Analysis of radiation-induced angiosarcoma of the breast.
Identifieur interne : 002D57 ( Main/Exploration ); précédent : 002D56; suivant : 002D58Analysis of radiation-induced angiosarcoma of the breast.
Auteurs : M. Zemanova ; K. Rauova ; E. Boljesikova ; K. Machalekova ; I. Krajcovicova ; V. Lehotska ; M. Mikulova ; J. SvecSource :
- Bratislavske lekarske listy [ 0006-9248 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte, Association thérapeutique (), Biopsie, Carcinome canalaire du sein (), Carcinome canalaire du sein (radiothérapie), Femelle, Humains, Hémangiosarcome (diagnostic), Imagerie par résonance magnétique, Invasion tumorale, Lymphadénectomie, Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique), Tumeurs du sein (), Tumeurs du sein (diagnostic), Tumeurs du sein (radiothérapie), Tumeurs radio-induites (diagnostic).
- MESH :
- diagnostic : Hémangiosarcome, Tumeurs du sein, Tumeurs radio-induites.
- radiothérapie : Carcinome canalaire du sein, Tumeurs du sein.
- usage thérapeutique : Protocoles de polychimiothérapie antinéoplasique.
- Adulte, Association thérapeutique, Biopsie, Carcinome canalaire du sein, Femelle, Humains, Imagerie par résonance magnétique, Invasion tumorale, Lymphadénectomie, Tumeurs du sein.
English descriptors
- KwdEn :
- Adult, Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Biopsy, Breast Neoplasms (diagnosis), Breast Neoplasms (radiotherapy), Breast Neoplasms (therapy), Carcinoma, Ductal, Breast (radiotherapy), Carcinoma, Ductal, Breast (therapy), Combined Modality Therapy (methods), Female, Hemangiosarcoma (diagnosis), Humans, Lymph Node Excision, Magnetic Resonance Imaging, Neoplasm Invasiveness, Neoplasms, Radiation-Induced (diagnosis).
- MESH :
- diagnosis : Breast Neoplasms, Hemangiosarcoma, Neoplasms, Radiation-Induced.
- methods : Combined Modality Therapy.
- radiotherapy : Breast Neoplasms, Carcinoma, Ductal, Breast.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols.
- therapy : Breast Neoplasms, Carcinoma, Ductal, Breast.
- Adult, Biopsy, Female, Humans, Lymph Node Excision, Magnetic Resonance Imaging, Neoplasm Invasiveness.
Abstract
Breast angiosarcoma may occur de novo, or as a complication of radiation therapy, or chronic lymphedema secondary to axillary lymph node dissection for mammary carcinoma. Both primary and secondary angiosarcomas may present with bruise like skin discoloration, which may delay the diagnosis. Imaging findings are nonspecific. In case of high-grade tumours, MRI may be used effectively to determine lesion extent by showing rapid enhancement, nevertheless earliest possible diagnostics is crucial therefore any symptoms of angiosarcoma have to be carefully analysed. The case analysed here reports on results of 44-year old premenopausal woman who was treated for a T1N1M0 invasive ductal carcinoma. After a biopsy diagnosis of carcinoma, the patient underwent quadrantectomy with axillary lymph node dissection. She received partial 4 cycles of chemotherapy with adriamycin and cyclophosphamide, followed by radiation treatment. Thereafter, a standard postoperative radiotherapy was applied at our institution four months after chemotherapy (TD 46 Gy in 23 fractions followed by a 10 Gy electron boost to the tumour bed). Adjuvant chemotherapy was finished six months after operation, followed by tamoxifen. Follow up: no further complications were detected during regular check-ups. However, 12-years later, patient reported significant changes at breast region which was exposed to radiation during treatment of original tumour. In this article, we describe the clinical presentation, imaging and pathological findings of secondary angiosarcoma of the breast after radiotherapy (Fig. 2, Ref. 26).
PubMed: 25174061
Affiliations:
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<term>Breast Neoplasms (diagnosis)</term>
<term>Breast Neoplasms (radiotherapy)</term>
<term>Breast Neoplasms (therapy)</term>
<term>Carcinoma, Ductal, Breast (radiotherapy)</term>
<term>Carcinoma, Ductal, Breast (therapy)</term>
<term>Combined Modality Therapy (methods)</term>
<term>Female</term>
<term>Hemangiosarcoma (diagnosis)</term>
<term>Humans</term>
<term>Lymph Node Excision</term>
<term>Magnetic Resonance Imaging</term>
<term>Neoplasm Invasiveness</term>
<term>Neoplasms, Radiation-Induced (diagnosis)</term>
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<term>Carcinome canalaire du sein (radiothérapie)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hémangiosarcome (diagnostic)</term>
<term>Imagerie par résonance magnétique</term>
<term>Invasion tumorale</term>
<term>Lymphadénectomie</term>
<term>Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique)</term>
<term>Tumeurs du sein ()</term>
<term>Tumeurs du sein (diagnostic)</term>
<term>Tumeurs du sein (radiothérapie)</term>
<term>Tumeurs radio-induites (diagnostic)</term>
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<term>Hemangiosarcoma</term>
<term>Neoplasms, Radiation-Induced</term>
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<term>Tumeurs radio-induites</term>
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<term>Biopsie</term>
<term>Carcinome canalaire du sein</term>
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<term>Imagerie par résonance magnétique</term>
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<front><div type="abstract" xml:lang="en">Breast angiosarcoma may occur de novo, or as a complication of radiation therapy, or chronic lymphedema secondary to axillary lymph node dissection for mammary carcinoma. Both primary and secondary angiosarcomas may present with bruise like skin discoloration, which may delay the diagnosis. Imaging findings are nonspecific. In case of high-grade tumours, MRI may be used effectively to determine lesion extent by showing rapid enhancement, nevertheless earliest possible diagnostics is crucial therefore any symptoms of angiosarcoma have to be carefully analysed. The case analysed here reports on results of 44-year old premenopausal woman who was treated for a T1N1M0 invasive ductal carcinoma. After a biopsy diagnosis of carcinoma, the patient underwent quadrantectomy with axillary lymph node dissection. She received partial 4 cycles of chemotherapy with adriamycin and cyclophosphamide, followed by radiation treatment. Thereafter, a standard postoperative radiotherapy was applied at our institution four months after chemotherapy (TD 46 Gy in 23 fractions followed by a 10 Gy electron boost to the tumour bed). Adjuvant chemotherapy was finished six months after operation, followed by tamoxifen. Follow up: no further complications were detected during regular check-ups. However, 12-years later, patient reported significant changes at breast region which was exposed to radiation during treatment of original tumour. In this article, we describe the clinical presentation, imaging and pathological findings of secondary angiosarcoma of the breast after radiotherapy (Fig. 2, Ref. 26).</div>
</front>
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<tree><noCountry><name sortKey="Boljesikova, E" sort="Boljesikova, E" uniqKey="Boljesikova E" first="E" last="Boljesikova">E. Boljesikova</name>
<name sortKey="Krajcovicova, I" sort="Krajcovicova, I" uniqKey="Krajcovicova I" first="I" last="Krajcovicova">I. Krajcovicova</name>
<name sortKey="Lehotska, V" sort="Lehotska, V" uniqKey="Lehotska V" first="V" last="Lehotska">V. Lehotska</name>
<name sortKey="Machalekova, K" sort="Machalekova, K" uniqKey="Machalekova K" first="K" last="Machalekova">K. Machalekova</name>
<name sortKey="Mikulova, M" sort="Mikulova, M" uniqKey="Mikulova M" first="M" last="Mikulova">M. Mikulova</name>
<name sortKey="Rauova, K" sort="Rauova, K" uniqKey="Rauova K" first="K" last="Rauova">K. Rauova</name>
<name sortKey="Svec, J" sort="Svec, J" uniqKey="Svec J" first="J" last="Svec">J. Svec</name>
<name sortKey="Zemanova, M" sort="Zemanova, M" uniqKey="Zemanova M" first="M" last="Zemanova">M. Zemanova</name>
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