Lymphangiogenesis and Metastasis—A Closer Look at the Neuropilin/Semaphorin3 Axis
Identifieur interne : 002911 ( Main/Exploration ); précédent : 002910; suivant : 002912Lymphangiogenesis and Metastasis—A Closer Look at the Neuropilin/Semaphorin3 Axis
Auteurs : Matthew T. Migliozzi ; Patrick Mucka ; Diane R. BielenbergSource :
- Microvascular research [ 0026-2862 ] ; 2014.
Abstract
Metastasis is the leading cause of cancer-related deaths. Understanding how the lymphatic system responds to its environment and local stimuli may lead to therapies to combat metastasis and other lymphatic-associated diseases. This review compares lymphatic vessels and blood vessels, discusses markers of lymphatic vasculature, and elucidates some of the signaling motifs involved in lymphangiogenesis. Recent progress implicating the neuropilin and semaphorin axes in this process is discussed.
Url:
DOI: 10.1016/j.mvr.2014.07.006
PubMed: 25087623
PubMed Central: 4268048
Affiliations:
Links toward previous steps (curation, corpus...)
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="P1">Metastasis is the leading cause of cancer-related deaths. Understanding how the
lymphatic system responds to its environment and local stimuli may lead to therapies to
combat metastasis and other lymphatic-associated diseases. This review compares lymphatic
vessels and blood vessels, discusses markers of lymphatic vasculature, and elucidates some
of the signaling motifs involved in lymphangiogenesis. Recent progress implicating the
neuropilin and semaphorin axes in this process is discussed.</p>
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