VEGF-C and VEGF-C156S in the pro-lymphangiogenic growth factor therapy of lymphedema: a large animal study.
Identifieur interne : 001635 ( Main/Exploration ); précédent : 001634; suivant : 001636VEGF-C and VEGF-C156S in the pro-lymphangiogenic growth factor therapy of lymphedema: a large animal study.
Auteurs : Mikko T. Visuri [Finlande] ; Krista M. Honkonen ; Pauliina Hartiala ; Tomi V. Tervala ; Paavo J. Halonen ; Heikki Junkkari ; Nina Knuutinen ; Seppo Yl Herttuala ; Kari K. Alitalo ; Anne M. SaarikkoSource :
- Angiogenesis [ 1573-7209 ] ; 2015.
Descripteurs français
- KwdFr :
- Adenoviridae (génétique), Adenoviridae (métabolisme), Animaux, Cellules endothéliales de la veine ombilicale humaine, Cicatrisation de plaie, Facteur de croissance endothéliale vasculaire de type C (génétique), Facteur de croissance endothéliale vasculaire de type C (physiologie), Femelle, Humains, Lymphangiogenèse (), Lymphoedème (génétique), Lymphoedème (métabolisme), Modèles animaux de maladie humaine, Noeuds lymphatiques, Récepteur-2 au facteur croissance endothéliale vasculaire (métabolisme), Récepteur-3 au facteur croissance endothéliale vasculaire (métabolisme), Régulation de l'expression des gènes, Suidae, Vaisseaux lymphatiques (métabolisme).
- MESH :
- génétique : Adenoviridae, Facteur de croissance endothéliale vasculaire de type C, Lymphoedème.
- métabolisme : Adenoviridae, Lymphoedème, Récepteur-2 au facteur croissance endothéliale vasculaire, Récepteur-3 au facteur croissance endothéliale vasculaire, Vaisseaux lymphatiques.
- physiologie : Facteur de croissance endothéliale vasculaire de type C.
- Animaux, Cellules endothéliales de la veine ombilicale humaine, Cicatrisation de plaie, Femelle, Humains, Lymphangiogenèse, Modèles animaux de maladie humaine, Noeuds lymphatiques, Régulation de l'expression des gènes, Suidae.
English descriptors
- KwdEn :
- Adenoviridae (genetics), Adenoviridae (metabolism), Animals, Disease Models, Animal, Female, Gene Expression Regulation, Human Umbilical Vein Endothelial Cells, Humans, Lymph Nodes, Lymphangiogenesis (drug effects), Lymphatic Vessels (metabolism), Lymphedema (genetics), Lymphedema (metabolism), Swine, Vascular Endothelial Growth Factor C (genetics), Vascular Endothelial Growth Factor C (physiology), Vascular Endothelial Growth Factor Receptor-2 (metabolism), Vascular Endothelial Growth Factor Receptor-3 (metabolism), Wound Healing.
- MESH :
- chemical , genetics : Vascular Endothelial Growth Factor C.
- drug effects : Lymphangiogenesis.
- genetics : Adenoviridae, Lymphedema.
- metabolism : Adenoviridae, Lymphatic Vessels, Lymphedema, Vascular Endothelial Growth Factor Receptor-2, Vascular Endothelial Growth Factor Receptor-3.
- chemical , physiology : Vascular Endothelial Growth Factor C.
- Animals, Disease Models, Animal, Female, Gene Expression Regulation, Human Umbilical Vein Endothelial Cells, Humans, Lymph Nodes, Swine, Wound Healing.
Abstract
VEGF-C156S, a lymphangiogenesis-specific form of vascular endothelial growth factor C (VEGF-C), has been considered as a promising candidate for the experimental pro-lymphangiogenic treatment, as it lacks potential angiogenic effects. As a precursor to future clinical trials, the therapeutic efficacy and blood vascular side effects of VEGF-C and VEGF-C156S were compared in a large animal model of secondary lymphedema. Combination of lymphatic growth factor treatment and autologous lymph node transfer was used to normalize the lymphatic anatomy after surgical excision of lymphatic tissue.
DOI: 10.1007/s10456-015-9469-2
PubMed: 26018927
Affiliations:
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Visuri</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plastic and General Surgery, Turku University Hospital, P.O. Box 52, Kiinamyllynkatu 4-8, 20251, Turku, Finland, mikko.visuri@tyks.fi.</nlm:affiliation><country wicri:rule="url">Finlande</country><wicri:regionArea>Department of Plastic and General Surgery, Turku University Hospital, P.O. Box 52, Kiinamyllynkatu 4-8, 20251, Turku, Finland</wicri:regionArea><wicri:noRegion>Finland</wicri:noRegion></affiliation></author><author><name sortKey="Honkonen, Krista M" sort="Honkonen, Krista M" uniqKey="Honkonen K" first="Krista M" last="Honkonen">Krista M. Honkonen</name></author><author><name sortKey="Hartiala, Pauliina" sort="Hartiala, Pauliina" uniqKey="Hartiala P" first="Pauliina" last="Hartiala">Pauliina Hartiala</name></author><author><name sortKey="Tervala, Tomi V" sort="Tervala, Tomi V" uniqKey="Tervala T" first="Tomi V" last="Tervala">Tomi V. Tervala</name></author><author><name sortKey="Halonen, Paavo J" sort="Halonen, Paavo J" uniqKey="Halonen P" first="Paavo J" last="Halonen">Paavo J. Halonen</name></author><author><name sortKey="Junkkari, Heikki" sort="Junkkari, Heikki" uniqKey="Junkkari H" first="Heikki" last="Junkkari">Heikki Junkkari</name></author><author><name sortKey="Knuutinen, Nina" sort="Knuutinen, Nina" uniqKey="Knuutinen N" first="Nina" last="Knuutinen">Nina Knuutinen</name></author><author><name sortKey="Yl Herttuala, Seppo" sort="Yl Herttuala, Seppo" uniqKey="Yl Herttuala S" first="Seppo" last="Yl Herttuala">Seppo Yl Herttuala</name></author><author><name sortKey="Alitalo, Kari K" sort="Alitalo, Kari K" uniqKey="Alitalo K" first="Kari K" last="Alitalo">Kari K. Alitalo</name></author><author><name sortKey="Saarikko, Anne M" sort="Saarikko, Anne M" uniqKey="Saarikko A" first="Anne M" last="Saarikko">Anne M. Saarikko</name></author></analytic><series><title level="j">Angiogenesis</title><idno type="eISSN">1573-7209</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenoviridae (genetics)</term><term>Adenoviridae (metabolism)</term><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Gene Expression Regulation</term><term>Human Umbilical Vein Endothelial Cells</term><term>Humans</term><term>Lymph Nodes</term><term>Lymphangiogenesis (drug effects)</term><term>Lymphatic Vessels (metabolism)</term><term>Lymphedema (genetics)</term><term>Lymphedema (metabolism)</term><term>Swine</term><term>Vascular Endothelial Growth Factor C (genetics)</term><term>Vascular Endothelial Growth Factor C (physiology)</term><term>Vascular Endothelial Growth Factor Receptor-2 (metabolism)</term><term>Vascular Endothelial Growth Factor Receptor-3 (metabolism)</term><term>Wound Healing</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adenoviridae (génétique)</term><term>Adenoviridae (métabolisme)</term><term>Animaux</term><term>Cellules endothéliales de la veine ombilicale humaine</term><term>Cicatrisation de plaie</term><term>Facteur de croissance endothéliale vasculaire de type C (génétique)</term><term>Facteur de croissance endothéliale vasculaire de type C (physiologie)</term><term>Femelle</term><term>Humains</term><term>Lymphangiogenèse ()</term><term>Lymphoedème (génétique)</term><term>Lymphoedème (métabolisme)</term><term>Modèles animaux de maladie humaine</term><term>Noeuds lymphatiques</term><term>Récepteur-2 au facteur croissance endothéliale vasculaire (métabolisme)</term><term>Récepteur-3 au facteur croissance endothéliale vasculaire (métabolisme)</term><term>Régulation de l'expression des gènes</term><term>Suidae</term><term>Vaisseaux lymphatiques (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Vascular Endothelial Growth Factor C</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Lymphangiogenesis</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adenoviridae</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adenoviridae</term><term>Facteur de croissance endothéliale vasculaire de type C</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Adenoviridae</term><term>Lymphatic Vessels</term><term>Lymphedema</term><term>Vascular Endothelial Growth Factor Receptor-2</term><term>Vascular Endothelial Growth Factor Receptor-3</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Adenoviridae</term><term>Lymphoedème</term><term>Récepteur-2 au facteur croissance endothéliale vasculaire</term><term>Récepteur-3 au facteur croissance endothéliale vasculaire</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type C</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Vascular Endothelial Growth Factor C</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Gene Expression Regulation</term><term>Human Umbilical Vein Endothelial Cells</term><term>Humans</term><term>Lymph Nodes</term><term>Swine</term><term>Wound Healing</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules endothéliales de la veine ombilicale humaine</term><term>Cicatrisation de plaie</term><term>Femelle</term><term>Humains</term><term>Lymphangiogenèse</term><term>Modèles animaux de maladie humaine</term><term>Noeuds lymphatiques</term><term>Régulation de l'expression des gènes</term><term>Suidae</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">VEGF-C156S, a lymphangiogenesis-specific form of vascular endothelial growth factor C (VEGF-C), has been considered as a promising candidate for the experimental pro-lymphangiogenic treatment, as it lacks potential angiogenic effects. As a precursor to future clinical trials, the therapeutic efficacy and blood vascular side effects of VEGF-C and VEGF-C156S were compared in a large animal model of secondary lymphedema. Combination of lymphatic growth factor treatment and autologous lymph node transfer was used to normalize the lymphatic anatomy after surgical excision of lymphatic tissue.</div></front></TEI><affiliations><list><country><li>Finlande</li></country></list><tree><noCountry><name sortKey="Alitalo, Kari K" sort="Alitalo, Kari K" uniqKey="Alitalo K" first="Kari K" last="Alitalo">Kari K. Alitalo</name><name sortKey="Halonen, Paavo J" sort="Halonen, Paavo J" uniqKey="Halonen P" first="Paavo J" last="Halonen">Paavo J. Halonen</name><name sortKey="Hartiala, Pauliina" sort="Hartiala, Pauliina" uniqKey="Hartiala P" first="Pauliina" last="Hartiala">Pauliina Hartiala</name><name sortKey="Honkonen, Krista M" sort="Honkonen, Krista M" uniqKey="Honkonen K" first="Krista M" last="Honkonen">Krista M. Honkonen</name><name sortKey="Junkkari, Heikki" sort="Junkkari, Heikki" uniqKey="Junkkari H" first="Heikki" last="Junkkari">Heikki Junkkari</name><name sortKey="Knuutinen, Nina" sort="Knuutinen, Nina" uniqKey="Knuutinen N" first="Nina" last="Knuutinen">Nina Knuutinen</name><name sortKey="Saarikko, Anne M" sort="Saarikko, Anne M" uniqKey="Saarikko A" first="Anne M" last="Saarikko">Anne M. Saarikko</name><name sortKey="Tervala, Tomi V" sort="Tervala, Tomi V" uniqKey="Tervala T" first="Tomi V" last="Tervala">Tomi V. Tervala</name><name sortKey="Yl Herttuala, Seppo" sort="Yl Herttuala, Seppo" uniqKey="Yl Herttuala S" first="Seppo" last="Yl Herttuala">Seppo Yl Herttuala</name></noCountry><country name="Finlande"><noRegion><name sortKey="Visuri, Mikko T" sort="Visuri, Mikko T" uniqKey="Visuri M" first="Mikko T" last="Visuri">Mikko T. Visuri</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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