Integrin-α5β1 is not required for mural cell functions during development of blood vessels but is required for lymphatic-blood vessel separation and lymphovenous valve formation
Identifieur interne : 002980 ( Main/Exploration ); précédent : 002979; suivant : 002981Integrin-α5β1 is not required for mural cell functions during development of blood vessels but is required for lymphatic-blood vessel separation and lymphovenous valve formation
Auteurs : Christopher J. Turner ; Kwabena Badu-Nkansah ; Denise Crowley ; Arjan Van Der Flier ; Richard O. HynesSource :
- Developmental biology [ 0012-1606 ] ; 2014.
Abstract
Integrin α5β1 is essential for vascular development but it remains unclear precisely where and how it functions. Here, we report that deletion of the gene encoding the integrin-α5 subunit [
Url:
DOI: 10.1016/j.ydbio.2014.05.006
PubMed: 24858485
PubMed Central: 4113717
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Integrin-α5β1 is not required for mural cell functions during development of blood vessels but is required for lymphatic-blood vessel separation and lymphovenous valve formation</title><author><name sortKey="Turner, Christopher J" sort="Turner, Christopher J" uniqKey="Turner C" first="Christopher J." last="Turner">Christopher J. Turner</name></author><author><name sortKey="Badu Nkansah, Kwabena" sort="Badu Nkansah, Kwabena" uniqKey="Badu Nkansah K" first="Kwabena" last="Badu-Nkansah">Kwabena Badu-Nkansah</name></author><author><name sortKey="Crowley, Denise" sort="Crowley, Denise" uniqKey="Crowley D" first="Denise" last="Crowley">Denise Crowley</name></author><author><name sortKey="Van Der Flier, Arjan" sort="Van Der Flier, Arjan" uniqKey="Van Der Flier A" first="Arjan" last="Van Der Flier">Arjan Van Der Flier</name></author><author><name sortKey="Hynes, Richard O" sort="Hynes, Richard O" uniqKey="Hynes R" first="Richard O." last="Hynes">Richard O. Hynes</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24858485</idno><idno type="pmc">4113717</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113717</idno><idno type="RBID">PMC:4113717</idno><idno type="doi">10.1016/j.ydbio.2014.05.006</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">003355</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003355</idno><idno type="wicri:Area/Pmc/Curation">003354</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003354</idno><idno type="wicri:Area/Pmc/Checkpoint">001A81</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001A81</idno><idno type="wicri:Area/Ncbi/Merge">006686</idno><idno type="wicri:Area/Ncbi/Curation">006686</idno><idno type="wicri:Area/Ncbi/Checkpoint">006686</idno><idno type="wicri:doubleKey">0012-1606:2014:Turner C:integrin:is:not</idno><idno type="wicri:Area/Main/Merge">002984</idno><idno type="wicri:Area/Main/Curation">002980</idno><idno type="wicri:Area/Main/Exploration">002980</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Integrin-α5β1 is not required for mural cell functions during development of blood vessels but is required for lymphatic-blood vessel separation and lymphovenous valve formation</title><author><name sortKey="Turner, Christopher J" sort="Turner, Christopher J" uniqKey="Turner C" first="Christopher J." last="Turner">Christopher J. Turner</name></author><author><name sortKey="Badu Nkansah, Kwabena" sort="Badu Nkansah, Kwabena" uniqKey="Badu Nkansah K" first="Kwabena" last="Badu-Nkansah">Kwabena Badu-Nkansah</name></author><author><name sortKey="Crowley, Denise" sort="Crowley, Denise" uniqKey="Crowley D" first="Denise" last="Crowley">Denise Crowley</name></author><author><name sortKey="Van Der Flier, Arjan" sort="Van Der Flier, Arjan" uniqKey="Van Der Flier A" first="Arjan" last="Van Der Flier">Arjan Van Der Flier</name></author><author><name sortKey="Hynes, Richard O" sort="Hynes, Richard O" uniqKey="Hynes R" first="Richard O." last="Hynes">Richard O. Hynes</name></author></analytic><series><title level="j">Developmental biology</title><idno type="ISSN">0012-1606</idno><idno type="eISSN">1095-564X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p id="P3">Integrin α5β1 is essential for vascular development but it remains unclear precisely where and how it functions. Here, we report that deletion of the gene encoding the integrin-α5 subunit [<italic>Itga5</italic>] using the <italic>Pdgfrb-Cre</italic> transgenic mouse line, leads to oedema, haemorrhage and increased levels of embryonic lethality. Unexpectedly, these defects were not caused by loss of α5 from <italic>Pdgfrb-Cre</italic> expressing mural cells (pericytes and vascular smooth muscle cells), which wrap around the endothelium and stabilise blood vessels, nor by defects in the heart or great vessels, but were due to abnormal development of the lymphatic vasculature. Reminiscent of the pathologies seen in the human lymphatic malformation, fetal cystic hygroma, α5 mutants display defects both in the separation of their blood and lymphatic vasculature and in the formation of the lymphovenous valves. As a consequence, α5-deficient mice develop dilated, blood-filled lymphatic vessels and lymphatic capillaries that are ectopically covered with smooth muscle cells. Analysis of the expression of <italic>Pdgfrb</italic> during lymphatic development suggests that these defects probably arise from loss of α5β1 integrin in subsets of specialised <italic>Prox1<sup>+</sup> Pdgfr <sup>+</sup></italic> venous endothelial cells that are essential for the separation of the jugular lymph sac from the cardinal vein and formation of the lymphovenous valve leaflets.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Badu Nkansah, Kwabena" sort="Badu Nkansah, Kwabena" uniqKey="Badu Nkansah K" first="Kwabena" last="Badu-Nkansah">Kwabena Badu-Nkansah</name><name sortKey="Crowley, Denise" sort="Crowley, Denise" uniqKey="Crowley D" first="Denise" last="Crowley">Denise Crowley</name><name sortKey="Hynes, Richard O" sort="Hynes, Richard O" uniqKey="Hynes R" first="Richard O." last="Hynes">Richard O. Hynes</name><name sortKey="Turner, Christopher J" sort="Turner, Christopher J" uniqKey="Turner C" first="Christopher J." last="Turner">Christopher J. Turner</name><name sortKey="Van Der Flier, Arjan" sort="Van Der Flier, Arjan" uniqKey="Van Der Flier A" first="Arjan" last="Van Der Flier">Arjan Van Der Flier</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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