Gap junction modulation and its implications for heart function
Identifieur interne : 002A59 ( Main/Exploration ); précédent : 002A58; suivant : 002A60Gap junction modulation and its implications for heart function
Auteurs : Stefan Kurtenbach [Canada] ; Sarah Kurtenbach [Canada] ; Georg Zoidl [Canada]Source :
- Frontiers in Physiology [ 1664-042X ] ; 2014.
Abstract
Gap junction communication (GJC) mediated by connexins is critical for heart function. To gain insight into the causal relationship of molecular mechanisms of disease pathology, it is important to understand which mechanisms contribute to impairment of gap junctional communication. Here, we present an update on the known modulators of connexins, including various interaction partners, kinases, and signaling cascades. This gap junction network (GJN) can serve as a blueprint for data mining approaches exploring the growing number of publicly available data sets from experimental and clinical studies.
Url:
DOI: 10.3389/fphys.2014.00082
PubMed: 24578694
PubMed Central: 3936571
Affiliations:
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Sciences, 4301 West Markham Street, Little Rock</wicri:regionArea><wicri:noRegion>Little Rock</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Center for Vision Research, York University</institution><country>Toronto, ON, Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arkansas Nanomedicine Center, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock</wicri:regionArea><wicri:noRegion>Little Rock</wicri:noRegion></affiliation></author></analytic><series><title level="j">Frontiers in Physiology</title><idno type="eISSN">1664-042X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Gap junction communication (GJC) mediated by connexins is critical for heart function. To gain insight into the causal relationship of molecular mechanisms of disease pathology, it is important to understand which mechanisms contribute to impairment of gap junctional communication. Here, we present an update on the known modulators of connexins, including various interaction partners, kinases, and signaling cascades. This gap junction network (GJN) can serve as a blueprint for data mining approaches exploring the growing number of publicly available data sets from experimental and clinical studies.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abascal, F" uniqKey="Abascal F">F. Abascal</name></author><author><name sortKey="Zardoya, R" uniqKey="Zardoya R">R. Zardoya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abdelmohsen, K" uniqKey="Abdelmohsen K">K. Abdelmohsen</name></author><author><name sortKey="Gerber, P A" uniqKey="Gerber P">P. A. 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Tinker</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Kurtenbach, Stefan" sort="Kurtenbach, Stefan" uniqKey="Kurtenbach S" first="Stefan" last="Kurtenbach">Stefan Kurtenbach</name></noRegion><name sortKey="Kurtenbach, Sarah" sort="Kurtenbach, Sarah" uniqKey="Kurtenbach S" first="Sarah" last="Kurtenbach">Sarah Kurtenbach</name><name sortKey="Zoidl, Georg" sort="Zoidl, Georg" uniqKey="Zoidl G" first="Georg" last="Zoidl">Georg Zoidl</name><name sortKey="Zoidl, Georg" sort="Zoidl, Georg" uniqKey="Zoidl G" first="Georg" last="Zoidl">Georg Zoidl</name><name sortKey="Zoidl, Georg" sort="Zoidl, Georg" uniqKey="Zoidl G" first="Georg" last="Zoidl">Georg Zoidl</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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