Multiple Mouse Models of Primary Lymphedema Exhibit Distinct Defects in Lymphovenous Valve Development
Identifieur interne : 001A76 ( Main/Exploration ); précédent : 001A75; suivant : 001A77Multiple Mouse Models of Primary Lymphedema Exhibit Distinct Defects in Lymphovenous Valve Development
Auteurs : Xin Geng [États-Unis] ; Boksik Cha [États-Unis] ; Md. Riaj Mahamud [États-Unis] ; Kim-Chew Lim [États-Unis] ; Robert Silasi-Mansat [États-Unis] ; Mohammad K. M. Uddin [Japon] ; Naoyuki Miura [Japon] ; Lijun Xia [États-Unis] ; Alexander M. Simon [États-Unis] ; James Douglas Engel [États-Unis] ; Hong Chen [États-Unis] ; Florea Lupu [États-Unis] ; R. Sathish Srinivasan [États-Unis]Source :
- Developmental biology [ 0012-1606 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Animaux nouveau-nés, Cellules endothéliales (anatomopathologie), Cellules endothéliales (ultrastructure), Différenciation cellulaire, Lymphoedème (anatomopathologie), Lymphoedème (embryologie), Modèles animaux de maladie humaine, Morphogenèse, Phénotype, Pénétrance, Souris de lignée C57BL, Vaisseaux lymphatiques (embryologie), Vaisseaux lymphatiques (ultrastructure), Valves veineuses (embryologie), Valves veineuses (ultrastructure).
- MESH :
- anatomopathologie : Cellules endothéliales, Lymphoedème.
- embryologie : Lymphoedème, Vaisseaux lymphatiques, Valves veineuses.
- ultrastructure : Animaux, Animaux nouveau-nés, Cellules endothéliales, Différenciation cellulaire, Modèles animaux de maladie humaine, Morphogenèse, Phénotype, Pénétrance, Souris de lignée C57BL, Vaisseaux lymphatiques, Valves veineuses.
English descriptors
- KwdEn :
- Animals, Animals, Newborn, Cell Differentiation, Disease Models, Animal, Endothelial Cells (pathology), Endothelial Cells (ultrastructure), Lymphatic Vessels (embryology), Lymphatic Vessels (ultrastructure), Lymphedema (embryology), Lymphedema (pathology), Mice, Inbred C57BL, Morphogenesis, Penetrance, Phenotype, Venous Valves (embryology), Venous Valves (ultrastructure).
- MESH :
- embryology : Lymphatic Vessels, Lymphedema, Venous Valves.
- pathology : Endothelial Cells, Lymphedema.
- ultrastructure : Endothelial Cells, Lymphatic Vessels, Venous Valves.
- Animals, Animals, Newborn, Cell Differentiation, Disease Models, Animal, Mice, Inbred C57BL, Morphogenesis, Penetrance, Phenotype.
Abstract
Lymph is returned to the blood circulation exclusively via four lymphovenous valves (LVVs). Despite their vital importance, the architecture and development of LVVs is poorly understood. We analyzed the formation of LVVs at the molecular and ultrastructural levels during mouse embryogenesis and identified three critical steps. First, LVV-forming endothelial cells (LVV-ECs) differentiate from PROX1+ progenitors and delaminate from the luminal side of the veins. Second, LVV-ECs aggregate, align perpendicular to the direction of lymph flow and establish lympho-venous connections. Finally, LVVs mature with the recruitment of mural cells. LVV morphogenesis is disrupted in four different mouse models of primary lymphedema and the severity of LVV defects correlate with that of lymphedema. In summary, we have provided the first and the most comprehensive analysis of LVV development. Furthermore, our work suggests that aberrant LVVs contribute to lymphedema.
