A Chitin-Like Component on Sclerotic Cells of Fonsecaea pedrosoi Inhibits Dectin-1-Mediated Murine Th17 Development by Masking β-Glucans
Identifieur interne : 002E69 ( Main/Exploration ); précédent : 002E68; suivant : 002E70A Chitin-Like Component on Sclerotic Cells of Fonsecaea pedrosoi Inhibits Dectin-1-Mediated Murine Th17 Development by Masking β-Glucans
Auteurs : Bilin Dong [République populaire de Chine] ; Dongsheng Li [République populaire de Chine] ; Ruoyu Li [République populaire de Chine] ; Sharon C.-A. Chen [Australie] ; Weihuang Liu [République populaire de Chine] ; Wei Liu [République populaire de Chine] ; Liuqing Chen [République populaire de Chine] ; Yao Chen [République populaire de Chine] ; Xu Zhang [République populaire de Chine] ; Zhongsheng Tong [République populaire de Chine] ; Yun Xia [République populaire de Chine] ; Ping Xia [République populaire de Chine] ; Yan Wang [République populaire de Chine] ; Yiqun Duan [République populaire de Chine]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Abstract
Url:
DOI: 10.1371/journal.pone.0114113
PubMed: 25490199
PubMed Central: 4260783
Affiliations:
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Le document en format XML
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Inhibits Dectin-1-Mediated Murine Th17 Development by Masking β-Glucans</title>
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<author><name sortKey="Liu, Weihuang" sort="Liu, Weihuang" uniqKey="Liu W" first="Weihuang" last="Liu">Weihuang Liu</name>
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<author><name sortKey="Chen, Liuqing" sort="Chen, Liuqing" uniqKey="Chen L" first="Liuqing" last="Chen">Liuqing Chen</name>
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<author><name sortKey="Chen, Yao" sort="Chen, Yao" uniqKey="Chen Y" first="Yao" last="Chen">Yao Chen</name>
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<author><name sortKey="Zhang, Xu" sort="Zhang, Xu" uniqKey="Zhang X" first="Xu" last="Zhang">Xu Zhang</name>
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<author><name sortKey="Tong, Zhongsheng" sort="Tong, Zhongsheng" uniqKey="Tong Z" first="Zhongsheng" last="Tong">Zhongsheng Tong</name>
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<author><name sortKey="Xia, Yun" sort="Xia, Yun" uniqKey="Xia Y" first="Yun" last="Xia">Yun Xia</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Chitin-Like Component on Sclerotic Cells of <italic>Fonsecaea pedrosoi</italic>
Inhibits Dectin-1-Mediated Murine Th17 Development by Masking β-Glucans</title>
<author><name sortKey="Dong, Bilin" sort="Dong, Bilin" uniqKey="Dong B" first="Bilin" last="Dong">Bilin Dong</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Center for Infectious Skin Diseases, Department of Dermatology, No. 1 Hospital of Wuhan, Wuhan, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Center for Infectious Skin Diseases, Department of Dermatology, No. 1 Hospital of Wuhan, Wuhan</wicri:regionArea>
<wicri:noRegion>Wuhan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Dongsheng" sort="Li, Dongsheng" uniqKey="Li D" first="Dongsheng" last="Li">Dongsheng Li</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Center for Infectious Skin Diseases, Department of Dermatology, No. 1 Hospital of Wuhan, Wuhan, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
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</affiliation>
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<author><name sortKey="Li, Ruoyu" sort="Li, Ruoyu" uniqKey="Li R" first="Ruoyu" last="Li">Ruoyu Li</name>
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</nlm:aff>
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<author><name sortKey="Chen, Sharon C A" sort="Chen, Sharon C A" uniqKey="Chen S" first="Sharon C.-A." last="Chen">Sharon C.-A. Chen</name>
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</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Center for Infectious Diseases and Microbiology, Laboratory Services, ICPMR–Pathology West, Westmead Hospital, University of Sydney, Westmead</wicri:regionArea>
<wicri:noRegion>Westmead</wicri:noRegion>
