Incidence of donor‐specific antibodies in kidney transplant patients following conversion to an everolimus‐based calcineurin inhibitor‐free regimen
Identifieur interne : 003B33 ( Main/Exploration ); précédent : 003B32; suivant : 003B34Incidence of donor‐specific antibodies in kidney transplant patients following conversion to an everolimus‐based calcineurin inhibitor‐free regimen
Auteurs : Nassim Kamar [France] ; Arnaud Del Bello [France] ; Nicolas Congy-Jolivet [France] ; Céline Guilbeau-Frugier [France] ; Isabelle Cardeau-Desangles [France] ; Marylise Fort [France] ; Laure Esposito [France] ; Joelle Guitard [France] ; Xavier Gamé [France] ; Lionel Rostaing [France]Source :
- Clinical Transplantation [ 0902-0063 ] ; 2013-05.
Abstract
Scarce data exist regarding the incidence of donor‐specific antibodies (DSAs) in kidney transplant patients receiving everolimus‐based immunosuppression without calcineurin inhibitors (CNIs). The aim of this retrospective case–control study was to compare the incidence of de novo DSAs in patients converted to an everolimus‐based regimen without CNIs with that seen in patients maintained on CNIs. Sixty‐one DSA‐free kidney transplant patients who had been converted to an everolimus‐based regimen (everolimus group) were compared to 61 other patients maintained on CNIs‐based regimen (control group). Patients were matched according to age, gender, induction therapy, date of transplantation, and being DSA‐free at baseline. At last follow‐up, the incidence of DSAs was 9.8% in the everolimus group and 5% in the control group (p = ns). In the everolimus group, the increased incidence of DSAs between baseline and last follow‐up was statistically significant. Antibody‐mediated rejection occurred in 6.5% in the everolimus group and 0% in the CNIs group. The incidence of DSAs is numerically increased in kidney transplant patients treated with an everolimus‐based without CNIs. A study including a larger number of patients is required to determine whether a CNI‐free everolimus‐based immunosuppression significantly increases DSAs formation.
Url:
DOI: 10.1111/ctr.12127
Affiliations:
- France
- Midi-Pyrénées, Occitanie (région administrative)
- Toulouse
- Université Toulouse III - Paul Sabatier
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Paul Sabatier</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1043, IFR–BMT, CHU Purpan, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical Transplantation</title><title level="j" type="alt">CLINICAL TRANSPLANTATION</title><idno type="ISSN">0902-0063</idno><idno type="eISSN">1399-0012</idno><imprint><biblScope unit="vol">27</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="455">455</biblScope><biblScope unit="page" to="462">462</biblScope><biblScope unit="page-count">8</biblScope><date type="published" when="2013-05">2013-05</date></imprint><idno type="ISSN">0902-0063</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0902-0063</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Scarce data exist regarding the incidence of donor‐specific antibodies (DSAs) in kidney transplant patients receiving everolimus‐based immunosuppression without calcineurin inhibitors (CNIs). The aim of this retrospective case–control study was to compare the incidence of de novo DSAs in patients converted to an everolimus‐based regimen without CNIs with that seen in patients maintained on CNIs. Sixty‐one DSA‐free kidney transplant patients who had been converted to an everolimus‐based regimen (everolimus group) were compared to 61 other patients maintained on CNIs‐based regimen (control group). Patients were matched according to age, gender, induction therapy, date of transplantation, and being DSA‐free at baseline. At last follow‐up, the incidence of DSAs was 9.8% in the everolimus group and 5% in the control group (p = ns). In the everolimus group, the increased incidence of DSAs between baseline and last follow‐up was statistically significant. Antibody‐mediated rejection occurred in 6.5% in the everolimus group and 0% in the CNIs group. The incidence of DSAs is numerically increased in kidney transplant patients treated with an everolimus‐based without CNIs. A study including a larger number of patients is required to determine whether a CNI‐free everolimus‐based immunosuppression significantly increases DSAs formation.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li></region><settlement><li>Toulouse</li></settlement><orgName><li>Université Toulouse III - Paul Sabatier</li></orgName></list><tree><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Kamar, Nassim" sort="Kamar, Nassim" uniqKey="Kamar N" first="Nassim" last="Kamar">Nassim Kamar</name></region><name sortKey="Cardeau Esangles, Isabelle" sort="Cardeau Esangles, Isabelle" uniqKey="Cardeau Esangles I" first="Isabelle" last="Cardeau-Desangles">Isabelle Cardeau-Desangles</name><name sortKey="Congy Olivet, Nicolas" sort="Congy Olivet, Nicolas" uniqKey="Congy Olivet N" first="Nicolas" last="Congy-Jolivet">Nicolas Congy-Jolivet</name><name sortKey="Congy Olivet, Nicolas" sort="Congy Olivet, Nicolas" uniqKey="Congy Olivet N" first="Nicolas" last="Congy-Jolivet">Nicolas Congy-Jolivet</name><name sortKey="Congy Olivet, Nicolas" sort="Congy Olivet, Nicolas" uniqKey="Congy Olivet N" first="Nicolas" last="Congy-Jolivet">Nicolas Congy-Jolivet</name><name sortKey="Del Bello, Arnaud" sort="Del Bello, Arnaud" uniqKey="Del Bello A" first="Arnaud" last="Del Bello">Arnaud Del Bello</name><name sortKey="Del Bello, Arnaud" sort="Del Bello, Arnaud" uniqKey="Del Bello A" first="Arnaud" last="Del Bello">Arnaud Del Bello</name><name sortKey="Esposito, Laure" sort="Esposito, Laure" uniqKey="Esposito L" first="Laure" last="Esposito">Laure Esposito</name><name sortKey="Fort, Marylise" sort="Fort, Marylise" uniqKey="Fort M" first="Marylise" last="Fort">Marylise Fort</name><name sortKey="Game, Xavier" sort="Game, Xavier" uniqKey="Game X" first="Xavier" last="Gamé">Xavier Gamé</name><name sortKey="Guilbeau Rugier, Celine" sort="Guilbeau Rugier, Celine" uniqKey="Guilbeau Rugier C" first="Céline" last="Guilbeau-Frugier">Céline Guilbeau-Frugier</name><name sortKey="Guilbeau Rugier, Celine" sort="Guilbeau Rugier, Celine" uniqKey="Guilbeau Rugier C" first="Céline" last="Guilbeau-Frugier">Céline Guilbeau-Frugier</name><name sortKey="Guitard, Joelle" sort="Guitard, Joelle" uniqKey="Guitard J" first="Joelle" last="Guitard">Joelle Guitard</name><name sortKey="Kamar, Nassim" sort="Kamar, Nassim" uniqKey="Kamar N" first="Nassim" last="Kamar">Nassim Kamar</name><name sortKey="Kamar, Nassim" sort="Kamar, Nassim" uniqKey="Kamar N" first="Nassim" last="Kamar">Nassim Kamar</name><name sortKey="Kamar, Nassim" sort="Kamar, Nassim" uniqKey="Kamar N" first="Nassim" last="Kamar">Nassim Kamar</name><name sortKey="Rostaing, Lionel" sort="Rostaing, Lionel" uniqKey="Rostaing L" first="Lionel" last="Rostaing">Lionel Rostaing</name><name sortKey="Rostaing, Lionel" sort="Rostaing, Lionel" uniqKey="Rostaing L" first="Lionel" last="Rostaing">Lionel Rostaing</name><name sortKey="Rostaing, Lionel" sort="Rostaing, Lionel" uniqKey="Rostaing L" first="Lionel" last="Rostaing">Lionel Rostaing</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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