Drug targets for lymphatic filariasis: a bioinformatics approach.
Identifieur interne : 003702 ( Main/Exploration ); précédent : 003701; suivant : 003703Drug targets for lymphatic filariasis: a bioinformatics approach.
Auteurs : Om Prakash Sharma [Inde] ; Yellamandaya Vadlamudi ; Arun Gupta Kota ; Vikrant Kumar Sinha ; Muthuvel Suresh KumarSource :
- Journal of vector borne diseases [ 0972-9062 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Biologie informatique, Brugia malayi (), Brugia malayi (génétique), Découverte de médicament, Filaricides (pharmacologie), Filariose lymphatique (parasitologie), Filariose lymphatique (traitement médicamenteux), Génome d'helminthe (génétique), Humains, Protéines d'helminthes (), Protéines d'helminthes (génétique), Wuchereria bancrofti (), Wuchereria bancrofti (génétique).
- MESH :
- génétique : Brugia malayi, Génome d'helminthe, Protéines d'helminthes, Wuchereria bancrofti.
- parasitologie : Filariose lymphatique.
- pharmacologie : Filaricides.
- traitement médicamenteux : Filariose lymphatique.
- Animaux, Biologie informatique, Brugia malayi, Découverte de médicament, Humains, Protéines d'helminthes, Wuchereria bancrofti.
English descriptors
- KwdEn :
- Animals, Brugia malayi (drug effects), Brugia malayi (genetics), Computational Biology, Drug Discovery, Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (parasitology), Filaricides (pharmacology), Genome, Helminth (genetics), Helminth Proteins (drug effects), Helminth Proteins (genetics), Humans, Wuchereria bancrofti (drug effects), Wuchereria bancrofti (genetics).
- MESH :
- chemical , drug effects : Helminth Proteins.
- chemical , genetics : Helminth Proteins.
- chemical , pharmacology : Filaricides.
- drug effects : Brugia malayi, Wuchereria bancrofti.
- drug therapy : Elephantiasis, Filarial.
- genetics : Brugia malayi, Genome, Helminth, Wuchereria bancrofti.
- parasitology : Elephantiasis, Filarial.
- Animals, Computational Biology, Drug Discovery, Humans.
Abstract
This review article discusses the current scenario of the national and international burden due to lymphatic filariasis (LF) and describes the active elimination programmes for LF and their achievements to eradicate this most debilitating disease from the earth. Since, bioinformatics is a rapidly growing field of biological study, and it has an increasingly significant role in various fields of biology. We have reviewed its leading involvement in the filarial research using different approaches of bioinformatics and have summarized available existing drugs and their targets to re-examine and to keep away from the resisting conditions. Moreover, some of the novel drug targets have been assembled for further study to design fresh and better pharmacological therapeutics. Various bioinformatics-based web resources, and databases have been discussed, which may enrich the filarial research.
PubMed: 24220073
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001840
- to stream PubMed, to step Curation: 001840
- to stream PubMed, to step Checkpoint: 001840
- to stream Ncbi, to step Merge: 005F24
- to stream Ncbi, to step Curation: 005F24
- to stream Ncbi, to step Checkpoint: 005F24
- to stream Main, to step Merge: 003709
- to stream Main, to step Curation: 003702
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Drug targets for lymphatic filariasis: a bioinformatics approach.</title><author><name sortKey="Sharma, Om Prakash" sort="Sharma, Om Prakash" uniqKey="Sharma O" first="Om Prakash" last="Sharma">Om Prakash Sharma</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Bioinformatics, School of Life Science, Pondicherry University, Puducherry, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Centre for Bioinformatics, School of Life Science, Pondicherry University, Puducherry</wicri:regionArea><wicri:noRegion>Puducherry</wicri:noRegion></affiliation></author><author><name sortKey="Vadlamudi, Yellamandaya" sort="Vadlamudi, Yellamandaya" uniqKey="Vadlamudi Y" first="Yellamandaya" last="Vadlamudi">Yellamandaya Vadlamudi</name></author><author><name sortKey="Kota, Arun Gupta" sort="Kota, Arun Gupta" uniqKey="Kota A" first="Arun Gupta" last="Kota">Arun Gupta Kota</name></author><author><name sortKey="Sinha, Vikrant Kumar" sort="Sinha, Vikrant Kumar" uniqKey="Sinha V" first="Vikrant Kumar" last="Sinha">Vikrant Kumar Sinha</name></author><author><name sortKey="Kumar, Muthuvel Suresh" sort="Kumar, Muthuvel Suresh" uniqKey="Kumar M" first="Muthuvel Suresh" last="Kumar">Muthuvel Suresh Kumar</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:24220073</idno><idno type="pmid">24220073</idno><idno type="wicri:Area/PubMed/Corpus">001840</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001840</idno><idno type="wicri:Area/PubMed/Curation">001840</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001840</idno><idno type="wicri:Area/PubMed/Checkpoint">001840</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001840</idno><idno type="wicri:Area/Ncbi/Merge">005F24</idno><idno type="wicri:Area/Ncbi/Curation">005F24</idno><idno type="wicri:Area/Ncbi/Checkpoint">005F24</idno><idno type="wicri:doubleKey">0972-9062:2013:Sharma O:drug:targets:for</idno><idno type="wicri:Area/Main/Merge">003709</idno><idno type="wicri:Area/Main/Curation">003702</idno><idno type="wicri:Area/Main/Exploration">003702</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Drug targets for lymphatic filariasis: a bioinformatics approach.</title><author><name sortKey="Sharma, Om Prakash" sort="Sharma, Om Prakash" uniqKey="Sharma O" first="Om Prakash" last="Sharma">Om Prakash Sharma</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Bioinformatics, School of Life Science, Pondicherry University, Puducherry, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Centre for Bioinformatics, School of Life Science, Pondicherry University, Puducherry</wicri:regionArea><wicri:noRegion>Puducherry</wicri:noRegion></affiliation></author><author><name sortKey="Vadlamudi, Yellamandaya" sort="Vadlamudi, Yellamandaya" uniqKey="Vadlamudi Y" first="Yellamandaya" last="Vadlamudi">Yellamandaya Vadlamudi</name></author><author><name sortKey="Kota, Arun Gupta" sort="Kota, Arun Gupta" uniqKey="Kota A" first="Arun Gupta" last="Kota">Arun Gupta Kota</name></author><author><name sortKey="Sinha, Vikrant Kumar" sort="Sinha, Vikrant Kumar" uniqKey="Sinha V" first="Vikrant Kumar" last="Sinha">Vikrant Kumar Sinha</name></author><author><name sortKey="Kumar, Muthuvel Suresh" sort="Kumar, Muthuvel Suresh" uniqKey="Kumar M" first="Muthuvel Suresh" last="Kumar">Muthuvel Suresh Kumar</name></author></analytic><series><title level="j">Journal of vector borne diseases</title><idno type="ISSN">0972-9062</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Brugia malayi (drug effects)</term><term>Brugia malayi (genetics)</term><term>Computational Biology</term><term>Drug Discovery</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Filaricides (pharmacology)</term><term>Genome, Helminth (genetics)</term><term>Helminth Proteins (drug effects)</term><term>Helminth Proteins (genetics)</term><term>Humans</term><term>Wuchereria bancrofti (drug effects)</term><term>Wuchereria bancrofti (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Biologie informatique</term><term>Brugia malayi ()</term><term>Brugia malayi (génétique)</term><term>Découverte de médicament</term><term>Filaricides (pharmacologie)</term><term>Filariose lymphatique (parasitologie)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Génome d'helminthe (génétique)</term><term>Humains</term><term>Protéines d'helminthes ()</term><term>Protéines d'helminthes (génétique)</term><term>Wuchereria bancrofti ()</term><term>Wuchereria bancrofti (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Helminth Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Helminth Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Brugia malayi</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Brugia malayi</term><term>Genome, Helminth</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Brugia malayi</term><term>Génome d'helminthe</term><term>Protéines d'helminthes</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Computational Biology</term><term>Drug Discovery</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Biologie informatique</term><term>Brugia malayi</term><term>Découverte de médicament</term><term>Humains</term><term>Protéines d'helminthes</term><term>Wuchereria bancrofti</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This review article discusses the current scenario of the national and international burden due to lymphatic filariasis (LF) and describes the active elimination programmes for LF and their achievements to eradicate this most debilitating disease from the earth. Since, bioinformatics is a rapidly growing field of biological study, and it has an increasingly significant role in various fields of biology. We have reviewed its leading involvement in the filarial research using different approaches of bioinformatics and have summarized available existing drugs and their targets to re-examine and to keep away from the resisting conditions. Moreover, some of the novel drug targets have been assembled for further study to design fresh and better pharmacological therapeutics. Various bioinformatics-based web resources, and databases have been discussed, which may enrich the filarial research.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="Kota, Arun Gupta" sort="Kota, Arun Gupta" uniqKey="Kota A" first="Arun Gupta" last="Kota">Arun Gupta Kota</name><name sortKey="Kumar, Muthuvel Suresh" sort="Kumar, Muthuvel Suresh" uniqKey="Kumar M" first="Muthuvel Suresh" last="Kumar">Muthuvel Suresh Kumar</name><name sortKey="Sinha, Vikrant Kumar" sort="Sinha, Vikrant Kumar" uniqKey="Sinha V" first="Vikrant Kumar" last="Sinha">Vikrant Kumar Sinha</name><name sortKey="Vadlamudi, Yellamandaya" sort="Vadlamudi, Yellamandaya" uniqKey="Vadlamudi Y" first="Yellamandaya" last="Vadlamudi">Yellamandaya Vadlamudi</name></noCountry><country name="Inde"><noRegion><name sortKey="Sharma, Om Prakash" sort="Sharma, Om Prakash" uniqKey="Sharma O" first="Om Prakash" last="Sharma">Om Prakash Sharma</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003702 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003702 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:24220073
|texte= Drug targets for lymphatic filariasis: a bioinformatics approach.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24220073" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |