Response to MEK inhibitor in small cell neuroendocrine carcinoma of the cervix with a KRAS mutation
Identifieur interne : 002573 ( Main/Exploration ); précédent : 002572; suivant : 002574Response to MEK inhibitor in small cell neuroendocrine carcinoma of the cervix with a KRAS mutation
Auteurs : Yasmin A. Lyons [États-Unis] ; Michael Frumovitz [États-Unis] ; Pamela T. Soliman [États-Unis]Source :
- Gynecologic Oncology Reports [ 2352-5789 ] ; 2014.
Abstract
Molecular testing may play a role in the determination of targeted therapy treatment options. Targeted therapy provides treatment options for recurrent cervical cancer. MEK inhibitor is a treatment option for recurrent cervical cancer in a patient with KRAS mutation.
Url:
DOI: 10.1016/j.gore.2014.09.003
PubMed: 26075998
PubMed Central: 4434143
Affiliations:
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Lyons</name><affiliation wicri:level="1"><nlm:aff id="af0005">Department of Obstetrics and Gynecology, Houston Methodist Hospital, Houston, TX, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Obstetrics and Gynecology, Houston Methodist Hospital, Houston, TX</wicri:regionArea><wicri:noRegion>TX</wicri:noRegion></affiliation></author><author><name sortKey="Frumovitz, Michael" sort="Frumovitz, Michael" uniqKey="Frumovitz M" first="Michael" last="Frumovitz">Michael Frumovitz</name><affiliation wicri:level="1"><nlm:aff id="af0010">Department of Gynecologic Oncology and Reproductive Medicine, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Gynecologic Oncology and Reproductive Medicine, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX</wicri:regionArea><wicri:noRegion>TX</wicri:noRegion></affiliation></author><author><name sortKey="Soliman, Pamela T" sort="Soliman, Pamela T" uniqKey="Soliman P" first="Pamela T." last="Soliman">Pamela T. 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Lyons</name><affiliation wicri:level="1"><nlm:aff id="af0005">Department of Obstetrics and Gynecology, Houston Methodist Hospital, Houston, TX, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Obstetrics and Gynecology, Houston Methodist Hospital, Houston, TX</wicri:regionArea><wicri:noRegion>TX</wicri:noRegion></affiliation></author><author><name sortKey="Frumovitz, Michael" sort="Frumovitz, Michael" uniqKey="Frumovitz M" first="Michael" last="Frumovitz">Michael Frumovitz</name><affiliation wicri:level="1"><nlm:aff id="af0010">Department of Gynecologic Oncology and Reproductive Medicine, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Gynecologic Oncology and Reproductive Medicine, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX</wicri:regionArea><wicri:noRegion>TX</wicri:noRegion></affiliation></author><author><name sortKey="Soliman, Pamela T" sort="Soliman, Pamela T" uniqKey="Soliman P" first="Pamela T." last="Soliman">Pamela T. Soliman</name><affiliation wicri:level="1"><nlm:aff id="af0010">Department of Gynecologic Oncology and Reproductive Medicine, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Gynecologic Oncology and Reproductive Medicine, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX</wicri:regionArea><wicri:noRegion>TX</wicri:noRegion></affiliation></author></analytic><series><title level="j">Gynecologic Oncology Reports</title><idno type="eISSN">2352-5789</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple"><list-item id="u0005"><label>•</label><p>Molecular testing may play a role in the determination of targeted therapy treatment options.</p></list-item><list-item id="u0010"><label>•</label><p>Targeted therapy provides treatment options for recurrent cervical cancer.</p></list-item><list-item id="u0015"><label>•</label><p>MEK inhibitor is a treatment option for recurrent cervical cancer in a patient with KRAS mutation.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chan, J K" uniqKey="Chan J">J.K. 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