Intraoperative molecular analysis of sentinel lymph nodes following neoadjuvant chemotherapy in patients with clinical node negative breast cancer: An institutional study
Identifieur interne : 000F40 ( Main/Exploration ); précédent : 000F39; suivant : 000F41Intraoperative molecular analysis of sentinel lymph nodes following neoadjuvant chemotherapy in patients with clinical node negative breast cancer: An institutional study
Auteurs : David Parada [Espagne] ; Karla B. Pe A [Espagne] ; F. Francesc Riu [Espagne] ; A. Esther Aguilar [Espagne] ; Sebastian Cohan [Espagne]Source :
- Molecular and Clinical Oncology [ 2049-9450 ] ; 2016.
Abstract
Sentinel lymph node biopsy (SLNB) is an accurate, safe method for determining the axillary lymph node status. However, insufficient evidence exists to support the recommendation of SLNB in patients who have had neoadjuvant chemotherapy (NAC) to downsize tumours and allow for breast conservation surgery. The present study aimed to use molecular approaches to evaluate the feasibility and accuracy of SLNB in patients treated with NAC prior to SLN mapping and surgery. A total of 50 consecutive patients with operable invasive breast carcinomas who had received prior NAC were assessed using the one-step nucleic acid amplification (OSNA) method. The rate of SLN identification was 100%. The OSNA assay showed that 29 patients (58%) were negative for SLN and 21 patients (42%) were positive. In 19 of these 21 patients (90.48%), the SLN was the only positive lymph node. No axillary lymph nodes metastases were observed in patients with isolated tumour cells or with micrometastases. The OSNA assay is a highly sensitive, specific and reproducible diagnostic technique that can be used to analyse SLNs following NAC. The total tumoral load may assist with predicting additional non-SLN metastases.
Url:
DOI: 10.3892/mco.2016.1025
PubMed: 27882235
PubMed Central: 5103850
Affiliations:
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Pe A</name><affiliation wicri:level="1"><nlm:aff id="af1-mco-0-0-1025">Department of Pathology, University Hospital Sant Joan de Reus, University Rovira i Virgill, E-43201 Tarragona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pathology, University Hospital Sant Joan de Reus, University Rovira i Virgill, E-43201 Tarragona</wicri:regionArea><wicri:noRegion>E-43201 Tarragona</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-mco-0-0-1025">Pere Virgili Health Research Institute (IISPV), University Rovira i Virgill, E-43201 Tarragona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Pere Virgili Health Research Institute (IISPV), University Rovira i Virgill, E-43201 Tarragona</wicri:regionArea><wicri:noRegion>E-43201 Tarragona</wicri:noRegion></affiliation></author><author><name sortKey="Riu, F Francesc" sort="Riu, F Francesc" uniqKey="Riu F" first="F. Francesc" last="Riu">F. 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Pe A</name><affiliation wicri:level="1"><nlm:aff id="af1-mco-0-0-1025">Department of Pathology, University Hospital Sant Joan de Reus, University Rovira i Virgill, E-43201 Tarragona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pathology, University Hospital Sant Joan de Reus, University Rovira i Virgill, E-43201 Tarragona</wicri:regionArea><wicri:noRegion>E-43201 Tarragona</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-mco-0-0-1025">Pere Virgili Health Research Institute (IISPV), University Rovira i Virgill, E-43201 Tarragona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Pere Virgili Health Research Institute (IISPV), University Rovira i Virgill, E-43201 Tarragona</wicri:regionArea><wicri:noRegion>E-43201 Tarragona</wicri:noRegion></affiliation></author><author><name sortKey="Riu, F Francesc" sort="Riu, F Francesc" uniqKey="Riu F" first="F. Francesc" last="Riu">F. Francesc Riu</name><affiliation wicri:level="1"><nlm:aff id="af1-mco-0-0-1025">Department of Pathology, University Hospital Sant Joan de Reus, University Rovira i Virgill, E-43201 Tarragona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pathology, University Hospital Sant Joan de Reus, University Rovira i Virgill, E-43201 Tarragona</wicri:regionArea><wicri:noRegion>E-43201 Tarragona</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-mco-0-0-1025">Pere Virgili Health Research Institute (IISPV), University Rovira i Virgill, E-43201 Tarragona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Pere Virgili Health Research Institute (IISPV), University Rovira i Virgill, E-43201 Tarragona</wicri:regionArea><wicri:noRegion>E-43201 Tarragona</wicri:noRegion></affiliation></author><author><name sortKey="Aguilar, A Esther" sort="Aguilar, A Esther" uniqKey="Aguilar A" first="A. Esther" last="Aguilar">A. Esther Aguilar</name><affiliation wicri:level="1"><nlm:aff id="af3-mco-0-0-1025">Department of Gynecology, University Hospital Sant Joan de Reus, E-43204 Tarragona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Gynecology, University Hospital Sant Joan de Reus, E-43204 Tarragona</wicri:regionArea><wicri:noRegion>E-43204 Tarragona</wicri:noRegion></affiliation></author><author><name sortKey="Cohan, Sebastian" sort="Cohan, Sebastian" uniqKey="Cohan S" first="Sebastian" last="Cohan">Sebastian Cohan</name><affiliation wicri:level="1"><nlm:aff id="af4-mco-0-0-1025">Department of Radiodiagnostics, University Hospital Sant Joan de Reus, E-43204 Tarragona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Radiodiagnostics, University Hospital Sant Joan de Reus, E-43204 Tarragona</wicri:regionArea><wicri:noRegion>E-43204 Tarragona</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecular and Clinical Oncology</title><idno type="ISSN">2049-9450</idno><idno type="eISSN">2049-9469</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Sentinel lymph node biopsy (SLNB) is an accurate, safe method for determining the axillary lymph node status. However, insufficient evidence exists to support the recommendation of SLNB in patients who have had neoadjuvant chemotherapy (NAC) to downsize tumours and allow for breast conservation surgery. The present study aimed to use molecular approaches to evaluate the feasibility and accuracy of SLNB in patients treated with NAC prior to SLN mapping and surgery. A total of 50 consecutive patients with operable invasive breast carcinomas who had received prior NAC were assessed using the one-step nucleic acid amplification (OSNA) method. The rate of SLN identification was 100%. The OSNA assay showed that 29 patients (58%) were negative for SLN and 21 patients (42%) were positive. In 19 of these 21 patients (90.48%), the SLN was the only positive lymph node. No axillary lymph nodes metastases were observed in patients with isolated tumour cells or with micrometastases. The OSNA assay is a highly sensitive, specific and reproducible diagnostic technique that can be used to analyse SLNs following NAC. The total tumoral load may assist with predicting additional non-SLN metastases.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lyman, Gh" uniqKey="Lyman G">GH Lyman</name></author><author><name sortKey="Temin, S" uniqKey="Temin S">S Temin</name></author><author><name sortKey="Edge, Sb" uniqKey="Edge S">SB Edge</name></author><author><name sortKey="Newman, La" uniqKey="Newman L">LA Newman</name></author><author><name sortKey="Turner, Rr" uniqKey="Turner R">RR Turner</name></author><author><name sortKey="Weaver, Dl" uniqKey="Weaver D">DL Weaver</name></author><author><name sortKey="Benson, Ab" uniqKey="Benson A">AB Benson</name></author><author><name sortKey="Bosserman, Ld" uniqKey="Bosserman L">LD Bosserman</name></author><author><name sortKey="Burstein, Hj" uniqKey="Burstein H">HJ Burstein</name></author><author><name sortKey="Cody, H" uniqKey="Cody H">H 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sortKey="Giard, S" uniqKey="Giard S">S Giard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buchholz, Ta" uniqKey="Buchholz T">TA Buchholz</name></author><author><name sortKey="Lehman, Cd" uniqKey="Lehman C">CD Lehman</name></author><author><name sortKey="Harris, Jr" uniqKey="Harris J">JR Harris</name></author><author><name sortKey="Pockaj, Ba" uniqKey="Pockaj B">BA Pockaj</name></author><author><name sortKey="Khouri, N" uniqKey="Khouri N">N Khouri</name></author><author><name sortKey="Hylton, Nf" uniqKey="Hylton N">NF Hylton</name></author><author><name sortKey="Miller, Mj" uniqKey="Miller M">MJ Miller</name></author><author><name sortKey="Whelan, T" uniqKey="Whelan T">T Whelan</name></author><author><name sortKey="Pierce, Lj" uniqKey="Pierce L">LJ Pierce</name></author><author><name sortKey="Esserman, Lj" uniqKey="Esserman L">LJ Esserman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ohi, Y" uniqKey="Ohi Y">Y 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Diaz</name></author><author><name sortKey="Hardisson, D" uniqKey="Hardisson D">D Hardisson</name></author><author><name sortKey="Sagasta, A" uniqKey="Sagasta A">A Sagasta</name></author><author><name sortKey="Due As, B" uniqKey="Due As B">B Dueñas</name></author><author><name sortKey="Peg, V" uniqKey="Peg V">V Peg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Espinosa Bravo, M" uniqKey="Espinosa Bravo M">M Espinosa-Bravo</name></author><author><name sortKey="Sansano, I" uniqKey="Sansano I">I Sansano</name></author><author><name sortKey="Perez Hoyos, S" uniqKey="Perez Hoyos S">S Pérez-Hoyos</name></author><author><name sortKey="Ramos, M" uniqKey="Ramos M">M Ramos</name></author><author><name sortKey="Sancho, M" uniqKey="Sancho M">M Sancho</name></author><author><name sortKey="Xercavins, J" uniqKey="Xercavins J">J Xercavins</name></author><author><name sortKey="Rubio, It" uniqKey="Rubio I">IT Rubio</name></author><author><name sortKey="Peg, V" uniqKey="Peg V">V Peg</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Espagne</li></country></list><tree><country name="Espagne"><noRegion><name sortKey="Parada, David" sort="Parada, David" uniqKey="Parada D" first="David" last="Parada">David Parada</name></noRegion><name sortKey="Aguilar, A Esther" sort="Aguilar, A Esther" uniqKey="Aguilar A" first="A. Esther" last="Aguilar">A. Esther Aguilar</name><name sortKey="Cohan, Sebastian" sort="Cohan, Sebastian" uniqKey="Cohan S" first="Sebastian" last="Cohan">Sebastian Cohan</name><name sortKey="Parada, David" sort="Parada, David" uniqKey="Parada D" first="David" last="Parada">David Parada</name><name sortKey="Pe A, Karla B" sort="Pe A, Karla B" uniqKey="Pe A K" first="Karla B." last="Pe A">Karla B. Pe A</name><name sortKey="Pe A, Karla B" sort="Pe A, Karla B" uniqKey="Pe A K" first="Karla B." last="Pe A">Karla B. Pe A</name><name sortKey="Riu, F Francesc" sort="Riu, F Francesc" uniqKey="Riu F" first="F. Francesc" last="Riu">F. Francesc Riu</name><name sortKey="Riu, F Francesc" sort="Riu, F Francesc" uniqKey="Riu F" first="F. Francesc" last="Riu">F. Francesc Riu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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