Relationship between Arm Morbidity and Patient-Reported Outcomes Following Surgery in Women with Node-Negative Breast Cancer: NSABP Protocol B-32
Identifieur interne : 003217 ( Main/Exploration ); précédent : 003216; suivant : 003218Relationship between Arm Morbidity and Patient-Reported Outcomes Following Surgery in Women with Node-Negative Breast Cancer: NSABP Protocol B-32
Auteurs : Jacek A. Kopec [États-Unis, Canada] ; Linda H. Colangelo [États-Unis] ; Stephanie R. Land [États-Unis] ; Thomas B. Julian [États-Unis] ; Ann M. Brown [États-Unis] ; Stewart J. Anderson [États-Unis] ; David N. Krag [États-Unis] ; Takamaru Ashikaga [États-Unis] ; Joseph P. Costantino [États-Unis] ; Norman Wolmark [États-Unis] ; Patricia A. Ganz [États-Unis]Source :
- The journal of supportive oncology [ 1544-6794 ] ; 2013.
Descripteurs français
- KwdFr :
- Activités de la vie quotidienne, Adulte d'âge moyen, Amplitude articulaire, Autorapport (utilisation), Bras (), Bras (physiopathologie), Complications postopératoires, Femelle, Humains, Lymphoedème (étiologie), Mastectomie (effets indésirables), Morbidité, Participation du patient, Pronostic, Qualité de vie, Tumeurs du sein (), Études de suivi, Évaluation de résultat (soins).
- MESH :
- effets indésirables : Mastectomie.
- physiopathologie : Bras.
- utilisation : Autorapport.
- étiologie : Lymphoedème.
- Activités de la vie quotidienne, Adulte d'âge moyen, Amplitude articulaire, Bras, Complications postopératoires, Femelle, Humains, Morbidité, Participation du patient, Pronostic, Qualité de vie, Tumeurs du sein, Études de suivi, Évaluation de résultat (soins).
English descriptors
- KwdEn :
- Activities of Daily Living, Arm (physiopathology), Arm (surgery), Breast Neoplasms (complications), Breast Neoplasms (surgery), Female, Follow-Up Studies, Humans, Lymphedema (etiology), Mastectomy (adverse effects), Middle Aged, Morbidity, Outcome Assessment (Health Care), Patient Participation, Postoperative Complications, Prognosis, Quality of Life, Range of Motion, Articular, Self Report (utilization).
- MESH :
- adverse effects : Mastectomy.
- complications : Breast Neoplasms.
- etiology : Lymphedema.
- physiopathology : Arm.
- surgery : Arm, Breast Neoplasms.
- utilization : Self Report.
- Activities of Daily Living, Female, Follow-Up Studies, Humans, Middle Aged, Morbidity, Outcome Assessment (Health Care), Patient Participation, Postoperative Complications, Prognosis, Quality of Life, Range of Motion, Articular.
Abstract
The impact of arm morbidity following breast cancer surgery on patient-observed changes in daily functioning and health-related quality of life (HRQoL) have not been well-studied.
To examine the association of objective measures such as range of motion (ROM) and lymphedema, with patient-reported outcomes (PROs) in the arm and breast, upper extremity function, activities, and HRQoL.
The National Surgical Adjuvant Breast and Bowel Project Protocol B-32 was a randomized trial comparing sentinel node resection (SNR) with axillary dissection (AD) in women with node-negative breast cancer. ROM and arm volume were measured objectively. PROs included symptoms; arm function; limitations in social, recreational, occupational, and other regular activities; and a global index of HRQoL. Statistical methods included cross-tabulations and multivariable linear regression models.
In all, 744 women provided at least 1 postsurgery assessment. About one-third of the patients experienced arm mobility restrictions. A similar number of patients avoided the use of the arm 6 months after surgery. Limitations in work and other regular activities were reported by about a quarter of the patients. In this multivariable analysis, arm mobility and sensory neuropathy were predictors of patient-reported arm function and overall HRQoL. Predictors for activity limitations also included side of surgery (dominant vs nondominant). Edema was not significant after adjustment for sensory neuropathy and ROM.
Arm mobility and edema were measured simultaneously only once during the follow-up (6 months).
Clinical measures of sensory neuropathy and restrictions in arm mobility following breast cancer surgery are associated with self-reported limitations in activity and reductions in overall HRQoL.
Url:
DOI: 10.1016/j.suponc.2012.05.003
PubMed: 22951047
PubMed Central: 4131548
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 003484
- to stream Pmc, to step Curation: 003483
- to stream Pmc, to step Checkpoint: 002013
- to stream PubMed, to step Corpus: 001F71
- to stream PubMed, to step Curation: 001F71
- to stream PubMed, to step Checkpoint: 001F71
- to stream Ncbi, to step Merge: 005100
- to stream Ncbi, to step Curation: 005100
- to stream Ncbi, to step Checkpoint: 005100
- to stream Main, to step Merge: 003222
- to stream Main, to step Curation: 003217
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Relationship between Arm Morbidity and Patient-Reported Outcomes Following Surgery in Women with Node-Negative Breast Cancer: NSABP Protocol B-32</title><author><name sortKey="Kopec, Jacek A" sort="Kopec, Jacek A" uniqKey="Kopec J" first="Jacek A." last="Kopec">Jacek A. Kopec</name><affiliation wicri:level="2"><nlm:aff id="A1">National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>School of Population and Public Health, University of British Columbia, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Colangelo, Linda H" sort="Colangelo, Linda H" uniqKey="Colangelo L" first="Linda H." last="Colangelo">Linda H. Colangelo</name><affiliation wicri:level="2"><nlm:aff id="A1">National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A3">Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Land, Stephanie R" sort="Land, Stephanie R" uniqKey="Land S" first="Stephanie R." last="Land">Stephanie R. Land</name><affiliation wicri:level="2"><nlm:aff id="A1">National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A3">Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Julian, Thomas B" sort="Julian, Thomas B" uniqKey="Julian T" first="Thomas B." last="Julian">Thomas B. Julian</name><affiliation wicri:level="2"><nlm:aff id="A1">National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Allegheny General Hospital, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Allegheny General Hospital, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Brown, Ann M" sort="Brown, Ann M" uniqKey="Brown A" first="Ann M." last="Brown">Ann M. Brown</name><affiliation wicri:level="2"><nlm:aff id="A1">National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A3">Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Anderson, Stewart J" sort="Anderson, Stewart J" uniqKey="Anderson S" first="Stewart J." last="Anderson">Stewart J. Anderson</name><affiliation wicri:level="2"><nlm:aff id="A1">National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A3">Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Krag, David N" sort="Krag, David N" uniqKey="Krag D" first="David N." last="Krag">David N. Krag</name><affiliation wicri:level="2"><nlm:aff id="A1">National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">University of Vermont College of Medicine and Breast Care Center, United Health Care, Burlington, VT</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Vermont</region></placeName><wicri:cityArea>University of Vermont College of Medicine and Breast Care Center, United Health Care, Burlington</wicri:cityArea></affiliation></author><author><name sortKey="Ashikaga, Takamaru" sort="Ashikaga, Takamaru" uniqKey="Ashikaga T" first="Takamaru" last="Ashikaga">Takamaru Ashikaga</name><affiliation wicri:level="2"><nlm:aff id="A5">University of Vermont College of Medicine and Breast Care Center, United Health Care, Burlington, VT</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Vermont</region></placeName><wicri:cityArea>University of Vermont College of Medicine and Breast Care Center, United Health Care, Burlington</wicri:cityArea></affiliation></author><author><name sortKey="Costantino, Joseph P" sort="Costantino, Joseph P" uniqKey="Costantino J" first="Joseph P." last="Costantino">Joseph P. Costantino</name><affiliation wicri:level="2"><nlm:aff id="A1">National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A3">Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Wolmark, Norman" sort="Wolmark, Norman" uniqKey="Wolmark N" first="Norman" last="Wolmark">Norman Wolmark</name><affiliation wicri:level="2"><nlm:aff id="A1">National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Allegheny General Hospital, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Allegheny General Hospital, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A." last="Ganz">Patricia A. Ganz</name><affiliation wicri:level="2"><nlm:aff id="A1">National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A6">Schools of Medicine and Public Health and the Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Schools of Medicine and Public Health and the Jonsson Comprehensive Cancer Center, University of California, Los Angeles</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22951047</idno><idno type="pmc">4131548</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131548</idno><idno type="RBID">PMC:4131548</idno><idno type="doi">10.1016/j.suponc.2012.05.003</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">003484</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003484</idno><idno type="wicri:Area/Pmc/Curation">003483</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003483</idno><idno type="wicri:Area/Pmc/Checkpoint">002013</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002013</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001F71</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001F71</idno><idno type="wicri:Area/PubMed/Curation">001F71</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001F71</idno><idno type="wicri:Area/PubMed/Checkpoint">001F71</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001F71</idno><idno type="wicri:Area/Ncbi/Merge">005100</idno><idno type="wicri:Area/Ncbi/Curation">005100</idno><idno type="wicri:Area/Ncbi/Checkpoint">005100</idno><idno type="wicri:doubleKey">1544-6794:2013:Kopec J:relationship:between:arm</idno><idno type="wicri:Area/Main/Merge">003222</idno><idno type="wicri:Area/Main/Curation">003217</idno><idno type="wicri:Area/Main/Exploration">003217</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Relationship between Arm Morbidity and Patient-Reported Outcomes Following Surgery in Women with Node-Negative Breast Cancer: NSABP Protocol B-32</title><author><name sortKey="Kopec, Jacek A" sort="Kopec, Jacek A" uniqKey="Kopec J" first="Jacek A." last="Kopec">Jacek A. Kopec</name><affiliation wicri:level="2"><nlm:aff id="A1">National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>School of Population and Public Health, University of British Columbia, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Colangelo, Linda H" sort="Colangelo, Linda H" uniqKey="Colangelo L" first="Linda H." last="Colangelo">Linda H. Colangelo</name><affiliation wicri:level="2"><nlm:aff id="A1">National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A3">Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Land, Stephanie R" sort="Land, Stephanie R" uniqKey="Land S" first="Stephanie R." last="Land">Stephanie R. Land</name><affiliation wicri:level="2"><nlm:aff id="A1">National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A3">Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Julian, Thomas B" sort="Julian, Thomas B" uniqKey="Julian T" first="Thomas B." last="Julian">Thomas B. Julian</name><affiliation wicri:level="2"><nlm:aff id="A1">National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Allegheny General Hospital, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Allegheny General Hospital, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Brown, Ann M" sort="Brown, Ann M" uniqKey="Brown A" first="Ann M." last="Brown">Ann M. Brown</name><affiliation wicri:level="2"><nlm:aff id="A1">National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A3">Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Anderson, Stewart J" sort="Anderson, Stewart J" uniqKey="Anderson S" first="Stewart J." last="Anderson">Stewart J. Anderson</name><affiliation wicri:level="2"><nlm:aff id="A1">National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A3">Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Krag, David N" sort="Krag, David N" uniqKey="Krag D" first="David N." last="Krag">David N. Krag</name><affiliation wicri:level="2"><nlm:aff id="A1">National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">University of Vermont College of Medicine and Breast Care Center, United Health Care, Burlington, VT</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Vermont</region></placeName><wicri:cityArea>University of Vermont College of Medicine and Breast Care Center, United Health Care, Burlington</wicri:cityArea></affiliation></author><author><name sortKey="Ashikaga, Takamaru" sort="Ashikaga, Takamaru" uniqKey="Ashikaga T" first="Takamaru" last="Ashikaga">Takamaru Ashikaga</name><affiliation wicri:level="2"><nlm:aff id="A5">University of Vermont College of Medicine and Breast Care Center, United Health Care, Burlington, VT</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Vermont</region></placeName><wicri:cityArea>University of Vermont College of Medicine and Breast Care Center, United Health Care, Burlington</wicri:cityArea></affiliation></author><author><name sortKey="Costantino, Joseph P" sort="Costantino, Joseph P" uniqKey="Costantino J" first="Joseph P." last="Costantino">Joseph P. Costantino</name><affiliation wicri:level="2"><nlm:aff id="A1">National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A3">Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Wolmark, Norman" sort="Wolmark, Norman" uniqKey="Wolmark N" first="Norman" last="Wolmark">Norman Wolmark</name><affiliation wicri:level="2"><nlm:aff id="A1">National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Allegheny General Hospital, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Allegheny General Hospital, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A." last="Ganz">Patricia A. Ganz</name><affiliation wicri:level="2"><nlm:aff id="A1">National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Center, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A6">Schools of Medicine and Public Health and the Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Schools of Medicine and Public Health and the Jonsson Comprehensive Cancer Center, University of California, Los Angeles</wicri:cityArea></affiliation></author></analytic><series><title level="j">The journal of supportive oncology</title><idno type="ISSN">1544-6794</idno><idno type="eISSN">1879-596X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living</term><term>Arm (physiopathology)</term><term>Arm (surgery)</term><term>Breast Neoplasms (complications)</term><term>Breast Neoplasms (surgery)</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Lymphedema (etiology)</term><term>Mastectomy (adverse effects)</term><term>Middle Aged</term><term>Morbidity</term><term>Outcome Assessment (Health Care)</term><term>Patient Participation</term><term>Postoperative Complications</term><term>Prognosis</term><term>Quality of Life</term><term>Range of Motion, Articular</term><term>Self Report (utilization)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activités de la vie quotidienne</term><term>Adulte d'âge moyen</term><term>Amplitude articulaire</term><term>Autorapport (utilisation)</term><term>Bras ()</term><term>Bras (physiopathologie)</term><term>Complications postopératoires</term><term>Femelle</term><term>Humains</term><term>Lymphoedème (étiologie)</term><term>Mastectomie (effets indésirables)</term><term>Morbidité</term><term>Participation du patient</term><term>Pronostic</term><term>Qualité de vie</term><term>Tumeurs du sein ()</term><term>Études de suivi</term><term>Évaluation de résultat (soins)</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Mastectomy</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Mastectomie</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Bras</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Arm</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Arm</term><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="utilisation" xml:lang="fr"><term>Autorapport</term></keywords><keywords scheme="MESH" qualifier="utilization" xml:lang="en"><term>Self Report</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Activities of Daily Living</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Middle Aged</term><term>Morbidity</term><term>Outcome Assessment (Health Care)</term><term>Patient Participation</term><term>Postoperative Complications</term><term>Prognosis</term><term>Quality of Life</term><term>Range of Motion, Articular</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activités de la vie quotidienne</term><term>Adulte d'âge moyen</term><term>Amplitude articulaire</term><term>Bras</term><term>Complications postopératoires</term><term>Femelle</term><term>Humains</term><term>Morbidité</term><term>Participation du patient</term><term>Pronostic</term><term>Qualité de vie</term><term>Tumeurs du sein</term><term>Études de suivi</term><term>Évaluation de résultat (soins)</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P2">The impact of arm morbidity following breast cancer surgery on patient-observed changes in daily functioning and health-related quality of life (HRQoL) have not been well-studied.</p></sec><sec id="S2"><title>Objective</title><p id="P3">To examine the association of objective measures such as range of motion (ROM) and lymphedema, with patient-reported outcomes (PROs) in the arm and breast, upper extremity function, activities, and HRQoL.</p></sec><sec id="S3"><title>Methods</title><p id="P4">The National Surgical Adjuvant Breast and Bowel Project Protocol B-32 was a randomized trial comparing sentinel node resection (SNR) with axillary dissection (AD) in women with node-negative breast cancer. ROM and arm volume were measured objectively. PROs included symptoms; arm function; limitations in social, recreational, occupational, and other regular activities; and a global index of HRQoL. Statistical methods included cross-tabulations and multivariable linear regression models.</p></sec><sec id="S4"><title>Results</title><p id="P5">In all, 744 women provided at least 1 postsurgery assessment. About one-third of the patients experienced arm mobility restrictions. A similar number of patients avoided the use of the arm 6 months after surgery. Limitations in work and other regular activities were reported by about a quarter of the patients. In this multivariable analysis, arm mobility and sensory neuropathy were predictors of patient-reported arm function and overall HRQoL. Predictors for activity limitations also included side of surgery (dominant vs nondominant). Edema was not significant after adjustment for sensory neuropathy and ROM.</p></sec><sec id="S5"><title>Limitations</title><p id="P6">Arm mobility and edema were measured simultaneously only once during the follow-up (6 months).</p></sec><sec id="S6"><title>Conclusion</title><p id="P7">Clinical measures of sensory neuropathy and restrictions in arm mobility following breast cancer surgery are associated with self-reported limitations in activity and reductions in overall HRQoL.</p></sec></div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Californie</li><li>Pennsylvanie</li><li>Vermont</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Kopec, Jacek A" sort="Kopec, Jacek A" uniqKey="Kopec J" first="Jacek A." last="Kopec">Jacek A. Kopec</name></region><name sortKey="Anderson, Stewart J" sort="Anderson, Stewart J" uniqKey="Anderson S" first="Stewart J." last="Anderson">Stewart J. Anderson</name><name sortKey="Anderson, Stewart J" sort="Anderson, Stewart J" uniqKey="Anderson S" first="Stewart J." last="Anderson">Stewart J. Anderson</name><name sortKey="Ashikaga, Takamaru" sort="Ashikaga, Takamaru" uniqKey="Ashikaga T" first="Takamaru" last="Ashikaga">Takamaru Ashikaga</name><name sortKey="Brown, Ann M" sort="Brown, Ann M" uniqKey="Brown A" first="Ann M." last="Brown">Ann M. Brown</name><name sortKey="Brown, Ann M" sort="Brown, Ann M" uniqKey="Brown A" first="Ann M." last="Brown">Ann M. Brown</name><name sortKey="Colangelo, Linda H" sort="Colangelo, Linda H" uniqKey="Colangelo L" first="Linda H." last="Colangelo">Linda H. Colangelo</name><name sortKey="Colangelo, Linda H" sort="Colangelo, Linda H" uniqKey="Colangelo L" first="Linda H." last="Colangelo">Linda H. Colangelo</name><name sortKey="Costantino, Joseph P" sort="Costantino, Joseph P" uniqKey="Costantino J" first="Joseph P." last="Costantino">Joseph P. Costantino</name><name sortKey="Costantino, Joseph P" sort="Costantino, Joseph P" uniqKey="Costantino J" first="Joseph P." last="Costantino">Joseph P. Costantino</name><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A." last="Ganz">Patricia A. Ganz</name><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A." last="Ganz">Patricia A. Ganz</name><name sortKey="Julian, Thomas B" sort="Julian, Thomas B" uniqKey="Julian T" first="Thomas B." last="Julian">Thomas B. Julian</name><name sortKey="Julian, Thomas B" sort="Julian, Thomas B" uniqKey="Julian T" first="Thomas B." last="Julian">Thomas B. Julian</name><name sortKey="Krag, David N" sort="Krag, David N" uniqKey="Krag D" first="David N." last="Krag">David N. Krag</name><name sortKey="Krag, David N" sort="Krag, David N" uniqKey="Krag D" first="David N." last="Krag">David N. Krag</name><name sortKey="Land, Stephanie R" sort="Land, Stephanie R" uniqKey="Land S" first="Stephanie R." last="Land">Stephanie R. Land</name><name sortKey="Land, Stephanie R" sort="Land, Stephanie R" uniqKey="Land S" first="Stephanie R." last="Land">Stephanie R. Land</name><name sortKey="Wolmark, Norman" sort="Wolmark, Norman" uniqKey="Wolmark N" first="Norman" last="Wolmark">Norman Wolmark</name><name sortKey="Wolmark, Norman" sort="Wolmark, Norman" uniqKey="Wolmark N" first="Norman" last="Wolmark">Norman Wolmark</name></country><country name="Canada"><noRegion><name sortKey="Kopec, Jacek A" sort="Kopec, Jacek A" uniqKey="Kopec J" first="Jacek A." last="Kopec">Jacek A. Kopec</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003217 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003217 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4131548
|texte= Relationship between Arm Morbidity and Patient-Reported Outcomes Following Surgery in Women with Node-Negative Breast Cancer: NSABP Protocol B-32
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:22951047" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |