Efficacy of a short course of complex lymphedema therapy or graduated compression stocking therapy in the treatment of post-thrombotic syndrome.
Identifieur interne : 002B32 ( Main/Exploration ); précédent : 002B31; suivant : 002B33Efficacy of a short course of complex lymphedema therapy or graduated compression stocking therapy in the treatment of post-thrombotic syndrome.
Auteurs : Chris E. Holmes [États-Unis] ; Nadia M. Bambace ; Patricia Lewis ; Peter W. Callas ; Mary CushmanSource :
- Vascular medicine (London, England) [ 1477-0377 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- physiology : Exercise.
- therapy : Lymphedema, Postthrombotic Syndrome, Venous Insufficiency.
- Adult, Aged, Female, Humans, Male, Middle Aged, Quality of Life, Stockings, Compression, Surveys and Questionnaires, Treatment Outcome.
Abstract
Treatment options for established post-thrombotic syndrome (PTS) are limited. Complex lymphedema therapy (CLT), a non-invasive treatment that improves lymphatic flow, may have the potential to improve PTS. We conducted a single-center, investigator-blind, randomized controlled trial of 31 patients with a clinically established diagnosis of PTS and compared the efficacy of graduated compression stockings alone (30-40 mmHg) with CLT, a treatment that includes compression stockings, exercise, patient education, skin care and lymphatic drainage. Primary outcomes were the 1- and 3-month changes in PTS severity by the Villalta score and disease-specific quality of life using the VEINES-QOL (Venous Insufficiency Epidemiological and Economic Study Quality of Life) questionnaire. Analysis was by intent-to-treat. We found from a baseline average score of 9.9 points, CLT reduced mean PTS severity scores by -2.4 points (p=0.02) at the 1-month and -2.3 points (p=0.05) at the 3-month follow-up. Score reductions with stockings only were similar at -2.1 (p=0.03) and -3.3 points (p=0.03) at 1 and 3 months. The differences in score between treatments were not significant. Neither treatment significantly changed the VEINES-QOL score except in patients with severe disease. Patients with moderate to severe PTS derived the greatest benefit from either therapy and the two therapies differentially impacted PTS signs and symptoms. We found a short course of lymphedema therapy and compression stockings offer similar benefit in patients with PTS; however, larger studies are needed to further explore the potential use of CLT in PTS, particularly in patients with more severe disease. ClinicalTrials.gov Identifier: NCT00633971.
DOI: 10.1177/1358863X14521883
PubMed: 24558028
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001667
- to stream PubMed, to step Curation: 001667
- to stream PubMed, to step Checkpoint: 001667
- to stream Ncbi, to step Merge: 006336
- to stream Ncbi, to step Curation: 006336
- to stream Ncbi, to step Checkpoint: 006336
- to stream Main, to step Merge: 002B36
- to stream Main, to step Curation: 002B32
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Efficacy of a short course of complex lymphedema therapy or graduated compression stocking therapy in the treatment of post-thrombotic syndrome.</title><author><name sortKey="Holmes, Chris E" sort="Holmes, Chris E" uniqKey="Holmes C" first="Chris E" last="Holmes">Chris E. Holmes</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, University of Vermont, Burlington, VT, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Vermont, Burlington, VT</wicri:regionArea><placeName><region type="state">Vermont</region></placeName></affiliation></author><author><name sortKey="Bambace, Nadia M" sort="Bambace, Nadia M" uniqKey="Bambace N" first="Nadia M" last="Bambace">Nadia M. Bambace</name></author><author><name sortKey="Lewis, Patricia" sort="Lewis, Patricia" uniqKey="Lewis P" first="Patricia" last="Lewis">Patricia Lewis</name></author><author><name sortKey="Callas, Peter W" sort="Callas, Peter W" uniqKey="Callas P" first="Peter W" last="Callas">Peter W. Callas</name></author><author><name sortKey="Cushman, Mary" sort="Cushman, Mary" uniqKey="Cushman M" first="Mary" last="Cushman">Mary Cushman</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24558028</idno><idno type="pmid">24558028</idno><idno type="doi">10.1177/1358863X14521883</idno><idno type="wicri:Area/PubMed/Corpus">001667</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001667</idno><idno type="wicri:Area/PubMed/Curation">001667</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001667</idno><idno type="wicri:Area/PubMed/Checkpoint">001667</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001667</idno><idno type="wicri:Area/Ncbi/Merge">006336</idno><idno type="wicri:Area/Ncbi/Curation">006336</idno><idno type="wicri:Area/Ncbi/Checkpoint">006336</idno><idno type="wicri:Area/Main/Merge">002B36</idno><idno type="wicri:Area/Main/Curation">002B32</idno><idno type="wicri:Area/Main/Exploration">002B32</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Efficacy of a short course of complex lymphedema therapy or graduated compression stocking therapy in the treatment of post-thrombotic syndrome.</title><author><name sortKey="Holmes, Chris E" sort="Holmes, Chris E" uniqKey="Holmes C" first="Chris E" last="Holmes">Chris E. Holmes</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, University of Vermont, Burlington, VT, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Vermont, Burlington, VT</wicri:regionArea><placeName><region type="state">Vermont</region></placeName></affiliation></author><author><name sortKey="Bambace, Nadia M" sort="Bambace, Nadia M" uniqKey="Bambace N" first="Nadia M" last="Bambace">Nadia M. Bambace</name></author><author><name sortKey="Lewis, Patricia" sort="Lewis, Patricia" uniqKey="Lewis P" first="Patricia" last="Lewis">Patricia Lewis</name></author><author><name sortKey="Callas, Peter W" sort="Callas, Peter W" uniqKey="Callas P" first="Peter W" last="Callas">Peter W. Callas</name></author><author><name sortKey="Cushman, Mary" sort="Cushman, Mary" uniqKey="Cushman M" first="Mary" last="Cushman">Mary Cushman</name></author></analytic><series><title level="j">Vascular medicine (London, England)</title><idno type="eISSN">1477-0377</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Exercise (physiology)</term><term>Female</term><term>Humans</term><term>Lymphedema (therapy)</term><term>Male</term><term>Middle Aged</term><term>Postthrombotic Syndrome (therapy)</term><term>Quality of Life</term><term>Stockings, Compression</term><term>Surveys and Questionnaires</term><term>Treatment Outcome</term><term>Venous Insufficiency (therapy)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Bas de contention</term><term>Enquêtes et questionnaires</term><term>Exercice physique (physiologie)</term><term>Femelle</term><term>Humains</term><term>Insuffisance veineuse ()</term><term>Lymphoedème ()</term><term>Mâle</term><term>Qualité de vie</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Syndrome post-thrombotique ()</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Exercice physique</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Exercise</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Lymphedema</term><term>Postthrombotic Syndrome</term><term>Venous Insufficiency</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Quality of Life</term><term>Stockings, Compression</term><term>Surveys and Questionnaires</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Bas de contention</term><term>Enquêtes et questionnaires</term><term>Femelle</term><term>Humains</term><term>Insuffisance veineuse</term><term>Lymphoedème</term><term>Mâle</term><term>Qualité de vie</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Syndrome post-thrombotique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Treatment options for established post-thrombotic syndrome (PTS) are limited. Complex lymphedema therapy (CLT), a non-invasive treatment that improves lymphatic flow, may have the potential to improve PTS. We conducted a single-center, investigator-blind, randomized controlled trial of 31 patients with a clinically established diagnosis of PTS and compared the efficacy of graduated compression stockings alone (30-40 mmHg) with CLT, a treatment that includes compression stockings, exercise, patient education, skin care and lymphatic drainage. Primary outcomes were the 1- and 3-month changes in PTS severity by the Villalta score and disease-specific quality of life using the VEINES-QOL (Venous Insufficiency Epidemiological and Economic Study Quality of Life) questionnaire. Analysis was by intent-to-treat. We found from a baseline average score of 9.9 points, CLT reduced mean PTS severity scores by -2.4 points (p=0.02) at the 1-month and -2.3 points (p=0.05) at the 3-month follow-up. Score reductions with stockings only were similar at -2.1 (p=0.03) and -3.3 points (p=0.03) at 1 and 3 months. The differences in score between treatments were not significant. Neither treatment significantly changed the VEINES-QOL score except in patients with severe disease. Patients with moderate to severe PTS derived the greatest benefit from either therapy and the two therapies differentially impacted PTS signs and symptoms. We found a short course of lymphedema therapy and compression stockings offer similar benefit in patients with PTS; however, larger studies are needed to further explore the potential use of CLT in PTS, particularly in patients with more severe disease. ClinicalTrials.gov Identifier: NCT00633971.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Vermont</li></region></list><tree><noCountry><name sortKey="Bambace, Nadia M" sort="Bambace, Nadia M" uniqKey="Bambace N" first="Nadia M" last="Bambace">Nadia M. Bambace</name><name sortKey="Callas, Peter W" sort="Callas, Peter W" uniqKey="Callas P" first="Peter W" last="Callas">Peter W. Callas</name><name sortKey="Cushman, Mary" sort="Cushman, Mary" uniqKey="Cushman M" first="Mary" last="Cushman">Mary Cushman</name><name sortKey="Lewis, Patricia" sort="Lewis, Patricia" uniqKey="Lewis P" first="Patricia" last="Lewis">Patricia Lewis</name></noCountry><country name="États-Unis"><region name="Vermont"><name sortKey="Holmes, Chris E" sort="Holmes, Chris E" uniqKey="Holmes C" first="Chris E" last="Holmes">Chris E. Holmes</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002B32 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002B32 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:24558028
|texte= Efficacy of a short course of complex lymphedema therapy or graduated compression stocking therapy in the treatment of post-thrombotic syndrome.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24558028" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |