LymphedemaV1, Main, Exploration, bibRecord, 002A69

Functional Lymphatic Collectors in Breast Cancer-Related Lymphedema Arm

Identifieur interne : 002A69 ( Main/Exploration ); précédent : 002A68; suivant : 002A70

Functional Lymphatic Collectors in Breast Cancer-Related Lymphedema Arm

Auteurs : Ning-Fei Liu ; Bing-Shun Wang

Source :

Lymphatic Research and Biology [ 1539-6851 ] ; 2014.

RBID : PMC:4267712

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Association thérapeutique, Bras (anatomopathologie), Composés organométalliques, Femelle, Humains, Lymphoedème (), Lymphoedème (anatomopathologie), Lymphoedème (étiologie), Lymphographie, Méglumine (analogues et dérivés), Produits de contraste, Pronostic, Stade de la tumeur, Sujet âgé, Sujet âgé de 80 ans ou plus, Système lymphatique (anatomopathologie), Tumeurs du sein (), Tumeurs du sein (anatomopathologie), Études de suivi.
MESH :
- analogues et dérivés : Méglumine.
- anatomopathologie : Bras, Lymphoedème, Système lymphatique, Tumeurs du sein.
- étiologie : Lymphoedème.
- Adulte, Adulte d'âge moyen, Association thérapeutique, Composés organométalliques, Femelle, Humains, Lymphoedème, Lymphographie, Produits de contraste, Pronostic, Stade de la tumeur, Sujet âgé, Sujet âgé de 80 ans ou plus, Tumeurs du sein, Études de suivi.

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Arm (pathology), Breast Neoplasms (complications), Breast Neoplasms (pathology), Combined Modality Therapy, Contrast Media, Female, Follow-Up Studies, Humans, Lymphatic System (pathology), Lymphedema (etiology), Lymphedema (pathology), Lymphedema (therapy), Lymphography, Meglumine (analogs & derivatives), Middle Aged, Neoplasm Staging, Organometallic Compounds, Prognosis.
MESH :
- chemical , analogs & derivatives : Meglumine.
- chemical : Contrast Media, Organometallic Compounds.
- complications : Breast Neoplasms.
- etiology : Lymphedema.
- pathology : Arm, Breast Neoplasms, Lymphatic System, Lymphedema.
- therapy : Lymphedema.
- Adult, Aged, Aged, 80 and over, Combined Modality Therapy, Female, Follow-Up Studies, Humans, Lymphography, Middle Aged, Neoplasm Staging, Prognosis.

Abstract

Background: The pathophysiology of breast cancer-related lymphedema (BCRL) is poorly understood. The present study evaluated the lymphatic collectors in the arms of patients with BCRL.

Methods and Results: In total, 123 patients with ipsilateral BCRL who had undergone magnetic resonance lymphangiography using gadobenate dimeglumine as a contrast agent were enrolled in this study. Morphological changes and the numbers of collecting lymphatic vessels were recorded. Associations between the number of visualized lymphatic collectors and edema accumulation, subcutis thickness, and the BCRL duration and latency were analyzed. Tortuous and significantly dilated lymphatic collectors were visualized in the lymphedematous arms of 104 patients (85%). The median number of visualized lymphatic collectors was four. The duration of BCRL was weakly but significantly correlated with the number of lymphatic collectors (r_s=0.2054, p=0.0226). The differences in the tissue water content and thickness of the subcutis between the bilateral arms demonstrated moderate correlations with the number of collecting lymphatics (r_s=0.31 and 0.35, respectively; p<0.01). More lymphatic collectors tended to be seen in more advanced cases. There was no statistical difference in the amount of lymphatic vessels among different breast cancer treatment methods.

Conclusions: The number of functional remaining lymphatic collectors increases with the prolongation and severity of BCRL. This may imply persistent reactions of lymphatic collectors in response to lymphostasis.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267712

DOI: 10.1089/lrb.2014.0021
PubMed: 25495381
PubMed Central: 4267712

Affiliations:

Le document en format XML

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<term>Breast Neoplasms (complications)</term>
<term>Breast Neoplasms (pathology)</term>
<term>Combined Modality Therapy</term>
<term>Contrast Media</term>
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<term>Lymphedema (etiology)</term>
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<term>Composés organométalliques</term>
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<term>Lymphoedème ()</term>
<term>Lymphoedème (anatomopathologie)</term>
<term>Lymphoedème (étiologie)</term>
<term>Lymphographie</term>
<term>Méglumine (analogues et dérivés)</term>
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<term>Tumeurs du sein ()</term>
<term>Tumeurs du sein (anatomopathologie)</term>
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<term>Système lymphatique</term>
<term>Tumeurs du sein</term>
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<term>Breast Neoplasms</term>
<term>Lymphatic System</term>
<term>Lymphedema</term>
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<term>Aged</term>
<term>Aged, 80 and over</term>
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<term>Female</term>
<term>Follow-Up Studies</term>
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<term>Middle Aged</term>
<term>Neoplasm Staging</term>
<term>Prognosis</term>
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<term>Adulte d'âge moyen</term>
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<term>Composés organométalliques</term>
<term>Femelle</term>
<term>Humains</term>
<term>Lymphoedème</term>
<term>Lymphographie</term>
<term>Produits de contraste</term>
<term>Pronostic</term>
<term>Stade de la tumeur</term>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p><bold><italic>Background:</italic>
</bold>
 The pathophysiology of breast cancer-related lymphedema (BCRL) is poorly understood. The present study evaluated the lymphatic collectors in the arms of patients with BCRL.</p>
<p><bold><italic>Methods and Results:</italic>
</bold>
 In total, 123 patients with ipsilateral BCRL who had undergone magnetic resonance lymphangiography using gadobenate dimeglumine as a contrast agent were enrolled in this study. Morphological changes and the numbers of collecting lymphatic vessels were recorded. Associations between the number of visualized lymphatic collectors and edema accumulation, subcutis thickness, and the BCRL duration and latency were analyzed. Tortuous and significantly dilated lymphatic collectors were visualized in the lymphedematous arms of 104 patients (85%). The median number of visualized lymphatic collectors was four. The duration of BCRL was weakly but significantly correlated with the number of lymphatic collectors (<italic>r</italic>
<sub>s</sub>
=0.2054, <italic>p</italic>
=0.0226). The differences in the tissue water content and thickness of the subcutis between the bilateral arms demonstrated moderate correlations with the number of collecting lymphatics (<italic>r</italic>
<sub>s</sub>
=0.31 and 0.35, respectively; <italic>p</italic>
<0.01). More lymphatic collectors tended to be seen in more advanced cases. There was no statistical difference in the amount of lymphatic vessels among different breast cancer treatment methods.</p>
<p><bold><italic>Conclusions:</italic>
</bold>
 The number of functional remaining lymphatic collectors increases with the prolongation and severity of BCRL. This may imply persistent reactions of lymphatic collectors in response to lymphostasis.</p>
</div>
</front>
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<tree><noCountry><name sortKey="Liu, Ning Fei" sort="Liu, Ning Fei" uniqKey="Liu N" first="Ning-Fei" last="Liu">Ning-Fei Liu</name>
<name sortKey="Wang, Bing Shun" sort="Wang, Bing Shun" uniqKey="Wang B" first="Bing-Shun" last="Wang">Bing-Shun Wang</name>
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Serveur d'exploration sur le lymphœdème

Functional Lymphatic Collectors in Breast Cancer-Related Lymphedema Arm

Functional Lymphatic Collectors in Breast Cancer-Related Lymphedema Arm

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
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