Thalidomide Combined with Neoadjuvant Chemotherapy in Angiosarcoma of the Breast with Complete Pathologic Response: Case Report and Review of Literature
Identifieur interne : 003100 ( Main/Exploration ); précédent : 003099; suivant : 003101Thalidomide Combined with Neoadjuvant Chemotherapy in Angiosarcoma of the Breast with Complete Pathologic Response: Case Report and Review of Literature
Auteurs : Alberto Alvarado-Miranda [Mexique] ; Ludwing Bacon-Fonseca [Mexique] ; Fernando Ulises Lara-Medina [Mexique] ; Hector Maldonado-Martínez [Mexique] ; Claudia Arce-Salinas [Mexique]Source :
- Breast Care [ 1661-3791 ] ; 2013.
Abstract
Primary angiosarcoma of the breast is a rare malignancy.
We report on a 41-year-old female patient who initially presented with locally advanced disease. Core biopsy showed angiosarcoma of the breast, grade 1, CD31-positive. The patient was treated with neoadjuvant systemic chemotherapy based on cisplatin, doxorubicin, and paclitaxel, given concurrently with thalidomide. After treatment completion, the patient underwent radical mastectomy. Pathologic complete response in the breast and axillary lymph nodes was achieved. The patient has no evidence of disease recurrence 6 months after her initial diagnosis.
Anti-angiogenic therapy may be considered as part of the management of primary angiosarcoma of the breast.
Url:
DOI: 10.1159/000346822
PubMed: 24715848
PubMed Central: 3971808
Affiliations:
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first="Ludwing" last="Bacon-Fonseca">Ludwing Bacon-Fonseca</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Oncology Department, National Cancer Institute (INCan), Mexico City, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Medical Oncology Department, National Cancer Institute (INCan), Mexico City</wicri:regionArea><wicri:noRegion>Mexico City</wicri:noRegion></affiliation></author><author><name sortKey="Ulises Lara Medina, Fernando" sort="Ulises Lara Medina, Fernando" uniqKey="Ulises Lara Medina F" first="Fernando" last="Ulises Lara-Medina">Fernando Ulises Lara-Medina</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Oncology Department, National Cancer Institute (INCan), Mexico City, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Medical Oncology Department, National Cancer Institute (INCan), Mexico City</wicri:regionArea><wicri:noRegion>Mexico City</wicri:noRegion></affiliation></author><author><name sortKey="Maldonado Martinez, Hector" sort="Maldonado Martinez, Hector" uniqKey="Maldonado Martinez H" first="Hector" last="Maldonado-Martínez">Hector Maldonado-Martínez</name><affiliation wicri:level="1"><nlm:aff id="aff2">Pathology Department, National Cancer Institute (INCan), Mexico City, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Pathology Department, National Cancer Institute (INCan), Mexico City</wicri:regionArea><wicri:noRegion>Mexico City</wicri:noRegion></affiliation></author><author><name sortKey="Arce Salinas, Claudia" sort="Arce Salinas, Claudia" uniqKey="Arce Salinas C" first="Claudia" last="Arce-Salinas">Claudia Arce-Salinas</name><affiliation wicri:level="1"><nlm:aff id="aff1">Medical Oncology Department, National Cancer Institute (INCan), Mexico City, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Medical Oncology Department, National Cancer Institute (INCan), Mexico City</wicri:regionArea><wicri:noRegion>Mexico City</wicri:noRegion></affiliation></author></analytic><series><title level="j">Breast Care</title><idno type="ISSN">1661-3791</idno><idno type="eISSN">1661-3805</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><sec><title>Background</title><p>Primary angiosarcoma of the breast is a rare malignancy.</p></sec><sec><title>Case Report</title><p>We report on a 41-year-old female patient who initially presented with locally advanced disease. Core biopsy showed angiosarcoma of the breast, grade 1, CD31-positive. The patient was treated with neoadjuvant systemic chemotherapy based on cisplatin, doxorubicin, and paclitaxel, given concurrently with thalidomide. After treatment completion, the patient underwent radical mastectomy. Pathologic complete response in the breast and axillary lymph nodes was achieved. The patient has no evidence of disease recurrence 6 months after her initial diagnosis.</p></sec><sec><title>Conclusion</title><p>Anti-angiogenic therapy may be considered as part of the management of primary angiosarcoma of the breast.</p></sec></div></front></TEI><affiliations><list><country><li>Mexique</li></country></list><tree><country name="Mexique"><noRegion><name sortKey="Alvarado Miranda, Alberto" sort="Alvarado Miranda, Alberto" uniqKey="Alvarado Miranda A" first="Alberto" last="Alvarado-Miranda">Alberto Alvarado-Miranda</name></noRegion><name sortKey="Arce Salinas, Claudia" sort="Arce Salinas, Claudia" uniqKey="Arce Salinas C" first="Claudia" last="Arce-Salinas">Claudia Arce-Salinas</name><name sortKey="Bacon Fonseca, Ludwing" sort="Bacon Fonseca, Ludwing" uniqKey="Bacon Fonseca L" first="Ludwing" last="Bacon-Fonseca">Ludwing Bacon-Fonseca</name><name sortKey="Maldonado Martinez, Hector" sort="Maldonado Martinez, Hector" uniqKey="Maldonado Martinez H" first="Hector" last="Maldonado-Martínez">Hector Maldonado-Martínez</name><name sortKey="Ulises Lara Medina, Fernando" sort="Ulises Lara Medina, Fernando" uniqKey="Ulises Lara Medina F" first="Fernando" last="Ulises Lara-Medina">Fernando Ulises Lara-Medina</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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