LymphedemaV1, Main, Exploration, bibRecord, 004A42

The value of dual-time-point 18F-FDG PET/CT for identifying axillary lymph node metastasis in breast cancer patients

Identifieur interne : 004A42 ( Main/Exploration ); précédent : 004A41; suivant : 004A43

The value of dual-time-point 18F-FDG PET/CT for identifying axillary lymph node metastasis in breast cancer patients

Auteurs : W H Choi ; I R Yoo ; J H O ; S H Kim ; S K Chung

Source :

The British Journal of Radiology [ 0007-1285 ] ; 2011.

RBID : PMC:3473484

Abstract

Objective

The sensitivity of 18-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography (PET) for detecting axillary lymph node (ALN) metastases in breast cancer is reported to be low. Several studies have shown, however, that dual-time-point ¹⁸F-FDG PET imaging provides improved accuracy in the diagnosis of certain primary tumours when compared with single-scan imaging. The purpose of this study was to assess whether the use of dual-time-point ¹⁸F-FDG PET/CT scans could improve the diagnostic accuracy of ALN metastasis in breast cancer.

Method

The study included 171 breast cancer patients who underwent pre-operative ¹⁸F-FDG PET/CT scans at 2 time-points, the first at 1 h after radiotracer injection and the second 3 h after injection. Where ¹⁸F-FDG uptake was in the ALN perceptibly increased, the maximum standardised uptake values for both time-points (SUVmax1 and SUVmax2) and the retention index (RI) were calculated. Correlation between the PET/CT results and post-operative histological results was assessed.

Results

The performance of 1 h and 3 h PET/CT scans was equal, with sensitivity 60.3% and specificity 84.7%, in detecting ALN metastasis. Out of 171 patients, 60 had ALNs with increased ¹⁸F-FDG uptake on 1 h or 3 h images. There was no significant difference in RI between the metastatic ALN-positive group and the node-negative group. The area under the receiver operating characteristic (ROC) curve for SUVmax1 was 0.90 (p<0.001) and 0.87 for SUVmax2 (p<0.001).

Conclusion

Dual time-point imaging did not improve the overall performance of ¹⁸F-FDG PET/CT in detecting ALN metastasis in breast cancer patients.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473484

DOI: 10.1259/bjr/56324742
PubMed: 21081574
PubMed Central: 3473484

Affiliations:

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<front><div type="abstract" xml:lang="en"><sec><title>Objective</title>
<p>The sensitivity of 18-fluorodeoxyglucose <bold>(</bold>
<sup>18</sup>
F-FDG) positron emission tomography (PET) for detecting axillary lymph node (ALN) metastases in breast cancer is reported to be low. Several studies have shown, however, that dual-time-point <sup>18</sup>
F-FDG PET imaging provides improved accuracy in the diagnosis of certain primary tumours when compared with single-scan imaging. The purpose of this study was to assess whether the use of dual-time-point <sup>18</sup>
F-FDG PET/CT scans could improve the diagnostic accuracy of ALN metastasis in breast cancer.</p>
</sec>
<sec><title>Method</title>
<p>The study included 171 breast cancer patients who underwent pre-operative <sup>18</sup>
F-FDG PET/CT scans at 2 time-points, the first at 1 h after radiotracer injection and the second 3 h after injection. Where <sup>18</sup>
F-FDG uptake was in the ALN perceptibly increased, the maximum standardised uptake values for both time-points (SUVmax1 and SUVmax2) and the retention index (RI) were calculated. Correlation between the PET/CT results and post-operative histological results was assessed.</p>
</sec>
<sec><title>Results</title>
<p>The performance of 1 h and 3 h PET/CT scans was equal, with sensitivity 60.3% and specificity 84.7%, in detecting ALN metastasis. Out of 171 patients, 60 had ALNs with increased <sup>18</sup>
F-FDG uptake on 1 h or 3 h images. There was no significant difference in RI between the metastatic ALN-positive group and the node-negative group. The area under the receiver operating characteristic (ROC) curve for SUVmax1 was 0.90 (<italic>p</italic>
<0.001) and 0.87 for SUVmax2 (<italic>p</italic>
<0.001).</p>
</sec>
<sec><title>Conclusion</title>
<p>Dual time-point imaging did not improve the overall performance of <sup>18</sup>
F-FDG PET/CT in detecting ALN metastasis in breast cancer patients.</p>
</sec>
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The value of dual-time-point 18F-FDG PET/CT for identifying axillary lymph node metastasis in breast cancer patients

The value of dual-time-point 18F-FDG PET/CT for identifying axillary lymph node metastasis in breast cancer patients

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