miller, Kathy" uniqKey="Miller K" first="Kathy" last="Miller">Kathy Miller</name>
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<front><div type="abstract" xml:lang="en"><p id="P1">The purpose of this study was to examine health-related quality of life (HRQL) among women with metastatic breast cancer treated on E2100 with paclitaxel or paclitaxel plus bevacizumab. Trial participants (<italic>N</italic>
= 670) completed the Functional Assessment of Cancer Therapy-Breast (FACT-B) pre-treatment and following 4 and 8 cycles of treatment to assess HRQL and breast cancer-specific concerns. A significantly higher proportion of missing FACT-B assessments was observed among patients receiving paclitaxel only, due to faster time to death. To account for this non-ignorable pattern of missing data, we conducted a survival-adjusted HRQL analysis by jointly modeling the longitudinal HRQL outcome and time to non-ignorable dropout using a two-stage model. FACT scores assessing HRQL did not differ following 4 and 8 cycles of treatment; however mean scores on the 9-item Breast Cancer Scale were significantly higher after 4 and 8 cycles of treatment among patients receiving paclitaxel plus bevacizumab. No differences were observed between treatment arms on FACT-B total scores. The addition of bevacizumab was not associated with additional side effect burden from the patient perspective and was associated with a greater reduction in breast cancer-specific concerns. No other differences were noted.</p>
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<name sortKey="Wagner, Lynne" sort="Wagner, Lynne" uniqKey="Wagner L" first="Lynne" last="Wagner">Lynne Wagner</name>
<name sortKey="Wang, Molin" sort="Wang, Molin" uniqKey="Wang M" first="Molin" last="Wang">Molin Wang</name>
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