Inflammation-associated lymphangiogenesis: a double-edged sword?
Identifieur interne : 002988 ( Main/Exploration ); précédent : 002987; suivant : 002989Inflammation-associated lymphangiogenesis: a double-edged sword?
Auteurs : Honsoul Kim [Corée du Sud] ; Raghu P. Kataru [Corée du Sud] ; Gou Young Koh [Corée du Sud]Source :
- The Journal of Clinical Investigation [ 0021-9738 ] ; 2014.
Abstract
Lymphangiogenesis and lymphatic vessel remodeling are complex biological processes frequently observed during inflammation. Accumulating evidence indicates that inflammation-associated lymphangiogenesis (IAL) is not merely an endpoint event, but actually a phenomenon actively involved in the pathophysiology of various inflammatory disorders. The VEGF-C/VEGFR-3 and VEGF-A/VEGF-R2 signaling pathways are two of the best-studied pathways in IAL. Methods targeting these molecules, such as prolymphangiogenic or antilymphatic treatments, were found to be beneficial in various preclinical and/or clinical studies. This Review focuses on the most recent achievements in the fields of lymphatic biology relevant to inflammatory conditions. Additionally, preclinical and clinical therapies that modulate IAL are summarized.
Url:
DOI: 10.1172/JCI71607
PubMed: 24590279
PubMed Central: 3938274
Affiliations:
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Kataru</name><affiliation><nlm:aff wicri:cut=" and" id="JCI71607">Laboratory of Vascular Biology and Stem Cells</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="JCI71607">Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Koh, Gou Young" sort="Koh, Gou Young" uniqKey="Koh G" first="Gou Young" last="Koh">Gou Young Koh</name><affiliation><nlm:aff wicri:cut=" and" id="JCI71607">Laboratory of Vascular Biology and Stem Cells</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="JCI71607">Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Journal of Clinical Investigation</title><idno type="ISSN">0021-9738</idno><idno type="eISSN">1558-8238</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Lymphangiogenesis and lymphatic vessel remodeling are complex biological processes frequently observed during inflammation. Accumulating evidence indicates that inflammation-associated lymphangiogenesis (IAL) is not merely an endpoint event, but actually a phenomenon actively involved in the pathophysiology of various inflammatory disorders. The VEGF-C/VEGFR-3 and VEGF-A/VEGF-R2 signaling pathways are two of the best-studied pathways in IAL. Methods targeting these molecules, such as prolymphangiogenic or antilymphatic treatments, were found to be beneficial in various preclinical and/or clinical studies. This Review focuses on the most recent achievements in the fields of lymphatic biology relevant to inflammatory conditions. Additionally, preclinical and clinical therapies that modulate IAL are summarized.</p></div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Kim, Honsoul" sort="Kim, Honsoul" uniqKey="Kim H" first="Honsoul" last="Kim">Honsoul Kim</name></region><name sortKey="Kataru, Raghu P" sort="Kataru, Raghu P" uniqKey="Kataru R" first="Raghu P." last="Kataru">Raghu P. Kataru</name><name sortKey="Koh, Gou Young" sort="Koh, Gou Young" uniqKey="Koh G" first="Gou Young" last="Koh">Gou Young Koh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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