Long-term Follow-up Data from Pivotal Studies of Adjuvant Trastuzumab in Early Breast Cancer
Identifieur interne : 000E89 ( Main/Exploration ); précédent : 000E88; suivant : 000E90Long-term Follow-up Data from Pivotal Studies of Adjuvant Trastuzumab in Early Breast Cancer
Auteurs : Hartmut Kristeleit [Royaume-Uni] ; Marina Parton [Royaume-Uni] ; Mark Beresford [Royaume-Uni] ; Iain R. Macpherson [Royaume-Uni] ; Rajan Sharma [Royaume-Uni] ; Loren Lazarus [Royaume-Uni] ; Muireann Kelleher [Royaume-Uni]Source :
- Targeted Oncology [ 1776-2596 ] ; 2016.
Abstract
The addition of adjuvant trastuzumab therapy for 1 year to standard chemotherapy significantly improved disease-free survival and overall survival versus chemotherapy alone in a number of pivotal early breast cancer studies. Here we review long-term follow-up data on the efficacy, cardiac safety, and general safety of trastuzumab in these pivotal studies. We also evaluate ongoing phase II/III adjuvant trials with newer HER2-targeted agents and the efficacy and safety of the recently developed subcutaneous (SC) formulation of trastuzumab in early breast cancer. Long-term follow-up data confirm the significant survival benefit afforded by the addition of trastuzumab to chemotherapy in patients with HER2-positive disease, with an acceptable safety profile. Long-term cardiac safety data suggest that the incidence of cardiac adverse events is maintained at a relatively low level with continued follow-up. At this present time, 1 year of trastuzumab treatment remains the standard of care in HER2-positive early breast cancer. Future adjuvant trastuzumab treatment strategies should focus on reducing cardiotoxicity, particularly in elderly patients, by identifying potential predictive biomarkers of cardiac dysfunction. Clinicians must also decide whether to omit trastuzumab in women who would achieve little benefit from treatment to avoid cardiotoxicity.
Url:
DOI: 10.1007/s11523-016-0438-5
PubMed: 27181019
PubMed Central: 5054055
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000E83
- to stream Pmc, to step Curation: 000E82
- to stream Pmc, to step Checkpoint: 000833
- to stream Ncbi, to step Merge: 008293
- to stream Ncbi, to step Curation: 008293
- to stream Ncbi, to step Checkpoint: 008293
- to stream Main, to step Merge: 000E91
- to stream Main, to step Curation: 000E89
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Long-term Follow-up Data from Pivotal Studies of Adjuvant Trastuzumab in Early Breast Cancer</title><author><name sortKey="Kristeleit, Hartmut" sort="Kristeleit, Hartmut" uniqKey="Kristeleit H" first="Hartmut" last="Kristeleit">Hartmut Kristeleit</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Guy’s and St Thomas’ NHS Foundation Trust, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Guy’s and St Thomas’ NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Parton, Marina" sort="Parton, Marina" uniqKey="Parton M" first="Marina" last="Parton">Marina Parton</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Royal Marsden NHS Foundation Trust and Kingston NHS Foundation Trust, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Marsden NHS Foundation Trust and Kingston NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Beresford, Mark" sort="Beresford, Mark" uniqKey="Beresford M" first="Mark" last="Beresford">Mark Beresford</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Royal United Hospital, Bath, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal United Hospital, Bath</wicri:regionArea><wicri:noRegion>Bath</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff4">Bath University, Bath, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Bath University, Bath</wicri:regionArea><wicri:noRegion>Bath</wicri:noRegion></affiliation></author><author><name sortKey="Macpherson, Iain R" sort="Macpherson, Iain R" uniqKey="Macpherson I" first="Iain R." last="Macpherson">Iain R. Macpherson</name><affiliation wicri:level="1"><nlm:aff id="Aff5">Beatson West of Scotland Cancer Centre, Glasgow, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Beatson West of Scotland Cancer Centre, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Rajan" sort="Sharma, Rajan" uniqKey="Sharma R" first="Rajan" last="Sharma">Rajan Sharma</name><affiliation wicri:level="3"><nlm:aff id="Aff6">St George’s Hospital NHS Trust, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>St George’s Hospital NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lazarus, Loren" sort="Lazarus, Loren" uniqKey="Lazarus L" first="Loren" last="Lazarus">Loren Lazarus</name><affiliation wicri:level="1"><nlm:aff id="Aff7">Roche Products Ltd, Welwyn Garden City, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Roche Products Ltd, Welwyn Garden City</wicri:regionArea><wicri:noRegion>Welwyn Garden City</wicri:noRegion></affiliation></author><author><name sortKey="Kelleher, Muireann" sort="Kelleher, Muireann" uniqKey="Kelleher M" first="Muireann" last="Kelleher">Muireann Kelleher</name><affiliation wicri:level="3"><nlm:aff id="Aff6">St George’s Hospital NHS Trust, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>St George’s Hospital NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27181019</idno><idno type="pmc">5054055</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054055</idno><idno type="RBID">PMC:5054055</idno><idno type="doi">10.1007/s11523-016-0438-5</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000E83</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000E83</idno><idno type="wicri:Area/Pmc/Curation">000E82</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000E82</idno><idno type="wicri:Area/Pmc/Checkpoint">000833</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000833</idno><idno type="wicri:Area/Ncbi/Merge">008293</idno><idno type="wicri:Area/Ncbi/Curation">008293</idno><idno type="wicri:Area/Ncbi/Checkpoint">008293</idno><idno type="wicri:doubleKey">1776-2596:2016:Kristeleit H:long:term:follow</idno><idno type="wicri:Area/Main/Merge">000E91</idno><idno type="wicri:Area/Main/Curation">000E89</idno><idno type="wicri:Area/Main/Exploration">000E89</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Long-term Follow-up Data from Pivotal Studies of Adjuvant Trastuzumab in Early Breast Cancer</title><author><name sortKey="Kristeleit, Hartmut" sort="Kristeleit, Hartmut" uniqKey="Kristeleit H" first="Hartmut" last="Kristeleit">Hartmut Kristeleit</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Guy’s and St Thomas’ NHS Foundation Trust, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Guy’s and St Thomas’ NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Parton, Marina" sort="Parton, Marina" uniqKey="Parton M" first="Marina" last="Parton">Marina Parton</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Royal Marsden NHS Foundation Trust and Kingston NHS Foundation Trust, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Marsden NHS Foundation Trust and Kingston NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Beresford, Mark" sort="Beresford, Mark" uniqKey="Beresford M" first="Mark" last="Beresford">Mark Beresford</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Royal United Hospital, Bath, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal United Hospital, Bath</wicri:regionArea><wicri:noRegion>Bath</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff4">Bath University, Bath, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Bath University, Bath</wicri:regionArea><wicri:noRegion>Bath</wicri:noRegion></affiliation></author><author><name sortKey="Macpherson, Iain R" sort="Macpherson, Iain R" uniqKey="Macpherson I" first="Iain R." last="Macpherson">Iain R. Macpherson</name><affiliation wicri:level="1"><nlm:aff id="Aff5">Beatson West of Scotland Cancer Centre, Glasgow, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Beatson West of Scotland Cancer Centre, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Rajan" sort="Sharma, Rajan" uniqKey="Sharma R" first="Rajan" last="Sharma">Rajan Sharma</name><affiliation wicri:level="3"><nlm:aff id="Aff6">St George’s Hospital NHS Trust, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>St George’s Hospital NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lazarus, Loren" sort="Lazarus, Loren" uniqKey="Lazarus L" first="Loren" last="Lazarus">Loren Lazarus</name><affiliation wicri:level="1"><nlm:aff id="Aff7">Roche Products Ltd, Welwyn Garden City, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Roche Products Ltd, Welwyn Garden City</wicri:regionArea><wicri:noRegion>Welwyn Garden City</wicri:noRegion></affiliation></author><author><name sortKey="Kelleher, Muireann" sort="Kelleher, Muireann" uniqKey="Kelleher M" first="Muireann" last="Kelleher">Muireann Kelleher</name><affiliation wicri:level="3"><nlm:aff id="Aff6">St George’s Hospital NHS Trust, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>St George’s Hospital NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j">Targeted Oncology</title><idno type="ISSN">1776-2596</idno><idno type="eISSN">1776-260X</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The addition of adjuvant trastuzumab therapy for 1 year to standard chemotherapy significantly improved disease-free survival and overall survival versus chemotherapy alone in a number of pivotal early breast cancer studies. Here we review long-term follow-up data on the efficacy, cardiac safety, and general safety of trastuzumab in these pivotal studies. We also evaluate ongoing phase II/III adjuvant trials with newer HER2-targeted agents and the efficacy and safety of the recently developed subcutaneous (SC) formulation of trastuzumab in early breast cancer. Long-term follow-up data confirm the significant survival benefit afforded by the addition of trastuzumab to chemotherapy in patients with HER2-positive disease, with an acceptable safety profile. Long-term cardiac safety data suggest that the incidence of cardiac adverse events is maintained at a relatively low level with continued follow-up. At this present time, 1 year of trastuzumab treatment remains the standard of care in HER2-positive early breast cancer. Future adjuvant trastuzumab treatment strategies should focus on reducing cardiotoxicity, particularly in elderly patients, by identifying potential predictive biomarkers of cardiac dysfunction. Clinicians must also decide whether to omit trastuzumab in women who would achieve little benefit from treatment to avoid cardiotoxicity.<graphic position="anchor" xlink:href="11523_2016_438_Figa_HTML" id="d30e248"></graphic></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Schechter, Al" uniqKey="Schechter A">AL Schechter</name></author><author><name sortKey="Stern, Df" uniqKey="Stern D">DF Stern</name></author><author><name sortKey="Vaidyanathan, L" uniqKey="Vaidyanathan L">L Vaidyanathan</name></author><author><name sortKey="Decker, Sj" uniqKey="Decker S">SJ Decker</name></author><author><name sortKey="Drebin, Ja" uniqKey="Drebin J">JA Drebin</name></author><author><name sortKey="Greene, Mi" uniqKey="Greene M">MI Greene</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coussens, L" uniqKey="Coussens L">L Coussens</name></author><author><name sortKey="Yang Feng, Tl" uniqKey="Yang Feng T">TL Yang-Feng</name></author><author><name sortKey="Liao, Yc" uniqKey="Liao Y">YC Liao</name></author><author><name sortKey="Chen, E" uniqKey="Chen E">E Chen</name></author><author><name sortKey="Gray, A" uniqKey="Gray A">A Gray</name></author><author><name sortKey="Mcgrath, J" uniqKey="Mcgrath J">J McGrath</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Slamon, Dj" uniqKey="Slamon D">DJ Slamon</name></author><author><name sortKey="Clark, Gm" uniqKey="Clark G">GM Clark</name></author><author><name sortKey="Wong, Sg" uniqKey="Wong S">SG Wong</name></author><author><name sortKey="Levin, Wj" uniqKey="Levin W">WJ Levin</name></author><author><name sortKey="Ullrich, A" uniqKey="Ullrich A">A Ullrich</name></author><author><name sortKey="Mcguire, Wl" uniqKey="Mcguire W">WL McGuire</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shalaby, Mr" uniqKey="Shalaby M">MR Shalaby</name></author><author><name sortKey="Shepard, Hm" uniqKey="Shepard H">HM Shepard</name></author><author><name sortKey="Presta, L" uniqKey="Presta L">L Presta</name></author><author><name sortKey="Rodrigues, Ml" uniqKey="Rodrigues M">ML Rodrigues</name></author><author><name sortKey="Beverley, Pc" uniqKey="Beverley P">PC Beverley</name></author><author><name sortKey="Feldmann, M" uniqKey="Feldmann M">M Feldmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Slamon, Dj" uniqKey="Slamon D">DJ Slamon</name></author><author><name sortKey="Leyland Jones, B" uniqKey="Leyland Jones B">B Leyland-Jones</name></author><author><name sortKey="Shak, S" uniqKey="Shak S">S Shak</name></author><author><name sortKey="Fuchs, H" uniqKey="Fuchs H">H Fuchs</name></author><author><name sortKey="Paton, V" uniqKey="Paton V">V Paton</name></author><author><name sortKey="Bajamonde, A" uniqKey="Bajamonde A">A Bajamonde</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marty, M" uniqKey="Marty M">M Marty</name></author><author><name sortKey="Cognetti, F" uniqKey="Cognetti F">F Cognetti</name></author><author><name sortKey="Maraninchi, D" uniqKey="Maraninchi D">D Maraninchi</name></author><author><name sortKey="Snyder, R" uniqKey="Snyder R">R Snyder</name></author><author><name sortKey="Mauriac, L" uniqKey="Mauriac L">L Mauriac</name></author><author><name sortKey="Tubiana Hulin, M" uniqKey="Tubiana Hulin M">M Tubiana-Hulin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bechmann, T" uniqKey="Bechmann T">T Bechmann</name></author><author><name sortKey="Olsen, Da" uniqKey="Olsen D">DA Olsen</name></author><author><name sortKey="Jakobsen, Eh" uniqKey="Jakobsen E">EH Jakobsen</name></author><author><name sortKey="Madsen, Js" uniqKey="Madsen J">JS Madsen</name></author><author><name sortKey="Brandslund, I" uniqKey="Brandslund I">I Brandslund</name></author><author><name sortKey="Jylling, Am" uniqKey="Jylling A">AM Jylling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Slamon, Dj" uniqKey="Slamon D">DJ Slamon</name></author><author><name sortKey="Godolphin, W" uniqKey="Godolphin W">W Godolphin</name></author><author><name sortKey="Jones, La" uniqKey="Jones L">LA Jones</name></author><author><name sortKey="Holt, Ja" uniqKey="Holt J">JA Holt</name></author><author><name sortKey="Wong, Sg" uniqKey="Wong S">SG Wong</name></author><author><name sortKey="Keith, De" uniqKey="Keith D">DE Keith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Piccart Gebhart, Mj" uniqKey="Piccart Gebhart M">MJ Piccart-Gebhart</name></author><author><name sortKey="Procter, M" uniqKey="Procter M">M Procter</name></author><author><name sortKey="Leyland Jones, B" uniqKey="Leyland Jones B">B Leyland-Jones</name></author><author><name sortKey="Goldhirsch, A" uniqKey="Goldhirsch A">A Goldhirsch</name></author><author><name sortKey="Untch, M" uniqKey="Untch M">M Untch</name></author><author><name sortKey="Smith, I" uniqKey="Smith I">I Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Romond, Eh" uniqKey="Romond E">EH Romond</name></author><author><name sortKey="Perez, Ea" uniqKey="Perez E">EA Perez</name></author><author><name sortKey="Bryant, J" uniqKey="Bryant J">J Bryant</name></author><author><name sortKey="Suman, Vj" uniqKey="Suman V">VJ Suman</name></author><author><name sortKey="Geyer, Ce" uniqKey="Geyer C">CE Geyer</name></author><author><name sortKey="Davidson, Ne" uniqKey="Davidson N">NE Davidson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, I" uniqKey="Smith I">I Smith</name></author><author><name sortKey="Procter, M" uniqKey="Procter M">M Procter</name></author><author><name sortKey="Gelber, Rd" uniqKey="Gelber R">RD Gelber</name></author><author><name sortKey="Guillaume, S" uniqKey="Guillaume S">S Guillaume</name></author><author><name sortKey="Feyereislova, A" uniqKey="Feyereislova A">A Feyereislova</name></author><author><name sortKey="Dowsett, M" uniqKey="Dowsett M">M Dowsett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Slamon, D" uniqKey="Slamon D">D Slamon</name></author><author><name sortKey="Eiermann, W" uniqKey="Eiermann W">W Eiermann</name></author><author><name sortKey="Robert, N" uniqKey="Robert N">N Robert</name></author><author><name sortKey="Pienkowski, T" uniqKey="Pienkowski T">T Pienkowski</name></author><author><name sortKey="Martin, M" uniqKey="Martin M">M Martin</name></author><author><name sortKey="Press, M" uniqKey="Press M">M Press</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gianni, L" uniqKey="Gianni L">L Gianni</name></author><author><name sortKey="Eiermann, W" uniqKey="Eiermann W">W Eiermann</name></author><author><name sortKey="Semiglazov, V" uniqKey="Semiglazov V">V Semiglazov</name></author><author><name sortKey="Manikhas, A" uniqKey="Manikhas A">A Manikhas</name></author><author><name sortKey="Lluch, A" uniqKey="Lluch A">A Lluch</name></author><author><name sortKey="Tjulandin, S" uniqKey="Tjulandin S">S Tjulandin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goldhirsch, A" uniqKey="Goldhirsch A">A Goldhirsch</name></author><author><name sortKey="Gelber, Rd" uniqKey="Gelber R">RD Gelber</name></author><author><name sortKey="Piccart Gebhart, Mj" uniqKey="Piccart Gebhart M">MJ Piccart-Gebhart</name></author><author><name sortKey="De Azambuja, E" uniqKey="De Azambuja E">E de Azambuja</name></author><author><name sortKey="Procter, M" uniqKey="Procter M">M Procter</name></author><author><name sortKey="Suter, Tm" uniqKey="Suter T">TM Suter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perez, Ea" uniqKey="Perez E">EA Perez</name></author><author><name sortKey="Romond, Eh" uniqKey="Romond E">EH Romond</name></author><author><name sortKey="Suman, Vj" uniqKey="Suman V">VJ Suman</name></author><author><name sortKey="Jeong, Jh" uniqKey="Jeong J">JH Jeong</name></author><author><name sortKey="Davidson, Ne" uniqKey="Davidson N">NE Davidson</name></author><author><name sortKey="Geyer, Ce" uniqKey="Geyer C">CE Geyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perez, Ea" uniqKey="Perez E">EA Perez</name></author><author><name sortKey="Romond, Eh" uniqKey="Romond E">EH Romond</name></author><author><name sortKey="Suman, Vj" uniqKey="Suman V">VJ Suman</name></author><author><name sortKey="Jeong, Jh" uniqKey="Jeong J">JH Jeong</name></author><author><name sortKey="Sledge, G" uniqKey="Sledge G">G Sledge</name></author><author><name sortKey="Geyer, Ce" uniqKey="Geyer C">CE Geyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perez, Ea" uniqKey="Perez E">EA Perez</name></author><author><name sortKey="Suman, Vj" uniqKey="Suman V">VJ Suman</name></author><author><name sortKey="Davidson, Ne" uniqKey="Davidson N">NE Davidson</name></author><author><name sortKey="Gralow, Jr" uniqKey="Gralow J">JR Gralow</name></author><author><name sortKey="Kaufman, Pa" uniqKey="Kaufman P">PA Kaufman</name></author><author><name sortKey="Visscher, Dw" uniqKey="Visscher D">DW Visscher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gianni, L" uniqKey="Gianni L">L Gianni</name></author><author><name sortKey="Eiermann, W" uniqKey="Eiermann W">W Eiermann</name></author><author><name sortKey="Semiglazov, V" uniqKey="Semiglazov V">V Semiglazov</name></author><author><name sortKey="Lluch, A" uniqKey="Lluch A">A Lluch</name></author><author><name sortKey="Tjulandin, S" uniqKey="Tjulandin S">S Tjulandin</name></author><author><name sortKey="Zambetti, M" uniqKey="Zambetti M">M Zambetti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Joensuu, H" uniqKey="Joensuu H">H Joensuu</name></author><author><name sortKey="Kellokumpu Lehtinen, Pl" uniqKey="Kellokumpu Lehtinen P">PL Kellokumpu-Lehtinen</name></author><author><name sortKey="Bono, P" uniqKey="Bono P">P Bono</name></author><author><name sortKey="Alanko, T" uniqKey="Alanko T">T Alanko</name></author><author><name sortKey="Kataja, V" uniqKey="Kataja V">V Kataja</name></author><author><name sortKey="Asola, R" uniqKey="Asola R">R Asola</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Joensuu, H" uniqKey="Joensuu H">H Joensuu</name></author><author><name sortKey="Bono, P" uniqKey="Bono P">P Bono</name></author><author><name sortKey="Kataja, V" uniqKey="Kataja V">V Kataja</name></author><author><name sortKey="Alanko, T" uniqKey="Alanko T">T Alanko</name></author><author><name sortKey="Kokko, R" uniqKey="Kokko R">R Kokko</name></author><author><name sortKey="Asola, R" uniqKey="Asola R">R Asola</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pivot, X" uniqKey="Pivot X">X Pivot</name></author><author><name sortKey="Romieu, G" uniqKey="Romieu G">G Romieu</name></author><author><name sortKey="Debled, M" uniqKey="Debled M">M Debled</name></author><author><name sortKey="Pierga, Jy" uniqKey="Pierga J">JY Pierga</name></author><author><name sortKey="Kerbrat, P" uniqKey="Kerbrat P">P Kerbrat</name></author><author><name sortKey="Bachelot, T" uniqKey="Bachelot T">T Bachelot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spielmann, M" uniqKey="Spielmann M">M Spielmann</name></author><author><name sortKey="Roche, H" uniqKey="Roche H">H Roché</name></author><author><name sortKey="Delozier, T" uniqKey="Delozier T">T Delozier</name></author><author><name sortKey="Canon, Jl" uniqKey="Canon J">JL Canon</name></author><author><name sortKey="Romieu, G" uniqKey="Romieu G">G Romieu</name></author><author><name sortKey="Bourgeois, H" uniqKey="Bourgeois H">H Bourgeois</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seidman, A" uniqKey="Seidman A">A Seidman</name></author><author><name sortKey="Hudis, C" uniqKey="Hudis C">C Hudis</name></author><author><name sortKey="Pierri, Mk" uniqKey="Pierri M">MK Pierri</name></author><author><name sortKey="Shak, S" uniqKey="Shak S">S Shak</name></author><author><name sortKey="Paton, V" uniqKey="Paton V">V Paton</name></author><author><name sortKey="Ashby, M" uniqKey="Ashby M">M Ashby</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Swain, Sm" uniqKey="Swain S">SM Swain</name></author><author><name sortKey="Ewer, Ms" uniqKey="Ewer M">MS Ewer</name></author><author><name sortKey="Cortes, J" uniqKey="Cortes J">J Cortés</name></author><author><name sortKey="Amadori, D" uniqKey="Amadori D">D Amadori</name></author><author><name sortKey="Miles, D" uniqKey="Miles D">D Miles</name></author><author><name sortKey="Knott, A" uniqKey="Knott A">A Knott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sendur, Ma" uniqKey="Sendur M">MA Sendur</name></author><author><name sortKey="Aksoy, S" uniqKey="Aksoy S">S Aksoy</name></author><author><name sortKey="Yorgun, H" uniqKey="Yorgun H">H Yorgun</name></author><author><name sortKey="Ozdemir, N" uniqKey="Ozdemir N">N Ozdemir</name></author><author><name sortKey="Yilmaz, Fm" uniqKey="Yilmaz F">FM Yilmaz</name></author><author><name sortKey="Yaz C, O" uniqKey="Yaz C O">O Yazıcı</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, Af" uniqKey="Yu A">AF Yu</name></author><author><name sortKey="Yadav, Nu" uniqKey="Yadav N">NU Yadav</name></author><author><name sortKey="Lung, By" uniqKey="Lung B">BY Lung</name></author><author><name sortKey="Eaton, Aa" uniqKey="Eaton A">AA Eaton</name></author><author><name sortKey="Thaler, Ht" uniqKey="Thaler H">HT Thaler</name></author><author><name sortKey="Hudis, Ca" uniqKey="Hudis C">CA Hudis</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Jones, Al" uniqKey="Jones A">AL Jones</name></author><author><name sortKey="Barlow, M" uniqKey="Barlow M">M Barlow</name></author><author><name sortKey="Barrett Lee, Pj" uniqKey="Barrett Lee P">PJ Barrett-Lee</name></author><author><name sortKey="Canney, Pa" uniqKey="Canney P">PA Canney</name></author><author><name sortKey="Gilmour, Im" uniqKey="Gilmour I">IM Gilmour</name></author><author><name sortKey="Robb, Sd" uniqKey="Robb S">SD Robb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Curigliano, G" uniqKey="Curigliano G">G Curigliano</name></author><author><name sortKey="Cardinale, D" uniqKey="Cardinale D">D Cardinale</name></author><author><name sortKey="Suter, T" uniqKey="Suter T">T Suter</name></author><author><name sortKey="Plataniotis, G" uniqKey="Plataniotis G">G Plataniotis</name></author><author><name sortKey="De Azambuja, E" uniqKey="De Azambuja E">E de Azambuja</name></author><author><name sortKey="Sandri, Mt" uniqKey="Sandri M">MT Sandri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ismael, G" uniqKey="Ismael G">G Ismael</name></author><author><name sortKey="Hegg, R" uniqKey="Hegg R">R Hegg</name></author><author><name sortKey="Muehlbauer, S" uniqKey="Muehlbauer S">S Muehlbauer</name></author><author><name sortKey="Heinzmann, D" uniqKey="Heinzmann D">D Heinzmann</name></author><author><name sortKey="Lum, B" uniqKey="Lum B">B Lum</name></author><author><name sortKey="Kim, Sb" uniqKey="Kim S">SB Kim</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Pivot, X" uniqKey="Pivot X">X Pivot</name></author><author><name sortKey="Gligorov, J" uniqKey="Gligorov J">J Gligorov</name></author><author><name sortKey="Muller, V" uniqKey="Muller V">V Müller</name></author><author><name sortKey="Barrett Lee, P" uniqKey="Barrett Lee P">P Barrett-Lee</name></author><author><name sortKey="Verma, S" uniqKey="Verma S">S Verma</name></author><author><name sortKey="Knoop, A" uniqKey="Knoop A">A Knoop</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pivot, X" uniqKey="Pivot X">X Pivot</name></author><author><name sortKey="Gligorov, J" uniqKey="Gligorov J">J Gligorov</name></author><author><name sortKey="Muller, V" uniqKey="Muller V">V Müller</name></author><author><name sortKey="Curigliano, G" uniqKey="Curigliano G">G Curigliano</name></author><author><name sortKey="Knoop, A" uniqKey="Knoop A">A Knoop</name></author><author><name sortKey="Verma, S" uniqKey="Verma S">S Verma</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Pinto, Ac" uniqKey="Pinto A">AC Pinto</name></author><author><name sortKey="Ades, F" uniqKey="Ades F">F Ades</name></author><author><name sortKey="De Azambuja, E" uniqKey="De Azambuja E">E de Azambuja</name></author><author><name sortKey="Piccart Gebhart, M" uniqKey="Piccart Gebhart M">M Piccart-Gebhart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mavroudis, D" uniqKey="Mavroudis D">D Mavroudis</name></author><author><name sortKey="Saloustros, E" uniqKey="Saloustros E">E Saloustros</name></author><author><name sortKey="Malamos, N" uniqKey="Malamos N">N Malamos</name></author><author><name sortKey="Kakolyris, S" uniqKey="Kakolyris S">S Kakolyris</name></author><author><name sortKey="Boukovinas, I" uniqKey="Boukovinas I">I Boukovinas</name></author><author><name sortKey="Papakotoulas, P" uniqKey="Papakotoulas P">P Papakotoulas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arteaga, Cl" uniqKey="Arteaga C">CL Arteaga</name></author><author><name sortKey="Sliwkowski, Mx" uniqKey="Sliwkowski M">MX Sliwkowski</name></author><author><name sortKey="Osborne, Ck" uniqKey="Osborne C">CK Osborne</name></author><author><name sortKey="Perez, Ea" uniqKey="Perez E">EA Perez</name></author><author><name sortKey="Puglisi, F" uniqKey="Puglisi F">F Puglisi</name></author><author><name sortKey="Gianni, L" uniqKey="Gianni L">L Gianni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mustacchi, G" uniqKey="Mustacchi G">G Mustacchi</name></author><author><name sortKey="Puglisi, F" uniqKey="Puglisi F">F Puglisi</name></author><author><name sortKey="Molino, Am" uniqKey="Molino A">AM Molino</name></author><author><name sortKey="Crivellari, D" uniqKey="Crivellari D">D Crivellari</name></author><author><name sortKey="Ghiotto, C" uniqKey="Ghiotto C">C Ghiotto</name></author><author><name sortKey="Ferro, A" uniqKey="Ferro A">A Ferro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Russell, Sd" uniqKey="Russell S">SD Russell</name></author><author><name sortKey="Blackwell, Kl" uniqKey="Blackwell K">KL Blackwell</name></author><author><name sortKey="Lawrence, J" uniqKey="Lawrence J">J Lawrence</name></author><author><name sortKey="Pippen, Je" uniqKey="Pippen J">JE Pippen</name></author><author><name sortKey="Roe, Mt" uniqKey="Roe M">MT Roe</name></author><author><name sortKey="Wood, F" uniqKey="Wood F">F Wood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bonifazi, M" uniqKey="Bonifazi M">M Bonifazi</name></author><author><name sortKey="Franchi, M" uniqKey="Franchi M">M Franchi</name></author><author><name sortKey="Rossi, M" uniqKey="Rossi M">M Rossi</name></author><author><name sortKey="Moja, L" uniqKey="Moja L">L Moja</name></author><author><name sortKey="Zambelli, A" uniqKey="Zambelli A">A Zambelli</name></author><author><name sortKey="Zambon, A" uniqKey="Zambon A">A Zambon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author><author><name sortKey="Long, Jb" uniqKey="Long J">JB Long</name></author><author><name sortKey="Hurria, A" uniqKey="Hurria A">A Hurria</name></author><author><name sortKey="Owusu, C" uniqKey="Owusu C">C Owusu</name></author><author><name sortKey="Steingart, Rm" uniqKey="Steingart R">RM Steingart</name></author><author><name sortKey="Gross, Cp" uniqKey="Gross C">CP Gross</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tarantini, L" uniqKey="Tarantini L">L Tarantini</name></author><author><name sortKey="Gori, S" uniqKey="Gori S">S Gori</name></author><author><name sortKey="Faggiano, P" uniqKey="Faggiano P">P Faggiano</name></author><author><name sortKey="Pulignano, G" uniqKey="Pulignano G">G Pulignano</name></author><author><name sortKey="Simoncini, E" uniqKey="Simoncini E">E Simoncini</name></author><author><name sortKey="Tuccia, F" uniqKey="Tuccia F">F Tuccia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Romond, Eh" uniqKey="Romond E">EH Romond</name></author><author><name sortKey="Jeong, Jh" uniqKey="Jeong J">JH Jeong</name></author><author><name sortKey="Rastogi, P" uniqKey="Rastogi P">P Rastogi</name></author><author><name sortKey="Swain, Sm" uniqKey="Swain S">SM Swain</name></author><author><name sortKey="Geyer, Ce" uniqKey="Geyer C">CE Geyer</name></author><author><name sortKey="Ewer, Ms" uniqKey="Ewer M">MS Ewer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vaz Luis, I" uniqKey="Vaz Luis I">I Vaz-Luis</name></author><author><name sortKey="Keating, Nl" uniqKey="Keating N">NL Keating</name></author><author><name sortKey="Lin, Nu" uniqKey="Lin N">NU Lin</name></author><author><name sortKey="Lii, H" uniqKey="Lii H">H Lii</name></author><author><name sortKey="Winer, Ep" uniqKey="Winer E">EP Winer</name></author><author><name sortKey="Freedman, Ra" uniqKey="Freedman R">RA Freedman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tonyali, O" uniqKey="Tonyali O">O Tonyali</name></author><author><name sortKey="Coskun, U" uniqKey="Coskun U">U Coskun</name></author><author><name sortKey="Sener, N" uniqKey="Sener N">N Sener</name></author><author><name sortKey="Inanc, M" uniqKey="Inanc M">M Inanc</name></author><author><name sortKey="Akman, T" uniqKey="Akman T">T Akman</name></author><author><name sortKey="Ulas, A" uniqKey="Ulas A">A Ulas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Puglisi, F" uniqKey="Puglisi F">F Puglisi</name></author><author><name sortKey="Fontanella, C" uniqKey="Fontanella C">C Fontanella</name></author><author><name sortKey="Amoroso, V" uniqKey="Amoroso V">V Amoroso</name></author><author><name sortKey="Bianchi, Gv" uniqKey="Bianchi G">GV Bianchi</name></author><author><name sortKey="Bisagni, G" uniqKey="Bisagni G">G Bisagni</name></author><author><name sortKey="Fontana, A" uniqKey="Fontana A">A Fontana</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stachowiak, P" uniqKey="Stachowiak P">P Stachowiak</name></author><author><name sortKey="Kornacewicz Jach, Z" uniqKey="Kornacewicz Jach Z">Z Kornacewicz-Jach</name></author><author><name sortKey="Safranow, K" uniqKey="Safranow K">K Safranow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Katsurada, K" uniqKey="Katsurada K">K Katsurada</name></author><author><name sortKey="Ichida, M" uniqKey="Ichida M">M Ichida</name></author><author><name sortKey="Sakuragi, M" uniqKey="Sakuragi M">M Sakuragi</name></author><author><name sortKey="Takehara, M" uniqKey="Takehara M">M Takehara</name></author><author><name sortKey="Hozumi, Y" uniqKey="Hozumi Y">Y Hozumi</name></author><author><name sortKey="Kario, K" uniqKey="Kario K">K Kario</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cardinale, D" uniqKey="Cardinale D">D Cardinale</name></author><author><name sortKey="Colombo, A" uniqKey="Colombo A">A Colombo</name></author><author><name sortKey="Torrisi, R" uniqKey="Torrisi R">R Torrisi</name></author><author><name sortKey="Sandri, Mt" uniqKey="Sandri M">MT Sandri</name></author><author><name sortKey="Civelli, M" uniqKey="Civelli M">M Civelli</name></author><author><name sortKey="Salvatici, M" uniqKey="Salvatici M">M Salvatici</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Tolaney, Sm" uniqKey="Tolaney S">SM Tolaney</name></author><author><name sortKey="Barry, Wt" uniqKey="Barry W">WT Barry</name></author><author><name sortKey="Dang, Ct" uniqKey="Dang C">CT Dang</name></author><author><name sortKey="Yardley, Da" uniqKey="Yardley D">DA Yardley</name></author><author><name sortKey="Moy, B" uniqKey="Moy B">B Moy</name></author><author><name sortKey="Marcom, Pk" uniqKey="Marcom P">PK Marcom</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Kristeleit, Hartmut" sort="Kristeleit, Hartmut" uniqKey="Kristeleit H" first="Hartmut" last="Kristeleit">Hartmut Kristeleit</name></region><name sortKey="Beresford, Mark" sort="Beresford, Mark" uniqKey="Beresford M" first="Mark" last="Beresford">Mark Beresford</name><name sortKey="Beresford, Mark" sort="Beresford, Mark" uniqKey="Beresford M" first="Mark" last="Beresford">Mark Beresford</name><name sortKey="Kelleher, Muireann" sort="Kelleher, Muireann" uniqKey="Kelleher M" first="Muireann" last="Kelleher">Muireann Kelleher</name><name sortKey="Lazarus, Loren" sort="Lazarus, Loren" uniqKey="Lazarus L" first="Loren" last="Lazarus">Loren Lazarus</name><name sortKey="Macpherson, Iain R" sort="Macpherson, Iain R" uniqKey="Macpherson I" first="Iain R." last="Macpherson">Iain R. Macpherson</name><name sortKey="Parton, Marina" sort="Parton, Marina" uniqKey="Parton M" first="Marina" last="Parton">Marina Parton</name><name sortKey="Sharma, Rajan" sort="Sharma, Rajan" uniqKey="Sharma R" first="Rajan" last="Sharma">Rajan Sharma</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E89 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000E89 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:5054055
|texte= Long-term Follow-up Data from Pivotal Studies of Adjuvant Trastuzumab in Early Breast Cancer
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27181019" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |