Vulvar cancer: epidemiology, clinical presentation, and management options
Identifieur interne : 001620 ( Main/Exploration ); précédent : 001619; suivant : 001621Vulvar cancer: epidemiology, clinical presentation, and management options
Auteurs : Ibrahim Alkatout [Allemagne] ; Melanie Schubert [Allemagne] ; Nele Garbrecht [Allemagne] ; Marion Tina Weigel [Allemagne] ; Walter Jonat [Allemagne] ; Christoph Mundhenke [Allemagne] ; Veronika Günther [Allemagne]Source :
- International Journal of Women's Health [ 1179-1411 ] ; 2015.
Abstract
Vulvar cancer can be classified into two groups according to predisposing factors: the first type correlates with a HPV infection and occurs mostly in younger patients. The second group is not HPV associated and occurs often in elderly women without neoplastic epithelial disorders.
Squamous cell carcinoma (SCC) is the most common malignant tumor of the vulva (95%).
Pruritus is the most common and long-lasting reported symptom of vulvar cancer, followed by vulvar bleeding, discharge, dysuria, and pain.
The gold standard for even a small invasive carcinoma of the vulva was historically radical vulvectomy with removal of the tumor with a wide margin followed by an en bloc resection of the inguinal and often the pelvic lymph nodes. Currently, a more individualized and less radical treatment is suggested: a radical wide local excision is possible in the case of localized lesions (T1). A sentinel lymph node (SLN) biopsy may be performed to reduce wound complications and lymphedema.
The survival of patients with vulvar cancer is good when convenient therapy is arranged quickly after initial diagnosis. Inguinal and/or femoral node involvement is the most significant prognostic factor for survival.
Url:
DOI: 10.2147/IJWH.S68979
PubMed: 25848321
PubMed Central: 4374790
Affiliations:
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nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Schubert, Melanie" sort="Schubert, Melanie" uniqKey="Schubert M" first="Melanie" last="Schubert">Melanie Schubert</name><affiliation wicri:level="3"><nlm:aff id="af1-ijwh-7-305">Department of Gynecology and Obstetrics, University Hospitals Schleswig-Holstein, Campus Kiel, Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gynecology and Obstetrics, University Hospitals Schleswig-Holstein, Campus Kiel, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Garbrecht, Nele" sort="Garbrecht, Nele" uniqKey="Garbrecht N" first="Nele" last="Garbrecht">Nele Garbrecht</name><affiliation wicri:level="3"><nlm:aff id="af2-ijwh-7-305">Institute for Pathology, University Hospitals Schleswig-Holstein, Campus Kiel, Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Pathology, University Hospitals Schleswig-Holstein, Campus Kiel, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Weigel, Marion Tina" sort="Weigel, Marion Tina" uniqKey="Weigel M" first="Marion Tina" last="Weigel">Marion Tina Weigel</name><affiliation wicri:level="3"><nlm:aff id="af1-ijwh-7-305">Department of Gynecology and Obstetrics, University Hospitals Schleswig-Holstein, Campus Kiel, Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gynecology and Obstetrics, University Hospitals Schleswig-Holstein, Campus Kiel, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Jonat, Walter" sort="Jonat, Walter" uniqKey="Jonat W" first="Walter" last="Jonat">Walter Jonat</name><affiliation wicri:level="3"><nlm:aff id="af1-ijwh-7-305">Department of Gynecology and Obstetrics, University Hospitals Schleswig-Holstein, Campus Kiel, Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gynecology and Obstetrics, University Hospitals Schleswig-Holstein, Campus Kiel, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Mundhenke, Christoph" sort="Mundhenke, Christoph" uniqKey="Mundhenke C" first="Christoph" last="Mundhenke">Christoph Mundhenke</name><affiliation wicri:level="3"><nlm:aff id="af1-ijwh-7-305">Department of Gynecology and Obstetrics, University Hospitals Schleswig-Holstein, Campus Kiel, Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gynecology and Obstetrics, University Hospitals Schleswig-Holstein, Campus Kiel, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Gunther, Veronika" sort="Gunther, Veronika" uniqKey="Gunther V" first="Veronika" last="Günther">Veronika Günther</name><affiliation wicri:level="3"><nlm:aff id="af1-ijwh-7-305">Department of Gynecology and Obstetrics, University Hospitals Schleswig-Holstein, Campus Kiel, Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gynecology and Obstetrics, University Hospitals Schleswig-Holstein, Campus Kiel, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author></analytic><series><title level="j">International Journal of Women's Health</title><idno type="eISSN">1179-1411</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Epidemiology</title><p>Vulvar cancer can be classified into two groups according to predisposing factors: the first type correlates with a HPV infection and occurs mostly in younger patients. The second group is not HPV associated and occurs often in elderly women without neoplastic epithelial disorders.</p></sec><sec><title>Histology</title><p>Squamous cell carcinoma (SCC) is the most common malignant tumor of the vulva (95%).</p></sec><sec><title>Clinical features</title><p>Pruritus is the most common and long-lasting reported symptom of vulvar cancer, followed by vulvar bleeding, discharge, dysuria, and pain.</p></sec><sec><title>Therapy</title><p>The gold standard for even a small invasive carcinoma of the vulva was historically radical vulvectomy with removal of the tumor with a wide margin followed by an en bloc resection of the inguinal and often the pelvic lymph nodes. Currently, a more individualized and less radical treatment is suggested: a radical wide local excision is possible in the case of localized lesions (T1). A sentinel lymph node (SLN) biopsy may be performed to reduce wound complications and lymphedema.</p></sec><sec><title>Prognosis</title><p>The survival of patients with vulvar cancer is good when convenient therapy is arranged quickly after initial diagnosis. Inguinal and/or femoral node involvement is the most significant prognostic factor for survival.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Siegel, R" uniqKey="Siegel R">R Siegel</name></author><author><name sortKey="Naishadham, D" uniqKey="Naishadham D">D Naishadham</name></author><author><name sortKey="Jemal, A" uniqKey="Jemal A">A Jemal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hunter, Dj" uniqKey="Hunter D">DJ Hunter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gunther, V" uniqKey="Gunther V">V Gunther</name></author><author><name sortKey="Alkatout, I" uniqKey="Alkatout I">I Alkatout</name></author><author><name sortKey="Lez, C" uniqKey="Lez C">C Lez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Way, S" uniqKey="Way S">S Way</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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Jm" uniqKey="Woolderink J">JM Woolderink</name></author><author><name sortKey="De Bock, Gh" uniqKey="De Bock G">GH de Bock</name></author><author><name sortKey="De Hullu, Ja" uniqKey="De Hullu J">JA de Hullu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lupi, G" uniqKey="Lupi G">G Lupi</name></author><author><name sortKey="Raspagliesi, F" uniqKey="Raspagliesi F">F Raspagliesi</name></author><author><name sortKey="Zucali, R" uniqKey="Zucali R">R Zucali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schunke, M" uniqKey="Schunke M">M Schünke</name></author><author><name sortKey="Schulte, E" uniqKey="Schulte E">E Schulte</name></author><author><name sortKey="Schumacher, U" uniqKey="Schumacher U">U Schumacher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beller, U" uniqKey="Beller U">U Beller</name></author><author><name sortKey="Quinn, Ma" uniqKey="Quinn M">MA Quinn</name></author><author><name sortKey="Benedet, Jl" uniqKey="Benedet J">JL Benedet</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Schleswig-Holstein</li></region><settlement><li>Kiel</li></settlement></list><tree><country name="Allemagne"><region name="Schleswig-Holstein"><name sortKey="Alkatout, Ibrahim" sort="Alkatout, Ibrahim" uniqKey="Alkatout I" first="Ibrahim" last="Alkatout">Ibrahim Alkatout</name></region><name sortKey="Garbrecht, Nele" sort="Garbrecht, Nele" uniqKey="Garbrecht N" first="Nele" last="Garbrecht">Nele Garbrecht</name><name sortKey="Gunther, Veronika" sort="Gunther, Veronika" uniqKey="Gunther V" first="Veronika" last="Günther">Veronika Günther</name><name sortKey="Jonat, Walter" sort="Jonat, Walter" uniqKey="Jonat W" first="Walter" last="Jonat">Walter Jonat</name><name sortKey="Mundhenke, Christoph" sort="Mundhenke, Christoph" uniqKey="Mundhenke C" first="Christoph" last="Mundhenke">Christoph Mundhenke</name><name sortKey="Schubert, Melanie" sort="Schubert, Melanie" uniqKey="Schubert M" first="Melanie" last="Schubert">Melanie Schubert</name><name sortKey="Weigel, Marion Tina" sort="Weigel, Marion Tina" uniqKey="Weigel M" first="Marion Tina" last="Weigel">Marion Tina Weigel</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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