Late effects of treatment in survivors of childhood cancer from a tertiary cancer center in South India
Identifieur interne : 002949 ( Main/Exploration ); précédent : 002948; suivant : 002950Late effects of treatment in survivors of childhood cancer from a tertiary cancer center in South India
Auteurs : Rejiv Rajendranath [Inde] ; Surendran Veeraiah [Inde] ; Anita Ramesh [Inde] ; Tenali Gnana Sagar [Inde]Source :
- South Asian Journal of Cancer [ 2278-330X ] ; 2014.
Abstract
Improved survival after childhood cancer is attributed to intensive, aggressive therapy, adverse sequelae of which can manifest months to years after completion of treatment. There is little information about the late adverse effects of both childhood cancer and its therapy in survivors in India.
To determine the long-term sequelae associated with therapy in childhood cancer survivors attending a tertiary cancer center in India.
We studied 155 consecutive survivors of childhood cancer who were ≤14 years at the time of diagnosis and had completed 3 years of follow-up. The study included a complete history and clinical examination, with specific investigations to detect organ toxicity. Quality of life (QOL) was assessed from responses to a standardized questionnaire. Neurocognitive assessment was carried out in 20 survivors with an adaptation of the revised Wechsler adult intelligence scale for adults and the Malins intelligence scale for children.
The late effects included impaired fertility in 38 patients (24.5%), impaired growth pattern in 7 (4.5%), endocrine dysfunction in 7 (4.5%) and second malignancy in 2 (1.2%). Three of the 20 patients assessed had severe neurocognitive impairment. A high QOL was reported by 60% of survivors and an “average” QOL by 38%.
Our study showed that most survivors had a good QOL and our results will help clinicians to better monitor childhood cancer survivors in countries with limited resources.
Url:
DOI: 10.4103/2278-330X.126529
PubMed: 24665450
PubMed Central: 3961872
Affiliations:
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Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Veeraiah, Surendran" sort="Veeraiah, Surendran" uniqKey="Veeraiah S" first="Surendran" last="Veeraiah">Surendran Veeraiah</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Psycho Oncology, Cancer Institute Adyar, Chennai, Tamil Nadu, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Psycho Oncology, Cancer Institute Adyar, Chennai, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Ramesh, Anita" sort="Ramesh, Anita" uniqKey="Ramesh A" first="Anita" last="Ramesh">Anita Ramesh</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Medicine, Sri Ram Chandra Medical College, Chennai, Tamil Nadu, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Medicine, Sri Ram Chandra Medical College, Chennai, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Sagar, Tenali Gnana" sort="Sagar, Tenali Gnana" uniqKey="Sagar T" first="Tenali Gnana" last="Sagar">Tenali Gnana Sagar</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Oncology, Cancer Institute Adyar, Chennai, Tamil Nadu, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Medical Oncology, Cancer Institute Adyar, Chennai, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author></analytic><series><title level="j">South Asian Journal of Cancer</title><idno type="ISSN">2278-330X</idno><idno type="eISSN">2278-4306</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background:</title><p>Improved survival after childhood cancer is attributed to intensive, aggressive therapy, adverse sequelae of which can manifest months to years after completion of treatment. There is little information about the late adverse effects of both childhood cancer and its therapy in survivors in India.</p></sec><sec id="st2"><title>Aim:</title><p>To determine the long-term sequelae associated with therapy in childhood cancer survivors attending a tertiary cancer center in India.</p></sec><sec id="st3"><title>Materials and Methods:</title><p>We studied 155 consecutive survivors of childhood cancer who were ≤14 years at the time of diagnosis and had completed 3 years of follow-up. The study included a complete history and clinical examination, with specific investigations to detect organ toxicity. Quality of life (QOL) was assessed from responses to a standardized questionnaire. Neurocognitive assessment was carried out in 20 survivors with an adaptation of the revised Wechsler adult intelligence scale for adults and the Malins intelligence scale for children.</p></sec><sec id="st4"><title>Results:</title><p>The late effects included impaired fertility in 38 patients (24.5%), impaired growth pattern in 7 (4.5%), endocrine dysfunction in 7 (4.5%) and second malignancy in 2 (1.2%). Three of the 20 patients assessed had severe neurocognitive impairment. A high QOL was reported by 60% of survivors and an “average” QOL by 38%.</p></sec><sec id="st5"><title>Conclusion:</title><p>Our study showed that most survivors had a good QOL and our results will help clinicians to better monitor childhood cancer survivors in countries with limited resources.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ries, Lag" uniqKey="Ries L">LAG Ries</name></author><author><name sortKey="Smith, Ma" uniqKey="Smith M">MA Smith</name></author><author><name sortKey="Gurney, Jg" uniqKey="Gurney J">JG Gurney</name></author><author><name sortKey="Linet, M" uniqKey="Linet M">M Linet</name></author><author><name sortKey="Tamra, T" uniqKey="Tamra T">T Tamra</name></author><author><name sortKey="Young, Jl" uniqKey="Young J">JL Young</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shanta, Ma" uniqKey="Shanta M">MA Shanta</name></author><author><name sortKey="Gajalakshmi, 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sort="Ramesh, Anita" uniqKey="Ramesh A" first="Anita" last="Ramesh">Anita Ramesh</name><name sortKey="Sagar, Tenali Gnana" sort="Sagar, Tenali Gnana" uniqKey="Sagar T" first="Tenali Gnana" last="Sagar">Tenali Gnana Sagar</name><name sortKey="Veeraiah, Surendran" sort="Veeraiah, Surendran" uniqKey="Veeraiah S" first="Surendran" last="Veeraiah">Surendran Veeraiah</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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