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<author><name sortKey="Liu, Weihuang" sort="Liu, Weihuang" uniqKey="Liu W" first="Weihuang" last="Liu">Weihuang Liu</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Medical Research Center of Wuhan University, Wuhan, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Medical Research Center of Wuhan University, Wuhan</wicri:regionArea>
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</affiliation>
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<author><name sortKey="Liu, Wei" sort="Liu, Wei" uniqKey="Liu W" first="Wei" last="Liu">Wei Liu</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan</wicri:regionArea>
<wicri:noRegion>Wuhan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Liuqing" sort="Chen, Liuqing" uniqKey="Chen L" first="Liuqing" last="Chen">Liuqing Chen</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Center for Infectious Skin Diseases, Department of Dermatology, No. 1 Hospital of Wuhan, Wuhan, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Center for Infectious Skin Diseases, Department of Dermatology, No. 1 Hospital of Wuhan, Wuhan</wicri:regionArea>
<wicri:noRegion>Wuhan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Yao" sort="Chen, Yao" uniqKey="Chen Y" first="Yao" last="Chen">Yao Chen</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Center for Infectious Skin Diseases, Department of Dermatology, No. 1 Hospital of Wuhan, Wuhan, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Center for Infectious Skin Diseases, Department of Dermatology, No. 1 Hospital of Wuhan, Wuhan</wicri:regionArea>
<wicri:noRegion>Wuhan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Xu" sort="Zhang, Xu" uniqKey="Zhang X" first="Xu" last="Zhang">Xu Zhang</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Center for Infectious Skin Diseases, Department of Dermatology, No. 1 Hospital of Wuhan, Wuhan, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Center for Infectious Skin Diseases, Department of Dermatology, No. 1 Hospital of Wuhan, Wuhan</wicri:regionArea>
<wicri:noRegion>Wuhan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tong, Zhongsheng" sort="Tong, Zhongsheng" uniqKey="Tong Z" first="Zhongsheng" last="Tong">Zhongsheng Tong</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Center for Infectious Skin Diseases, Department of Dermatology, No. 1 Hospital of Wuhan, Wuhan, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Center for Infectious Skin Diseases, Department of Dermatology, No. 1 Hospital of Wuhan, Wuhan</wicri:regionArea>
<wicri:noRegion>Wuhan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xia, Yun" sort="Xia, Yun" uniqKey="Xia Y" first="Yun" last="Xia">Yun Xia</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Center for Infectious Skin Diseases, Department of Dermatology, No. 1 Hospital of Wuhan, Wuhan, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Center for Infectious Skin Diseases, Department of Dermatology, No. 1 Hospital of Wuhan, Wuhan</wicri:regionArea>
<wicri:noRegion>Wuhan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xia, Ping" sort="Xia, Ping" uniqKey="Xia P" first="Ping" last="Xia">Ping Xia</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Center for Infectious Skin Diseases, Department of Dermatology, No. 1 Hospital of Wuhan, Wuhan, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Center for Infectious Skin Diseases, Department of Dermatology, No. 1 Hospital of Wuhan, Wuhan</wicri:regionArea>
<wicri:noRegion>Wuhan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Yan" sort="Wang, Yan" uniqKey="Wang Y" first="Yan" last="Wang">Yan Wang</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan</wicri:regionArea>
<wicri:noRegion>Wuhan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Duan, Yiqun" sort="Duan, Yiqun" uniqKey="Duan Y" first="Yiqun" last="Duan">Yiqun Duan</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Center for Infectious Skin Diseases, Department of Dermatology, No. 1 Hospital of Wuhan, Wuhan, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Center for Infectious Skin Diseases, Department of Dermatology, No. 1 Hospital of Wuhan, Wuhan</wicri:regionArea>
<wicri:noRegion>Wuhan</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2014">2014</date>
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<front><div type="abstract" xml:lang="en"><p><italic>Fonsecaea pedrosoi</italic>
