Overcoming the challenges of drug discovery for neglected tropical diseases: the A·WOL experience.
Identifieur interne : 002744 ( Main/Exploration ); précédent : 002743; suivant : 002745Overcoming the challenges of drug discovery for neglected tropical diseases: the A·WOL experience.
Auteurs : Kelly L. Johnston [Royaume-Uni] ; Louise Ford ; Mark J. TaylorSource :
- Journal of biomolecular screening [ 1552-454X ] ; 2014.
Descripteurs français
- KwdFr :
- Découverte de médicament, Filariose lymphatique (), Filariose lymphatique (diagnostic), Filariose lymphatique (traitement médicamenteux), Humains, Maladies négligées (), Maladies négligées (diagnostic), Maladies négligées (traitement médicamenteux), Médecine tropicale, Onchocercose (), Onchocercose (diagnostic), Onchocercose (traitement médicamenteux), Organisation mondiale de la santé, Santé mondiale, Wolbachia ().
- MESH :
- diagnostic : Filariose lymphatique, Maladies négligées, Onchocercose.
- traitement médicamenteux : Filariose lymphatique, Maladies négligées, Onchocercose.
- Découverte de médicament, Filariose lymphatique, Humains, Maladies négligées, Médecine tropicale, Onchocercose, Organisation mondiale de la santé, Santé mondiale, Wolbachia.
English descriptors
- KwdEn :
- Drug Discovery, Elephantiasis, Filarial (diagnosis), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (prevention & control), Global Health, Humans, Neglected Diseases (diagnosis), Neglected Diseases (drug therapy), Neglected Diseases (prevention & control), Onchocerciasis (diagnosis), Onchocerciasis (drug therapy), Onchocerciasis (prevention & control), Tropical Medicine, Wolbachia (drug effects), World Health Organization.
- MESH :
- diagnosis : Elephantiasis, Filarial, Neglected Diseases, Onchocerciasis.
- drug effects : Wolbachia.
- drug therapy : Elephantiasis, Filarial, Neglected Diseases, Onchocerciasis.
- prevention & control : Elephantiasis, Filarial, Neglected Diseases, Onchocerciasis.
- Drug Discovery, Global Health, Humans, Tropical Medicine, World Health Organization.
Abstract
Neglected tropical diseases (NTDs) are a group of 17 diseases that typically affect poor people in tropical countries. Each has been neglected for decades in terms of funding, research, and policy, but the recent grouping of them into one unit, which can be targeted using integrated control measures, together with increased advocacy has helped to place them on the global health agenda. The World Health Organization has set ambitious goals to control or eliminate 10 NTDs by 2020 and launched a roadmap in January 2012 to guide this global plan. The result of the launch meeting, which brought together representatives from the pharmaceutical industry, donors, and politicians, was the London Declaration: a series of commitments to provide more drugs, research, and funds to achieve the 2020 goals. Drug discovery and development for these diseases are extremely challenging, and this article highlights these challenges in the context of the London Declaration, before focusing on an example of a drug discovery and development program for the NTDs onchocerciasis and lymphatic filariasis (the anti-Wolbachia consortium, A·WOL).
DOI: 10.1177/1087057113511270
PubMed: 24241712
Affiliations:
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Johnston</name><affiliation wicri:level="1"><nlm:affiliation>1Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>1Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool</wicri:regionArea><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author><author><name sortKey="Ford, Louise" sort="Ford, Louise" uniqKey="Ford L" first="Louise" last="Ford">Louise Ford</name></author><author><name sortKey="Taylor, Mark J" sort="Taylor, Mark J" uniqKey="Taylor M" first="Mark J" last="Taylor">Mark J. Taylor</name></author></analytic><series><title level="j">Journal of biomolecular screening</title><idno type="eISSN">1552-454X</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Drug Discovery</term><term>Elephantiasis, Filarial (diagnosis)</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Elephantiasis, Filarial (prevention & control)</term><term>Global Health</term><term>Humans</term><term>Neglected Diseases (diagnosis)</term><term>Neglected Diseases (drug therapy)</term><term>Neglected Diseases (prevention & control)</term><term>Onchocerciasis (diagnosis)</term><term>Onchocerciasis (drug therapy)</term><term>Onchocerciasis (prevention & control)</term><term>Tropical Medicine</term><term>Wolbachia (drug effects)</term><term>World Health Organization</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Découverte de médicament</term><term>Filariose lymphatique ()</term><term>Filariose lymphatique (diagnostic)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Humains</term><term>Maladies négligées ()</term><term>Maladies négligées (diagnostic)</term><term>Maladies négligées (traitement médicamenteux)</term><term>Médecine tropicale</term><term>Onchocercose ()</term><term>Onchocercose (diagnostic)</term><term>Onchocercose (traitement médicamenteux)</term><term>Organisation mondiale de la santé</term><term>Santé mondiale</term><term>Wolbachia ()</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Neglected Diseases</term><term>Onchocerciasis</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Filariose lymphatique</term><term>Maladies négligées</term><term>Onchocercose</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Wolbachia</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Neglected Diseases</term><term>Onchocerciasis</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Neglected Diseases</term><term>Onchocerciasis</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term><term>Maladies négligées</term><term>Onchocercose</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Drug Discovery</term><term>Global Health</term><term>Humans</term><term>Tropical Medicine</term><term>World Health Organization</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Découverte de médicament</term><term>Filariose lymphatique</term><term>Humains</term><term>Maladies négligées</term><term>Médecine tropicale</term><term>Onchocercose</term><term>Organisation mondiale de la santé</term><term>Santé mondiale</term><term>Wolbachia</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Neglected tropical diseases (NTDs) are a group of 17 diseases that typically affect poor people in tropical countries. Each has been neglected for decades in terms of funding, research, and policy, but the recent grouping of them into one unit, which can be targeted using integrated control measures, together with increased advocacy has helped to place them on the global health agenda. The World Health Organization has set ambitious goals to control or eliminate 10 NTDs by 2020 and launched a roadmap in January 2012 to guide this global plan. The result of the launch meeting, which brought together representatives from the pharmaceutical industry, donors, and politicians, was the London Declaration: a series of commitments to provide more drugs, research, and funds to achieve the 2020 goals. Drug discovery and development for these diseases are extremely challenging, and this article highlights these challenges in the context of the London Declaration, before focusing on an example of a drug discovery and development program for the NTDs onchocerciasis and lymphatic filariasis (the anti-Wolbachia consortium, A·WOL).</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><noCountry><name sortKey="Ford, Louise" sort="Ford, Louise" uniqKey="Ford L" first="Louise" last="Ford">Louise Ford</name><name sortKey="Taylor, Mark J" sort="Taylor, Mark J" uniqKey="Taylor M" first="Mark J" last="Taylor">Mark J. Taylor</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Johnston, Kelly L" sort="Johnston, Kelly L" uniqKey="Johnston K" first="Kelly L" last="Johnston">Kelly L. Johnston</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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