Management of Vulvar Cancer.
Identifieur interne : 001B31 ( Main/Exploration ); précédent : 001B30; suivant : 001B32Management of Vulvar Cancer.
Auteurs : Shalini Rajaram ; Bindiya GuptaSource :
- Reviews on recent clinical trials [ 1876-1038 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Association thérapeutique, Carcinome épidermoïde (), Carcinome épidermoïde (anatomopathologie), Carcinome épidermoïde (épidémiologie), Femelle, Humains, Immunohistochimie, Invasion tumorale (anatomopathologie), Maladies rares, Ponction-biopsie à l'aiguille, Pronostic, Radiothérapie adjuvante, Stade de la tumeur, Sujet âgé, Taux de survie, Traitement médicamenteux adjuvant, Tumeurs de la vulve (), Tumeurs de la vulve (anatomopathologie), Tumeurs de la vulve (épidémiologie), Vulve ().
- MESH :
- anatomopathologie : Carcinome épidermoïde, Invasion tumorale, Tumeurs de la vulve.
- épidémiologie : Carcinome épidermoïde, Tumeurs de la vulve.
- Adulte, Adulte d'âge moyen, Association thérapeutique, Carcinome épidermoïde, Femelle, Humains, Immunohistochimie, Maladies rares, Ponction-biopsie à l'aiguille, Pronostic, Radiothérapie adjuvante, Stade de la tumeur, Sujet âgé, Taux de survie, Traitement médicamenteux adjuvant, Tumeurs de la vulve, Vulve.
English descriptors
- KwdEn :
- Adult, Aged, Biopsy, Needle, Carcinoma, Squamous Cell (epidemiology), Carcinoma, Squamous Cell (pathology), Carcinoma, Squamous Cell (therapy), Chemotherapy, Adjuvant, Combined Modality Therapy, Female, Humans, Immunohistochemistry, Middle Aged, Neoplasm Invasiveness (pathology), Neoplasm Staging, Prognosis, Radiotherapy, Adjuvant, Rare Diseases, Survival Rate, Vulva (surgery), Vulvar Neoplasms (epidemiology), Vulvar Neoplasms (pathology), Vulvar Neoplasms (therapy).
- MESH :
- epidemiology : Carcinoma, Squamous Cell, Vulvar Neoplasms.
- pathology : Carcinoma, Squamous Cell, Neoplasm Invasiveness, Vulvar Neoplasms.
- surgery : Vulva.
- therapy : Carcinoma, Squamous Cell, Vulvar Neoplasms.
- Adult, Aged, Biopsy, Needle, Chemotherapy, Adjuvant, Combined Modality Therapy, Female, Humans, Immunohistochemistry, Middle Aged, Neoplasm Staging, Prognosis, Radiotherapy, Adjuvant, Rare Diseases, Survival Rate.
Abstract
Vulvar cancer is an uncommon malignancy and accounts for around 5% of all gynecologic cancers. Incidence rates have increased for young adults and may be linked to increasing HPV prevalence. Treatment of vulvar cancer has evolved from 'en-bloc' surgery with high morbidity to more conservative approaches without compromising oncological safety. In recent years sentinel node evaluation has been advocated in early stage cancers to reduce complications of inguino-femoral lymphadenectomy. Minimising extent of radical excision for the vulvar growth and separate incisions for groin dissection have reduced the number of wound breakdowns, infection, lymphocoele and chronic lymphedema but complication rate is still as high as 60%. Incorporating sentinel node evaluation into clinical practice has brought down complications to less than 10% for both lymphedema and wound infection. Role of imaging is increasing in vulvar cancer, especially for locally advanced disease as a result of transition from exenterative and extensive surgery to use of neoadjuvant chemoradiation and a less moribund approach to management. Locally advanced vulvar cancer includes large primary tumors or locally advanced disease i.e. FIGO stages III and IV. Treatment decision here is still a challenge as there is no standard recommended treatment strategy. Neoadjuvant chemoradiation is an effective modality for locally advanced vulvar cancer, as it reduces tumor size and renders the lesion operable. Primary chemoradiation without post treatment surgery has been used as an alternative treatment to avoid extensive radical surgery and complex reconstructive procedures.
PubMed: 26411953
Affiliations:
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xml:lang="en"><term>Adult</term><term>Aged</term><term>Biopsy, Needle</term><term>Chemotherapy, Adjuvant</term><term>Combined Modality Therapy</term><term>Female</term><term>Humans</term><term>Immunohistochemistry</term><term>Middle Aged</term><term>Neoplasm Staging</term><term>Prognosis</term><term>Radiotherapy, Adjuvant</term><term>Rare Diseases</term><term>Survival Rate</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association thérapeutique</term><term>Carcinome épidermoïde</term><term>Femelle</term><term>Humains</term><term>Immunohistochimie</term><term>Maladies rares</term><term>Ponction-biopsie à l'aiguille</term><term>Pronostic</term><term>Radiothérapie adjuvante</term><term>Stade de la tumeur</term><term>Sujet âgé</term><term>Taux de survie</term><term>Traitement médicamenteux adjuvant</term><term>Tumeurs de la vulve</term><term>Vulve</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Vulvar cancer is an uncommon malignancy and accounts for around 5% of all gynecologic cancers. Incidence rates have increased for young adults and may be linked to increasing HPV prevalence. Treatment of vulvar cancer has evolved from 'en-bloc' surgery with high morbidity to more conservative approaches without compromising oncological safety. In recent years sentinel node evaluation has been advocated in early stage cancers to reduce complications of inguino-femoral lymphadenectomy. Minimising extent of radical excision for the vulvar growth and separate incisions for groin dissection have reduced the number of wound breakdowns, infection, lymphocoele and chronic lymphedema but complication rate is still as high as 60%. Incorporating sentinel node evaluation into clinical practice has brought down complications to less than 10% for both lymphedema and wound infection. Role of imaging is increasing in vulvar cancer, especially for locally advanced disease as a result of transition from exenterative and extensive surgery to use of neoadjuvant chemoradiation and a less moribund approach to management. Locally advanced vulvar cancer includes large primary tumors or locally advanced disease i.e. FIGO stages III and IV. Treatment decision here is still a challenge as there is no standard recommended treatment strategy. Neoadjuvant chemoradiation is an effective modality for locally advanced vulvar cancer, as it reduces tumor size and renders the lesion operable. Primary chemoradiation without post treatment surgery has been used as an alternative treatment to avoid extensive radical surgery and complex reconstructive procedures.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Gupta, Bindiya" sort="Gupta, Bindiya" uniqKey="Gupta B" first="Bindiya" last="Gupta">Bindiya Gupta</name><name sortKey="Rajaram, Shalini" sort="Rajaram, Shalini" uniqKey="Rajaram S" first="Shalini" last="Rajaram">Shalini Rajaram</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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