Inhibition of breast cancer growth and metastasis by a biomimetic peptide
Identifieur interne : 002983 ( Main/Exploration ); précédent : 002982; suivant : 002984Inhibition of breast cancer growth and metastasis by a biomimetic peptide
Auteurs : Esak Lee [États-Unis] ; Seung Jae Lee [États-Unis] ; Jacob E. Koskimaki [États-Unis] ; Zheyi Han [États-Unis] ; Niranjan B. Pandey [États-Unis] ; Aleksander S. Popel [États-Unis]Source :
- Scientific Reports [ 2045-2322 ] ; 2014.
Abstract
Metastasis is the main cause of mortality in cancer patients. Though there are many anti-cancer drugs targeting primary tumor growth, anti-metastatic agents are rarely developed. Angiogenesis and lymphangiogenesis are crucial for cancer progression, particularly, lymphangiogenesis is pivotal for metastasis in breast cancer. Here we report that a novel collagen IV derived biomimetic peptide inhibits breast cancer growth and metastasis by blocking angiogenesis and lymphangiogenesis. The peptide inhibits blood and lymphatic endothelial cell viability, migration, adhesion, and tube formation by targeting IGF1R and Met signals. The peptide blocks MDA-MB-231 tumor growth by inhibiting tumor angiogenesis in vivo. Moreover, the peptide inhibits lymphangiogenesis in primary tumors. MDA-MB-231 tumor conditioned media (TCM) was employed to accelerate spontaneous metastasis in tumor xenografts, and the anti-metastatic activity of the peptide was tested in this model. The peptide prevents metastasis to the lungs and lymph nodes by inhibiting TCM-induced lymphangiogenesis and angiogenesis in the pre-metastatic organs. In summary, a novel biomimetic peptide inhibits breast cancer growth and metastasis by blocking angiogenesis and lymphangiogenesis in the pre-metastatic organs as well as primary tumors.
Url:
DOI: 10.1038/srep07139
PubMed: 25409905
PubMed Central: 4238022
Affiliations:
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Koskimaki</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Biomedical Engineering, Johns Hopkins University School of Medicine</institution>, Baltimore, MD 21205, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>, Baltimore, MD 21205</wicri:regionArea><wicri:noRegion>MD 21205</wicri:noRegion></affiliation></author><author><name sortKey="Han, Zheyi" sort="Han, Zheyi" uniqKey="Han Z" first="Zheyi" last="Han">Zheyi Han</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Biomedical Engineering, Johns Hopkins University School of Medicine</institution>, Baltimore, MD 21205, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>, Baltimore, MD 21205</wicri:regionArea><wicri:noRegion>MD 21205</wicri:noRegion></affiliation></author><author><name sortKey="Pandey, Niranjan B" sort="Pandey, Niranjan B" uniqKey="Pandey N" first="Niranjan B." last="Pandey">Niranjan B. Pandey</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Biomedical Engineering, Johns Hopkins University School of Medicine</institution>, Baltimore, MD 21205, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>, Baltimore, MD 21205</wicri:regionArea><wicri:noRegion>MD 21205</wicri:noRegion></affiliation></author><author><name sortKey="Popel, Aleksander S" sort="Popel, Aleksander S" uniqKey="Popel A" first="Aleksander S." last="Popel">Aleksander S. Popel</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Biomedical Engineering, Johns Hopkins University School of Medicine</institution>, Baltimore, MD 21205, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>, Baltimore, MD 21205</wicri:regionArea><wicri:noRegion>MD 21205</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Oncology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine</institution>, Baltimore, MD 21231, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>, Baltimore, MD 21231</wicri:regionArea><wicri:noRegion>MD 21231</wicri:noRegion></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Metastasis is the main cause of mortality in cancer patients. Though there are many anti-cancer drugs targeting primary tumor growth, anti-metastatic agents are rarely developed. Angiogenesis and lymphangiogenesis are crucial for cancer progression, particularly, lymphangiogenesis is pivotal for metastasis in breast cancer. Here we report that a novel collagen IV derived biomimetic peptide inhibits breast cancer growth and metastasis by blocking angiogenesis and lymphangiogenesis. The peptide inhibits blood and lymphatic endothelial cell viability, migration, adhesion, and tube formation by targeting IGF1R and Met signals. The peptide blocks MDA-MB-231 tumor growth by inhibiting tumor angiogenesis in vivo. Moreover, the peptide inhibits lymphangiogenesis in primary tumors. MDA-MB-231 tumor conditioned media (TCM) was employed to accelerate spontaneous metastasis in tumor xenografts, and the anti-metastatic activity of the peptide was tested in this model. The peptide prevents metastasis to the lungs and lymph nodes by inhibiting TCM-induced lymphangiogenesis and angiogenesis in the pre-metastatic organs. In summary, a novel biomimetic peptide inhibits breast cancer growth and metastasis by blocking angiogenesis and lymphangiogenesis in the pre-metastatic organs as well as primary tumors.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Desantis, C" uniqKey="Desantis C">C. DeSantis</name></author><author><name sortKey="Ma, J" uniqKey="Ma J">J. Ma</name></author><author><name sortKey="Bryan, L" uniqKey="Bryan L">L. Bryan</name></author><author><name sortKey="Jemal, A" uniqKey="Jemal A">A. Jemal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shamloo, B K" uniqKey="Shamloo B">B. K. Shamloo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schoppmann, S F" uniqKey="Schoppmann S">S. F. Schoppmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, E" uniqKey="Lee E">E. Lee</name></author><author><name sortKey="Koskimaki, J E" uniqKey="Koskimaki J">J. E. Koskimaki</name></author><author><name sortKey="Pandey, N B" uniqKey="Pandey N">N. B. Pandey</name></author><author><name sortKey="Popel, A S" uniqKey="Popel A">A. S. Popel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, E" uniqKey="Lee E">E. Lee</name></author><author><name sortKey="Rosca, E V" uniqKey="Rosca E">E. V. Rosca</name></author><author><name sortKey="Pandey, N B" uniqKey="Pandey N">N. B. Pandey</name></author><author><name sortKey="Popel, A S" uniqKey="Popel A">A. S. Popel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koskimaki, J E" uniqKey="Koskimaki J">J. E. Koskimaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karagiannis, E D" uniqKey="Karagiannis E">E. D. Karagiannis</name></author><author><name sortKey="Popel, A S" uniqKey="Popel A">A. S. Popel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosca, E V" uniqKey="Rosca E">E. V. Rosca</name></author><author><name sortKey="Koskimaki, J E" uniqKey="Koskimaki J">J. E. Koskimaki</name></author><author><name sortKey="Pandey, N B" uniqKey="Pandey N">N. B. Pandey</name></author><author><name sortKey="Wolff, A C" uniqKey="Wolff A">A. C. Wolff</name></author><author><name sortKey="Popel, A S" uniqKey="Popel A">A. S. Popel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosca, E V" uniqKey="Rosca E">E. V. Rosca</name></author><author><name sortKey="Koskimaki, J E" uniqKey="Koskimaki J">J. E. Koskimaki</name></author><author><name sortKey="Pandey, N B" uniqKey="Pandey N">N. B. Pandey</name></author><author><name sortKey="Tamiz, A P" uniqKey="Tamiz A">A. P. Tamiz</name></author><author><name sortKey="Popel, A S" uniqKey="Popel A">A. S. Popel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rivera, C G" uniqKey="Rivera C">C. G. Rivera</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, E" uniqKey="Lee E">E. Lee</name></author><author><name sortKey="Pandey, N B" uniqKey="Pandey N">N. B. Pandey</name></author><author><name sortKey="Popel, A S" uniqKey="Popel A">A. S. Popel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, E" uniqKey="Lee E">E. Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oommen, S" uniqKey="Oommen S">S. Oommen</name></author><author><name sortKey="Gupta, S K" uniqKey="Gupta S">S. K. Gupta</name></author><author><name sortKey="Vlahakis, N E" uniqKey="Vlahakis N">N. E. Vlahakis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mitra, A K" uniqKey="Mitra A">A. K. Mitra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kabir Salmani, M" uniqKey="Kabir Salmani M">M. Kabir-Salmani</name></author><author><name sortKey="Shiokawa, S" uniqKey="Shiokawa S">S. Shiokawa</name></author><author><name sortKey="Akimoto, Y" uniqKey="Akimoto Y">Y. Akimoto</name></author><author><name sortKey="Sakai, K" uniqKey="Sakai K">K. Sakai</name></author><author><name sortKey="Iwashita, M" uniqKey="Iwashita M">M. Iwashita</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, X" uniqKey="Yu X">X. Yu</name></author><author><name sortKey="Miyamoto, S" uniqKey="Miyamoto S">S. Miyamoto</name></author><author><name sortKey="Mekada, E" uniqKey="Mekada E">E. Mekada</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bahr, C" uniqKey="Bahr C">C. Bahr</name></author><author><name sortKey="Groner, B" uniqKey="Groner B">B. Groner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sennino, B" uniqKey="Sennino B">B. Sennino</name></author><author><name sortKey="Ishiguro Oonuma, T" uniqKey="Ishiguro Oonuma T">T. Ishiguro-Oonuma</name></author><author><name sortKey="Schriver, B J" uniqKey="Schriver B">B. J. Schriver</name></author><author><name sortKey="Christensen, J G" uniqKey="Christensen J">J. G. Christensen</name></author><author><name sortKey="Mcdonald, D M" uniqKey="Mcdonald D">D. M. McDonald</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, S" uniqKey="Xu S">S. Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sloan, K E" uniqKey="Sloan K">K. E. Sloan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Glunde, K" uniqKey="Glunde K">K. Glunde</name></author><author><name sortKey="Stasinopoulos, I" uniqKey="Stasinopoulos I">I. Stasinopoulos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pacher, M" uniqKey="Pacher M">M. Pacher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peyrat, J P" uniqKey="Peyrat J">J. P. Peyrat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parr, C" uniqKey="Parr C">C. Parr</name></author><author><name sortKey="Jiang, W G" uniqKey="Jiang W">W. G. Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sakai, K" uniqKey="Sakai K">K. Sakai</name></author><author><name sortKey="Yamashita, J" uniqKey="Yamashita J">J. Yamashita</name></author><author><name sortKey="Ogawa, M" uniqKey="Ogawa M">M. Ogawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vora, H H" uniqKey="Vora H">H. H. Vora</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoganson, D M" uniqKey="Hoganson D">D. M. Hoganson</name></author><author><name sortKey="Pryor, H I" uniqKey="Pryor H">H. I. Pryor</name></author><author><name sortKey="Vacanti, J P" uniqKey="Vacanti J">J. P. Vacanti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cao, Y" uniqKey="Cao Y">Y. Cao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilker, E" uniqKey="Wilker E">E. Wilker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thompson, A D" uniqKey="Thompson A">A. D. Thompson</name></author><author><name sortKey="Kakar, S S" uniqKey="Kakar S">S. S. Kakar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gotte, M" uniqKey="Gotte M">M. Gotte</name></author><author><name sortKey="Kersting, C" uniqKey="Kersting C">C. Kersting</name></author><author><name sortKey="Radke, I" uniqKey="Radke I">I. Radke</name></author><author><name sortKey="Kiesel, L" uniqKey="Kiesel L">L. Kiesel</name></author><author><name sortKey="Wulfing, P" uniqKey="Wulfing P">P. Wulfing</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saito, Y" uniqKey="Saito Y">Y. Saito</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, D" uniqKey="Zhao D">D. Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maroun, C R" uniqKey="Maroun C">C. R. Maroun</name></author><author><name sortKey="Rowlands, T" uniqKey="Rowlands T">T. Rowlands</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krumbach, R" uniqKey="Krumbach R">R. Krumbach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Etnyre, D" uniqKey="Etnyre D">D. Etnyre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paulson, A K" uniqKey="Paulson A">A. K. Paulson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mueller, K L" uniqKey="Mueller K">K. L. Mueller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Desgrosellier, J S" uniqKey="Desgrosellier J">J. S. Desgrosellier</name></author><author><name sortKey="Cheresh, D A" uniqKey="Cheresh D">D. A. Cheresh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Avraamides, C J" uniqKey="Avraamides C">C. J. Avraamides</name></author><author><name sortKey="Garmy Susini, B" uniqKey="Garmy Susini B">B. Garmy-Susini</name></author><author><name sortKey="Varner, J A" uniqKey="Varner J">J. A. Varner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soung, Y H" uniqKey="Soung Y">Y. H. Soung</name></author><author><name sortKey="Clifford, J L" uniqKey="Clifford J">J. L. Clifford</name></author><author><name sortKey="Chung, J" uniqKey="Chung J">J. Chung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, J" uniqKey="Lin J">J. Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Das, S" uniqKey="Das S">S. Das</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, X" uniqKey="Zheng X">X. Zheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, M Q" uniqKey="Gao M">M. Q. Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Padera, T P" uniqKey="Padera T">T. P. Padera</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosca, E V" uniqKey="Rosca E">E. V. Rosca</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bhise, N S" uniqKey="Bhise N">N. S. Bhise</name></author><author><name sortKey="Shmueli, R B" uniqKey="Shmueli R">R. B. Shmueli</name></author><author><name sortKey="Sunshine, J C" uniqKey="Sunshine J">J. C. Sunshine</name></author><author><name sortKey="Tzeng, S Y" uniqKey="Tzeng S">S. Y. Tzeng</name></author><author><name sortKey="Green, J J" uniqKey="Green J">J. J. Green</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shmueli, R B" uniqKey="Shmueli R">R. B. Shmueli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ito, Y" uniqKey="Ito Y">Y. Ito</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hood, J L" uniqKey="Hood J">J. L. Hood</name></author><author><name sortKey="San, R S" uniqKey="San R">R. S. San</name></author><author><name sortKey="Wickline, S A" uniqKey="Wickline S">S. A. Wickline</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Lee, Esak" sort="Lee, Esak" uniqKey="Lee E" first="Esak" last="Lee">Esak Lee</name></noRegion><name sortKey="Han, Zheyi" sort="Han, Zheyi" uniqKey="Han Z" first="Zheyi" last="Han">Zheyi Han</name><name sortKey="Koskimaki, Jacob E" sort="Koskimaki, Jacob E" uniqKey="Koskimaki J" first="Jacob E." last="Koskimaki">Jacob E. Koskimaki</name><name sortKey="Lee, Seung Jae" sort="Lee, Seung Jae" uniqKey="Lee S" first="Seung Jae" last="Lee">Seung Jae Lee</name><name sortKey="Pandey, Niranjan B" sort="Pandey, Niranjan B" uniqKey="Pandey N" first="Niranjan B." last="Pandey">Niranjan B. Pandey</name><name sortKey="Popel, Aleksander S" sort="Popel, Aleksander S" uniqKey="Popel A" first="Aleksander S." last="Popel">Aleksander S. Popel</name><name sortKey="Popel, Aleksander S" sort="Popel, Aleksander S" uniqKey="Popel A" first="Aleksander S." last="Popel">Aleksander S. Popel</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|étape= Exploration
|type= RBID
|clé= PMC:4238022
|texte= Inhibition of breast cancer growth and metastasis by a biomimetic peptide
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25409905" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |