The solution structure of the forkhead box-O DNA binding domain of Brugia malayi DAF-16a
Identifieur interne : 002401 ( Main/Exploration ); précédent : 002400; suivant : 002402The solution structure of the forkhead box-O DNA binding domain of Brugia malayi DAF-16a
Auteurs : Sarah K. Casper [États-Unis] ; Scott J. Schoeller [États-Unis] ; Danielle M. Zgoba [États-Unis] ; Andrew J. Phillips [États-Unis] ; Thomas J. Morien [États-Unis] ; Gary R. Chaffee [États-Unis] ; Peter C. Sackett [États-Unis] ; Francis C. Peterson [États-Unis] ; Kirsten Crossgrove [États-Unis] ; Christopher T. Veldkamp [États-Unis]Source :
- Proteins [ 0887-3585 ] ; 2014.
Abstract
Url:
DOI: 10.1002/prot.24701
PubMed: 25297652
PubMed Central: 4809524
Affiliations:
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Le document en format XML
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DAF-16a</title>
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DAF-16a</title>
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<affiliation wicri:level="2"><nlm:aff id="A1">Department of Biological Sciences, University of Wisconsin-Whitewater, 800 West Main Street, Whitewater, WI 53190</nlm:aff>
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<author><name sortKey="Veldkamp, Christopher T" sort="Veldkamp, Christopher T" uniqKey="Veldkamp C" first="Christopher T." last="Veldkamp">Christopher T. Veldkamp</name>
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<country xml:lang="fr">États-Unis</country>
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<front><div type="abstract" xml:lang="en"><p id="P1"><italic>Brugia malayi</italic>
is a parasitic nematode that causes lymphatic filariasis in humans. Here the solution structure of the forkhead DNA binding domain of <italic>Brugia malayi</italic>
DAF-16a, a putative ortholog of <italic>Caenorhabditis elegans</italic>
DAF-16, is reported. It is believed to be the first structure of a forkhead or winged helix domain from an invertebrate. <italic>C. elegans</italic>
DAF-16 is involved in the insulin/IGF-I signaling pathway and helps control metabolism, longevity, and development. Conservation of sequence and structure with human FOXO proteins suggest that <italic>B. malayi</italic>
DAF-16a is a member of the FOXO family of forkhead proteins.</p>
</div>
</front>
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</country>
<region><li>Wisconsin</li>
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<name sortKey="Casper, Sarah K" sort="Casper, Sarah K" uniqKey="Casper S" first="Sarah K." last="Casper">Sarah K. Casper</name>
<name sortKey="Chaffee, Gary R" sort="Chaffee, Gary R" uniqKey="Chaffee G" first="Gary R." last="Chaffee">Gary R. Chaffee</name>
<name sortKey="Crossgrove, Kirsten" sort="Crossgrove, Kirsten" uniqKey="Crossgrove K" first="Kirsten" last="Crossgrove">Kirsten Crossgrove</name>
<name sortKey="Morien, Thomas J" sort="Morien, Thomas J" uniqKey="Morien T" first="Thomas J." last="Morien">Thomas J. Morien</name>
<name sortKey="Peterson, Francis C" sort="Peterson, Francis C" uniqKey="Peterson F" first="Francis C." last="Peterson">Francis C. Peterson</name>
<name sortKey="Phillips, Andrew J" sort="Phillips, Andrew J" uniqKey="Phillips A" first="Andrew J." last="Phillips">Andrew J. Phillips</name>
<name sortKey="Sackett, Peter C" sort="Sackett, Peter C" uniqKey="Sackett P" first="Peter C." last="Sackett">Peter C. Sackett</name>
<name sortKey="Schoeller, Scott J" sort="Schoeller, Scott J" uniqKey="Schoeller S" first="Scott J." last="Schoeller">Scott J. Schoeller</name>
<name sortKey="Veldkamp, Christopher T" sort="Veldkamp, Christopher T" uniqKey="Veldkamp C" first="Christopher T." last="Veldkamp">Christopher T. Veldkamp</name>
<name sortKey="Veldkamp, Christopher T" sort="Veldkamp, Christopher T" uniqKey="Veldkamp C" first="Christopher T." last="Veldkamp">Christopher T. Veldkamp</name>
<name sortKey="Zgoba, Danielle M" sort="Zgoba, Danielle M" uniqKey="Zgoba D" first="Danielle M." last="Zgoba">Danielle M. Zgoba</name>
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