Association between Lymph Node Ratio and Disease Specific Survival in Breast Cancer Patients with One or Two Positive Lymph Nodes Stratified by Different Local Treatment Modalities
Identifieur interne : 002113 ( Main/Exploration ); précédent : 002112; suivant : 002114Association between Lymph Node Ratio and Disease Specific Survival in Breast Cancer Patients with One or Two Positive Lymph Nodes Stratified by Different Local Treatment Modalities
Auteurs : Ruoxi Hong [République populaire de Chine] ; Zhen Dai [République populaire de Chine] ; Wenjie Zhu [République populaire de Chine] ; Binghe Xu [République populaire de Chine]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
Abstract
Results of the American College of Surgeons Oncology Group (ACOSOG) Z0011 trial indicated that complete axillary node dissection (ALND) may not be warranted in some breast cancer patients with low tumor burden who are undergoing breast-conserving surgery following whole-breast irradiation. However, this study did not address patients undergoing mastectomy or those undergoing breast-conserving surgery without whole-breast radiotherapy. Given that lymph node ratio (LNR; ratio of positive lymph nodes to the total number removed) has been shown to be a prognostic factor in breast cancer, we first sought to determine the prognostic value of LNR in a low risk population comparable to that of the Z0011 trial and further to investigate whether the prognostic significance differs with local treatment modality.
We used the Surveillance Epidemiology and End Results (SEER) database to identify breast cancer patients with T1-T2 tumor and 1–2 positive nodes. Patients were subclassified by the local therapy they underwent for the primary tumor. The prognostic value of LNR in predicting disease-specific survival (DSS) was examined in each treatment group.
A total of 53,109 patients were included. In the subgroup of 20,602 patients who underwent lumpectomy following radiotherapy, LNR was not found to be significantly associated with DSS in both the univariate and multivariate model. For the 4,664 patients treated with mastectomy following radiotherapy, 6,811 treated with lumpectomy without radiotherapy and 21,031 with mastectomy without radiotherapy, LNR independently predict DSS in each of these subgroups.
Our results
Url:
DOI: 10.1371/journal.pone.0138908
PubMed: 26513258
PubMed Central: 4626029
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Association between Lymph Node Ratio and Disease Specific Survival in Breast Cancer Patients with One or Two Positive Lymph Nodes Stratified by Different Local Treatment Modalities</title><author><name sortKey="Hong, Ruoxi" sort="Hong, Ruoxi" uniqKey="Hong R" first="Ruoxi" last="Hong">Ruoxi Hong</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Dai, Zhen" sort="Dai, Zhen" uniqKey="Dai Z" first="Zhen" last="Dai">Zhen Dai</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Chengdu Center for Disease Control and Prevention, Chengdu, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chengdu Center for Disease Control and Prevention, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Wenjie" sort="Zhu, Wenjie" uniqKey="Zhu W" first="Wenjie" last="Zhu">Wenjie Zhu</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Xu, Binghe" sort="Xu, Binghe" uniqKey="Xu B" first="Binghe" last="Xu">Binghe Xu</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26513258</idno><idno type="pmc">4626029</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626029</idno><idno type="RBID">PMC:4626029</idno><idno type="doi">10.1371/journal.pone.0138908</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000440</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000440</idno><idno type="wicri:Area/Pmc/Curation">000440</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000440</idno><idno type="wicri:Area/Pmc/Checkpoint">001490</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001490</idno><idno type="wicri:Area/Ncbi/Merge">007A87</idno><idno type="wicri:Area/Ncbi/Curation">007A87</idno><idno type="wicri:Area/Ncbi/Checkpoint">007A87</idno><idno type="wicri:Area/Main/Merge">002116</idno><idno type="wicri:Area/Main/Curation">002113</idno><idno type="wicri:Area/Main/Exploration">002113</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Association between Lymph Node Ratio and Disease Specific Survival in Breast Cancer Patients with One or Two Positive Lymph Nodes Stratified by Different Local Treatment Modalities</title><author><name sortKey="Hong, Ruoxi" sort="Hong, Ruoxi" uniqKey="Hong R" first="Ruoxi" last="Hong">Ruoxi Hong</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Dai, Zhen" sort="Dai, Zhen" uniqKey="Dai Z" first="Zhen" last="Dai">Zhen Dai</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Chengdu Center for Disease Control and Prevention, Chengdu, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chengdu Center for Disease Control and Prevention, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Wenjie" sort="Zhu, Wenjie" uniqKey="Zhu W" first="Wenjie" last="Zhu">Wenjie Zhu</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Xu, Binghe" sort="Xu, Binghe" uniqKey="Xu B" first="Binghe" last="Xu">Binghe Xu</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Purpose</title><p>Results of the American College of Surgeons Oncology Group (ACOSOG) Z0011 trial indicated that complete axillary node dissection (ALND) may not be warranted in some breast cancer patients with low tumor burden who are undergoing breast-conserving surgery following whole-breast irradiation. However, this study did not address patients undergoing mastectomy or those undergoing breast-conserving surgery without whole-breast radiotherapy. Given that lymph node ratio (LNR; ratio of positive lymph nodes to the total number removed) has been shown to be a prognostic factor in breast cancer, we first sought to determine the prognostic value of LNR in a low risk population comparable to that of the Z0011 trial and further to investigate whether the prognostic significance differs with local treatment modality.</p></sec><sec id="sec002"><title>Method</title><p>We used the Surveillance Epidemiology and End Results (SEER) database to identify breast cancer patients with T1-T2 tumor and 1–2 positive nodes. Patients were subclassified by the local therapy they underwent for the primary tumor. The prognostic value of LNR in predicting disease-specific survival (DSS) was examined in each treatment group.</p></sec><sec id="sec003"><title>Results</title><p>A total of 53,109 patients were included. In the subgroup of 20,602 patients who underwent lumpectomy following radiotherapy, LNR was not found to be significantly associated with DSS in both the univariate and multivariate model. For the 4,664 patients treated with mastectomy following radiotherapy, 6,811 treated with lumpectomy without radiotherapy and 21,031 with mastectomy without radiotherapy, LNR independently predict DSS in each of these subgroups.</p></sec><sec id="sec004"><title>Conclusions</title><p>Our results <italic>add evidence to the concept</italic> that axillary dissection could be omitted in patients with one or two positive nodes following breast-conserving surgery and whole breast radiation.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Halsted, Ws" uniqKey="Halsted W">WS Halsted</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fisher, B" uniqKey="Fisher B">B Fisher</name></author><author><name sortKey="Wolmark, N" uniqKey="Wolmark N">N Wolmark</name></author><author><name sortKey="Bauer, M" uniqKey="Bauer M">M Bauer</name></author><author><name sortKey="Redmond, C" uniqKey="Redmond C">C Redmond</name></author><author><name sortKey="Gebhardt, M" uniqKey="Gebhardt M">M Gebhardt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Graversen, Hp" uniqKey="Graversen H">HP Graversen</name></author><author><name sortKey="Blichert Toft, M" uniqKey="Blichert Toft M">M Blichert-Toft</name></author><author><name sortKey="Andersen, Ja" uniqKey="Andersen J">JA Andersen</name></author><author><name sortKey="Zedeler, K" uniqKey="Zedeler K">K Zedeler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giuliano, Ae" uniqKey="Giuliano A">AE Giuliano</name></author><author><name sortKey="Dale, Ps" uniqKey="Dale P">PS Dale</name></author><author><name sortKey="Turner, Rr" uniqKey="Turner R">RR Turner</name></author><author><name sortKey="Morton, Dl" uniqKey="Morton D">DL Morton</name></author><author><name sortKey="Evans, Sw" uniqKey="Evans S">SW Evans</name></author><author><name sortKey="Krasne, Dl" uniqKey="Krasne D">DL Krasne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krag, Dn" uniqKey="Krag D">DN Krag</name></author><author><name sortKey="Anderson, Sj" uniqKey="Anderson S">SJ Anderson</name></author><author><name sortKey="Julian, Tb" uniqKey="Julian T">TB Julian</name></author><author><name sortKey="Brown, Am" uniqKey="Brown A">AM Brown</name></author><author><name sortKey="Harlow, Sp" uniqKey="Harlow S">SP Harlow</name></author><author><name sortKey="Costantino, Jp" uniqKey="Costantino J">JP Costantino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Veronesi, U" uniqKey="Veronesi U">U Veronesi</name></author><author><name sortKey="Viale, G" uniqKey="Viale G">G Viale</name></author><author><name sortKey="Paganelli, G" uniqKey="Paganelli G">G Paganelli</name></author><author><name sortKey="Zurrida, S" uniqKey="Zurrida S">S Zurrida</name></author><author><name sortKey="Luini, A" uniqKey="Luini A">A Luini</name></author><author><name sortKey="Galimberti, V" uniqKey="Galimberti V">V Galimberti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Orr, Rk" uniqKey="Orr R">RK Orr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fisher, B" uniqKey="Fisher B">B Fisher</name></author><author><name sortKey="Jeong, Jh" uniqKey="Jeong J">JH Jeong</name></author><author><name sortKey="Anderson, S" uniqKey="Anderson S">S Anderson</name></author><author><name sortKey="Bryant, J" uniqKey="Bryant J">J Bryant</name></author><author><name sortKey="Fisher, Er" uniqKey="Fisher E">ER Fisher</name></author><author><name sortKey="Wolmark, N" uniqKey="Wolmark N">N Wolmark</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clarke, M" uniqKey="Clarke M">M Clarke</name></author><author><name sortKey="Collins, R" uniqKey="Collins R">R Collins</name></author><author><name sortKey="Darby, S" uniqKey="Darby S">S Darby</name></author><author><name sortKey="Davies, C" uniqKey="Davies C">C Davies</name></author><author><name sortKey="Elphinstone, P" uniqKey="Elphinstone P">P Elphinstone</name></author><author><name sortKey="Evans, E" uniqKey="Evans E">E Evans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giuliano, Ae" uniqKey="Giuliano A">AE Giuliano</name></author><author><name sortKey="Hunt, Kk" uniqKey="Hunt K">KK Hunt</name></author><author><name sortKey="Ballman, Kv" uniqKey="Ballman K">KV Ballman</name></author><author><name sortKey="Beitsch, Pd" uniqKey="Beitsch P">PD Beitsch</name></author><author><name sortKey="Whitworth, Pw" uniqKey="Whitworth P">PW Whitworth</name></author><author><name sortKey="Blumencranz, Pw" uniqKey="Blumencranz P">PW Blumencranz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giuliano, Ae" uniqKey="Giuliano A">AE Giuliano</name></author><author><name sortKey="Mccall, L" uniqKey="Mccall L">L McCall</name></author><author><name sortKey="Beitsch, P" uniqKey="Beitsch P">P Beitsch</name></author><author><name sortKey="Whitworth, Pw" uniqKey="Whitworth P">PW Whitworth</name></author><author><name sortKey="Blumencranz, P" uniqKey="Blumencranz P">P Blumencranz</name></author><author><name sortKey="Leitch, Am" uniqKey="Leitch A">AM Leitch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goldhirsch, A" uniqKey="Goldhirsch A">A Goldhirsch</name></author><author><name sortKey="Wood, Wc" uniqKey="Wood W">WC Wood</name></author><author><name sortKey="Coates, As" uniqKey="Coates A">AS Coates</name></author><author><name sortKey="Gelber, Rd" uniqKey="Gelber R">RD Gelber</name></author><author><name sortKey="Thurlimann, B" uniqKey="Thurlimann B">B Thurlimann</name></author><author><name sortKey="Senn, Hj" uniqKey="Senn H">HJ Senn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morrow, M" uniqKey="Morrow M">M Morrow</name></author><author><name sortKey="Giuliano, Ae" uniqKey="Giuliano A">AE Giuliano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Axelsson, Ck" uniqKey="Axelsson C">CK Axelsson</name></author><author><name sortKey="Mouridsen, Ht" uniqKey="Mouridsen H">HT Mouridsen</name></author><author><name sortKey="Zedeler, K" uniqKey="Zedeler K">K Zedeler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weir, L" uniqKey="Weir L">L Weir</name></author><author><name sortKey="Speers, C" uniqKey="Speers C">C Speers</name></author><author><name sortKey="D Yachkova, Y" uniqKey="D Yachkova Y">Y D'Yachkova</name></author><author><name sortKey="Olivotto, Ia" uniqKey="Olivotto I">IA Olivotto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blancas, I" uniqKey="Blancas I">I Blancas</name></author><author><name sortKey="Garcia Puche, Jl" uniqKey="Garcia Puche J">JL Garcia-Puche</name></author><author><name sortKey="Bermejo, B" uniqKey="Bermejo B">B Bermejo</name></author><author><name sortKey="Hanrahan, Eo" uniqKey="Hanrahan E">EO Hanrahan</name></author><author><name sortKey="Monteagudo, C" uniqKey="Monteagudo C">C Monteagudo</name></author><author><name sortKey="Martinez Agullo, A" uniqKey="Martinez Agullo A">A Martinez-Agullo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuru, B" uniqKey="Kuru B">B Kuru</name></author><author><name sortKey="Bozgul, M" uniqKey="Bozgul M">M Bozgul</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woodward, Wa" uniqKey="Woodward W">WA Woodward</name></author><author><name sortKey="Vinh Hung, V" uniqKey="Vinh Hung V">V Vinh-Hung</name></author><author><name sortKey="Ueno, Nt" uniqKey="Ueno N">NT Ueno</name></author><author><name sortKey="Cheng, Yc" uniqKey="Cheng Y">YC Cheng</name></author><author><name sortKey="Royce, M" uniqKey="Royce M">M Royce</name></author><author><name sortKey="Tai, P" uniqKey="Tai P">P Tai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vinh Hung, V" uniqKey="Vinh Hung V">V Vinh-Hung</name></author><author><name sortKey="Verkooijen, Hm" uniqKey="Verkooijen H">HM Verkooijen</name></author><author><name sortKey="Fioretta, G" uniqKey="Fioretta G">G Fioretta</name></author><author><name sortKey="Neyroud Caspar, I" uniqKey="Neyroud Caspar I">I Neyroud-Caspar</name></author><author><name sortKey="Rapiti, E" uniqKey="Rapiti E">E Rapiti</name></author><author><name sortKey="Vlastos, G" uniqKey="Vlastos G">G Vlastos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tausch, C" uniqKey="Tausch C">C Tausch</name></author><author><name sortKey="Taucher, S" uniqKey="Taucher S">S Taucher</name></author><author><name sortKey="Dubsky, P" uniqKey="Dubsky P">P Dubsky</name></author><author><name sortKey="Seifert, M" uniqKey="Seifert M">M Seifert</name></author><author><name sortKey="Reitsamer, R" uniqKey="Reitsamer R">R Reitsamer</name></author><author><name sortKey="Kwasny, W" uniqKey="Kwasny W">W Kwasny</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Voordeckers, M" uniqKey="Voordeckers M">M Voordeckers</name></author><author><name sortKey="Vinh Hung, V" uniqKey="Vinh Hung V">V Vinh-Hung</name></author><author><name sortKey="Van De Steene, J" uniqKey="Van De Steene J">J Van de Steene</name></author><author><name sortKey="Lamote, J" uniqKey="Lamote J">J Lamote</name></author><author><name sortKey="Storme, G" uniqKey="Storme G">G Storme</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dings, Pj" uniqKey="Dings P">PJ Dings</name></author><author><name sortKey="Elferink, Ma" uniqKey="Elferink M">MA Elferink</name></author><author><name sortKey="Strobbe, Lj" uniqKey="Strobbe L">LJ Strobbe</name></author><author><name sortKey="De Wilt, Jh" uniqKey="De Wilt J">JH de Wilt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vinh Hung, V" uniqKey="Vinh Hung V">V Vinh-Hung</name></author><author><name sortKey="Joseph, Sa" uniqKey="Joseph S">SA Joseph</name></author><author><name sortKey="Coutty, N" uniqKey="Coutty N">N Coutty</name></author><author><name sortKey="Ly, Bh" uniqKey="Ly B">BH Ly</name></author><author><name sortKey="Vlastos, G" uniqKey="Vlastos G">G Vlastos</name></author><author><name sortKey="Nguyen, Np" uniqKey="Nguyen N">NP Nguyen</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Edge Sb, Bd" uniqKey="Edge Sb B">BD Edge SB</name></author><author><name sortKey="Compton, Cc" uniqKey="Compton C">CC Compton</name></author><author><name sortKey="Fritz, Ag" uniqKey="Fritz A">AG Fritz</name></author><author><name sortKey="Greene, Fl" uniqKey="Greene F">FL Greene</name></author><author><name sortKey="Trotti, A" uniqKey="Trotti A">A Trotti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Si" uniqKey="Kim S">SI Kim</name></author><author><name sortKey="Cho, Sh" uniqKey="Cho S">SH Cho</name></author><author><name sortKey="Lee, Js" uniqKey="Lee J">JS Lee</name></author><author><name sortKey="Moon, Hg" uniqKey="Moon H">HG Moon</name></author><author><name sortKey="Noh, Wc" uniqKey="Noh W">WC Noh</name></author><author><name sortKey="Youn, Hj" uniqKey="Youn H">HJ Youn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wiznia, Le" uniqKey="Wiznia L">LE Wiznia</name></author><author><name sortKey="Lannin, Dr" uniqKey="Lannin D">DR Lannin</name></author><author><name sortKey="Evans, Sb" uniqKey="Evans S">SB Evans</name></author><author><name sortKey="Hofstatter, Ew" uniqKey="Hofstatter E">EW Hofstatter</name></author><author><name sortKey="Horowitz, Nr" uniqKey="Horowitz N">NR Horowitz</name></author><author><name sortKey="Killelea, Bk" uniqKey="Killelea B">BK Killelea</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goldhirsch, A" uniqKey="Goldhirsch A">A Goldhirsch</name></author><author><name sortKey="Winer, Ep" uniqKey="Winer E">EP Winer</name></author><author><name sortKey="Coates, As" uniqKey="Coates A">AS Coates</name></author><author><name sortKey="Gelber, Rd" uniqKey="Gelber R">RD Gelber</name></author><author><name sortKey="Piccart Gebhart, M" uniqKey="Piccart Gebhart M">M Piccart-Gebhart</name></author><author><name sortKey="Thurlimann, B" uniqKey="Thurlimann B">B Thurlimann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boyer Chammard, A" uniqKey="Boyer Chammard A">A Boyer-Chammard</name></author><author><name sortKey="Taylor, Th" uniqKey="Taylor T">TH Taylor</name></author><author><name sortKey="Anton Culver, H" uniqKey="Anton Culver H">H Anton-Culver</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dehal, A" uniqKey="Dehal A">A Dehal</name></author><author><name sortKey="Abbas, A" uniqKey="Abbas A">A Abbas</name></author><author><name sortKey="Johna, S" uniqKey="Johna S">S Johna</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aizer, Aa" uniqKey="Aizer A">AA Aizer</name></author><author><name sortKey="Chen, Mh" uniqKey="Chen M">MH Chen</name></author><author><name sortKey="Mccarthy, Ep" uniqKey="Mccarthy E">EP McCarthy</name></author><author><name sortKey="Mendu, Ml" uniqKey="Mendu M">ML Mendu</name></author><author><name sortKey="Koo, S" uniqKey="Koo S">S Koo</name></author><author><name sortKey="Wilhite, Tj" uniqKey="Wilhite T">TJ Wilhite</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schaapveld, M" uniqKey="Schaapveld M">M Schaapveld</name></author><author><name sortKey="Otter, R" uniqKey="Otter R">R Otter</name></author><author><name sortKey="De Vries, Eg" uniqKey="De Vries E">EG de Vries</name></author><author><name sortKey="Fidler, V" uniqKey="Fidler V">V Fidler</name></author><author><name sortKey="Grond, Ja" uniqKey="Grond J">JA Grond</name></author><author><name sortKey="Van Der Graaf, Wt" uniqKey="Van Der Graaf W">WT van der Graaf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lyman, Gh" uniqKey="Lyman G">GH Lyman</name></author><author><name sortKey="Giuliano, Ae" uniqKey="Giuliano A">AE Giuliano</name></author><author><name sortKey="Somerfield, Mr" uniqKey="Somerfield M">MR Somerfield</name></author><author><name sortKey="Benson, Ab" uniqKey="Benson A">AB Benson</name></author><author><name sortKey="Bodurka, Dc" uniqKey="Bodurka D">DC Bodurka</name></author><author><name sortKey="Burstein, Hj" uniqKey="Burstein H">HJ Burstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ivens, D" uniqKey="Ivens D">D Ivens</name></author><author><name sortKey="Hoe, Al" uniqKey="Hoe A">AL Hoe</name></author><author><name sortKey="Podd, Tj" uniqKey="Podd T">TJ Podd</name></author><author><name sortKey="Hamilton, Cr" uniqKey="Hamilton C">CR Hamilton</name></author><author><name sortKey="Taylor, I" uniqKey="Taylor I">I Taylor</name></author><author><name sortKey="Royle, Gt" uniqKey="Royle G">GT Royle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yeoh, Ek" uniqKey="Yeoh E">EK Yeoh</name></author><author><name sortKey="Denham, Jw" uniqKey="Denham J">JW Denham</name></author><author><name sortKey="Davies, Sa" uniqKey="Davies S">SA Davies</name></author><author><name sortKey="Spittle, Mf" uniqKey="Spittle M">MF Spittle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lotze, Mt" uniqKey="Lotze M">MT Lotze</name></author><author><name sortKey="Duncan, Ma" uniqKey="Duncan M">MA Duncan</name></author><author><name sortKey="Gerber, Lh" uniqKey="Gerber L">LH Gerber</name></author><author><name sortKey="Woltering, Ea" uniqKey="Woltering E">EA Woltering</name></author><author><name sortKey="Rosenberg, Sa" uniqKey="Rosenberg S">SA Rosenberg</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Hong, Ruoxi" sort="Hong, Ruoxi" uniqKey="Hong R" first="Ruoxi" last="Hong">Ruoxi Hong</name></noRegion><name sortKey="Dai, Zhen" sort="Dai, Zhen" uniqKey="Dai Z" first="Zhen" last="Dai">Zhen Dai</name><name sortKey="Xu, Binghe" sort="Xu, Binghe" uniqKey="Xu B" first="Binghe" last="Xu">Binghe Xu</name><name sortKey="Zhu, Wenjie" sort="Zhu, Wenjie" uniqKey="Zhu W" first="Wenjie" last="Zhu">Wenjie Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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