Url:
DOI: 10.1016/j.ydbio.2015.10.022
PubMed: 26542011
PubMed Central: 4688075
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 003358
- to stream Pmc, to step Curation: 003357
- to stream Pmc, to step Checkpoint: 001050
- to stream PubMed, to step Corpus: 000B48
- to stream PubMed, to step Curation: 000B48
- to stream PubMed, to step Checkpoint: 000B48
- to stream Ncbi, to step Merge: 007B05
- to stream Ncbi, to step Curation: 007B05
- to stream Ncbi, to step Checkpoint: 007B05
- to stream Main, to step Merge: 001A79
- to stream Main, to step Curation: 001A76
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Multiple Mouse Models of Primary Lymphedema Exhibit Distinct Defects in Lymphovenous Valve Development</title><author><name sortKey="Geng, Xin" sort="Geng, Xin" uniqKey="Geng X" first="Xin" last="Geng">Xin Geng</name><affiliation wicri:level="2"><nlm:aff id="A1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea><placeName><region type="state">Oklahoma</region></placeName></affiliation></author><author><name sortKey="Cha, Boksik" sort="Cha, Boksik" uniqKey="Cha B" first="Boksik" last="Cha">Boksik Cha</name><affiliation wicri:level="2"><nlm:aff id="A1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea><placeName><region type="state">Oklahoma</region></placeName></affiliation></author><author><name sortKey="Mahamud, Md Riaj" sort="Mahamud, Md Riaj" uniqKey="Mahamud M" first="Md. Riaj" last="Mahamud">Md. Riaj Mahamud</name><affiliation wicri:level="2"><nlm:aff id="A1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea><placeName><region type="state">Oklahoma</region></placeName></affiliation></author><author><name sortKey="Lim, Kim Chew" sort="Lim, Kim Chew" uniqKey="Lim K" first="Kim-Chew" last="Lim">Kim-Chew Lim</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Silasi Mansat, Robert" sort="Silasi Mansat, Robert" uniqKey="Silasi Mansat R" first="Robert" last="Silasi-Mansat">Robert Silasi-Mansat</name><affiliation wicri:level="2"><nlm:aff id="A1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea><placeName><region type="state">Oklahoma</region></placeName></affiliation></author><author><name sortKey="Uddin, Mohammad K M" sort="Uddin, Mohammad K M" uniqKey="Uddin M" first="Mohammad K. M." last="Uddin">Mohammad K. M. Uddin</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Biochemistry, Hamamatsu University School of Medicine, Hamamatsu, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biochemistry, Hamamatsu University School of Medicine, Hamamatsu</wicri:regionArea><wicri:noRegion>Hamamatsu</wicri:noRegion></affiliation></author><author><name sortKey="Miura, Naoyuki" sort="Miura, Naoyuki" uniqKey="Miura N" first="Naoyuki" last="Miura">Naoyuki Miura</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Biochemistry, Hamamatsu University School of Medicine, Hamamatsu, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biochemistry, Hamamatsu University School of Medicine, Hamamatsu</wicri:regionArea><wicri:noRegion>Hamamatsu</wicri:noRegion></affiliation></author><author><name sortKey="Xia, Lijun" sort="Xia, Lijun" uniqKey="Xia L" first="Lijun" last="Xia">Lijun Xia</name><affiliation wicri:level="2"><nlm:aff id="A1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea><placeName><region type="state">Oklahoma</region></placeName></affiliation></author><author><name sortKey="Simon, Alexander M" sort="Simon, Alexander M" uniqKey="Simon A" first="Alexander M." last="Simon">Alexander M. Simon</name><affiliation wicri:level="2"><nlm:aff id="A5">Department of Physiology, University of Arizona, Tucson, Arizona, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physiology, University of Arizona, Tucson, Arizona</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Engel, James Douglas" sort="Engel, James Douglas" uniqKey="Engel J" first="James Douglas" last="Engel">James Douglas Engel</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Chen, Hong" sort="Chen, Hong" uniqKey="Chen H" first="Hong" last="Chen">Hong Chen</name><affiliation wicri:level="2"><nlm:aff id="A1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea><placeName><region type="state">Oklahoma</region></placeName></affiliation></author><author><name sortKey="Lupu, Florea" sort="Lupu, Florea" uniqKey="Lupu F" first="Florea" last="Lupu">Florea Lupu</name><affiliation wicri:level="2"><nlm:aff id="A1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea><placeName><region type="state">Oklahoma</region></placeName></affiliation></author><author><name sortKey="Srinivasan, R Sathish" sort="Srinivasan, R Sathish" uniqKey="Srinivasan R" first="R. Sathish" last="Srinivasan">R. Sathish Srinivasan</name><affiliation wicri:level="2"><nlm:aff id="A1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea><placeName><region type="state">Oklahoma</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma</wicri:regionArea><placeName><region type="state">Oklahoma</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26542011</idno><idno type="pmc">4688075</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688075</idno><idno type="RBID">PMC:4688075</idno><idno type="doi">10.1016/j.ydbio.2015.10.022</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">003358</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003358</idno><idno type="wicri:Area/Pmc/Curation">003357</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003357</idno><idno type="wicri:Area/Pmc/Checkpoint">001050</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001050</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000B48</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000B48</idno><idno type="wicri:Area/PubMed/Curation">000B48</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000B48</idno><idno type="wicri:Area/PubMed/Checkpoint">000B48</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000B48</idno><idno type="wicri:Area/Ncbi/Merge">007B05</idno><idno type="wicri:Area/Ncbi/Curation">007B05</idno><idno type="wicri:Area/Ncbi/Checkpoint">007B05</idno><idno type="wicri:doubleKey">0012-1606:2015:Geng X:multiple:mouse:models</idno><idno type="wicri:Area/Main/Merge">001A79</idno><idno type="wicri:Area/Main/Curation">001A76</idno><idno type="wicri:Area/Main/Exploration">001A76</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Multiple Mouse Models of Primary Lymphedema Exhibit Distinct Defects in Lymphovenous Valve Development</title><author><name sortKey="Geng, Xin" sort="Geng, Xin" uniqKey="Geng X" first="Xin" last="Geng">Xin Geng</name><affiliation wicri:level="2"><nlm:aff id="A1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea><placeName><region type="state">Oklahoma</region></placeName></affiliation></author><author><name sortKey="Cha, Boksik" sort="Cha, Boksik" uniqKey="Cha B" first="Boksik" last="Cha">Boksik Cha</name><affiliation wicri:level="2"><nlm:aff id="A1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea><placeName><region type="state">Oklahoma</region></placeName></affiliation></author><author><name sortKey="Mahamud, Md Riaj" sort="Mahamud, Md Riaj" uniqKey="Mahamud M" first="Md. Riaj" last="Mahamud">Md. Riaj Mahamud</name><affiliation wicri:level="2"><nlm:aff id="A1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea><placeName><region type="state">Oklahoma</region></placeName></affiliation></author><author><name sortKey="Lim, Kim Chew" sort="Lim, Kim Chew" uniqKey="Lim K" first="Kim-Chew" last="Lim">Kim-Chew Lim</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Silasi Mansat, Robert" sort="Silasi Mansat, Robert" uniqKey="Silasi Mansat R" first="Robert" last="Silasi-Mansat">Robert Silasi-Mansat</name><affiliation wicri:level="2"><nlm:aff id="A1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea><placeName><region type="state">Oklahoma</region></placeName></affiliation></author><author><name sortKey="Uddin, Mohammad K M" sort="Uddin, Mohammad K M" uniqKey="Uddin M" first="Mohammad K. M." last="Uddin">Mohammad K. M. Uddin</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Biochemistry, Hamamatsu University School of Medicine, Hamamatsu, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biochemistry, Hamamatsu University School of Medicine, Hamamatsu</wicri:regionArea><wicri:noRegion>Hamamatsu</wicri:noRegion></affiliation></author><author><name sortKey="Miura, Naoyuki" sort="Miura, Naoyuki" uniqKey="Miura N" first="Naoyuki" last="Miura">Naoyuki Miura</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Biochemistry, Hamamatsu University School of Medicine, Hamamatsu, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biochemistry, Hamamatsu University School of Medicine, Hamamatsu</wicri:regionArea><wicri:noRegion>Hamamatsu</wicri:noRegion></affiliation></author><author><name sortKey="Xia, Lijun" sort="Xia, Lijun" uniqKey="Xia L" first="Lijun" last="Xia">Lijun Xia</name><affiliation wicri:level="2"><nlm:aff id="A1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea><placeName><region type="state">Oklahoma</region></placeName></affiliation></author><author><name sortKey="Simon, Alexander M" sort="Simon, Alexander M" uniqKey="Simon A" first="Alexander M." last="Simon">Alexander M. Simon</name><affiliation wicri:level="2"><nlm:aff id="A5">Department of Physiology, University of Arizona, Tucson, Arizona, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physiology, University of Arizona, Tucson, Arizona</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Engel, James Douglas" sort="Engel, James Douglas" uniqKey="Engel J" first="James Douglas" last="Engel">James Douglas Engel</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Chen, Hong" sort="Chen, Hong" uniqKey="Chen H" first="Hong" last="Chen">Hong Chen</name><affiliation wicri:level="2"><nlm:aff id="A1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea><placeName><region type="state">Oklahoma</region></placeName></affiliation></author><author><name sortKey="Lupu, Florea" sort="Lupu, Florea" uniqKey="Lupu F" first="Florea" last="Lupu">Florea Lupu</name><affiliation wicri:level="2"><nlm:aff id="A1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea><placeName><region type="state">Oklahoma</region></placeName></affiliation></author><author><name sortKey="Srinivasan, R Sathish" sort="Srinivasan, R Sathish" uniqKey="Srinivasan R" first="R. Sathish" last="Srinivasan">R. Sathish Srinivasan</name><affiliation wicri:level="2"><nlm:aff id="A1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma</wicri:regionArea><placeName><region type="state">Oklahoma</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma</wicri:regionArea><placeName><region type="state">Oklahoma</region></placeName></affiliation></author></analytic><series><title level="j">Developmental biology</title><idno type="ISSN">0012-1606</idno><idno type="eISSN">1095-564X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Animals, Newborn</term><term>Cell Differentiation</term><term>Disease Models, Animal</term><term>Endothelial Cells (pathology)</term><term>Endothelial Cells (ultrastructure)</term><term>Lymphatic Vessels (embryology)</term><term>Lymphatic Vessels (ultrastructure)</term><term>Lymphedema (embryology)</term><term>Lymphedema (pathology)</term><term>Mice, Inbred C57BL</term><term>Morphogenesis</term><term>Penetrance</term><term>Phenotype</term><term>Venous Valves (embryology)</term><term>Venous Valves (ultrastructure)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Animaux nouveau-nés</term><term>Cellules endothéliales (anatomopathologie)</term><term>Cellules endothéliales (ultrastructure)</term><term>Différenciation cellulaire</term><term>Lymphoedème (anatomopathologie)</term><term>Lymphoedème (embryologie)</term><term>Modèles animaux de maladie humaine</term><term>Morphogenèse</term><term>Phénotype</term><term>Pénétrance</term><term>Souris de lignée C57BL</term><term>Vaisseaux lymphatiques (embryologie)</term><term>Vaisseaux lymphatiques (ultrastructure)</term><term>Valves veineuses (embryologie)</term><term>Valves veineuses (ultrastructure)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Cellules endothéliales</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Lymphoedème</term><term>Vaisseaux lymphatiques</term><term>Valves veineuses</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Lymphatic Vessels</term><term>Lymphedema</term><term>Venous Valves</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Endothelial Cells</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Endothelial Cells</term><term>Lymphatic Vessels</term><term>Venous Valves</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Animals, Newborn</term><term>Cell Differentiation</term><term>Disease Models, Animal</term><term>Mice, Inbred C57BL</term><term>Morphogenesis</term><term>Penetrance</term><term>Phenotype</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="fr"><term>Animaux</term><term>Animaux nouveau-nés</term><term>Cellules endothéliales</term><term>Différenciation cellulaire</term><term>Modèles animaux de maladie humaine</term><term>Morphogenèse</term><term>Phénotype</term><term>Pénétrance</term><term>Souris de lignée C57BL</term><term>Vaisseaux lymphatiques</term><term>Valves veineuses</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Lymph is returned to the blood circulation exclusively via four lymphovenous valves (LVVs). Despite their vital importance, the architecture and development of LVVs is poorly understood. We analyzed the formation of LVVs at the molecular and ultrastructural levels during mouse embryogenesis and identified three critical steps. First, LVV-forming endothelial cells (LVV-ECs) differentiate from PROX1<sup>+</sup> progenitors and delaminate from the luminal side of the veins. Second, LVV-ECs aggregate, align perpendicular to the direction of lymph flow and establish lympho-venous connections. Finally, LVVs mature with the recruitment of mural cells. LVV morphogenesis is disrupted in four different mouse models of primary lymphedema and the severity of LVV defects correlate with that of lymphedema. In summary, we have provided the first and the most comprehensive analysis of LVV development. Furthermore, our work suggests that aberrant LVVs contribute to lymphedema.</p></div></front></TEI><affiliations><list><country><li>Japon</li><li>États-Unis</li></country><region><li>Arizona</li><li>Michigan</li><li>Oklahoma</li></region></list><tree><country name="États-Unis"><region name="Oklahoma"><name sortKey="Geng, Xin" sort="Geng, Xin" uniqKey="Geng X" first="Xin" last="Geng">Xin Geng</name></region><name sortKey="Cha, Boksik" sort="Cha, Boksik" uniqKey="Cha B" first="Boksik" last="Cha">Boksik Cha</name><name sortKey="Chen, Hong" sort="Chen, Hong" uniqKey="Chen H" first="Hong" last="Chen">Hong Chen</name><name sortKey="Engel, James Douglas" sort="Engel, James Douglas" uniqKey="Engel J" first="James Douglas" last="Engel">James Douglas Engel</name><name sortKey="Lim, Kim Chew" sort="Lim, Kim Chew" uniqKey="Lim K" first="Kim-Chew" last="Lim">Kim-Chew Lim</name><name sortKey="Lupu, Florea" sort="Lupu, Florea" uniqKey="Lupu F" first="Florea" last="Lupu">Florea Lupu</name><name sortKey="Mahamud, Md Riaj" sort="Mahamud, Md Riaj" uniqKey="Mahamud M" first="Md. Riaj" last="Mahamud">Md. Riaj Mahamud</name><name sortKey="Silasi Mansat, Robert" sort="Silasi Mansat, Robert" uniqKey="Silasi Mansat R" first="Robert" last="Silasi-Mansat">Robert Silasi-Mansat</name><name sortKey="Simon, Alexander M" sort="Simon, Alexander M" uniqKey="Simon A" first="Alexander M." last="Simon">Alexander M. Simon</name><name sortKey="Srinivasan, R Sathish" sort="Srinivasan, R Sathish" uniqKey="Srinivasan R" first="R. Sathish" last="Srinivasan">R. Sathish Srinivasan</name><name sortKey="Srinivasan, R Sathish" sort="Srinivasan, R Sathish" uniqKey="Srinivasan R" first="R. Sathish" last="Srinivasan">R. Sathish Srinivasan</name><name sortKey="Xia, Lijun" sort="Xia, Lijun" uniqKey="Xia L" first="Lijun" last="Xia">Lijun Xia</name></country><country name="Japon"><noRegion><name sortKey="Uddin, Mohammad K M" sort="Uddin, Mohammad K M" uniqKey="Uddin M" first="Mohammad K. M." last="Uddin">Mohammad K. M. Uddin</name></noRegion><name sortKey="Miura, Naoyuki" sort="Miura, Naoyuki" uniqKey="Miura N" first="Naoyuki" last="Miura">Naoyuki Miura</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A76 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001A76 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4688075
|texte= Multiple Mouse Models of Primary Lymphedema Exhibit Distinct Defects in Lymphovenous Valve Development
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26542011" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |