LymphedemaV1, Main, Exploration, bibRecord, 002401

The solution structure of the forkhead box-O DNA binding domain of Brugia malayi DAF-16a

Identifieur interne : 002401 ( Main/Exploration ); précédent : 002400; suivant : 002402

The solution structure of the forkhead box-O DNA binding domain of Brugia malayi DAF-16a

Auteurs : Sarah K. Casper [États-Unis] ; Scott J. Schoeller [États-Unis] ; Danielle M. Zgoba [États-Unis] ; Andrew J. Phillips [États-Unis] ; Thomas J. Morien [États-Unis] ; Gary R. Chaffee [États-Unis] ; Peter C. Sackett [États-Unis] ; Francis C. Peterson [États-Unis] ; Kirsten Crossgrove [États-Unis] ; Christopher T. Veldkamp [États-Unis]

Source :

Proteins [ 0887-3585 ] ; 2014.

RBID : PMC:4809524

Abstract

Brugia malayi is a parasitic nematode that causes lymphatic filariasis in humans. Here the solution structure of the forkhead DNA binding domain of Brugia malayi DAF-16a, a putative ortholog of Caenorhabditis elegans DAF-16, is reported. It is believed to be the first structure of a forkhead or winged helix domain from an invertebrate. C. elegans DAF-16 is involved in the insulin/IGF-I signaling pathway and helps control metabolism, longevity, and development. Conservation of sequence and structure with human FOXO proteins suggest that B. malayi DAF-16a is a member of the FOXO family of forkhead proteins.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809524

DOI: 10.1002/prot.24701
PubMed: 25297652
PubMed Central: 4809524

Affiliations:

Le document en format XML

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 DAF-16a</title>
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<front><div type="abstract" xml:lang="en"><p id="P1"><italic>Brugia malayi</italic>
 is a parasitic nematode that causes lymphatic filariasis in humans. Here the solution structure of the forkhead DNA binding domain of <italic>Brugia malayi</italic>
 DAF-16a, a putative ortholog of <italic>Caenorhabditis elegans</italic>
 DAF-16, is reported. It is believed to be the first structure of a forkhead or winged helix domain from an invertebrate. <italic>C. elegans</italic>
 DAF-16 is involved in the insulin/IGF-I signaling pathway and helps control metabolism, longevity, and development. Conservation of sequence and structure with human FOXO proteins suggest that <italic>B. malayi</italic>
 DAF-16a is a member of the FOXO family of forkhead proteins.</p>
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The solution structure of the forkhead box-O DNA binding domain of Brugia malayi DAF-16a

The solution structure of the forkhead box-O DNA binding domain of Brugia malayi DAF-16a

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Abstract

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