(<italic>F. pedrosoi</italic>
), a major agent of chromoblastomycosis, has been shown to be recognized primarily by C-type lectin receptors (CLRs) in a murine model of chromoblastomycosis. Specifically, the β-glucan receptor, Dectin-1, mediates Th17 development and consequent recruitment of neutrophils, and is evidenced to have the capacity to bind to saprophytic hyphae of <italic>F. pedrosoi</italic>
in vitro. However, when embedded in tissue, most etiological agents of chromoblastomycosis including <italic>F. pedrosoi</italic>
will transform into the sclerotic cells, which are linked to the greatest survival of melanized fungi in tissue. In this study, using immunocompetent and athymic (nu/nu) murine models infected subcutaneously or intraperitoneally with <italic>F. pedrosoi</italic>
, we demonstrated that T lymphocytes play an active role in the resolution of localized footpad infection, and there existed a significantly decreased expression of Th17-defining transcription factor Rorγt and inefficient recruitment of neutrophils in chronically infected spleen where the inoculated mycelium of <italic>F. pedrosoi</italic>
transformed into the sclerotic cells. We also found that Dectin-1-expressing histocytes and neutrophils participated in the enclosure of transformed sclerotic cells in the infectious foci. Furthermore, we induced the formation of sclerotic cells in vitro, and evidenced a significantly decreased binding capacity of human or murine-derived Dectin-1 to the induced sclerotic cells in comparison with the saprophytic mycelial forms. Our analysis of β-glucans-masking components revealed that it is a chitin-like component, but not the mannose moiety on the sclerotic cells, that interferes with the binding of β-glucans by human or murine Dectin-1. Notably, we demonstrated that although Dectin-1 contributed to the development of IL-17A-producing CD3+CD4+ murine splenocytes upon in vitro-stimulation by saprophytic <italic>F. pedrosoi</italic>
, the masking effect of chitin components partly inhibited Dectin-1-mediated Th17 development upon in vitro-stimulation by induced sclerotic cells. Therefore, these findings extend our understanding of the chronicity of chromoblastomycosis.</p>
</div>
</front>
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</author>
<author><name sortKey="Carrasco Gerard, E" uniqKey="Carrasco Gerard E">E Carrasco-Gerard</name>
</author>
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</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Ameen, M" uniqKey="Ameen M">M Ameen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sousa Mda, G" uniqKey="Sousa Mda G">G Sousa Mda</name>
</author>
<author><name sortKey="Reid, Dm" uniqKey="Reid D">DM Reid</name>
</author>
<author><name sortKey="Schweighoffer, E" uniqKey="Schweighoffer E">E Schweighoffer</name>
</author>
<author><name sortKey="Tybulewicz, V" uniqKey="Tybulewicz V">V Tybulewicz</name>
</author>
<author><name sortKey="Ruland, J" uniqKey="Ruland J">J Ruland</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ogawa, Mm" uniqKey="Ogawa M">MM Ogawa</name>
</author>
<author><name sortKey="Alchorne, Mm" uniqKey="Alchorne M">MM Alchorne</name>
</author>
<author><name sortKey="Barbieri, A" uniqKey="Barbieri A">A Barbieri</name>
</author>
<author><name sortKey="Castiglioni, Ml" uniqKey="Castiglioni M">ML Castiglioni</name>
</author>
<author><name sortKey="Penna, Ap" uniqKey="Penna A">AP Penna</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jamil, A" uniqKey="Jamil A">A Jamil</name>
</author>
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</TEI>
<affiliations><list><country><li>Australie</li>
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</country>
<settlement><li>Pékin</li>
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<orgName><li>Université de Pékin</li>
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</list>
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<name sortKey="Chen, Yao" sort="Chen, Yao" uniqKey="Chen Y" first="Yao" last="Chen">Yao Chen</name>
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<name sortKey="Liu, Wei" sort="Liu, Wei" uniqKey="Liu W" first="Wei" last="Liu">Wei Liu</name>
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</tree>
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