T and B Cell Deficiency Associated with Yellow Nail Syndrome
Identifieur interne : 004656 ( Main/Exploration ); précédent : 004655; suivant : 004657T and B Cell Deficiency Associated with Yellow Nail Syndrome
Auteurs : S. Gupta [États-Unis] ; D. Samra [États-Unis] ; L. Yel [États-Unis] ; S. Agrawal [États-Unis]Source :
- Scandinavian Journal of Immunology [ 0300-9475 ] ; 2012-03.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Déficit immunitaire commun variable (immunologie), Déficits immunitaires (immunologie), Femelle, Humains, Immunoglobulines (usage thérapeutique), Jeune adulte, Lymphocytes B (cytologie), Lymphocytes B (immunologie), Lymphocytes T CD4+ (cytologie), Lymphocytes T CD4+ (immunologie), Lymphocytes T CD8+ (cytologie), Lymphocytes T CD8+ (immunologie), Mâle, Sujet âgé, Syndrome des ongles jaunes (), Syndrome des ongles jaunes (immunologie).
- MESH :
- cytologie : Lymphocytes B, Lymphocytes T CD4+, Lymphocytes T CD8+.
- immunologie : Déficit immunitaire commun variable, Déficits immunitaires, Lymphocytes B, Lymphocytes T CD4+, Lymphocytes T CD8+, Syndrome des ongles jaunes.
- usage thérapeutique : Immunoglobulines.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Jeune adulte, Mâle, Sujet âgé, Syndrome des ongles jaunes.
English descriptors
- KwdEn :
- Adult, Aged, B-Lymphocytes (cytology), B-Lymphocytes (immunology), CD4-Positive T-Lymphocytes (cytology), CD4-Positive T-Lymphocytes (immunology), CD8-Positive T-Lymphocytes (cytology), CD8-Positive T-Lymphocytes (immunology), Common Variable Immunodeficiency (immunology), Female, Humans, Immunoglobulins (therapeutic use), Immunologic Deficiency Syndromes (immunology), Male, Middle Aged, Yellow Nail Syndrome (immunology), Yellow Nail Syndrome (therapy), Young Adult.
- MESH :
- chemical , therapeutic use : Immunoglobulins.
- cytology : B-Lymphocytes, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes.
- immunology : B-Lymphocytes, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Common Variable Immunodeficiency, Immunologic Deficiency Syndromes, Yellow Nail Syndrome.
- therapy : Yellow Nail Syndrome.
- Adult, Aged, Female, Humans, Male, Middle Aged, Young Adult.
Abstract
Yellow nail syndrome (YNS) is a rare disorder of unknown aetiology that is characterized by yellow nails associated with lymphoedema and chronic respiratory manifestations. There are no detailed immunological studies in YNS. In this study, we present first extensive immunological analysis of both adaptive and innate immunity in two patients with YNS. One patient has common variable immunodeficiency, whereas second patient has specific antibody deficiency syndrome. Severe lymphopaenia, a striking deficiency of naïve CD4+ and CD8+ T cells and total B cells, and increased transitional B cells were observed. T cell proliferative response to mitogens and antigens was significantly reduced in both patients. Both patients failed to make specific antibody response to pneumococci. Complement, natural killer cell activity and neutrophil oxidative burst were normal. Immunoglobulin administration resulted in decreased frequency and severity of infections, and an impressive effect was observed on lymphoedema and on the recurrence of pleural effusion. Our data show that YNS is associated with both T and B cell defects. Furthermore, Immunoglobulin may be beneficial in clinical manifestations of lymphoedema.
Url:
DOI: 10.1111/j.1365-3083.2011.02653.x
Affiliations:
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Yel</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Basic and Clinical Immunology, University of California, Irvine, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Agrawal, S" sort="Agrawal, S" uniqKey="Agrawal S" first="S." last="Agrawal">S. Agrawal</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Basic and Clinical Immunology, University of California, Irvine, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Scandinavian Journal of Immunology</title><title level="j" type="alt">SCANDINAVIAN JOURNAL IMMUNOLOGY</title><idno type="ISSN">0300-9475</idno><idno type="eISSN">1365-3083</idno><imprint><biblScope unit="vol">75</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="329">329</biblScope><biblScope unit="page" to="335">335</biblScope><biblScope unit="page-count">7</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2012-03">2012-03</date></imprint><idno type="ISSN">0300-9475</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0300-9475</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>B-Lymphocytes (cytology)</term><term>B-Lymphocytes (immunology)</term><term>CD4-Positive T-Lymphocytes (cytology)</term><term>CD4-Positive T-Lymphocytes (immunology)</term><term>CD8-Positive T-Lymphocytes (cytology)</term><term>CD8-Positive T-Lymphocytes (immunology)</term><term>Common Variable Immunodeficiency (immunology)</term><term>Female</term><term>Humans</term><term>Immunoglobulins (therapeutic use)</term><term>Immunologic Deficiency Syndromes (immunology)</term><term>Male</term><term>Middle Aged</term><term>Yellow Nail Syndrome (immunology)</term><term>Yellow Nail Syndrome (therapy)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Déficit immunitaire commun variable (immunologie)</term><term>Déficits immunitaires (immunologie)</term><term>Femelle</term><term>Humains</term><term>Immunoglobulines (usage thérapeutique)</term><term>Jeune adulte</term><term>Lymphocytes B (cytologie)</term><term>Lymphocytes B (immunologie)</term><term>Lymphocytes T CD4+ (cytologie)</term><term>Lymphocytes T CD4+ (immunologie)</term><term>Lymphocytes T CD8+ (cytologie)</term><term>Lymphocytes T CD8+ (immunologie)</term><term>Mâle</term><term>Sujet âgé</term><term>Syndrome des ongles jaunes ()</term><term>Syndrome des ongles jaunes (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Immunoglobulins</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Lymphocytes B</term><term>Lymphocytes T CD4+</term><term>Lymphocytes T CD8+</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>B-Lymphocytes</term><term>CD4-Positive T-Lymphocytes</term><term>CD8-Positive T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Déficit immunitaire commun variable</term><term>Déficits immunitaires</term><term>Lymphocytes B</term><term>Lymphocytes T CD4+</term><term>Lymphocytes T CD8+</term><term>Syndrome des ongles jaunes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>B-Lymphocytes</term><term>CD4-Positive T-Lymphocytes</term><term>CD8-Positive T-Lymphocytes</term><term>Common Variable Immunodeficiency</term><term>Immunologic Deficiency Syndromes</term><term>Yellow Nail Syndrome</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Yellow Nail Syndrome</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Immunoglobulines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Sujet âgé</term><term>Syndrome des ongles jaunes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Yellow nail syndrome (YNS) is a rare disorder of unknown aetiology that is characterized by yellow nails associated with lymphoedema and chronic respiratory manifestations. There are no detailed immunological studies in YNS. In this study, we present first extensive immunological analysis of both adaptive and innate immunity in two patients with YNS. One patient has common variable immunodeficiency, whereas second patient has specific antibody deficiency syndrome. Severe lymphopaenia, a striking deficiency of naïve CD4+ and CD8+ T cells and total B cells, and increased transitional B cells were observed. T cell proliferative response to mitogens and antigens was significantly reduced in both patients. Both patients failed to make specific antibody response to pneumococci. Complement, natural killer cell activity and neutrophil oxidative burst were normal. Immunoglobulin administration resulted in decreased frequency and severity of infections, and an impressive effect was observed on lymphoedema and on the recurrence of pleural effusion. Our data show that YNS is associated with both T and B cell defects. Furthermore, Immunoglobulin may be beneficial in clinical manifestations of lymphoedema.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Gupta, S" sort="Gupta, S" uniqKey="Gupta S" first="S." last="Gupta">S. Gupta</name></region><name sortKey="Agrawal, S" sort="Agrawal, S" uniqKey="Agrawal S" first="S." last="Agrawal">S. Agrawal</name><name sortKey="Samra, D" sort="Samra, D" uniqKey="Samra D" first="D." last="Samra">D. Samra</name><name sortKey="Yel, L" sort="Yel, L" uniqKey="Yel L" first="L." last="Yel">L. Yel</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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