Protein Phosphatase 2A in Lipopolysaccharide-Induced Cyclooxygenase-2 Expression in Murine Lymphatic Endothelial Cells
Identifieur interne : 001946 ( Main/Exploration ); précédent : 001945; suivant : 001947Protein Phosphatase 2A in Lipopolysaccharide-Induced Cyclooxygenase-2 Expression in Murine Lymphatic Endothelial Cells
Auteurs : Yu-Fan Chuang [Taïwan] ; Mei-Chieh Chen [Taïwan] ; Shiu-Wen Huang [Taïwan] ; Ya-Fen Hsu [Taïwan] ; George Ou [Canada] ; Yu-Jou Tsai [Taïwan] ; Ming-Jen Hsu [Taïwan]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
Abstract
The lymphatic endothelium plays an important role in the maintenance of tissue fluid homeostasis. It also participates in the pathogenesis of several inflammatory diseases. However, little is known about the underlying mechanisms by which lymphatic endothelial cell responds to inflammatory stimuli. In this study, we explored the mechanisms by which lipopolysaccharide (LPS) induces cyclooxygenase (COX)-2 expression in murine lymphatic endothelial cells (SV-LECs). LPS caused increases in
Url:
DOI: 10.1371/journal.pone.0137177
PubMed: 26317424
PubMed Central: 4552685
Affiliations:
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of Medicine, Taipei Medical University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Mei Chieh" sort="Chen, Mei Chieh" uniqKey="Chen M" first="Mei-Chieh" last="Chen">Mei-Chieh Chen</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Department of Microbiology and Immunology, College of Medicine, Taipei Medical University, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Microbiology and Immunology, College of Medicine, Taipei Medical University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Shiu Wen" sort="Huang, Shiu Wen" uniqKey="Huang S" first="Shiu-Wen" last="Huang">Shiu-Wen Huang</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Hsu, Ya Fen" sort="Hsu, Ya Fen" uniqKey="Hsu Y" first="Ya-Fen" last="Hsu">Ya-Fen Hsu</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Division of General Surgery, Department of Surgery, Landseed Hospital, Taoyuan, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Division of General Surgery, Department of Surgery, Landseed Hospital, Taoyuan</wicri:regionArea><wicri:noRegion>Taoyuan</wicri:noRegion></affiliation></author><author><name sortKey="Ou, George" sort="Ou, George" uniqKey="Ou G" first="George" last="Ou">George Ou</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Tsai, Yu Jou" sort="Tsai, Yu Jou" uniqKey="Tsai Y" first="Yu-Jou" last="Tsai">Yu-Jou Tsai</name><affiliation wicri:level="1"><nlm:aff id="aff006"><addr-line>Department of Internal Medicine, Yuan's General Hospital, Kaohsiung, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Internal Medicine, Yuan's General Hospital, Kaohsiung</wicri:regionArea><wicri:noRegion>Kaohsiung</wicri:noRegion></affiliation></author><author><name sortKey="Hsu, Ming Jen" sort="Hsu, Ming Jen" uniqKey="Hsu M" first="Ming-Jen" last="Hsu">Ming-Jen Hsu</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan</addr-line></nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The lymphatic endothelium plays an important role in the maintenance of tissue fluid homeostasis. It also participates in the pathogenesis of several inflammatory diseases. However, little is known about the underlying mechanisms by which lymphatic endothelial cell responds to inflammatory stimuli. In this study, we explored the mechanisms by which lipopolysaccharide (LPS) induces cyclooxygenase (COX)-2 expression in murine lymphatic endothelial cells (SV-LECs). LPS caused increases in <italic>cox-2 mRNA</italic> and protein levels, as well as in COX-2 promoter luciferase activity in SV-LECs. These actions were associated with protein phosphatase 2A (PP2A), apoptosis signal-regulating kinase 1 (ASK1), JNK1/2 and p38MAPK activation, and NF-κB subunit p65 and C/EBPβ phosphorylation. PP2A-ASK1 signaling blockade reduced LPS-induced JNK1/2, p38MAPK, p65 and C/EBPβ phosphorylation. Transfection with PP2A siRNA reduced LPS’s effects on p65 and C/EBPβ binding to the <italic>COX-2</italic> promoter region. Transfected with the NF-κB or C/EBPβ site deletion of COX-2 reporter construct also abrogated LPS’s enhancing effect on COX-2 promoter luciferase activity in SV-LECs. Taken together, the induction of COX-2 in SV-LECs exposed to LPS may involve PP2A-ASK1-JNK and/or p38MAPK-NF-κB and/or C/EBPβ cascade.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Schulte Merker, S" uniqKey="Schulte Merker S">S Schulte-Merker</name></author><author><name sortKey="Sabine, A" uniqKey="Sabine A">A Sabine</name></author><author><name sortKey="Petrova, Tv" uniqKey="Petrova T">TV Petrova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Forster, R" uniqKey="Forster R">R Forster</name></author><author><name sortKey="Braun, A" uniqKey="Braun A">A Braun</name></author><author><name sortKey="Worbs, T" uniqKey="Worbs T">T Worbs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Proulx, St" uniqKey="Proulx S">ST 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Mbonye</name></author><author><name sortKey="Yuan, C" uniqKey="Yuan C">C Yuan</name></author><author><name sortKey="Harris, Ce" uniqKey="Harris C">CE Harris</name></author><author><name sortKey="Sidhu, Rs" uniqKey="Sidhu R">RS Sidhu</name></author><author><name sortKey="Song, I" uniqKey="Song I">I Song</name></author><author><name sortKey="Arakawa, T" uniqKey="Arakawa T">T Arakawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dean, Jl" uniqKey="Dean J">JL Dean</name></author><author><name sortKey="Brook, M" uniqKey="Brook M">M Brook</name></author><author><name sortKey="Clark, Ar" uniqKey="Clark A">AR Clark</name></author><author><name sortKey="Saklatvala, J" uniqKey="Saklatvala J">J Saklatvala</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Chuang, Yu Fan" sort="Chuang, Yu Fan" uniqKey="Chuang Y" first="Yu-Fan" last="Chuang">Yu-Fan Chuang</name></noRegion><name sortKey="Chen, Mei Chieh" sort="Chen, Mei Chieh" uniqKey="Chen M" first="Mei-Chieh" last="Chen">Mei-Chieh Chen</name><name sortKey="Hsu, Ming Jen" sort="Hsu, Ming Jen" uniqKey="Hsu M" first="Ming-Jen" last="Hsu">Ming-Jen Hsu</name><name sortKey="Hsu, Ming Jen" sort="Hsu, Ming Jen" uniqKey="Hsu M" first="Ming-Jen" last="Hsu">Ming-Jen Hsu</name><name sortKey="Hsu, Ya Fen" sort="Hsu, Ya Fen" uniqKey="Hsu Y" first="Ya-Fen" last="Hsu">Ya-Fen Hsu</name><name sortKey="Huang, Shiu Wen" sort="Huang, Shiu Wen" uniqKey="Huang S" first="Shiu-Wen" last="Huang">Shiu-Wen Huang</name><name sortKey="Tsai, Yu Jou" sort="Tsai, Yu Jou" uniqKey="Tsai Y" first="Yu-Jou" last="Tsai">Yu-Jou Tsai</name></country><country name="Canada"><noRegion><name sortKey="Ou, George" sort="Ou, George" uniqKey="Ou G" first="George" last="Ou">George Ou</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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