Assessment of lymphatic impairment and interstitial protein accumulation in patients with breast cancer treatment-related lymphedema using CEST MRI
Identifieur interne : 002117 ( Main/Exploration ); précédent : 002116; suivant : 002118Assessment of lymphatic impairment and interstitial protein accumulation in patients with breast cancer treatment-related lymphedema using CEST MRI
Auteurs : Manus J. Donahue [États-Unis] ; Paula C. M. Donahue [États-Unis] ; Swati Rane [États-Unis] ; Chris Thompson [États-Unis] ; Megan K. Strother [États-Unis] ; Allison Scott [États-Unis] ; Seth A. Smith [États-Unis]Source :
- Magnetic resonance in medicine [ 0740-3194 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Femelle, Humains, Imagerie moléculaire (), Imagerie par résonance magnétique (), Lymphoedème (anatomopathologie), Lymphoedème (métabolisme), Lymphoedème (étiologie), Marqueurs biologiques (métabolisme), Noeuds lymphatiques, Protéines (métabolisme), Reproductibilité des résultats, Résultat thérapeutique, Sensibilité et spécificité, Spectroscopie par résonance magnétique (), Sujet âgé, Tumeurs du sein (), Tumeurs du sein (anatomopathologie).
- MESH :
- anatomopathologie : Lymphoedème, Tumeurs du sein.
- métabolisme : Lymphoedème, Marqueurs biologiques, Protéines.
- étiologie : Lymphoedème.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Imagerie moléculaire, Imagerie par résonance magnétique, Noeuds lymphatiques, Reproductibilité des résultats, Résultat thérapeutique, Sensibilité et spécificité, Spectroscopie par résonance magnétique, Sujet âgé, Tumeurs du sein.
English descriptors
- KwdEn :
- Adult, Aged, Biomarkers (metabolism), Breast Neoplasms (complications), Breast Neoplasms (pathology), Breast Neoplasms (therapy), Female, Humans, Lymph Nodes, Lymphedema (etiology), Lymphedema (metabolism), Lymphedema (pathology), Magnetic Resonance Imaging (methods), Magnetic Resonance Spectroscopy (methods), Middle Aged, Molecular Imaging (methods), Proteins (metabolism), Reproducibility of Results, Sensitivity and Specificity, Treatment Outcome.
- MESH :
- chemical , metabolism : Biomarkers, Proteins.
- complications : Breast Neoplasms.
- etiology : Lymphedema.
- metabolism : Lymphedema.
- methods : Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Molecular Imaging.
- pathology : Breast Neoplasms, Lymphedema.
- therapy : Breast Neoplasms.
- Adult, Aged, Female, Humans, Lymph Nodes, Middle Aged, Reproducibility of Results, Sensitivity and Specificity, Treatment Outcome.
Abstract
Lymphatic impairment is known to reduce quality of life in some of the most crippling diseases of the 21st century, including obesity, lymphedema, and cancer. However, the lymphatics are not nearly as well-understood as other bodily systems, largely owing to a lack of sensitive imaging technologies that can be applied using standard clinical equipment. Here, proton exchange-weighted MRI is translated to the lymphatics in patients with breast cancer treatment-related lymphedema (BCRL).
Healthy volunteers (N=8) and BCRL patients (N=7) were scanned at 3T using customized structural MRI and amide proton transfer (APT) chemical exchange saturation transfer (CEST) MRI in sequence with the hypothesis that APT effects would be elevated in lymphedematous tissue. APT contrast, lymphedema stage, symptomatology, and histology information were evaluated.
No significant difference between proton-weighted APT contrast in the right and left arms of healthy controls was observed. An increase in APT contrast in the affected arms of patients was found (P=0.025; Cohen’s d=2.4), and variability among patients was consistent with documented damage to lymphatics as quantified by lymphedema stage.
APT CEST MRI may have relevance for evaluating lymphatic impairment in patients with BCRL, and may extend to other pathologies where lymphatic compromise is evident.
Url:
DOI: 10.1002/mrm.25649
PubMed: 25752499
PubMed Central: 4561605
Affiliations:
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Le document en format XML
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Donahue</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Radiology, Vanderbilt School of Medicine, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea> Department of Radiology, Vanderbilt School of Medicine, Nashville</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4"> Physics and Astronomy, Vanderbilt School of Medicine, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea> Physics and Astronomy, Vanderbilt School of Medicine, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Donahue, Paula C M" sort="Donahue, Paula C M" uniqKey="Donahue P" first="Paula C. M." last="Donahue">Paula C. M. Donahue</name><affiliation wicri:level="2"><nlm:aff id="A5">Physical Medicine and Rehabilitation, Vanderbilt School of Medicine, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Physical Medicine and Rehabilitation, Vanderbilt School of Medicine, Nashville</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A6">Dayani Center for Health and Wellness, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Dayani Center for Health and Wellness, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Rane, Swati" sort="Rane, Swati" uniqKey="Rane S" first="Swati" last="Rane">Swati Rane</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Radiology, Vanderbilt School of Medicine, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea> Department of Radiology, Vanderbilt School of Medicine, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Thompson, Chris" sort="Thompson, Chris" uniqKey="Thompson C" first="Chris" last="Thompson">Chris Thompson</name><affiliation wicri:level="2"><nlm:aff id="A7">Vanderbilt University Institute of Imaging Science, Vanderbilt School of Medicine, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt University Institute of Imaging Science, Vanderbilt School of Medicine, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Strother, Megan K" sort="Strother, Megan K" uniqKey="Strother M" first="Megan K." last="Strother">Megan K. Strother</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Radiology, Vanderbilt School of Medicine, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea> Department of Radiology, Vanderbilt School of Medicine, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Scott, Allison" sort="Scott, Allison" uniqKey="Scott A" first="Allison" last="Scott">Allison Scott</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Radiology, Vanderbilt School of Medicine, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea> Department of Radiology, Vanderbilt School of Medicine, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Smith, Seth A" sort="Smith, Seth A" uniqKey="Smith S" first="Seth A." last="Smith">Seth A. Smith</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Radiology, Vanderbilt School of Medicine, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea> Department of Radiology, Vanderbilt School of Medicine, Nashville</wicri:cityArea></affiliation></author></analytic><series><title level="j">Magnetic resonance in medicine</title><idno type="ISSN">0740-3194</idno><idno type="eISSN">1522-2594</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Biomarkers (metabolism)</term><term>Breast Neoplasms (complications)</term><term>Breast Neoplasms (pathology)</term><term>Breast Neoplasms (therapy)</term><term>Female</term><term>Humans</term><term>Lymph Nodes</term><term>Lymphedema (etiology)</term><term>Lymphedema (metabolism)</term><term>Lymphedema (pathology)</term><term>Magnetic Resonance Imaging (methods)</term><term>Magnetic Resonance Spectroscopy (methods)</term><term>Middle Aged</term><term>Molecular Imaging (methods)</term><term>Proteins (metabolism)</term><term>Reproducibility of Results</term><term>Sensitivity and Specificity</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Imagerie moléculaire ()</term><term>Imagerie par résonance magnétique ()</term><term>Lymphoedème (anatomopathologie)</term><term>Lymphoedème (métabolisme)</term><term>Lymphoedème (étiologie)</term><term>Marqueurs biologiques (métabolisme)</term><term>Noeuds lymphatiques</term><term>Protéines (métabolisme)</term><term>Reproductibilité des résultats</term><term>Résultat thérapeutique</term><term>Sensibilité et spécificité</term><term>Spectroscopie par résonance magnétique ()</term><term>Sujet âgé</term><term>Tumeurs du sein ()</term><term>Tumeurs du sein (anatomopathologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biomarkers</term><term>Proteins</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphoedème</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term><term>Magnetic Resonance Spectroscopy</term><term>Molecular Imaging</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Lymphoedème</term><term>Marqueurs biologiques</term><term>Protéines</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Lymph Nodes</term><term>Middle Aged</term><term>Reproducibility of Results</term><term>Sensitivity and Specificity</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Imagerie moléculaire</term><term>Imagerie par résonance magnétique</term><term>Noeuds lymphatiques</term><term>Reproductibilité des résultats</term><term>Résultat thérapeutique</term><term>Sensibilité et spécificité</term><term>Spectroscopie par résonance magnétique</term><term>Sujet âgé</term><term>Tumeurs du sein</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title><p id="P2">Lymphatic impairment is known to reduce quality of life in some of the most crippling diseases of the 21<sup>st</sup> century, including obesity, lymphedema, and cancer. However, the lymphatics are not nearly as well-understood as other bodily systems, largely owing to a lack of sensitive imaging technologies that can be applied using standard clinical equipment. Here, proton exchange-weighted MRI is translated to the lymphatics in patients with breast cancer treatment-related lymphedema (BCRL).</p></sec><sec id="S2"><title>Methods</title><p id="P3">Healthy volunteers (N=8) and BCRL patients (N=7) were scanned at 3T using customized structural MRI and amide proton transfer (APT) chemical exchange saturation transfer (CEST) MRI in sequence with the hypothesis that APT effects would be elevated in lymphedematous tissue. APT contrast, lymphedema stage, symptomatology, and histology information were evaluated.</p></sec><sec id="S3"><title>Results</title><p id="P4">No significant difference between proton-weighted APT contrast in the right and left arms of healthy controls was observed. An increase in APT contrast in the affected arms of patients was found (P=0.025; Cohen’s d=2.4), and variability among patients was consistent with documented damage to lymphatics as quantified by lymphedema stage.</p></sec><sec id="S4"><title>Conclusions</title><p id="P5">APT CEST MRI may have relevance for evaluating lymphatic impairment in patients with BCRL, and may extend to other pathologies where lymphatic compromise is evident.</p></sec></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Tennessee</li></region></list><tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Donahue, Manus J" sort="Donahue, Manus J" uniqKey="Donahue M" first="Manus J." last="Donahue">Manus J. Donahue</name></region><name sortKey="Donahue, Manus J" sort="Donahue, Manus J" uniqKey="Donahue M" first="Manus J." last="Donahue">Manus J. Donahue</name><name sortKey="Donahue, Paula C M" sort="Donahue, Paula C M" uniqKey="Donahue P" first="Paula C. M." last="Donahue">Paula C. M. Donahue</name><name sortKey="Donahue, Paula C M" sort="Donahue, Paula C M" uniqKey="Donahue P" first="Paula C. M." last="Donahue">Paula C. M. Donahue</name><name sortKey="Rane, Swati" sort="Rane, Swati" uniqKey="Rane S" first="Swati" last="Rane">Swati Rane</name><name sortKey="Scott, Allison" sort="Scott, Allison" uniqKey="Scott A" first="Allison" last="Scott">Allison Scott</name><name sortKey="Smith, Seth A" sort="Smith, Seth A" uniqKey="Smith S" first="Seth A." last="Smith">Seth A. Smith</name><name sortKey="Strother, Megan K" sort="Strother, Megan K" uniqKey="Strother M" first="Megan K." last="Strother">Megan K. Strother</name><name sortKey="Thompson, Chris" sort="Thompson, Chris" uniqKey="Thompson C" first="Chris" last="Thompson">Chris Thompson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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