LymphedemaV1, Main, Exploration, bibRecord, 002435

The Selenium Metabolite Methylselenol Regulates the Expression of Ligands That Trigger Immune Activation through the Lymphocyte Receptor NKG2D*

Identifieur interne : 002435 ( Main/Exploration ); précédent : 002434; suivant : 002436

The Selenium Metabolite Methylselenol Regulates the Expression of Ligands That Trigger Immune Activation through the Lymphocyte Receptor NKG2D*

Auteurs : Michael Hagemann-Jensen ; Franziska Uhlenbrock ; Stephanie Kehlet ; Lars Andresen ; Charlotte Gabel-Jensen ; Lars Ellgaard [Danemark] ; Bente Gammelgaard ; S Ren Skov

Source :

The Journal of Biological Chemistry [ 0021-9258 ] ; 2014.

RBID : PMC:4223354

Abstract

Background: Immune activation through a balanced cell surface expression of human NKG2D ligands is crucial for the elimination of diseased cells.

Results: Methylselenol induces the expression of the NKG2D ligands MICA/B but specifically inhibits ULBP2 protein expression.

Conclusion: Methylselenol regulates NKG2D ligand expression on transcriptional and posttranscriptional levels.

Significance: Methylselenol is the first identified metabolite that diversely regulates NKG2D ligands, and, therefore, its implementation could improve NKG2D-based immune therapy.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223354

DOI: 10.1074/jbc.M114.591537
PubMed: 25258323
PubMed Central: 4223354

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
 Immune activation through a balanced cell surface expression of human NKG2D ligands is crucial for the elimination of diseased cells.</p>
<p><bold>Results:</bold>
 Methylselenol induces the expression of the NKG2D ligands MICA/B but specifically inhibits ULBP2 protein expression.</p>
<p><bold>Conclusion:</bold>
 Methylselenol regulates NKG2D ligand expression on transcriptional and posttranscriptional levels.</p>
<p><bold>Significance:</bold>
 Methylselenol is the first identified metabolite that diversely regulates NKG2D ligands, and, therefore, its implementation could improve NKG2D-based immune therapy.</p>
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The Selenium Metabolite Methylselenol Regulates the Expression of Ligands That Trigger Immune Activation through the Lymphocyte Receptor NKG2D*

The Selenium Metabolite Methylselenol Regulates the Expression of Ligands That Trigger Immune Activation through the Lymphocyte Receptor NKG2D*

Source :

Abstract

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