LymphedemaV1, Main, Exploration, bibRecord, 003091

The Multicomponent Medication Lymphomyosot Improves the Outcome of Experimental Lymphedema

Identifieur interne : 003091 ( Main/Exploration ); précédent : 003090; suivant : 003092

The Multicomponent Medication Lymphomyosot Improves the Outcome of Experimental Lymphedema

Auteurs : Alex P. Keim ; Justin R. Slis ; Uziel Mendez ; Emily M. Stroup ; Yvonne Burmeister ; Natalie Tsolaki ; Oliver Gailing ; Jeremy Goldman

Source :

Lymphatic Research and Biology [ 1539-6851 ] ; 2013.

RBID : PMC:3696932

Descripteurs français

KwdFr :
- Animaux, Cicatrisation de plaie, Extraits de plantes (usage thérapeutique), Femelle, Lymphoedème (anatomopathologie), Lymphoedème (traitement médicamenteux), Macrophages (anatomopathologie), Modèles animaux de maladie humaine, Souris, Souris de lignée BALB C.
MESH :
- anatomopathologie : Lymphoedème, Macrophages.
- traitement médicamenteux : Lymphoedème.
- usage thérapeutique : Extraits de plantes.
- Animaux, Cicatrisation de plaie, Femelle, Modèles animaux de maladie humaine, Souris, Souris de lignée BALB C.

English descriptors

KwdEn :
- Animals, Disease Models, Animal, Female, Lymphedema (drug therapy), Lymphedema (pathology), Macrophages (pathology), Mice, Mice, Inbred BALB C, Plant Extracts (therapeutic use), Wound Healing.
MESH :
- chemical , therapeutic use : Plant Extracts.
- drug therapy : Lymphedema.
- pathology : Lymphedema, Macrophages.
- Animals, Disease Models, Animal, Female, Mice, Mice, Inbred BALB C, Wound Healing.

Abstract

AbstractBackground

Secondary lymphedema is a life-long disease of painful tissue swelling that often follows axillary lymph node dissection to treat breast cancer. It is hypothesized that poor lymphatic regeneration across the obstructive scar tissue during the wound healing process may predispose the tissue to swell at a later date. Treatment for lymphedema remains suboptimal and is in most cases palliative. The purpose of this study was to evaluate the ability of Lymphomyosot to treat tissue swelling and promote lymphangiogenesis in experimental models of murine lymphedema.

Methods

Experimental models of mouse lymphedema were injected with varied amounts of Lymphomyosot and saline as control. Measurements of tail swelling and wound closure were taken and compared amongst the groups. Three separate groups of mice were analyzed for lymphatic capillary migration, lymphatic vessel regeneration, and macrophage recruitment.

Results

Lymphomyosot significantly reduced swelling and increased the rate of surgical wound closure. Lymphomyosot did not increase the migration of lymph capillaries in a mouse tail skin regeneration model or regeneration of lymph vessels following murine axillary lymph node dissection.

Conclusions

Lymphomyosot may act through inflammatory and wound repair pathways to reduce experimental lymphedema. Its ability to regulate inflammation as well as assist in tissue repair and extracellular formation may allow for the production of a scar-free matrix bridge through which migrating cells and accumulated interstitial fluid can freely spread.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696932

DOI: 10.1089/lrb.2012.0024
PubMed: 23725444
PubMed Central: 3696932

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<sec><title>Background</title>
<p>Secondary lymphedema is a life-long disease of painful tissue swelling that often follows axillary lymph node dissection to treat breast cancer. It is hypothesized that poor lymphatic regeneration across the obstructive scar tissue during the wound healing process may predispose the tissue to swell at a later date. Treatment for lymphedema remains suboptimal and is in most cases palliative. The purpose of this study was to evaluate the ability of Lymphomyosot to treat tissue swelling and promote lymphangiogenesis in experimental models of murine lymphedema.</p>
</sec>
<sec><title>Methods</title>
<p>Experimental models of mouse lymphedema were injected with varied amounts of Lymphomyosot and saline as control. Measurements of tail swelling and wound closure were taken and compared amongst the groups. Three separate groups of mice were analyzed for lymphatic capillary migration, lymphatic vessel regeneration, and macrophage recruitment.</p>
</sec>
<sec><title>Results</title>
<p>Lymphomyosot significantly reduced swelling and increased the rate of surgical wound closure. Lymphomyosot did not increase the migration of lymph capillaries in a mouse tail skin regeneration model or regeneration of lymph vessels following murine axillary lymph node dissection.</p>
</sec>
<sec><title>Conclusions</title>
<p>Lymphomyosot may act through inflammatory and wound repair pathways to reduce experimental lymphedema. Its ability to regulate inflammation as well as assist in tissue repair and extracellular formation may allow for the production of a scar-free matrix bridge through which migrating cells and accumulated interstitial fluid can freely spread.</p>
</sec>
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<name sortKey="Gailing, Oliver" sort="Gailing, Oliver" uniqKey="Gailing O" first="Oliver" last="Gailing">Oliver Gailing</name>
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<name sortKey="Keim, Alex P" sort="Keim, Alex P" uniqKey="Keim A" first="Alex P." last="Keim">Alex P. Keim</name>
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<name sortKey="Slis, Justin R" sort="Slis, Justin R" uniqKey="Slis J" first="Justin R." last="Slis">Justin R. Slis</name>
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Serveur d'exploration sur le lymphœdème

The Multicomponent Medication Lymphomyosot Improves the Outcome of Experimental Lymphedema

The Multicomponent Medication Lymphomyosot Improves the Outcome of Experimental Lymphedema

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

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