Efficacy of AdipoDren® in Reducing Interleukin-1-Induced Lymphatic Endothelial Hyperpermeability
Identifieur interne : 001125 ( Main/Exploration ); précédent : 001124; suivant : 001126Efficacy of AdipoDren® in Reducing Interleukin-1-Induced Lymphatic Endothelial Hyperpermeability
Auteurs : Valerio Ciccone [Italie] ; Martina Monti [Italie] ; Giulia Antonini [Italie] ; Luisa Mattoli [Italie] ; Michela Burico [Italie] ; Francesca Marini [Italie] ; Anna Maidecchi [Italie] ; Lucia Morbidelli [Italie]Source :
- Journal of Vascular Research [ 1018-1172 ] ; 2016.
Descripteurs français
- KwdFr :
- Catalase (métabolisme), Cellules cultivées, Cellules endothéliales (), Cellules endothéliales (métabolisme), Cyclooxygenase 2 (métabolisme), Endothélium lymphatique (), Endothélium lymphatique (métabolisme), Endothélium lymphatique (physiopathologie), Endothélium vasculaire (), Endothélium vasculaire (métabolisme), Extraits de plantes (pharmacologie), Humains, Interleukine-1 bêta (pharmacologie), Jonctions serrées (), Jonctions serrées (métabolisme), Lymphoedème (métabolisme), Lymphoedème (physiopathologie), Lymphoedème (traitement médicamenteux), NADPH oxidase (métabolisme), Occludine (métabolisme), Perméabilité capillaire (), Protéine-1 de la zonula occludens (métabolisme), Préparations à base de plantes (pharmacologie), Relation dose-effet des médicaments, Rutoside (pharmacologie), Superoxide dismutase-1 (métabolisme), Survie cellulaire ().
- MESH :
- métabolisme : Catalase, Cellules endothéliales, Cyclooxygenase 2, Endothélium lymphatique, Endothélium vasculaire, Jonctions serrées, Lymphoedème, NADPH oxidase, Occludine, Protéine-1 de la zonula occludens, Superoxide dismutase-1.
- pharmacologie : Extraits de plantes, Interleukine-1 bêta, Préparations à base de plantes, Rutoside.
- physiopathologie : Endothélium lymphatique, Lymphoedème.
- traitement médicamenteux : Lymphoedème.
- Cellules cultivées, Cellules endothéliales, Endothélium lymphatique, Endothélium vasculaire, Humains, Jonctions serrées, Perméabilité capillaire, Relation dose-effet des médicaments, Survie cellulaire.
English descriptors
- KwdEn :
- Capillary Permeability (drug effects), Catalase (metabolism), Cell Survival (drug effects), Cells, Cultured, Cyclooxygenase 2 (metabolism), Dose-Response Relationship, Drug, Endothelial Cells (drug effects), Endothelial Cells (metabolism), Endothelium, Lymphatic (drug effects), Endothelium, Lymphatic (metabolism), Endothelium, Lymphatic (physiopathology), Endothelium, Vascular (drug effects), Endothelium, Vascular (metabolism), Humans, Interleukin-1beta (pharmacology), Lymphedema (drug therapy), Lymphedema (metabolism), Lymphedema (physiopathology), NADPH Oxidase (metabolism), Occludin (metabolism), Plant Extracts (pharmacology), Plant Preparations (pharmacology), Rutin (pharmacology), Superoxide Dismutase-1 (metabolism), Tight Junctions (drug effects), Tight Junctions (metabolism), Zonula Occludens-1 Protein (metabolism).
- MESH :
- chemical , metabolism : Catalase, Cyclooxygenase 2, NADPH Oxidase, Occludin, Superoxide Dismutase-1, Zonula Occludens-1 Protein.
- drug effects : Capillary Permeability, Cell Survival, Endothelial Cells, Endothelium, Lymphatic, Endothelium, Vascular, Tight Junctions.
- drug therapy : Lymphedema.
- metabolism : Endothelial Cells, Endothelium, Lymphatic, Endothelium, Vascular, Lymphedema, Tight Junctions.
- chemical , pharmacology : Interleukin-1beta, Plant Extracts, Plant Preparations, Rutin.
- physiopathology : Endothelium, Lymphatic, Lymphedema.
- Cells, Cultured, Dose-Response Relationship, Drug, Humans.
Abstract
Lymphatic leakage can be seen as a detrimental phenomenon associated with fluid retention and deposition as well as gain of weight. Moreover, lymphatic dysfunction is associated with an inflammatory environment and can be a substrate for other health conditions. A number of treatments can ameliorate lymphatic vasculature: natural substances have been used as treatment options particularly suitable for their consolidated effectiveness and safety profile. Here we report the protective effect of AdipoDren®, an association of a series of plant-derived natural complexes, on lymphatic endothelium permeability promoted by interleukin-1 beta (IL-1β) and the associated molecular mechanisms. AdipoDren® demonstrated a protective effect on dermal lymphatic endothelial cell permeability increased by IL-1β. Reduced permeability was due to the maintenance of tight junctions and cell-cell localisation of occludin and zonula occludens-1 (ZO-1). Moreover, AdipoDren® reduced the expression of the inflammatory key element cyclooxygenase-2 (COX-2), while not altering the levels of endothelial and inducible nitric oxide synthases (eNOS and iNOS). The upregulation of antioxidant enzymatic systems (catalase and superoxide dismutase-1, SOD-1) and the downregulation of pro-oxidant markers (p22 phox subunit of NADPH oxidase) were also evident. In conclusion, AdipoDren® would be useful to ameliorate conditions of altered lymphatic vasculature and to support the physiological functionality of the lymphatic endothelium.
Url:
DOI: 10.1159/000452798
PubMed: 27923233
PubMed Central: 5348734
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002F99
- to stream Pmc, to step Curation: 002F98
- to stream Pmc, to step Checkpoint: 000A03
- to stream PubMed, to step Corpus: 000482
- to stream PubMed, to step Curation: 000482
- to stream PubMed, to step Checkpoint: 000482
- to stream Ncbi, to step Merge: 008A80
- to stream Ncbi, to step Curation: 008A80
- to stream Ncbi, to step Checkpoint: 008A80
- to stream Main, to step Merge: 001127
- to stream Main, to step Curation: 001125
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Efficacy of AdipoDren® in Reducing Interleukin-1-Induced Lymphatic Endothelial Hyperpermeability</title><author><name sortKey="Ciccone, Valerio" sort="Ciccone, Valerio" uniqKey="Ciccone V" first="Valerio" last="Ciccone">Valerio Ciccone</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Life Sciences, University of Siena, Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Life Sciences, University of Siena, Siena</wicri:regionArea><wicri:noRegion>Siena</wicri:noRegion></affiliation></author><author><name sortKey="Monti, Martina" sort="Monti, Martina" uniqKey="Monti M" first="Martina" last="Monti">Martina Monti</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Life Sciences, University of Siena, Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Life Sciences, University of Siena, Siena</wicri:regionArea><wicri:noRegion>Siena</wicri:noRegion></affiliation></author><author><name sortKey="Antonini, Giulia" sort="Antonini, Giulia" uniqKey="Antonini G" first="Giulia" last="Antonini">Giulia Antonini</name><affiliation wicri:level="1"><nlm:aff id="aff2">Aboca S.p.a. Società Agricola, Sansepolcro, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Aboca S.p.a. Società Agricola, Sansepolcro</wicri:regionArea><wicri:noRegion>Sansepolcro</wicri:noRegion></affiliation></author><author><name sortKey="Mattoli, Luisa" sort="Mattoli, Luisa" uniqKey="Mattoli L" first="Luisa" last="Mattoli">Luisa Mattoli</name><affiliation wicri:level="1"><nlm:aff id="aff2">Aboca S.p.a. Società Agricola, Sansepolcro, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Aboca S.p.a. Società Agricola, Sansepolcro</wicri:regionArea><wicri:noRegion>Sansepolcro</wicri:noRegion></affiliation></author><author><name sortKey="Burico, Michela" sort="Burico, Michela" uniqKey="Burico M" first="Michela" last="Burico">Michela Burico</name><affiliation wicri:level="1"><nlm:aff id="aff2">Aboca S.p.a. Società Agricola, Sansepolcro, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Aboca S.p.a. Società Agricola, Sansepolcro</wicri:regionArea><wicri:noRegion>Sansepolcro</wicri:noRegion></affiliation></author><author><name sortKey="Marini, Francesca" sort="Marini, Francesca" uniqKey="Marini F" first="Francesca" last="Marini">Francesca Marini</name><affiliation wicri:level="1"><nlm:aff id="aff2">Aboca S.p.a. Società Agricola, Sansepolcro, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Aboca S.p.a. Società Agricola, Sansepolcro</wicri:regionArea><wicri:noRegion>Sansepolcro</wicri:noRegion></affiliation></author><author><name sortKey="Maidecchi, Anna" sort="Maidecchi, Anna" uniqKey="Maidecchi A" first="Anna" last="Maidecchi">Anna Maidecchi</name><affiliation wicri:level="1"><nlm:aff id="aff2">Aboca S.p.a. Società Agricola, Sansepolcro, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Aboca S.p.a. Società Agricola, Sansepolcro</wicri:regionArea><wicri:noRegion>Sansepolcro</wicri:noRegion></affiliation></author><author><name sortKey="Morbidelli, Lucia" sort="Morbidelli, Lucia" uniqKey="Morbidelli L" first="Lucia" last="Morbidelli">Lucia Morbidelli</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Life Sciences, University of Siena, Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Life Sciences, University of Siena, Siena</wicri:regionArea><wicri:noRegion>Siena</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27923233</idno><idno type="pmc">5348734</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348734</idno><idno type="RBID">PMC:5348734</idno><idno type="doi">10.1159/000452798</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002F99</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002F99</idno><idno type="wicri:Area/Pmc/Curation">002F98</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002F98</idno><idno type="wicri:Area/Pmc/Checkpoint">000A03</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A03</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000482</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000482</idno><idno type="wicri:Area/PubMed/Curation">000482</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000482</idno><idno type="wicri:Area/PubMed/Checkpoint">000482</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000482</idno><idno type="wicri:Area/Ncbi/Merge">008A80</idno><idno type="wicri:Area/Ncbi/Curation">008A80</idno><idno type="wicri:Area/Ncbi/Checkpoint">008A80</idno><idno type="wicri:doubleKey">1018-1172:2016:Ciccone V:efficacy:of:adipodren</idno><idno type="wicri:Area/Main/Merge">001127</idno><idno type="wicri:Area/Main/Curation">001125</idno><idno type="wicri:Area/Main/Exploration">001125</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Efficacy of AdipoDren® in Reducing Interleukin-1-Induced Lymphatic Endothelial Hyperpermeability</title><author><name sortKey="Ciccone, Valerio" sort="Ciccone, Valerio" uniqKey="Ciccone V" first="Valerio" last="Ciccone">Valerio Ciccone</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Life Sciences, University of Siena, Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Life Sciences, University of Siena, Siena</wicri:regionArea><wicri:noRegion>Siena</wicri:noRegion></affiliation></author><author><name sortKey="Monti, Martina" sort="Monti, Martina" uniqKey="Monti M" first="Martina" last="Monti">Martina Monti</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Life Sciences, University of Siena, Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Life Sciences, University of Siena, Siena</wicri:regionArea><wicri:noRegion>Siena</wicri:noRegion></affiliation></author><author><name sortKey="Antonini, Giulia" sort="Antonini, Giulia" uniqKey="Antonini G" first="Giulia" last="Antonini">Giulia Antonini</name><affiliation wicri:level="1"><nlm:aff id="aff2">Aboca S.p.a. Società Agricola, Sansepolcro, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Aboca S.p.a. Società Agricola, Sansepolcro</wicri:regionArea><wicri:noRegion>Sansepolcro</wicri:noRegion></affiliation></author><author><name sortKey="Mattoli, Luisa" sort="Mattoli, Luisa" uniqKey="Mattoli L" first="Luisa" last="Mattoli">Luisa Mattoli</name><affiliation wicri:level="1"><nlm:aff id="aff2">Aboca S.p.a. Società Agricola, Sansepolcro, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Aboca S.p.a. Società Agricola, Sansepolcro</wicri:regionArea><wicri:noRegion>Sansepolcro</wicri:noRegion></affiliation></author><author><name sortKey="Burico, Michela" sort="Burico, Michela" uniqKey="Burico M" first="Michela" last="Burico">Michela Burico</name><affiliation wicri:level="1"><nlm:aff id="aff2">Aboca S.p.a. Società Agricola, Sansepolcro, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Aboca S.p.a. Società Agricola, Sansepolcro</wicri:regionArea><wicri:noRegion>Sansepolcro</wicri:noRegion></affiliation></author><author><name sortKey="Marini, Francesca" sort="Marini, Francesca" uniqKey="Marini F" first="Francesca" last="Marini">Francesca Marini</name><affiliation wicri:level="1"><nlm:aff id="aff2">Aboca S.p.a. Società Agricola, Sansepolcro, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Aboca S.p.a. Società Agricola, Sansepolcro</wicri:regionArea><wicri:noRegion>Sansepolcro</wicri:noRegion></affiliation></author><author><name sortKey="Maidecchi, Anna" sort="Maidecchi, Anna" uniqKey="Maidecchi A" first="Anna" last="Maidecchi">Anna Maidecchi</name><affiliation wicri:level="1"><nlm:aff id="aff2">Aboca S.p.a. Società Agricola, Sansepolcro, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Aboca S.p.a. Società Agricola, Sansepolcro</wicri:regionArea><wicri:noRegion>Sansepolcro</wicri:noRegion></affiliation></author><author><name sortKey="Morbidelli, Lucia" sort="Morbidelli, Lucia" uniqKey="Morbidelli L" first="Lucia" last="Morbidelli">Lucia Morbidelli</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Life Sciences, University of Siena, Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Life Sciences, University of Siena, Siena</wicri:regionArea><wicri:noRegion>Siena</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Vascular Research</title><idno type="ISSN">1018-1172</idno><idno type="eISSN">1423-0135</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Capillary Permeability (drug effects)</term><term>Catalase (metabolism)</term><term>Cell Survival (drug effects)</term><term>Cells, Cultured</term><term>Cyclooxygenase 2 (metabolism)</term><term>Dose-Response Relationship, Drug</term><term>Endothelial Cells (drug effects)</term><term>Endothelial Cells (metabolism)</term><term>Endothelium, Lymphatic (drug effects)</term><term>Endothelium, Lymphatic (metabolism)</term><term>Endothelium, Lymphatic (physiopathology)</term><term>Endothelium, Vascular (drug effects)</term><term>Endothelium, Vascular (metabolism)</term><term>Humans</term><term>Interleukin-1beta (pharmacology)</term><term>Lymphedema (drug therapy)</term><term>Lymphedema (metabolism)</term><term>Lymphedema (physiopathology)</term><term>NADPH Oxidase (metabolism)</term><term>Occludin (metabolism)</term><term>Plant Extracts (pharmacology)</term><term>Plant Preparations (pharmacology)</term><term>Rutin (pharmacology)</term><term>Superoxide Dismutase-1 (metabolism)</term><term>Tight Junctions (drug effects)</term><term>Tight Junctions (metabolism)</term><term>Zonula Occludens-1 Protein (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Catalase (métabolisme)</term><term>Cellules cultivées</term><term>Cellules endothéliales ()</term><term>Cellules endothéliales (métabolisme)</term><term>Cyclooxygenase 2 (métabolisme)</term><term>Endothélium lymphatique ()</term><term>Endothélium lymphatique (métabolisme)</term><term>Endothélium lymphatique (physiopathologie)</term><term>Endothélium vasculaire ()</term><term>Endothélium vasculaire (métabolisme)</term><term>Extraits de plantes (pharmacologie)</term><term>Humains</term><term>Interleukine-1 bêta (pharmacologie)</term><term>Jonctions serrées ()</term><term>Jonctions serrées (métabolisme)</term><term>Lymphoedème (métabolisme)</term><term>Lymphoedème (physiopathologie)</term><term>Lymphoedème (traitement médicamenteux)</term><term>NADPH oxidase (métabolisme)</term><term>Occludine (métabolisme)</term><term>Perméabilité capillaire ()</term><term>Protéine-1 de la zonula occludens (métabolisme)</term><term>Préparations à base de plantes (pharmacologie)</term><term>Relation dose-effet des médicaments</term><term>Rutoside (pharmacologie)</term><term>Superoxide dismutase-1 (métabolisme)</term><term>Survie cellulaire ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Catalase</term><term>Cyclooxygenase 2</term><term>NADPH Oxidase</term><term>Occludin</term><term>Superoxide Dismutase-1</term><term>Zonula Occludens-1 Protein</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Capillary Permeability</term><term>Cell Survival</term><term>Endothelial Cells</term><term>Endothelium, Lymphatic</term><term>Endothelium, Vascular</term><term>Tight Junctions</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Endothelial Cells</term><term>Endothelium, Lymphatic</term><term>Endothelium, Vascular</term><term>Lymphedema</term><term>Tight Junctions</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Catalase</term><term>Cellules endothéliales</term><term>Cyclooxygenase 2</term><term>Endothélium lymphatique</term><term>Endothélium vasculaire</term><term>Jonctions serrées</term><term>Lymphoedème</term><term>NADPH oxidase</term><term>Occludine</term><term>Protéine-1 de la zonula occludens</term><term>Superoxide dismutase-1</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Extraits de plantes</term><term>Interleukine-1 bêta</term><term>Préparations à base de plantes</term><term>Rutoside</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Interleukin-1beta</term><term>Plant Extracts</term><term>Plant Preparations</term><term>Rutin</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Endothélium lymphatique</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Endothelium, Lymphatic</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cells, Cultured</term><term>Dose-Response Relationship, Drug</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cellules cultivées</term><term>Cellules endothéliales</term><term>Endothélium lymphatique</term><term>Endothélium vasculaire</term><term>Humains</term><term>Jonctions serrées</term><term>Perméabilité capillaire</term><term>Relation dose-effet des médicaments</term><term>Survie cellulaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Lymphatic leakage can be seen as a detrimental phenomenon associated with fluid retention and deposition as well as gain of weight. Moreover, lymphatic dysfunction is associated with an inflammatory environment and can be a substrate for other health conditions. A number of treatments can ameliorate lymphatic vasculature: natural substances have been used as treatment options particularly suitable for their consolidated effectiveness and safety profile. Here we report the protective effect of AdipoDren®, an association of a series of plant-derived natural complexes, on lymphatic endothelium permeability promoted by interleukin-1 beta (IL-1β) and the associated molecular mechanisms. AdipoDren® demonstrated a protective effect on dermal lymphatic endothelial cell permeability increased by IL-1β. Reduced permeability was due to the maintenance of tight junctions and cell-cell localisation of occludin and zonula occludens-1 (ZO-1). Moreover, AdipoDren® reduced the expression of the inflammatory key element cyclooxygenase-2 (COX-2), while not altering the levels of endothelial and inducible nitric oxide synthases (eNOS and iNOS). The upregulation of antioxidant enzymatic systems (catalase and superoxide dismutase-1, SOD-1) and the downregulation of pro-oxidant markers (p22 phox subunit of NADPH oxidase) were also evident. In conclusion, AdipoDren® would be useful to ameliorate conditions of altered lymphatic vasculature and to support the physiological functionality of the lymphatic endothelium.</p></div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Ciccone, Valerio" sort="Ciccone, Valerio" uniqKey="Ciccone V" first="Valerio" last="Ciccone">Valerio Ciccone</name></noRegion><name sortKey="Antonini, Giulia" sort="Antonini, Giulia" uniqKey="Antonini G" first="Giulia" last="Antonini">Giulia Antonini</name><name sortKey="Burico, Michela" sort="Burico, Michela" uniqKey="Burico M" first="Michela" last="Burico">Michela Burico</name><name sortKey="Maidecchi, Anna" sort="Maidecchi, Anna" uniqKey="Maidecchi A" first="Anna" last="Maidecchi">Anna Maidecchi</name><name sortKey="Marini, Francesca" sort="Marini, Francesca" uniqKey="Marini F" first="Francesca" last="Marini">Francesca Marini</name><name sortKey="Mattoli, Luisa" sort="Mattoli, Luisa" uniqKey="Mattoli L" first="Luisa" last="Mattoli">Luisa Mattoli</name><name sortKey="Monti, Martina" sort="Monti, Martina" uniqKey="Monti M" first="Martina" last="Monti">Martina Monti</name><name sortKey="Morbidelli, Lucia" sort="Morbidelli, Lucia" uniqKey="Morbidelli L" first="Lucia" last="Morbidelli">Lucia Morbidelli</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001125 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001125 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:5348734
|texte= Efficacy of AdipoDren® in Reducing Interleukin-1-Induced Lymphatic Endothelial Hyperpermeability
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27923233" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |