LymphedemaV1, Main, Exploration, bibRecord, 002892

Lymphatic vessels and tertiary lymphoid organs

Identifieur interne : 002892 ( Main/Exploration ); précédent : 002891; suivant : 002893

Lymphatic vessels and tertiary lymphoid organs

Auteurs : Nancy H. Ruddle

Source :

The Journal of Clinical Investigation [ 0021-9738 ] ; 2014.

RBID : PMC:3934190

Descripteurs français

KwdFr :
- Animaux, Humains, Inflammation (anatomopathologie), Lymphoedème (immunologie), Maladies auto-immunes (immunologie), Noeuds lymphatiques (immunologie), Tumeurs (anatomopathologie), Vaisseaux lymphatiques (anatomopathologie), Vaisseaux lymphatiques (immunologie), Vaisseaux lymphatiques (physiopathologie).
MESH :
- anatomopathologie : Inflammation, Tumeurs, Vaisseaux lymphatiques.
- immunologie : Lymphoedème, Maladies auto-immunes, Noeuds lymphatiques, Vaisseaux lymphatiques.
- physiopathologie : Vaisseaux lymphatiques.
- Animaux, Humains.

English descriptors

KwdEn :
- Animals, Autoimmune Diseases (immunology), Humans, Inflammation (pathology), Lymph Nodes (immunology), Lymphatic Vessels (immunology), Lymphatic Vessels (pathology), Lymphatic Vessels (physiopathology), Lymphedema (immunology), Neoplasms (pathology).
MESH :
- immunology : Autoimmune Diseases, Lymph Nodes, Lymphatic Vessels, Lymphedema.
- pathology : Inflammation, Lymphatic Vessels, Neoplasms.
- physiopathology : Lymphatic Vessels.
- Animals, Humans.

Abstract

Tertiary lymphoid organs (TLOs) are accumulations of lymphoid cells in chronic inflammation that resemble LNs in their cellular content and organization, high endothelial venules, and lymphatic vessels (LVs). Although acute inflammation can result in defective LVs, TLO LVs appear to function normally in that they drain fluid and transport cells that respond to chemokines and sphingosine-1-phosphate (S1P) gradients. Molecular regulation of TLO LVs differs from lymphangiogenesis in ontogeny with a dependence on cytokines and hematopoietic cells. Ongoing work to elucidate the function and molecular regulation of LVs in TLOs is providing insight into therapies for conditions as diverse as lymphedema, autoimmunity, and cancer.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934190

DOI: 10.1172/JCI71611
PubMed: 24590281
PubMed Central: 3934190

Affiliations:

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<term>Lymphatic Vessels (immunology)</term>
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<term>Inflammation (anatomopathologie)</term>
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<term>Maladies auto-immunes (immunologie)</term>
<term>Noeuds lymphatiques (immunologie)</term>
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<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Lymphoedème</term>
<term>Maladies auto-immunes</term>
<term>Noeuds lymphatiques</term>
<term>Vaisseaux lymphatiques</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Autoimmune Diseases</term>
<term>Lymph Nodes</term>
<term>Lymphatic Vessels</term>
<term>Lymphedema</term>
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<front><div type="abstract" xml:lang="en"><p>Tertiary lymphoid organs (TLOs) are accumulations of lymphoid cells in chronic inflammation that resemble LNs in their cellular content and organization, high endothelial venules, and lymphatic vessels (LVs). Although acute inflammation can result in defective LVs, TLO LVs appear to function normally in that they drain fluid and transport cells that respond to chemokines and sphingosine-1-phosphate (S1P) gradients. Molecular regulation of TLO LVs differs from lymphangiogenesis in ontogeny with a dependence on cytokines and hematopoietic cells. Ongoing work to elucidate the function and molecular regulation of LVs in TLOs is providing insight into therapies for conditions as diverse as lymphedema, autoimmunity, and cancer.</p>
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Serveur d'exploration sur le lymphœdème

Lymphatic vessels and tertiary lymphoid organs

Lymphatic vessels and tertiary lymphoid organs

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
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