Microscopic lymph node tumor burden quantified by macroscopic dual-tracer molecular imaging
Identifieur interne : 002826 ( Main/Exploration ); précédent : 002825; suivant : 002827Microscopic lymph node tumor burden quantified by macroscopic dual-tracer molecular imaging
Auteurs : Kenneth M. Tichauer [États-Unis] ; Kimberley S. Samkoe [États-Unis] ; Jason R. Gunn [États-Unis] ; Stephen C. Kanick [États-Unis] ; P. Jack Hoopes [États-Unis] ; Richard J. Barth [États-Unis] ; Peter A. Kaufman [États-Unis] ; Tayyaba Hasan [États-Unis] ; Brian W. Pogue [États-Unis]Source :
- Nature medicine [ 1078-8956 ] ; 2014.
Abstract
Lymph node biopsy (LNB) is employed in many cancer surgeries to identify metastatic disease and stage the cancer, yet morbidity and diagnostic delays associated with LNB could be avoided if non-invasive imaging of nodal involvement was reliable. Molecular imaging has potential in this regard; however, variable delivery and nonspecific uptake of imaging tracers has made conventional approaches ineffective clinically. A method of correcting for non-specific uptake with injection of a second untargeted tracer is presented, allowing tumor burden in lymph nodes to be quantified. The approach was confirmed in an athymic mouse model of metastatic human breast cancer targeting epidermal growth factor receptor, a cell surface receptor overexpressed by many cancers. A significant correlation was observed between
Url:
DOI: 10.1038/nm.3732
PubMed: 25344739
PubMed Central: 4224611
Affiliations:
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Tichauer</name><affiliation wicri:level="2"><nlm:aff id="A1">Biomedical Engineering, Illinois Institute of Technology, Chicago, IL 60616</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Biomedical Engineering, Illinois Institute of Technology, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Samkoe, Kimberley S" sort="Samkoe, Kimberley S" uniqKey="Samkoe K" first="Kimberley S." last="Samkoe">Kimberley S. Samkoe</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Surgery, Geisel School of Medicine, Hanover, NH 03755</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Hampshire</region></placeName><wicri:cityArea>Department of Surgery, Geisel School of Medicine, Hanover</wicri:cityArea></affiliation></author><author><name sortKey="Gunn, Jason R" sort="Gunn, Jason R" uniqKey="Gunn J" first="Jason R." last="Gunn">Jason R. 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Molecular imaging has potential in this regard; however, variable delivery and nonspecific uptake of imaging tracers has made conventional approaches ineffective clinically. A method of correcting for non-specific uptake with injection of a second untargeted tracer is presented, allowing tumor burden in lymph nodes to be quantified. The approach was confirmed in an athymic mouse model of metastatic human breast cancer targeting epidermal growth factor receptor, a cell surface receptor overexpressed by many cancers. A significant correlation was observed between <italic>in vivo</italic> (dual-tracer) and <italic>ex vivo</italic> measures of tumor burden (<italic>r</italic> = 0.97, <italic>p</italic> < 0.01), with an ultimate sensitivity of approximately 200 cells (potentially more sensitive than conventional LNB).</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chen, Sl" uniqKey="Chen S">SL Chen</name></author><author><name sortKey="Iddings, Dm" uniqKey="Iddings D">DM Iddings</name></author><author><name sortKey="Scheri, Rp" uniqKey="Scheri R">RP Scheri</name></author><author><name sortKey="Bilchik, Aj" uniqKey="Bilchik A">AJ Bilchik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tobler, Ne" uniqKey="Tobler N">NE Tobler</name></author><author><name sortKey="Detmar, M" uniqKey="Detmar M">M Detmar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schrenk, P" uniqKey="Schrenk 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Ichise</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lammertsma, Aa" uniqKey="Lammertsma A">AA Lammertsma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kety, Ss" uniqKey="Kety S">SS Kety</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patel, D" uniqKey="Patel D">D Patel</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li><li>Massachusetts</li><li>New Hampshire</li></region></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Tichauer, Kenneth M" sort="Tichauer, Kenneth M" uniqKey="Tichauer K" first="Kenneth M." last="Tichauer">Kenneth M. Tichauer</name></region><name sortKey="Barth, Richard J" sort="Barth, Richard J" uniqKey="Barth R" first="Richard J." last="Barth">Richard J. Barth</name><name sortKey="Gunn, Jason R" sort="Gunn, Jason R" uniqKey="Gunn J" first="Jason R." last="Gunn">Jason R. Gunn</name><name sortKey="Hasan, Tayyaba" sort="Hasan, Tayyaba" uniqKey="Hasan T" first="Tayyaba" last="Hasan">Tayyaba Hasan</name><name sortKey="Hoopes, P Jack" sort="Hoopes, P Jack" uniqKey="Hoopes P" first="P. Jack" last="Hoopes">P. Jack Hoopes</name><name sortKey="Hoopes, P Jack" sort="Hoopes, P Jack" uniqKey="Hoopes P" first="P. Jack" last="Hoopes">P. Jack Hoopes</name><name sortKey="Kanick, Stephen C" sort="Kanick, Stephen C" uniqKey="Kanick S" first="Stephen C." last="Kanick">Stephen C. Kanick</name><name sortKey="Kaufman, Peter A" sort="Kaufman, Peter A" uniqKey="Kaufman P" first="Peter A." last="Kaufman">Peter A. Kaufman</name><name sortKey="Pogue, Brian W" sort="Pogue, Brian W" uniqKey="Pogue B" first="Brian W." last="Pogue">Brian W. Pogue</name><name sortKey="Pogue, Brian W" sort="Pogue, Brian W" uniqKey="Pogue B" first="Brian W." last="Pogue">Brian W. Pogue</name><name sortKey="Pogue, Brian W" sort="Pogue, Brian W" uniqKey="Pogue B" first="Brian W." last="Pogue">Brian W. Pogue</name><name sortKey="Samkoe, Kimberley S" sort="Samkoe, Kimberley S" uniqKey="Samkoe K" first="Kimberley S." last="Samkoe">Kimberley S. Samkoe</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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